Amit Anthwal

Amit Anthwal
Uttaranchal University | UIT · Department of Chemistry

Ph.D.

About

7
Publications
4,234
Reads
How we measure 'reads'
A 'read' is counted each time someone views a publication summary (such as the title, abstract, and list of authors), clicks on a figure, or views or downloads the full-text. Learn more
139
Citations
Citations since 2016
1 Research Item
125 Citations
201620172018201920202021202205101520
201620172018201920202021202205101520
201620172018201920202021202205101520
201620172018201920202021202205101520

Publications

Publications (7)
Article
A series of 4-piperidone based curcuminoids were synthesized and anticancer potential of these compounds were evaluated against human myeloid leukemia (KBM5) and colon cancer (HCT116) cell lines. Their anti-inflammatory potential was determined through the down-regulation of of tumor necrosis factor (TNF)-α-induced nuclear factor (NF)-κB. All compo...
Article
Full-text available
In the present study, we investigated In vivo & In vitro anti-diabetic activity of different fractions (petroleum ether, ethyl acetate and methanolic) of aerial part of Roylea cinerea. In vivo method Glibenclamide, an oral hypoglycemic agent was used as a positive control against alloxan-induced diabetic rats and In vitro method all three fractions...
Article
Full-text available
Hydantoins and chalcones both are the privileged pharmacophores with significant importance in medicinal chemistry. A series of eleven hydantoin-chalcone conjugates was synthesized and virtually screened for its physico-chemical properties . Molinspiration and Osiris software were used for theoretical prediction of physic oc he mic al properties of...
Article
Full-text available
In a search of new compounds active against cancer, synthesis of a series of C-5 curcumin analogues was carried out. The new compounds demonstrated good cytotoxicity against chronic myeloid leukemia (KBM5) and colon cancer (HCT116) cell lines. Further, these compounds were found to have better potential to inhibit TNF- α -induced NF- κ B activation...
Article
Full-text available
A series of C5-curcumin bearing morpholine based dithiocarbamates was synthesized. Molinspiration and Osiris software were used for theoretical prediction of physico-chemical properties of these molecules and the majority of the hybrids showed theoretical physico-chemical properties similar or better than curcumin. These hybrids (4a-4v) were evalua...
Article
Full-text available
Trichomoniasis is the most prevalent, curable sexually transmitted disease (STD), which increases risk of viral STDs and HIV. However, drug resistance has been developed by some strains of Trichomonas vaginalis against Metronidazole (MTZ), the FDA approved drug against trichomoniasis. In the present study twenty two chalcone hybrids of metronidazol...
Article
Full-text available
The potential of higher plants as a source of new drugs is still largely unexplored. Among the estimated 2.5-5 lakh plant species, only a small percentage has been investigated phytochemically and the fraction submitted to biological or pharmacological screening is even smaller. Cumulative studies have revealed that lauraceous plants, particularly...

Network

Cited By