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Introduction
Education
September 2015 - December 2015
March 2014 - August 2015
Ackerman Academy of Dermatopathology
Field of study
- Dermatopathology
October 2010 - May 2014
Publications
Publications (82)
Background:
Precancerous high grade squamous intraepithelial lesion (HSIL), the current consensus terminology for anogenital squamous cell carcinoma in situ, often presents with distinctive histopathologic findings that may be a function of anatomic site or associated human papillomavirus infection.
Methods:
Fifty-six specimens of anogenital HSI...
Background:
Diagnosis of lupus erythematosus (LE) in direct immunofluorescence testing is based on the finding of positive immunofluorescence at the dermoepidermal junction (DEJ).
Objectives:
We sought to evaluate the sensitivity of IgM deposition at the DEJ and adnexal structures in the diagnosis of lupus erythematosus.
Methods:
We conducted...
Background:
Many authors have described cytologic features in a variety of melanocytic lesions but, to our knowledge, a statistical analysis of sensitivity, specificity, and overall accuracy of these features alone or in combination has not been performed.
Objective:
We sought to determine the diagnostic value of nuclear and cytoplasmic characte...
Available at: http://emedicine.medscape.com/article/1134475-overview
Available at: http://emedicine.medscape.com/article/1122381-overview.
Treatment of onychomycosis includes topical and systemic agents. However, prolonged use of oral treatment could cause adverse effects and topical antifungal agents have limited penetration. To compare the clinical efficacy and the safety of fractional CO2 laser combined with topical tioconazole nail solution versus Q-switched 1064 Nd: YAG laser in...
Background
Micronized acellular dermal matrix (mADM) can induce tissue regeneration and repair, and filling.
Objectives
The efficacy and safety of (mADM) were evaluated in the treatment of atrophic acne scar.
Methods
In this single‐blinded, self‐controlled, split‐face study, 16 patients (48 scar sites) were divided into treatment group (24 scar s...
Epithelioid hemangioma (EH), also known as angiolymphoid hyperplasia with eosinophilia, is an unusual vascular proliferation that tends to manifest in the head and neck region. Its occurrence on the penis is rare, with only scarce reported cases in the literature. The histopathological examination of this condition poses a challenge because it shar...
Mycosis fungoides (MF) is the most common type of primary cutaneous T-cell lymphomas. This article discusses the management of MF at our institute in view of the international guidelines with modifications according to the available facilities and suggested a stepwise algorithm for management of different stages of MF focusing mainly on early stage...
Pemphigus vulgaris is a chronic autoimmune bullous disease, which requires long-term treatment with immunosuppressive drugs that are associated with many complications. Iatrogenic Kaposi's sarcoma (KS) is a variant of Kaposi sarcoma that might complicate long-term immunosuppressive therapy. Here, we report a pemphigus vulgaris patient who developed...
Background:
When peribulbar infiltrates are absent, other histopathologic findings are necessary to distinguish alopecia areata (AA) from pattern hair loss (PHL). The purpose of this study is to determine which histopathologic features are most useful for differentiation.
Methods:
A retrospective slide review was conducted of AA and PHL scalp bi...
The exact aetiology of pityriasis lichenoides chronica (PLC) remains unknown. While phototherapy is the most investigated therapeutic modality, azithromycin has been used scarcely. The aim of this study is to evaluate the therapeutic efficacy of azithromycin in the treatment of PLC compared to NB-UVB and evaluating the presence of streptococcal inf...
Background and objective:
New and improved treatment modalities, including lasers and energy-based devices, are promising treatment options for hypertrophic scars. This study aimed to assess the efficacy and safety of fractional microneedle radiofrequency (FMR) compared with fractional carbon dioxide (CO2 ) laser in the treatment of postburn hyper...
Background and aims
The level of albuminuria is used to evaluate diabetic nephropathy (DN). However, to detect or predict the early stages of DN, better biomarkers are needed.
Methods
This study is a case-control observational study. 80 Egyptians participated in the study: 60 patients with type 2 diabetes mellitus (T2DM) were divided into three gr...
Lucio phenomenon, or Lucio leprosy, is a rare severe lepra reaction that develops exclusively in patients with diffuse nonnodular lepromatous leprosy. It is characterized by irregular, angulated, or stellar necrotizing purpuric lesions that develop ulcerations. It mainly involves the extremities and develops as a result of massive invasion of vascu...
Background/Objectives
Pityriasis lichenoides chronica (PLC) lesions are reported to subside with post-inflammatory hypopigmentation (PIH); hence, the most widely perceived nature of hypopigmented macules in PLC is PIH. However, to the best of our knowledge, no studies describing histopathological findings in these lesions are reported in literature...
Purpose of review:
The main purpose of this review is to present newly reported cutaneous manifestations of systemic vasculitis, updates in investigations to verify systemic involvement in cases with cutaneous vasculitis and new therapeutic guidelines. The spectrum of COVID-19-related vasculitis is also covered.
Recent findings:
Only a few repor...
Background
In December 2020, Moderna released the mRNA-1273 vaccine. The most common side effects are headache, muscle pain, redness, swelling, and tenderness at the injection site. In addition, there have been dermatological adverse events, such as hypersensitivity reactions. Although rare, various bullous eruptions have been described following v...
To the editor,
While the whole world started Coronavirus Disease 2019 (COVID-19) vaccine campaign aiming at ending the pandemic other areas of the world started to suffer from a devastating new complication of the disease. Increased cases of COVID-19 Associated Mucormycosis (CAM) has been noted [[1], [2], [3]]. We had observed this phenomenon in Eg...
Since the start of the COVID-19 pandemic, a wide range of clinical pictures have been documented ranging from asymptomatic cases to respiratory failure. Accumulating evidence of co-infection and reactivation of viruses during COVID-19 started to emerge. Herein we report three cases of herpes virus reactivation in severely ill COVID-19 patients. Wit...
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Abstract
The Coronavirus disease 2019 (COVID‐19) pandemic spreads quickly all over the world. There are no sufficient data in the literature about COVID‐19 infection and cutaneous lymphomas. This review sheds the light on what is known so far about COVID‐19 with a cutaneous lymphoma perspective. Cutaneous T‐cell lymphoma (CTCL) diag...
Introduction: Over 4.9 million cases of Coronavirus disease 2019 (COVID-19) have been confirmed since the worldwide pandemic began. Since the emergence of COVID-19, a number of confirmed cases reported autoimmune manifestations. Herein, we reviewed the reported COVID-19 cases with associated autoimmune manifestations.
Methods: We searched PubMed d...
Click here for the corresponding questions to this CME article.
The Reclassification Working Group of the Histiocyte Society has adopted a stratification system by dividing Langerhans cell histiocytosis (LCH) into two major categories based on the extent of the disease: “Single‐system” LCH (SS‐LCH) and “Multi‐system” LCH (MS‐LCH).1 We reviewed findings in 43 patients presenting with cutaneous lesions of LCH fro...
Pemphigus vulgaris is an autoimmune disorder with many clinical variants. In this report, we present a 57-year-old female patient who presented with unilateral acral erosions, pustulations, and crusts, which was diagnosed as localized pemphigus vulgaris, which is a very rare variant of pemphigus.
Background:
Organ transplant recipients are vulnerable to multiple infectious agents and in a world with a circulating SARS-CoV-2 virus, it would be expected that patients who are immunosuppressed would have higher mortality.
Objective:
To determine the COVID-19 mortality in transplant recipients.
Methods:
We conducted a search in PubMed and G...
https://emedicine.medscape.com/article/1074054-overview
Necrolytic acral erythema is a distinct erythema that has been described as an extrahepatic manifestation of hepatitis C virus infection. Most reported cases have been in Africa, especially Egypt. We report the first case (to the best of our knowledge) of necrolytic acral erythema in a Chinese patient with HCV and HBV coinfection. We aim to increas...
Background:
Interpretation of Clark's nevi has generated debate over the years; although criteria has been proposed for grading morphological features of melanocytes, there is still confusion and variability in the assessment of these lesions.
Methods:
This is a retrospective observational study conducted on 100 Clark's nevi and 84 melanomas. A...
A 32-year-old man presented with an asymp-tomatic pigmented lesion on the left foot that developed over the course of 4 months. Physical examination revealed a 4-cm asymmetrical, deeply pigmented macule on the left foot. A shave biopsy of the lesion was performed. WHAT'S THE DIAGNOSIS? a. lentigo maligna b. lichen aureus c. purpura annularis telang...
Spitzoid melanocytic neoplasms, which consist of Spitz nevi, atypical Spitz tumors, and spitzoid melanomas, are difficult to distinguish from one another by light microscopy. Further information regarding spitzoid melanocytic neoplasms can aid in the diagnosis. The objective of this study was to review the current literature concerning spitzoid mel...
Background:
Paget disease, Bowen disease, and malignant melanoma in situ are intraepidermal neoplasms, characterized by the presence of pagetoid scatter of atypical cells in the epidermis. This study reviewed the frequency of select histologic criteria to validate their usefulness in the histologic distinction between these entities.
Methods:
On...
A 54-year-old man presented with a flesh-colored lesion on the chin. The nodule measured 0.6 cm in diameter. There was an underlying scle-rotic plaque with indistinct borders. What's the diagnosis? a. benign intradermal melanocytic nevus b. collision tumor c. desmoplastic trichoepithelioma d. microcystic adnexal carcinoma e. morpheaform basal cell...
Over the past decade or so, the treatment of patients with psoriasis has been revolutionized by the development of the biological agents,monoclonal antibodies that target specific aspects of the inflammatory cascades. The biologic agents approved by the Food and Drug Administration for psoriasis and psoriatic arthritis include adalimumab, etanercep...
A middle-aged woman with Fitzpatrick skin type IV was evaluated for progressive hyperpigmentation of several months' duration involving the neck, jawline, both sides of the face, and forehead. The lesions were mildly pruritic. She denied contact with any new substance and there was no history of an eruption preceding the hyperpigmentation. Medical...
Over the past decade or so, the treatment of patients with psoriasis has been revolutionized by the development of the biological agents,monoclonal antibodies that target specific aspects of the inflammatory cascades. The biologic agents approved by the Food and Drug Administration for psoriasis and psoriatic arthritis include adalimumab, etanercep...
Lupus erythematosus panniculitis, also known as lupus profundus, is a variant in the clinicopathological spectrum of lupus erythematosus (LE) affecting about 2%-3% of LE patients. A linear configuration of LE panniculitis has been reported rarely with rare reports describing the coexistence of different forms of cutaneous LE and localized morphea....
A 26-year-old healthy man was evaluated for a slowly growing, asymptomatic lesion on the medial aspect of his thigh of one year duration. The patient denied any history of trauma at the site. Physical examination revealed an indurated, nontender, brown, hyperkeratotic plaque on the medial side of his thigh [Figure 1]. The inguinal lymph nodes were...
Background:
The histopathologic features of tinea vary widely and its diagnosis could be easily missed if the index of suspicion is not high. We aimed in this study to detect histopathologic features that could be a clue for diagnosis
Methods:
We retrospectively reviewed 103 cases of tinea, confirmed by Periodic acid-Schiff (PAS) staining. For e...
Hidradenoma papilliferum is a benign cutaneous adnexal neoplasm, commonly occurring in the vulva and perianal region of adult women. It has characteristic histopathological features composed of anastomosing and branching tubules, lined by columnar cells, and a basal layer of myoepithelial cells. A 39-year-old woman was evaluated for 2 asymptomatic...
DEAR EDITOR, A 26-year-old woman presented with an asymp-tomatic linear atrophic lesion on the lower part of the right cheek. The lesion was of nine years' duration and had a very slowly progressive course. The lesion appears as multiple grouped skin-coloured pits taking a linear distribution, measuring about 6 cm in length and following Blaschko's...
Alterations in dermal collagen are noted in dermatofibroma, dermatofibrosarcoma protuberans, morphea, lichen sclerosus et atrophicus, hypertrophic scars, and keloids. The authors sought to determine whether variations in birefringence of collagen by polarized microscopy could be of help in diagnosing such conditions. Representative hematoxylin and...
Skin infections result from microbial invasion of the skin. They vary in their etiology, clinical presentation, and severity. Accurate diagnosis is important as these conditions may mimic other cutaneous inflammatory diseases. This review summarizes the common, emerging, and dangerous skin infections and their clinical presentation and management....
Fungal organisms could be present in the
nail without any clinical manifestations. As
onychomycosis in diabetics has more serious
complications, early detection of such infection
could be helpful to prevent them. We aim
in this study to assess the possibility of detecting
subclinical onychomycosis in type II diabetic
patients and addressing possibl...
Background:
Prior studies suggested that direct immunofluorescence (DIF) slides can be stored at room temperature.
Objectives:
We sought to determine the durability of DIF slides stored at room temperature for 5 years.
Methods:
This was a retrospective study of 83 DIF slides archived at room temperature during 2010. The pattern of immunoreacta...
Background/Objective: The diagnosis of Majocchi’s granuloma (MG), typically confirmed by fungal stains, may be missed if fungi are absent in the stratum corneum. Our objective was to assess the frequency of fungal stain negativity in the stratum corneum of (MG) and histologic features.
Methods: 35 cases of MG were obtained from the files of the Ack...
A 32-year-old man was evaluated for a pigmented lesion on his left foot that had
developed over the course of 4 months. Physical examination revealed an irregular,
asymmetrical, brown-red, deeply-pigmented macule measuring 4 3 3 cm on the left
foot surrounded by scattered smaller, golden-brown macules. The clinical appearance
was concerning for mel...
Available at: http://emedicine.medscape.com/article/1055606-overview.
Available at: http://emedicine.medscape.com/article/909807-overview.
Available at: http://emedicine.medscape.com/article/1110271-overview.
Background. Pemphigus vulgaris is an autoimmune vesiculobullous disease, affecting the skin and mucous membranes. It is reported to be associated with other autoimmune diseases including autoimmune thyroid diseases. However we report herein a case of pemphigus vulgaris associated with autonomous toxic nodule. Case Presentation. A 51-year-old woman...