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Publications (6)
Anxiety continues to represent a major unmet medical need. Despite the availability of numerous anxiolytic drugs, a large proportion of patients do not respond well to current pharmacotherapy, or their response diminishes with chronic drug application. To discover novel compounds and to investigate the mode of action of anxiolytic drugs, animal mod...
Ethanol consumption is a worldwide problem. Sensitivity to acute effects of ethanol
influences the development of chronic ethanol abuse and ethanol dependence.
Environmental and genetic factors have been found to contribute to differential effects
of acute ethanol. Animal models have been employed to investigate these factors. An
increasingly frequ...
Alcoholism and alcohol abuse represent a significant medical and societal problem,
and have been thoroughly investigated in humans as well as using animal models. A
less well understood aspect of alcohol related disorders is the possible effect of this
drug on offspring whose parents were exposed prior to conception. The zebrafish has
been successf...
The zebrafish has become increasingly utilized in behavioral neuroscience,
psychopharmacology, and behavior genetics research. However, little attention has
been paid to the potential effects of environmental conditions fish are exposed to
before and during behavioral testing. One such important factor is temperature, more
specifically, the differe...
Fetal Alcohol Spectrum Disorders (FASD) represent a worldwide problem. The severity and types of symptoms of FASD vary, which may be due to the genotype of the fetus and the developmental stage at which the fetus is exposed to alcohol. The most prevalent forms of FASD present less severe symptoms, including behavioral and cognitive abnormalities, a...
In recent years, Danio rerio (zebrafish) have increasingly been used as a laboratory organism to model and investigate CNS diseases and vertebrate behaviour. Several studies have analyzed learning and memory in adult zebrafish. However, juvenile zebrafish have only rarely been utilized for this purpose due to the paucity of learning paradigms. One...