Amir Lass

Amir Lass
Haipharm Ltd.

Doctor of Medicine

About

105
Publications
59,004
Reads
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2,919
Citations
Citations since 2017
29 Research Items
536 Citations
2017201820192020202120222023020406080
2017201820192020202120222023020406080
2017201820192020202120222023020406080
2017201820192020202120222023020406080
Additional affiliations
February 2010 - December 2013
Teva pharmaceuticals
Position
  • VP medical affairs Europe
January 2006 - present
haipharm Ltd
Position
  • Consultant
Description
  • independent medical and clinical development consultancy
July 2001 - December 2005
Serono
Position
  • medical director Northern Europe

Publications

Publications (105)
Article
Full-text available
Purpose: As part of the European risk management plan of a 91-day extended levonorgestrel-containing combined oral contraceptive (COCLNG ), a study was performed to assess its safety. This analysis was conducted to examine delayed pregnancy detection and return to fertility with extended combined oral contraceptives (COC). Methods: We conducted...
Article
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Large global inequalities in assisted reproduction technology (ART) utilisation have existed ever since the introduction of ART. The reasons for these inequalities are multifactorial and include national wealth and affordability, pronatalist policies, regulatory differences in provision, and sociocultural components such as racial, gender and educa...
Article
Objectives: To compare the safety profile of Seasonique, a 91-day levonorgestrel-containing combined oral contraceptive (COCLNG), to 28-day COCLNG regarding the risk of venous thromboembolism (VTE) and arterial thromboembolism (ATE). Study Design: A new user cohort study was conducted in a US healthcare database from 2006-2017. Each 91-day COCLNG t...
Article
Study question Are safety and effectiveness of Ovaleap® (follitropin alfa), and Gonal-f®, comparable in one treatment cycle of ART in routine clinical practice? Summary answer Safety in terms of incidence proportions of OHSS and OHSS severity, as well as pregnancy and live birth rates, were similar between Ovaleap® and Gonal-f®. What is known alr...
Article
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Study question Are there any correlations between a country’s wealth determined by GDP per capita and its total fertility rate (TFR) and utilisation of ART in Europe? Summary answer There is strong correlation across Europe between GDP and utilisation of ART. This correlation does not exist when only investigating the European Economic Area (EEA)...
Article
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Aim To explore the relationships between total fertility rate (TFR), utilization of assisted reproduction technology (ART) and gross domestic product (GDP) per capita in Europe Material and Methods Analysis of total ART cycles obtained from the latest European IVF-Monitoring Consortium (EIM) report for 2016. TFR, GDP and population size for that y...
Article
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Background Ovaleap ® (follitropin alfa), a recombinant human follicle stimulating hormone, is a biosimilar medicinal product to Gonal-f ® and is used for ovarian stimulation. The main objective of this study was to assess the safety and effectiveness of Ovaleap ® compared to Gonal-f ® in one treatment cycle in routine clinical practice. Methods Sa...
Article
Full-text available
Objective: As part of the risk management plan in Europe, this study was conducted to characterize drug utilization patterns of Seasonique, a 91-day extended levonorgestrel-containing combined oral contraceptive (COCLNG). Methods: A retrospective observational study was conducted in France, Italy and Belgium using electronic medical record database...
Conference Paper
Full-text available
Objectives To assess the proportion of women as editors, editorial management and editorial board in top ranking journals of obstetrics and gynaecology Methods There are currently 83 journals listed in Incite Citation Journal Reports of https://jcr.clarivate.com in the Obstetrics and Gynaecology category. Of them ,11 journals had impact factor (IF)...
Conference Paper
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Objectives To evaluate attributes to contraceptive among women across sample of large countries in west Europe and central and south America. Methods A quantitative, questionnaire-based, anonymous online survey was conducted in France, Germany, Italy, Spain UK Brazil and Mexico among women respondents aged 18-50 who were sexually active, non-pregna...
Conference Paper
Full-text available
Context The safety profile of Seasonique®, a 91-day levonorgestrel (LNG)-containing oral contraceptive regarding venous thromboembolic events (VTE) risk is not entirely known. Objective To compare risk of VTE, arterial thromboembolism (ATE), infertility, and delayed pregnancy detection among women exposed to Seasonique and those exposed to 28-day c...
Article
Full-text available
IVF is now a wide spread procedure globally, and currently 65 countries report annually all or part of their IVF/ICSI cycles, from which the International Committee Monitoring progress in Assisted Reproduction Technology (ICMART) published its report. There is considerable variation in the utilisation (number of cycles per population) globally. The...
Article
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Omega-3 polyunsaturated fatty acids (PUFAs) are essential fatty acids, derived mostly from fish oil, that have a significant anti-inflammatory effect. Data from animal studies support their role in the reproductive mechanism, and recent human studies suggest a positive effect on sperm quality and natural conception. Their general role in human fert...
Article
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It is very important that broad, sweeping conclusions concerning HRT are not made. It is essential that healthcare professionals, women, and also the media are aware that there are important differences between various HRT products. There is robust evidence demonstrating that transdermal oestrogen in association with natural MP could represent the...
Article
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Background: Despite its high prevalence, opioid-induced constipation (OIC) remains under-recognised and undertreated, and its true impact on wellbeing and quality of life (QoL) may be underestimated. Methods: A quantitative, questionnaire-based international survey was conducted. Results: Weak-opioid users appeared as bothered by constipation...
Article
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Vaginal progesterone via capsule, gel or tablet is the most common route for luteal phase support (LPS) in Europe. Although there is a wealth of data comparing products used at other stages of assisted reproductive technology cycles, there is a lack of systematically identified evidence comparing the wide range of vaginal progesterone products. Thi...
Conference Paper
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Type: Abstract Topic: 06. LOWER GI ﴾EXCLUDING IBD﴿ / 6.11. Lower GI motility disorders: Clinical
Patent
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A device for identifying a drug, the device including at least one sensor for sensing and recording selected characteristics of a drug to be identified for compatibility with a pre-selected drug regimen, elements for transferring the recorded characteristics for analysis, elements for receiving analyzed data of the recorded characteristics, and a d...
Conference Paper
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Fallen soldiers belong to two communities with different needs and perspectives. They are (mostly) young soldiers whose lives were cut short abruptly and who left beyond bereaved families and friends. Their death is a very traumatic personal and private event to their dear ones. But after their death their individuality is blended into a unique res...
Data
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Conference Paper
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Despite recent advances in assessing the impact of psoriasis on quality of life, more data are needed on psychological, social and work-related aspects of the condition. The aim of this study was to fill this knowledge gap. A web-based survey funded by a pharmaceutical company and designed for use in 17 European countries in 2009 included 30 questi...
Article
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The role of LH in sensitizing antral follicles to FSH is unclear. LH is required for normal hormone production and normal oocyte and embryo development, but follicular responses to LH may depend upon the stage of development. Potential roles at the early follicular phase were explored in a clinical setting by employing a sequential approach to stim...
Thesis
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The Israeli military has policy influence without parallel in advanced democracies. At the constitutional level, formal decisions are still ostensibly made by elected political leaders but in fact, the military is an equal, if not superior, partner in this policy process. The balance changes according to circumstance and the identity of the protago...
Article
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The technical advance of recombinant biotechnology to manufacture FSH has resulted in a biochemically pure FSH preparation with high batch-to-batch consistency. The protein content of recombinant human FSH (r-hFSH) can be reliably quantified in mass units by size exclusion high performance liquid chromatography (SE-HPLC) enabling r-hFSH follitropin...
Article
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Ovarian reserve depends on the number of primordial follicles in the ovarian cortex. It was suggested that determining the follicular density directly by obtaining ovarian biopsy might be more accurate than current indirect biochemical and ultrasonic tests, especially for women in the later stage of their reproductive life. It might also be importa...
Article
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To determine whether cycle monitoring using both serum E(2) and ultrasound findings yields superior clinical pregnancy rates during IVF-embryo transfer (ET) compared to monitoring with ultrasound alone. Prospective, randomized, multicenter, patient-blinded study. Four assisted conception units in the United Kingdom. Two hundred ninety-seven women b...
Article
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To assess whether ovarian volume of World Health Organization II anovulatory patients in the early follicular phase predicts the response to ovulation induction with gonadotropins. Retrospective data analysis of two prospective, randomized, multicenter studies. Clinical development unit of biotechnology company. Four hundred sixty-five World Health...
Conference Paper
Article
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To describe the clinical findings, expressions, interactions, and clinical implications of leukemia inhibitory factor (LIF) in human reproduction. Review of published articles. Clinical development unit of biotechnology company. None. In the endometrium, LIF is expressed in a menstrual cycle-dependent manner, with the highest level occurring at the...
Article
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In recent years, the survival of young males suffering from cancer has been improved. Development of new techniques such as IVF and intracytoplasmic sperm injection enables even low quality spermatozoa to be used successfully. It is possible therefore to preserve fertility potential of cancer patients before embarking on adjuvant chemotherapy and r...
Article
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Article
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The pool of primordial follicles in the ovary or `ovarian reserve' is a major factor in the human fertility potential. The ageing ovary is characterized by reduction of the number of primordial follicles and this loss accelerates in the late 30's and precedes the menopause by 10–12 years. Woman's age alone or with a combination of biochemical marke...
Article
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To assess the relevant factors affecting patients' decision when choosing a clinic for private, self-funded IVF treatment. Prospective anonymous closed questionnaires. Single tertiary-care private IVF center. New patients attending primary consultation in a period of 7 months from September 1999 to March 2000.Intervention(s): None. Primary knowledg...
Article
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The case of a 28 year old male with normal male phenotype, in whom repeated seminal analysis showed complete azoospermia, is presented. Peripheral blood culture for chromosome studies revealed 46 chromosomes with XX constitution. Polymerase chain reaction (PCR) analysis of genomic DNA failed to detect the presence of the sex-determining region of t...
Article
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The aim was to evaluate whether women who have early follicular follicle-stimulating hormone (FSH) levels > 12 mIU/ml have reduced response to follicular stimulation for in vitro fertilization (IVF) in a following month, in spite of normal FSH levels. In a 3-year period from January 1996 to December 1998, 303 women aged 38 years and above and/or wh...
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To evaluate the place of cervical dilatation performed at the initial visit in an IVF-ET cycle in patients with known cervical stenosis. Retrospective study. A tertiary care assisted conception unit. Fifty-seven patients who failed to conceive after a previous ET attempt and in whom the ET was classified as "difficult." Cervical dilatation under ge...
Article
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Our purpose was to investigate the effect of endometrial polyps on pregnancy outcome in an in vitro fertilization (IVF) program. Endometrial polyps less than 2 cm in diameter were suspected by transvaginal ultrasound before oocyte recovery in 83 patients. Forty-nine women (Group I) had standard IVF-embryo transfer, while in 34 women (Group II) hyst...
Article
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The incidence of having a single ovary is quite common in infertile patients and can reach up to 17% of women with severe tubal disease who require in-vitro fertilization (IVF) treatment. Data on the short- and long-term implications of having only one ovary are scarce, and patients in this situation are naturally concerned. This article reviews th...
Article
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Practice is essential to alleviate shortage of organs Editor—Nicholson and Bradley call for an increase in the donation of organs from living donors. 1 I have held this view for several years. 2 The negative attitudes of the directors of transplant programmes are one of the main causes of the low rate of living donation in Britain.
Article
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The human ovary is a dynamic organ which continually changes in size and activity through life, as an integral part of the changes that the female is going through before during and after her reproductive life. Following the rapid increase in the use of transvaginal scan in recent years, the measurement of ovarian volume has become quick, accurate...
Article
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To evaluate the results of IVF in women > or = 40 years of age using their own oocytes. Retrospective study. Wolfson and Royal Masonic in vitro fertilization units, London, United Kingdom. A total of 1,087 IVF cycles were started in women > or = 40 years of age. Medical records of patient outcomes were reviewed. Clinical pregnancy, miscarriage, and...
Article
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To investigate the effect of salpingectomy on the response of each ovary in patients undergoing an IVF-ET treatment cycle and to compare the results with those of patients who had not had surgery and were undergoing IVF-ET during the same period. A prospective study. Tertiary referral academic IVF unit. Twenty-nine ET cycles were evaluated in 29 pa...
Article
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The objective of this study was to evaluate the histopathological characteristics of endometrial biopsies taken on the day of oocyte recovery in in-vitro fertilization (IVF) cycles with a satisfactory response to ovulation induction. A group of 33 patients who went through ovulation induction for IVF, and in whom an endometrial polyp was suspected...
Article
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The improved survival in recent years of young males suffering from cancer, and an understanding of the gonadotoxic effects of chemotherapy treatment, have motivated patients and clinicians to preserve fertility potential before embarking on adjuvant therapy. Among 231 men (mean age 28.0; range 15-56 years) diagnosed with malignant disease and refe...
Article
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This study examines the relationship between the first cycle of in-vitro fertilization (IVF) and subsequent cycles. The results of all IVF cycles conducted at The Hammersmith Hospital or The Royal Masonic Hospital between 1988 and 1995 were studied including those cycles where egg recovery was abandoned due to poor ovarian response. All patients un...
Article
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Tumour necrosis factor alpha (TNF-alpha) is a cytokine with pleiotropic effects, modulating cell growth, differentiation, and synthesis of various substances. Recent demonstration of TNF-alpha mRNA and protein in the uteroplacental unit suggests that this cytokine may be involved in the development of the embryo. To determine whether the embryo its...
Article
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This study tests the hypothesis that there is a different response after gonadotrophin-releasing hormone and human menopausal gonadotrophins (GnRH/HMG) stimulation for in-vitro fertilization (IVF) in patients with either a right or left ovary. A total of 56 cycles in 44 women after left oophorectomy (group A) was compared with 42 cycles in 29 women...
Article
Full-text available
The ageing ovary appears to be characterized by depletion of primordial follicles. The relationship between infertility and the number of follicles in the ovarian cortex is not known. Moreover, there are no accurate markers or clinical methods to predict the decline in ovarian reserve. This study investigates the correlation between early follicula...
Article
Full-text available
The study tests the hypothesis that small ovaries measured on transvaginal sonography (TVS) are associated with a poor response to ovulation induction by human menopausal gonadotrophin (HMG) for in-vitro fertilization (IVF). A total of 140 infertile patients with morphologically normal ovaries undergoing IVF was studied. The mean ovarian volume of...
Article
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The study compares the response after gonadotrophin-releasing hormone agonist (GnRHa) and human menopausal gonadotrophin (HMG) stimulation for in-vitro fertilization (IVF) in patients with either one or two ovaries. The study group (group A) included 73 cycles in women who had unilateral oophorectomy before their IVF treatment and the control group...