Amir Haider

Amir Haider
University of Karachi · Department of Chemistry

Ph.D.

About

14
Publications
57,508
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67
Citations
Additional affiliations
September 2004 - present
University of Karachi
Position
  • tricyclic amines phamaceutical importance and antiviral activity
Description
  • organic synthesis
Education
September 2004
University of Karachi
Field of study
  • during reasearch found new compounds potentially active against H5N1.

Publications

Publications (14)
Article
The fresh specimens of Champia compressa Harvey, Gelidium usmanghanii Afaq-Husain and M. Shameel, Gracilaria foliifera (Forsskål) Børgesen and Hypnea musciformis (Wulfen) J. V. Lamouroux, were collected from the coastal areas of Karachi (Pakistan) and their yield of agar was observed. With preextraction technique the percentage of algal yield was f...
Article
Full-text available
The study was conducted to explore bioremediation potential of four commonly growing grass species e.g. Khabal (Cynodon dactylon) (Linnaeus) Persoon, Vetiver (Vetiveria zizanioides) (Linnaeus) Nash, Elephant (Pennisetum purpureum) Schumach. and jungle rice (Echinochloa colona) (Linnaeus) Link, common inhabitants of industrial disposal point, Sharaf...
Article
Full-text available
In the present study the 2-methylpropanamide and benzamide derivatives of carboxyterfenadine, have been synthesized by nucleophilic substitution at carboxylic acid moiety (C-33) of tertiary carbon C-19 substituted with benzene ring. The proficient and high yielding series was carried out in two steps by continuous monitoring with TLC. The carboxyli...
Article
Carboxyterfenadine, a primary metabolite of terfenadine, a second generation antihistaminic compound was introduced in therapy as a successor of terfenadine due to its cardiac arrhythmia. There are number of drug interactions of fexofenadine with erythromycin, ketoconazole and alike reported in the literature. In this paper, fexofenadine antacid in...
Article
Pregabalin an antiepileptic was the first compound approved by FDA for treating chronic pain. A sensitive, efficient, economical, environmental friendly and isocratic liquid chromatographic method for the determination of pregabalin in bulk drug, pharmaceutical dosage forms and human serum has been developed and validated according to ICH guideline...
Article
Full-text available
A simple, rapid, and sensitive high-performance liquid chromatography method was developed and validated for the simultaneous determination and quantification of fusidic acid and steroids (prednisone, betamethasone valerate, hydrocortisone acetate, and dexamethasone sodium) from bulk drugs and human plasma. A RP-HPLC, operated at ambient temperatur...
Article
Full-text available
Carboxyterfenadine, a primary metabolite of terfenadine, a second generation antihistaminic compound was introduced in therapy as a successor of terfenadine due to its cardiac arrhythmia. There are number of drug interactions of fexofenadine with erythromycin, ketoconazole and alike reported in the literature. In this paper, fexofenadine antacid in...
Article
Full-text available
Fexofenadine is a second generation H1-receptor antagonist, much widely used due to its non-sedative effects. The in vitro availability of fexofenadine in the presence of H2-receptor antagonist (cimetidine, ranitidine and famotidine) was studied on a BP 2005 dissolution test apparatus to observe the kinetics and energies of fexofenadine in the pres...
Article
Full-text available
An in vitro availability of fexofenadine in the presence of quinolones (enoxacin, levofloxacin and sparfloxacin) was carried out on a BP 2005 dissolution test apparatus. Fexofenadine second generation non sedative H1 receptor antagonist is an active carboxylic acid metabolite of terfenadine. These reactions were performed at different pH environmen...
Article
Amantadine was discovered in petroleum and name is derived from Greek name adamantinos (relating to steel or diamond), due to its diamond-like structure. The in vitro availability of H 1 and H 2-receptor Antagonists, Cephalosporins, ACE-inhibitors, Hydrochlorothiazide, NSAIDs and Quinolones with Amantadine was studied on a Compact Dissolution Test...
Article
Full-text available
Fexofenadine is a non-sedative and selective peripheral H1 receptor antagonist prescribed for allergic rhinitis and chronic urticaria. This article deals with a simple, feasible, and sensitive isocratic reverse-phase high-performance liquid chromatographic method for the determination of fexofenadine hydrochloride in bulk drug, pharmaceutical dosag...

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