Amir A Azari

Wills Eye Hospital · Cornea

Purpose: To describe demographic and clinical characteristics of patients with graft failure after keratoplasty, determine the cause of graft failure and outcomes. Methods: The charts of patients between 2008-2013 in the Cornea Service at Wills Eye Hospital with a history of a corneal transplant before the end of 2012 were retrospectively review...

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Conjunctivitis is a commonly encountered condition in ophthalmology clinics throughout the world. In the management of suspected cases of conjunctivitis, alarming signs for more serious intraocular conditions, such as severe pain, decreased vision, and painful pupillary reaction, must be considered. Additionally, a thorough medical and ophthalmic h...

During the planning meeting for the Collaborative Ocular Melanoma Study (COMS) prior to the start of patient recruitment in 1986, there was an interest expressed in determining whether a relationship existed between the presence of uveal melanoma (UM) and asteroid hyalosis (AH). To answer this question, the ophthalmic examination form (unlike the p...

Purpose: Long-standing corneal edema can lead to anterior stromal scarring that may limit visual acuity following Descemet stripping endothelial keratoplasty (DSEK). The ideal time to perform DSEK to prevent permanent changes is unclear. Our aim is to determine whether earlier DSEK is associated with improved visual outcomes. Design: Cohort stud...

Purpose: To review the indications and outcomes of children undergoing primary penetrating keratoplasty and identify prognostic factors for graft survival. Design: Retrospective, interventional case series. Methods: Medical records of every child 12 years of age or younger who underwent primary penetrating keratoplasty at Wills Eye Hospital Co...

Endothelial keratoplasty, most commonly Descemet’s stripping endothelial keratoplasty (DSEK), has become the procedure of choice for endothelial diseases. DSEK provides many unique advantages compared to traditional penetrating keratoplasty; these includes smaller risk of suprachoroidal hemorrhage during the surgery, minimal to no induced astigmati...

Purpose: To evaluate the treatment of autologous serum eye drops (ASED) on dry eyes in patients with graft-versus-host disease (GVHD). Methods: A retrospective chart review of 35 patients with history of ocular GVHD following hematopoietic stem cell transplantation (HSCT) that used ASED to alleviate dry eye symptoms was performed. Patients were...

Purpose: To evaluate the results of trocar-assisted, sutureless, scleral-fixated (SSF) intraocular lens (IOL) implantation combined with penetrating keratoplasty (PKP). Methods: This study comprised 4 eyes (4 patients) undergoing trocar-assisted SSF-IOL implantation during PKP. The combined technique was performed in 3 eyes of 3 patients with bu...

Purpose: Penetrating keratoplasties (PKs) carry a lifetime risk of developing wound dehiscence, which can lead to severe consequences to vision. To better understand the risk, we analyzed the characteristics and outcomes of a series of patients with wound dehiscence post-PK. Methods: Data were collected retrospectively on 31 eyes from 30 patient...

Fyodorov–Zuev keratoprosthesis is one of the oldest designs for the artificial cornea. This implant was developed in Russia and it is widely used in Russia and China but not well known to the rest of the world. The implant consists of a titanium plate which is embedded within the corneal stroma and an optical cylinder which is in contact with the...

A fully updated version of this popular, clinically oriented, user-friendly text on infectious disease, with even more helpful graphics, tables, algorithms and images. It is packed full of information on diagnosis, differential diagnosis and therapy. In addition to the traditional organization of organ-system and pathogen-related information, this...

The aim of this study was to review the demographics, causative organisms, seasonal and geographic variation, and antimicrobial resistance patterns of microbial keratitis at our institution over a 4-year period. Electronic medical records of all patients with microbial keratitis who underwent corneal culturing at a single institution in eastern Pen...

To examine the evidence for the role of autologous serum eye drops (ASD) in disease of the ocular surface. A search of the literature published through May 2014 using PubMed, the ISI Web of Knowledge database, and the Cochrane Library was performed. Qualified articles were selected after review of titles, abstracts, and references. There was a sign...

The objective of this study was to determine whether resveratrol or a defined, reconstituted grape powder can attenuate the formation of new blood vessels in a mouse model of choroidal neovascularization (CNV). To accomplish this objective, C57BL/6J mice were randomized into control or treatment groups which received either resveratrol or grape pow...

This chapter provides basic and useful information about handling and processing eye specimens as well as diagnosing common diseases encountered by ophthalmic pathologists. Each section is devoted to a specific part of the eye (cornea, conjunctiva, iris and cilliary body, choroid, retina, vitreous, and the optic nerve), providing useful pearls abou...

A 23-year-old man presented with a 2-year history of a slow growing lesion in the left eye. The lesion consisted of a vascularized, balloon-like mass straddling the limbus nasally (A). Histopathologic examination demonstrates (B) a conjunctival epithelium with solar elastosis, consistent with a pterygium (left side), and proliferation of melanocyti...

Purpose: To evaluate the refractive error quality of life (RQL) improvement, patient satisfaction, and clinical results of laser refractive surgery performed by residents or fellows. Setting: Department of Ophthalmology and Visual Sciences, University of Wisconsin, Madison, USA. Design: Case series. Methods: This study reviewed the clinical...

Aim: To report the cytology results of 25-gauge transconjunctival (25G-TSV) diagnostic vitrectomy in cases suspicious for intraocular lymphoma (IOL), and compare the results to those reported in the literature. Methods: Clinical and cytopathological records of 18 vitreous biopsy specimens obtained via 25G-TSV diagnostic vitrectomy in 12 patients...

Purpose: To review the frequency and cause of traumatic enucleation at the University of Wisconsin. Methods: A 12-year retrospective chart review (2000-2012) from the University of Wisconsin Hospital and Clinics of patients who underwent enucleation following ocular trauma with specimens submitted to the University of Wisconsin Eye Pathology Lab...

Figure 1. A 77-year-old man presented with corneal neovascularization and haze unresponsive to topical and subconjunctival steroids. Histopathology reveals corneal and conjunctival tissues with atypia of the surface epithelium (cytokeratin AE/AE3 [A]). The corneal stroma is infiltrated with atypical squamoid cells staining positive with cytokeratin...

Importance: To report the clinical and histopathologic findings of ocular adnexal angiolymphoid hyperplasia with eosinophilia, an unusual but often misdiagnosed benign disorder. Observations: The ophthalmologic findings of angiolymphoid hyperplasia with eosinophilia with ocular adnexal involvement are variable and include eyelid swelling, ptosis...

Importance Schnabel cavernous degeneration (SCD) has been observed in eyes with uveal melanoma (UM), but, to our knowledge, a definitive study establishing the association between SCD and UM has not been conducted.Objective To explore an association between SCD and UM.Design, Setting, and Participants A historical cohort analysis was performed u...

A 60-year-old white woman presented with a 2-year history of iris pigmentation in her right eye. A, Examination revealed hyperpigmentation of the anterior iris surface, peaking of the pupil in a superonasal direction, and involvement of the angle structures on gonioscopy (inset). An area of iris atrophy was also noted. The intraocular pressure was...

A 66-year-old man with a history of multiple myeloma presented with a superior scotoma in the left eye, jaw claudication, and arthralgias. A, A fundus examination revealed optic nerve edema, a small peripapillary hemorrhage, and a supratemporal cotton-wool spot. B, Visual field testing demonstrated a complete superior altitudinal defect. The patien...

Conjunctivitis is a common problem. To examine the diagnosis, management, and treatment of conjunctivitis, including various antibiotics and alternatives to antibiotic use in infectious conjunctivitis and use of antihistamines and mast cell stabilizers in allergic conjunctivitis. A search of the literature published through March 2013, using PubMed...

Importance: To establish that the intracranial and ophthalmologic findings present in victims of abusive head trauma can also be seen in shaken adults. Observations: We report 2 cases of shaken adults with intracranial and ophthalmologic findings that resulted from repetitive acceleration-deceleration injury. These findings included intracranial...

Abstract The purpose of this report is to describe the clinical, radiographica, and histopathologic findings in two pediatric patients with orbital IgG4-related disease.

Figure 1. A 55-year-old woman presented with an ill-defined mass (arrows) of the left lower eyelid fornix associated with excessive tearing and mattering for 5 weeks. Magnetic resonance imaging of the orbits revealed soft tissue swelling. The mass was excised and histologically diagnosed as a lower eyelid leiomyoma.Figure 2. A, Microscopic examinat...

A 48-year-old man had a central corneal ulcer (A) after trauma with a metal wire. The patient began oral and topical treatment with voriconazole after a filamentous fungus consistent with Rhizopus species was cultured. The fungus exhibited autofluorescence on a hematoxylin-eosin–stained slide under a fluorescence microscope (original magnification...

Transitional cell carcinomas (TCC) of the lacrimal sac are uncommon tumors that can have significant morbidity and mortality if not diagnosed and treated in a timely fashion. These tumors have variable clinical and histologic features. Bloody tears, also known as dacryohemorrhea, has been reported only once previously as a presenting sign of the tu...

The effectiveness of saline injection in reducing the toxicity profile of calcitriol when coadministered in mice was evaluated. Mortality was used as an end point to study the toxic effects of calcitriol; the relative risk of mortality in mice injected with saline was evaluated from our previously published animal experiments. We discovered that co...

Conjunctival nodule is very rarely seen in patients with rheumatoid arthritis. Previously reported cases were associated with the use of methotrexate. Here, we report a conjunctival rheumatoid nodule without such prior treatment. A 49-year-old woman with seropositive rheumatoid arthritis, who was being treated only with oral steroids and hydroxychl...

To define the retinal phenotype in patients with the Bardet-Biedl syndrome and mutations in the BBS1 gene. Ten patients (age range, 16-48 years), representing eight pedigrees, with BBS1 gene mutations were studied clinically and with kinetic perimetry, chromatic static perimetry, electroretinography (ERG), and optical coherence tomography. Of the 1...