Amir Asghari

Erasmus MC | Erasmus MC · Department of Neuroscience - Department of Neuropsychiatry

Introduction: An interaction between oxidative stress, neuroinflammation and nitric oxide (NO) has been suggested to have a role neurotoxicity. The aim of current research was to investigate the effect of aminoguanidine (AG) as an inducible NO synthase (iNOS) inhibitor, on brain-derived neurotrophic factor (BDNF), oxidative stress and interleukin-6...

The mediatory role of nitric oxide (NO) in neuronal dysfunction and brain damage has been considered. This project was aimed to investigate the effect of an inducible NO synthase (iNOS) inhibitor, aminoguanidine, on the hippocampal apoptosis of the neonates born from titanium dioxide (TiO2) nanoparticles-exposed rats. TiO2 exposure increased the nu...

Background: Spinal muscular atrophy (SMA) is an autosomal recessive destructive motor neuron disease which is characterized primarily by the degeneration of α-motor neurons in the ventral gray horn of the spinal cord. It mainly affects children and represents the most common reason of inherited infant mortality. Material and methods: We provide...

Traumatic brain injury (TBI) can result in permanent brain function impairment due to the poor regenerative ability of neural tissue. Tissue engineering has appeared as a promising approach to promote nerve regeneration and to ameliorate brain damage. The present study was designed to investigate the effect of transplantation of the human meningiom...

Developing a new strategy for an efficient targeted genome editing has always been a great perspective in biology. Although different approaches have been suggested in the last three decades, each one is confronting with limitations. CRISPR-Cas complex is a bacterial-derived system which made a breakthrough in the area of genome editing. This paper...

Liver is susceptible to oxidative stress and inflammation. The effect of metformin on lipopolysaccharide (LPS)-mediated liver malfunction was investigated. Rats were grouped into (1) control, (2) LPS, (3–5) LPS as well as 50, 100, and 150 mg/kg of metformin for 5 weeks. LPS increased liver enzymes, IL-6, and malondialdehyde (MDA) (p < 0.05 and p <...

Peroxisome proliferator-activated receptor gamma (PPAR-γ) agonists have been suggested to have some effects of central nervous system. In the present study, the effects of PPAR-γ agonist pioglitazone (pio) on anxiety and depression-like behaviors were investigated in lipopolysaccharide (LPS) injected rats. The animal groups include (n = 10 in each)...

Background The antidiabetic and antioxidant effects of Trigonella foenum-graceum have been suggested. The effects of hydroalcoholic extract of the plant seeds and metformin against the diabetes-induced memory impairment were investigated. Materials and methods The rats were treated: (1) control, (2) diabetic (3–6) and diabetic rats treated by 50,...

Objective: Serine/arginine-rich splicing factor 2 (SRSF2) mutations were detected frequently in myelodysplastic syndrome (MDS) and chronic myelomonocytic leukemia (CMML) patients. However, its prognostic value has not yet been fully clarified. Methods: In this meta-analysis, Hazard Ratio (HR) and 95% confidence interval (CI) for overall-survival (O...