Aminu Mohammed

Aminu Mohammed
Ahmadu Bello University | ABU · Department of Biochemistry

PhD

About

53
Publications
24,779
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544
Citations
Additional affiliations
January 2013 - March 2016
University of KwaZulu-Natal
Position
  • PhD Student
January 2013 - December 2015
University of KwaZulu-Natal
Position
  • PhD Student
November 2010 - present
Ahmadu Bello University
Position
  • Lecturer II

Publications

Publications (53)
Article
Background The PTP 1B is a negative regulator of insulin signal transduction and hence, serves as a therapeutic target in the treatment of diabetes. Objective The present study investigated the inhibitory effects of p-hydroxybenzaldehyde, vanillin, and syringaldehyde on the activity of protein tyrosine phosphatases phosphatase 1B (PTP 1B) in vitro...
Article
Full-text available
Africa has a rich biodiversity of plants and an active traditional medicine system that takes advantage of the rich biodiversity to treat various diseases, including diabetes mellitus (DM). The folkloric use of some of these plants in treating diabetes has been documented in various databases and publications, and validated with in vitro and in viv...
Article
Vanillin (4-hydroxy-3-methoxybenzaldehyde) is a known natural aromatic flavoring agent and the major component of vanilla extracted from cured vanilla pods. Vanillin has several applications in foods, beverages, pharmaceuticals, perfumes and cosmetics. The Food and Drug Administration (FDA) and Flavor and Extract Manufacturers Association (FEMA) ha...
Article
Diterpenes are a diverse group of structurally complex natural products with a wide spectrum of biological activities, including antidiabetic potential. In the last 25 years, numerous diterpenes have been investigated for antidiabetic activity, with some of them reaching the stage of clinical trials. However, these studies have not been comprehensi...
Article
Background Physcion is an active component of Rheum officinale Baill, a popular traditional Chinese medicine used locally to treat diabetes. Previous studies revealed that physcion possessed antidiabetic activity of physcion using various in vitro models and no information is available on the antidiabetic activity of physcion in animal model. There...
Article
Full-text available
Malaria and toxoplasmosis are two important parasitic diseases with significant public health concerns in the Sub-Saharan African countries. Some aspects of pathogenesis of the two parasitic diseases involve the central nervous system manifesting neuropsychiatric disorders. Studies have implicated the single infection by Plasmodium spp. and Toxopla...
Conference Paper
Full-text available
Malnutrition is of public health concern and major contributor of childhood morbidity and mortality among under-five children. Outpatient Therapeutic Programme (OTP) manages children with Severe Acute Malnutrition (SAM) without complications at community level. Performance and treatment outcomes of OTP for the management of SAM in children are less...
Article
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The present study was designed to investigate the role of methoxylation on the anti-diabetic potential of ρ-hydroxybenzaldehyde (ρ-BN) and its derivatives vanillin (VN) and syringaldehyde (SN) in type 2 diabetes (T2D). Fructose-fed streptozotocin-induced T2D rat model was used and orally treated with 50 and 100 mg/kg body weight of ρ-BN, VN and SN...
Article
Full-text available
Malaria and toxoplasmosis are two important parasitic diseases with significant public health concerns in the Sub‐Saharan African countries. Some aspects of pathogenesis of the two parasitic diseases involve the central nervous system manifesting neuropsychiatric disorders. Studies have implicated the single infection by Plasmodium spp. and Toxopla...
Article
Full-text available
The quorum sensing (QS) mechanism has become a viable research strategy for the discovery of plant-derived anti-virulent agents to control drug-resistant bacteria. The increasing incidences of drug-resistant bacteria and the effort to curb it necessitate this study. We investigated the QS inhibitory potential of Centaurea praecox extracts on Chromo...
Article
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Background Lemongrass (Cymbopogon citratus Stapf) tea is a widely consumed beverage for nourishment and the remedy of diabetes mellitus (DM) in Africa locally. The aim of the present study was to investigate the antidiabetic action of lemongrass tea (LGT) in a type 2 diabetes (T2D) model of rats. Methods The fructose-streptozotocin (STZ) animal mo...
Article
The present study was designed to review the antidiabetic potential of anthraquinones (AQs) with emphasis on the extent of blood glucose reduction, the half maximal inhibitory concentration values (in vitro studies), the proposed mechanisms of action, and the structure activity relationship studies. We sourced relevant data from the major scientifi...
Article
Full-text available
Ellagic acid has been previously found to possess trypanostatic effects and to alleviate some of organs' pathological complications, but it was not known whether these effects were mediated through an antioxidant-related mechanism or not. This work, therefore, investigates the effects of ellagic acid on lipid peroxidation and the antioxidants profi...
Article
Full-text available
Pistia strateotes L. (Araceae) commonly known as water lettuce is used traditionally for the treatment of diabetes mellitus in Nigeria. The present study was designed to validate these antidiabetic claims in alloxan-induced diabetic rats. Wister rats (weighing 150-200g) were divided into five groups of seven animals each, three of which were made d...
Article
The present study was designed to conduct the bioassay-guided isolation of possible bioactive compound(s) responsible for the antidiabetic action of Xylopia aethiopica (Dunal) A. Rich. fruit. The isolation of compound was guided by α-glycosidase and α-amylase inhibitory activities. Molecular docking with Autodock Vina was used to decipher the mode...
Chapter
Terpenoids are the largest and structurally most diverse group of secondary metabolites derived from natural sources. Empirical evidence from several bioassays points to the therapeutic potentials of terpenoids against protozoan parasitic diseases such as malaria, trypanosomiasis, and leishmaniasis. The versatility of the parent terpenoid backbones...
Article
Annona senegalensis Pers (Annonaceae) known as Wild Custard Apple is used locally in the treatment of diabetes in Nigeria. This study was aimed at investigating the inhibitory potential of A. senegalensis leaf extracts and fractions on the activities of some enzymes (α-amylase and α-glucosidase) linked to diabetes. Plant samples were extracted with...
Article
Full-text available
Spices possess tremendous therapeutic potential including antidiabetic action, attributed to their bioactive ingredients. However, there is no study that critically reviewed the antidiabetic potency, safety and the bioavailability of the spice-derived bioactive ingredients (SDBI). Therefore, the aim of the study was to comprehensively review all pu...
Article
Background Trypanosomiasis is one of the neglected tropical diseases and continues to cause serious morbidity, mortality and economic loss. Current anti-trypanosomal drugs are antiquated and suffer from a number of serious setbacks, thereby necessitating the search for new drugs. Stigmasterol has previously demonstrated in vitro and in vivo anti-tr...
Article
Full-text available
Capsicum annuum L. (Solanaceae) commonly known as red pepper is a spice that is readily available in different parts of the world. The fruit is locally used as a vegetable salad, blood tonic, stimulant and in the treatment of nerve weakness and pain due to diabetes in some parts of Africa and Asia. The present study investigated the anti-diabetic e...
Article
Full-text available
The fruit decoction of Xylopia aethiopica (Dunal) A. Rich. is widely used for the treatment of diseases associated with oxidative stress such as diabetes, particularly in Africa. The present study was aimed to investigate the effects of X. aethiopica fruit acetone (XAFA) fraction in ameliorating oxidative stress in a type 2 diabetes (T2D) model of...
Chapter
Full-text available
Abstract The African continent is endowed with the richest biodiversity in the world, with an abundance of plants used in traditional treatment of various diseases such as diabetes mellitus (DM). In the last few decades, scientists have investigated the antidiabetic potential of a number of African medicinal plants, and some bioactive compounds wer...
Article
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ABSTRACT Context: The use of Aframomum melegueta K. Schum. (Zingiberaceae) fruit for treatment of diabetes has recently been established in Nigeria. However, compounds responsible for the antidiabetic action have not been identified. Objective: The present study carried out the bioassay-guided isolation of possible bioactive compounds responsible f...
Article
Parasitic infections are among the leading global public health problems with very high economic and mortality burdens. Unfortunately, the available treatment drugs are beset with side effects and continuous parasite drug resistance is being reported. However, new findings reveal more promising compounds especially of plant origin. Among the promis...
Article
Full-text available
This study investigated and compared the antioxidative, antidiabetic effects and possible active compounds present in various solvent extracts of fruit, leaf and stem of Aframomum melegueta (Rosc.) K. Schum. Samples were sequentially extracted using solvents of increasing polarity. They were investigated for 1,1-diphenyl-2-picrylhydrazyl (DPPH) rad...
Article
Ethnopharmacological relevance: In the traditional medicine from West Africa, fruit decoction of Xylopia aethiopica (Dunal) A. Rich. is widely used for the treatment of diabetes mellitus (DM) either alone or in combination with other plants. The present study is designed to investigate the anti-diabetic effects of X. aethiopica acetone fraction (X...
Article
Full-text available
Eugenia caryophyllata Thunb. possesses a wide variety of therapeutic potential and has been recognized as a source of antioxidative and antidiabetic agents. This study was designed to investigate and compare the antioxidative and antidiabetic effects of different parts (bud, leaf, stem and root) of E. caryophyllata. Samples were sequentially extrac...
Conference Paper
Full-text available
Objective: Various parts of Aframomum melegueta K. Schum. (Zingiberaceae) are used locally in the treatment of diabetes mellitus in different parts of Africa. Therefore this study is aimed to investigate the antidiabetic effect of A. melegueta fruit ethyl acetate fraction (AMEF) in a type 2 diabetes (T2D) model of rats. Materials and methods: Six-...
Article
The effect of aqueous extract of Acacia albida stem bark was investigated in Wistar albino rats infected with Trypanosoma evansi. The extract showed highest reduction in parasitemia at the dose of 600 mg/kg body weight (bw). A dose of 300 mg/kg bw improved packed cell volume the most by 14.35%. The group treated with 150 and 600 mg/kg bw of the ext...
Article
Full-text available
Objective To study the in vitro antitrypanosomal activity, antioxidant property and phytochemical constituents of aqueous extracts of nine Nigerian medicinal plants. Methods In vitro antitrypanosomal activity test was carried out on aqueous extracts of dried leaves of Acacia albida (A. albida), Artemisia absinthium, Bryophyllum pinnatum, Gongronem...
Article
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This study investigated anti-hyperglycemic and anti-hyperlipidemic effects of aqueous stem bark extract (ASE) of Acacia albida Delile. in alloxan–induced diabetic rats. Animals were randomly divided into seven groups of five animals each: normal control (NC), normal treated with 500 mg/kg body weight (bw) ASE, diabetic control (DC), diabetics treat...
Article
Full-text available
Diabetes mellitus is one of the major health problems in Africa. The conventional oral synthetic antidiabetic drugs available to manage the disease are costly and not readily affordable to the majority of the affected population. Interestingly, the continent is endowed with a tremendous number of medicinal plants that have been explored for their f...
Article
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The study was conducted to evaluate some chemical constituents of the leaf and stem bark of Senna siamea. Standard methods were used in all the analysis. Preliminary phytochemical screening indicated the presence of flavonoids, tannins, polyphenols, anthraquinones, saponins, and glycosides. Quantitative study of some phytoconstituents showed a sign...
Article
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The present study was aimed to evaluate the stem bark aqueous extract of Psidium guajava for modulatory effect against CCl4 induced liver damage in rats. A total of thirty six male rats, were randomly divided into six groups of six rats each. The extract was administered orally for 15 days at 125, 250 and 500 mg kg-1 b.wt. The results obtained show...
Article
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Aqueous leaf extract of Carica papaya (CP) is used as medicine against some forms of liver diseases traditionally. The purpose of the study was to evaluate and determine the hepatoprotective effect of the aqueous leaf extract of CP in CCl4 induced liver damage in rats administered subcutaneously with 75mg/kg CCl4 after 48hours. The activities of se...
Article
Full-text available
Senna siamea is traditionally used for treatment of many diseases. This study was carried out to evaluate the antihyperglycemic and antihyperglycemic effect of the methanol extracts of the leaves and stem bark of S. siamea. The extracts were orally administered daily at 250 and 500 mg kg-1 b.wt. for three weeks. The effect of the extracts on Fastin...
Article
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The abilities of Ocimum suave (OS) and Ocimum basilicum (OB) to prevent high fat diet (HFD) induced hyperlipidemia and oxidative stress in Wister albino rats was investigated. Groups of rats maintained on a HFD, containing 31% fat, were given daily oral doses of 800 mg/kg of extracts of O. suave or O. basilicum for 21 days. High fat feeding caused...
Article
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The anti-diabetic action of the aqueous extract of Ocimum suave in alloxan-induced diabetic rats was investigated. Male Wister strain albino rats (120 to 150 g) were divided into five groups of five animals each, three of which were made diabetic using alloxan. All rats in the diabetic groups had initial fasting blood glucose (FBG) levels ≥150 mg/d...
Article
Full-text available
The pathological changes due to the oral administration of the aqueous extract of the leaves of Calotropis procera were studied in rats over a period of sixty days. The leaf extract was administered orally to rats in three groups receiving doses of 500, 1000 and 1500 mg/kg. The fourth group served as a control and received distilled water only. Res...
Data
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The proximate, anti-nutritional and mineral compositions of three vegetables green amaranth (Amaranthus tricolor), bitter leaf (Vernonia amygdalina) and fluted pumpkin (Teilferia occidentalis) consumed in Zaria, Nigeria were investigated. The results obtained revealed the presence of nutritional, anti-nutritional and mineral composition in these se...
Data
Full-text available
This study is aimed at investigating and comparing the in vitro antioxidant effects of ethanolic extracts of Psidium guajava stem bark and Telfairia occidentalis leaf using 2, 2-diphenyl 1-picrylhydrazyl (DPPH) free radical scavenging assay. Ascorbic acid and α-tocopherol were used as standards in this study. The results obtained showed that Telfai...
Data
Full-text available
ENGLISH/ ABSTRACT [ENGLISH/ ABSTRACT [ENGLISH/ ABSTRACT [ENGLISH/ANGLAIS ANGLAIS ANGLAIS ANGLAIS] ] ] ] Affiliations: This study was conducted to determine the proximate composition of some selected fish species. Four fish species; Tilapia (Tilapia zilli), Catfish (Hemisynodontis membranacea), Atlantic herring (Clupea harengus) and Mackerel (Scombe...
Data
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2(2):81-5. Increasing resistance of microorganisms to antibiotics and other orthodox drugs has resulted in the search for more organic molecules from plant source with antimicrobial properties. Therefore investigation of African medicinal plants for their antimicrobial activity rank highest among biological tests carried out on the plants and their...
Article
Full-text available
Aqueous leaf extract of Carica papaya (CP) is used as medicine against some forms of liver diseases traditionally. The purpose of the study was to evaluate and determine the hepatoprotective effect of the aqueous leaf extract of CP in CCl 4 induced liver damage in rats administered subcutaneously with 75mg/kg CCl 4 after 48hours. The activities of...
Data
Arachis hypogaea (Groundnuts) are not only rich in proteins, but also rich in B-complex vitamins and minerals. However the presence of antinutrients, such as oxalate, phytate, tannin and trypsin inhibitor, reduces their bioavailability and utilization. Therefore the effect of processing on the proximate composition and antinutrients level of local...

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Projects

Projects (3)
Project
Towards development of new drugs for type 2 diabetes with disease modifying potentials
Project
To provide an insight Into practice, determinants, prospects and implications of medicinal plants use
Project
Our overarching goal focuses on screening and isolation of potent ingredients/nutraceuticals with antidiabetic potentials from vast wealth of plants located in African region using modern spectroscopic techniques. In addition, we are interested in elucidating the possible mode of actions of extracts, compounds or nutraceuticals derived from the plants using various in vitro and in vivo models. Presently, we focus on the in silico computer simulation and improving bioavailability of spice-derived nutraceuticals as possible antidiabetic agents.