Aminael Sanchez-Rodriguez

Aminael Sanchez-Rodriguez
Universidad Técnica Particular de Loja | UTPL · Departamento de Ciencias Naturales

PhD in Bioscience-engineering

About

147
Publications
33,342
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1,783
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Additional affiliations
October 2013 - present
Universidad Técnica Particular de Loja
Position
  • Faculty Member

Publications

Publications (147)
Article
Full-text available
Phylogenomics and Systematics of Overlooked Mesoamerican and South American Polyploid Broad-Leaved Festuca Grasses Differentiate F. sects. Glabricarpae and Ruprechtia and F. subgen. Asperifolia, Erosiflorae, Mallopetalon and Coironhuecu (subgen. nov.) Abstract: Allopolyploidy is considered a driver of diversity in subtribe Loliinae. We investigate...
Article
p class="western" style="margin-top: 0.21cm; margin-bottom: 0.21cm; line-height: 100%;" lang="en-US">El confinamiento sanitario puso de manifiesto la necesidad del uso de herramientas tecnológicas y metodologías activas como métodos innovadores en los procesos de enseñanza y aprendizaje. Este trabajo pretende aportar un instrumento que permita eval...
Article
Full-text available
The repeatome is composed of diverse families of repetitive DNA that keep signatures on the historical events that shaped the evolution of their hosting species. The cold seasonal Loliinae subtribe includes worldwide distributed taxa, some of which are the most important forage and lawn species (fescues and ray-grasses). The Loliinae are prone to h...
Article
This work presents DeepReGraph, a novel method for co-clustering genes and cis-regulatory elements (CREs) into candidate regulatory networks. Gene expression data, as well as data from three CRE activity markers from a publicly available dataset of mouse fetal heart tissue, were used for DeepReGraph concept proofing. In this study we used open chro...
Article
Full-text available
In the original article, there was a mistake in Table 1, Figures 2A, 2B, 3A, 3B and 5, Supplementary Figures 1A, 1B, 1C, 1D, 2A, 2B, 2C and 3, and Supplementary Tables 1 and 2A as published. The name and authorship of Festuca fontqueri St-Yves were misspelled as Festuca fontqueriana (St-Yves) Romo. In addition, the GenBank accession codes of ITS, t...
Article
Full-text available
Video delivery is exploiting 5G networks to enable higher server consolidation and deployment flexibility. Performance optimization is also a key target in such network systems. We present a multi-objective optimization framework for service function chain deployment in the particular context of Live-Streaming in virtualized content delivery networ...
Article
Background Molecular phylogenetic algorithms frequently disagree with the approaches considering reproductive compatibility and morphological criteria for species delimitation. The question stems if the resulting species boundaries from molecular, reproductive and/or morphological data are definitively not reconcilable; or if the existing phylogene...
Article
Full-text available
Horizontal gene transfer (HGT) plays an important role for evolutionary innovations within prokaryotic communities and is a crucial event for their survival. Several computational approaches have arisen to identify HGT events in recipient genomes. However, this has been proven to be a complex task due to the generation of a great number of false po...
Article
The emergence of new virulent Vibrio strains resistant to common antibiotics has caused significant economic losses to shrimp farming worldwide. It is mandatory to adopt new strategies to control shrimp farming related vibriosis. Essential oils (EOs) have several biological properties among of which the quorum sensing (QS) inhibitory activity is ap...
Article
Full-text available
Oceanic islands constitute natural laboratories to study plant speciation and biogeographic patterns of island endemics. Juan Fernandez is a southern Pacific archipelago consisting of three small oceanic islands located 600–700 km west of the Chilean coastline. Exposed to current cold seasonal oceanic climate, these 5.8–1 Ma old islands harbor a re...
Article
The community structure of arbuscular mycorrhizal fungi (AMF) is wide in terms of composition and distribution and can be influenced by the host plant. The aim of this research was to compare the diversity of AMF communities associated with cultivated (Solanum betaceum) and wild tree tomato (Solanum cajanumensis) species. Roots of both species were...
Poster
Full-text available
El cultivo de camarón es una de las principales actividades acuícola a nivel mundial, y para Ecuador representa el primer producto de exportación no petrolero. A pesar de su crecimiento expansivo, la industria camaronera es frecuentemente amenazada por brotes de enfermedades. Recientemente, varios vibrios han sido asociados a la enfermedad de necro...
Article
Full-text available
The prediction of cell-lines sensitivity to a given set of compounds is a very important factor in the optimization of in-vitro assays. To date, the most common prediction strategies are based upon machine learning or other quantitative structure-activity relationships (QSAR) based approaches. In the present research, we propose and discuss a strai...
Article
Consensus scoring has become a commonly used strategy within structure-based virtual screening (VS) workflows with improved performance compared to those based in a single scoring function. However, no research has been devoted to analyze the worth of docking scoring functions components in consensus scoring. We implemented and tested a method that...
Preprint
Full-text available
Horizontal gene transfer (HGT) plays an important role in the evolution of many organisms, especially in prokaryotes where commonly occurs. Microbial communities can improve survival due to the evolutionary innovations induced by HGT events. Thus, several computational approaches have arisen to identify such events in recipient genomes. However, th...
Preprint
Full-text available
Consensus scoring has become a commonly used strategy within structure-based virtual screening (VS) workflows with improved performance compared to those based in a single scoring function. However, no research has been devoted to analyze the worth of docking scoring functions components in consensus scoring. We implemented and tested a method that...
Article
Full-text available
Interspecific interactions play an important role in community assembly. A basic ecological question is whether interactions are specialized (one to one) or generalized (many to many). Specialization of interactions should ideally be assessed across several populations because species could be specialists at a particular site but generalists when s...
Article
Full-text available
The marine biodiversity program of CENAIM-ESPOL focuses on sessile invertebrates from the “‘El Pelado’ marine reserve”. The present study aims at understanding the different hierarchical levels of biodiversity found at the “El Pelado” and to guide biodiscovery initiatives. Generated biodiversity data were systematized in a database (Darwin Core sta...
Article
Full-text available
The purpose of this study was to compare the efficacy of galactose and high initial ferrous iron concentrations as inducers for extracellular polymeric substances (EPS) production in planktonic cells of Leptospirillum ferrooxidans and to study cell attachment to a mineral surface in comparison to cells not exposed to such substances. Leptospirillum...
Article
Full-text available
In orchids, most of the root-associated fungal endophytes remain undescribed as well as the drivers that affect their interactions with the plants. We characterized root-associated fungal endophytes of co-existing orchids across sites in two areas of montane rainforest in the southern Ecuadorian Andes. We amplified the nrDNA ITS2 region of 130 orch...
Article
Full-text available
Microalgae biomethanization is driven by anaerobic sludge associated microorganisms and is generally limited by the incomplete hydrolysis of the microalgae cell wall, which results in a low availability of microalgal biomass for the methanogenic community. The application of enzymatic pretreatments, e.g., with hydrolytic enzymes, is among the strat...
Article
Full-text available
Gastric cancer is the third leading cause of cancer-related mortality worldwide and despite advances in prevention, diagnosis and therapy, it is still regarded as a global health concern. The efficacy of the therapies for gastric cancer is limited by a poor response to currently available therapeutic regimens. One of the reasons that may explain th...
Article
La fijación biológica del Nitrógeno es un proceso que aporta con un 65% de fijación anual de nitrógeno al ecosistema; ejecutada por microorganismos fúngicos capaces de reducir la forma atmosférica del N en una forma asimilable. Existen varias actividades antrópicas que han favorecido el aumento de la adicción de N, lo que ha generado la duplicación...
Article
Variovorax sp. WDL1 mediates hydrolysis of the herbicide linuron into 3,4-dichloroaniline (DCA) and N,O-dimethylhydroxylamine in a tripartite bacterial consortium with Comamonas testosteroni WDL7 and Hyphomicrobium sulfonivorans WDL6. Although strain WDL1 contains the dcaQTA1A2B operon for DCA oxidation, this conversion is mainly performed by WDL7....
Article
Full-text available
Rhizobium-legume symbioses play relevant roles in agriculture but have not been well studied in Ecuador. The aim of this study was to characterize the genetic and phenotypic diversity of Rhizobium isolates associated with Phaseolus vulgaris from southern Ecuador. Morphocultural characterization, biochemical tests and physiological analyses were con...
Data
Supplementary material is available on the publisher’s web site along with the published article.
Data
Supplementary material is available on the publisher’s web site along with the published article.
Preprint
Full-text available
Dear Professor, I have uploaded the file now. Thank you for your interest in our work. Selvaraj Thangaswamy. selvarajthangaswamy@gmail.com
Article
Hylocereus ocamponis e Hylocereus triangularis son dos especies de cactáceas estrechamente relacionadas filogenéticamente pero que muestran hábitos de crecimiento completamente contrastados. La primera abunda en ecosistemas secos y la segunda en bosque tropical lluvioso, en bosques secos occidentales y la región amazónica del Ecuador, respectivamen...
Article
Full-text available
Background Preeclampsia is a multifactorial disease with unknown pathogenesis. Even when recent studies explored this disease using several bioinformatics tools, the main objective was not directed to pathogenesis. Additionally, consensus prioritization was proved to be highly efficient in the recognition of genes-disease association. However, not...
Article
Full-text available
The presence of extracellular polymeric substances (EPS) and their relevance for biofilm formation on the mineral surface for a variety of microbial species play a fundamental role in the degradation of sulfide ores. EPS production is associated with induction or auto induction mechanisms as a response of bacteria to environmental conditions. In th...
Article
Mercury (Hg) accumulation capacity was assessed in three plant species (Axonopus compressus, Erato polymnioides, and Miconia zamorensis) that grow on soils polluted by artisanal small-scale gold mines in the Ecuadorian rainforest. Individuals of three species were collected at two sampling zones: i) an intensive zone (IZ, 4.8 mg Hg kg(-1) of soil)...
Article
The therapeutic effects of drugs are well known to result from their interaction with multiple intracellular targets. Accordingly, the pharma industry is currently moving from a reductionist approach based on a ‘one-target fixation’ to a holistic multitarget approach. However, many drug discovery practices are still procedural abstractions resultin...
Article
Full-text available
In epiphytic orchids, distinctive groups of fungi are involved in the symbiotic association. However, little is known about the factors that determine the mycorrhizal community structure. Here, we analyzed the orchid mycorrhizal fungi communities associated with three sympatric Cymbidieae epiphytic tropical orchids (Cyrtochilum flexuosum, Cyrtochil...
Article
Current advances in systems biology suggest a new change of paradigm reinforcing the holistic nature of the drug discovery process. According to the principles of systems biology, a simple drug perturbing a network of targets can trigger complex reactions. Therefore, it is possible to connect initial events with final outcomes and consequently prio...
Poster
Las esponjas marinas constituyen una fuente rica de metabolitos bioactivos con propiedades antibacterianas, antitumorales, antifúngicas, antivirales y antinflamatorias. Sin embargo, no todas estas moléculas son producidas por las esponjas, estudios recientes indican que muchos de estos metabolitos son productos de los microorganismos asociados, ent...
Poster
Las esponjas marinas constituyen una fuente rica de metabolitos bioactivos con propiedades antibacterianas, antitumorales, antifúngicas, antivirales y antinflamatorias. Sin embargo, no todas estas moléculas son producidas por las esponjas, estudios recientes indican que muchos de estos metabolitos son productos de los microorganismos asociados, ent...
Article
Full-text available
Background: In the context of the current drug discovery efforts to find disease modifying therapies for Parkinson´s disease (PD) the current single target strategy has proved inefficient. Consequently, the search for multi-potent agents is attracting more and more attention due to the multiple pathogenetic factors implicated in PD. Multiple evide...
Article
Background: Virtual methodologies have become essential components of the drug discovery pipeline. Specifically, structure-based drug design methodologies exploit the 3D structure of molecular targets to discover new drug candidates through molecular docking. Recently, dual target ligands of the Adenosine A2A Receptor and Monoamine Oxidase B enzym...
Poster
Full-text available
Las esponjas marinas constituyen una fuente rica de metabolitos bioactivos con propiedades antibacterianas, antitumorales, antifúngicas, antivirales y antinflamatorias. Sin embargo, no todas estas moléculas son producidas por las esponjas, estudios recientes indican que muchos de estos metabolitos son productos de los microorganismos asociados, ent...
Article
Full-text available
Pathogenic isolates of Fusarium spp. associated with babaco (Vasconcellea heilbornii var. pentagona Badillo) were characterized morphologically and molecularly. Babaco roots with symptoms of root rot were collected in major areas in southern Ecuador, and monosporic isolates were obtained. Twenty-one isolates associated with the vascular wilt of bab...
Article
Full-text available
Pathogenic isolates of Fusarium spp. associated with babaco (Vasconcellea heilbornii var. pentagona Badillo) were characterized morphologically and molecularly. Babaco roots with symptoms of root rot were collected in major areas in southern Ecuador, and monosporic isolates were obtained. Twenty-one isolates associated with the vascular wilt of bab...
Article
Full-text available
Tropical montane ecosystems of the Andes are critically threatened by a rapid land-use change which can potentially affect stream variables, aquatic communities, and ecosystem processes such as leaf litter breakdown. However, these effects have not been sufficiently investigated in the Andean region and at high altitude locations in general. Here,...
Data
Figure S1. Principal Component Analysis (PCA) of stream physico‐chemical variables measured along a riparian land‐use gradient in Andean streams.
Data
Table S1. Total area and percentage of each land‐use type of the Jipiro and El Carmen catchment.
Data
Table S2. List of fungal species associated with alder litter incubated along a riparian land‐use gradient in Andean streams over 56 days.
Data
Table S3. Results of permutational multivariate analysis of variance (perMANOVA) of benthic macroinvertebrate communities along a riparian land‐use gradient in Andean streams.
Data
Table S4. Summary of the multiple linear regression models and hierarchical partitioning showing relationships between (A) biological and stream physic‐chemical variables and (B) breakdown rates k (d−1) in coarse and fine mesh bags and stream and biological variables in Andean streams.
Data
Figure S2. Ergosterol concentration associated with alder litter in fine mesh bags incubated along a land use gradient in Andean streams over 56 days.
Data
Figure S3. Macroinvertebrate abundance associated with alder litter in coarse mesh bags incubated along a land use gradient in Andean streams over 56 days.
Article
A protocol for molecular characterization of soil microbial communities of tropical ecosystems (Tropical Dry Forest, TDF; Tropical Dry Scrub, TDS and Tropical Montane Forest, TMF) in southern Ecuador, was optimized. These ecosystems were selected due to their great biological interest, its high biodiversity and its vulnerability. Total genomic DNA...
Article
Full-text available
Tropical montane ecosystems of the Andes are critically threatened by a rapid land-use change which can potentially affect stream variables, aquatic communities, and ecosystem processes such as leaf litter breakdown. However, these effects have not been sufficiently investigated in the Andean region and at high altitude locations in general. Here,...
Article
Full-text available
In this work we report the first attempt to study the effect of activity cliffs over the generalization ability of machine learning (ML) based QSAR classifiers, using as study case a previously reported diverse and noisy dataset focused on drug induced liver injury (DILI) and more than 40 ML classification algorithms. Here, the hypothesis of struct...
Article
Full-text available
Abstract: Background: Virtual Screening methodologies have emerged as efficient alternatives for the discovery of new drug candidates. At the same time, ensemble methods are nowadays frequently used to overcome the limitations of employing a single model in ligand-based drug design. However, many applications of ensemble methods to this area do not...
Article
Full-text available
Background The systemic information enclosed in microarray data encodes relevant clues to overcome the poorly understood combination of genetic and environmental factors in Parkinson’s disease (PD), which represents the major obstacle to understand its pathogenesis and to develop disease-modifying therapeutics. While several gene prioritization app...