Amin Shavandi

Amin Shavandi
Université Libre de Bruxelles | ULB · Université libre de Bruxelles (ULB), École polytechnique de Bruxelles, 3BIO-BioMatter, Avenue F.D. Roosevelt, 50 - CP 165/61, 1050 Brussels, Belgium

About

151
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Introduction
BioMatter lab works at the interface of polymer science, physical chemistry, and biology. The overall focus of the lab is to valorize biomass toward biomedical application through the fundamental understanding and development of biohybrid/bioinspired materials with a specific emphasis on biomaterials, tissue engineering. While most of our target applications lie within tissue engineering, we also apply our engineered hydrogels/biomaterials in food and feed. http://biomatter.ulb.be/

Publications

Publications (151)
Article
Full-text available
Salivary gland (SG) dysfunction impairs the life quality of many patients, such as patients with radiation therapy for head and neck cancer and patients with Sjögren’s syndrome. Multiple SG engineering strategies have been considered for SG regeneration, repair, or whole organ replacement. An in-depth understanding of the development and differenti...
Article
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There have been many efforts to valorise lignin to produce bio-based chemicals and advanced materials. In this study, alkaline delignification was initially employed to recover lignin from the rind, pulp, and whole bagasse fractions of Moroccan sugarcane. The lignin fractions were subsequently modified via silanization and acetylation reactions. Th...
Article
In this study, we designed dual network hydrogels with antioxidant and antibacterial activities using marine poly-and oligosaccharides with skin wound healing potential. The synergy between dual enzymatic co-crosslinking based on glucose oxidize (GOx)/horseradish peroxidase (HRP) and electrostatic interaction between positively charged chitooligosa...
Article
Enzyme-mediated crosslinked hydrogels as soft materials for biomedical applications have gained considerable attention. In this article, we studied the effect of post-treatment with tannic acid on adhesiveness and physiochemical properties of an enzymatically crosslinked hydrogel based on chitosan and alginate. The hydrogels were soaked in TA solut...
Article
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The bacterium Pantoea sp. BCCS 001 GH produces an exopolysaccharide (EPS) named Pantoan through using sugar beet molasses (SBM) as an inexpensive and widely available carbon source. This study aims to investigate the kinetics and optimization of the Pantoan biosynthesis using Pantoea sp. BCCS 001 GH in submerged culture. During kinetics studies, th...
Article
Membrane separation is an emerging technology for secondary effluent (SE) recycling as an alternative water source. However, SE contains secondary metabolites which form a film on membrane surfaces, leading to a decrease in hydraulic capacity. This is an extensive study of the effect of fouling on UF performance, with a detailed analysis of foulant...
Article
Temperature-responsive hydrogels exhibit great potentials to encapsulate cells for 3D bioprinting and tissue engineering applications; however, cell aggregation and the hydrogel stiffness determine cell fate and limit its application. Here, we developed a new temperature-responsive hydrogel with interpenetrating polymer networks using poly (N-isopr...
Article
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Introduction: Exopolysaccharides (EPSs) are high-value functional biomaterials mainly produced by bacteria and fungi, with nutraceutical, therapeutic and industrial potentials. Objectives: This study sought to characterize and assess the biological properties of the EPS produced by the yeast Papiliotrema terrestris PT22AV. Methods: After extra...
Article
The development of new calcium phosphate nanoparticles with excellent cytocompatibility and antibacterial properties is generating substantial interest in the biomedical field. In this regard, the present study demonstrated the synthesis of magnesium-doped biphasic calcium phosphate nanoparticles containing silver (Ag MgB-NPs) via the employment of...
Article
Significant upsurge in animal by-products such as skin, bones, wool, hides, feathers, and fats has become a global challenge and, if not properly disposed of, can spread contamination and viral diseases. Animal by-products are rich in proteins, which can be used as nutritional, pharmacologically functional ingredients, and biomedical materials. The...
Preprint
Pomace is a waste stream that is generated during fruit processing and is regarded as highly polluting due to its high moisture content, biological instability and acidic properties. To facilitate pomace management, the current study has applied the biorefinery concept to develop systems that facilitate value extraction. In this regard, alternative...
Article
As a source of several valuable products, photosynthetic microorganisms (microalgae and cyanobacteria) have many applications in biomedical, electrochemical, and urban-space fields. Microalgal and cyanobacterial (photoautotrophs) implementations have been the subject matter of several reviews, which mainly focused on exploring effective methods of...
Article
Alginates are widely used polysaccharides for biomaterials engineering, which functional properties depend on guluronic and mannuronic acid as the building blocks. In this study, enzymatically crosslinked hydrogels based on sodium alginate (Na-Alg) and the exopolysaccharide (EPS) derived from Cryptococcus laurentii 70766 with glucuronic acid residu...
Article
Asparagus officinalis root (AR) contains valuable bioactive compounds that have beneficial health properties. The aim of this study was to optimize the extraction of polyphenols and flavonoids in green AR using two novel technologies; pulsed electric field (PEF) and ionic liquids (IL). Further, the antioxidant activity of the obtained extracts was...
Article
Scars are consequences of the wound healing process, and eliminating scar formation remains a significant challenge. Here, an injectable HMSC hydrogel was developed based on silk fibroin peptide grafted hydroxypropyl chitosan (HPCS-g-SFP) and oxidized microcrystalline cellulose (OMCC) via Schiff base bonds. The synthesized HPCS-g-SFP copolymer disp...
Article
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Three-dimensional (3D) printing is well acknowledged to constitute an important technology in tissue engineering, largely due to the increasing global demand for organ replacement and tissue regeneration. In 3D bioprinting, which is a step ahead of 3D biomaterial printing, the ink employed is impregnated with cells, without compromising ink printab...
Article
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In this present work, fungal nanochitosans, with very interesting particle size distribution of 22 µm, were efficiently generated in high-yield production using a high-pressure water jet system (Star Burst System, Sugino, Japan) after 10 passes of mechanical treatment under high pressure. The specific characterization of fungal chitosan nanofibers...
Article
Brewers' spent grain (BSG) is a brewery co-product rich in phenolic compounds which only within Europe, 3-4Mt is generated annually. This study aims to sustainably isolate low-molecular-weight phenolic compounds from Belgian BSG using a microwave-assisted method (MW). Two types of BSG (from light and red malted barley grains) were subjected to MW a...
Article
Fungal exopolysaccharides (EPSs) are natural biopolymers with diverse potential applications in the biomedical, packaging, cosmetic, and food industries. Fungal EPSs are easy to extract and purify polysaccharides that are biodegradable, biocompatible, with low immunogenicity, bioadhesion ability, antibacterial activity, and contain different reacti...
Article
Polysaccharides and proteins are important macromolecules for developing hydrogels devoted to biomedical applications. Chemical hydrogels offer chemical, mechanical, and dimensional stability than physical hydrogels due to the chemical bonds among the chains mediated by crosslinkers. There are many crosslinkers to synthesize polysaccharides and pro...
Article
In this study, the solubilization of waste coarse wool as a precursory step for the large-scale valorization of keratin was investigated using a green deep eutectic solvent (DES) based on L-cysteine and lactic acid. The investigation was undertaken via the response surface methodology and based on the Box–Behnken design for four process variables o...
Article
Full-text available
The global demand for acrylic acid (AA) is increasing due to its wide range of applications. Due to this growing demand, alternative AA production strategies must be explored to avoid the exacerbation of prevailing climate and global warming issues since current AA production strategies involve fossil resources. Investigations regarding alternative...
Article
The design of 3D printable bio-based hydrogels with enhanced mechanical properties and minimal chemical modification can open new opportunities in the field of biomedical applications. A facile and safe approach...
Chapter
Olive oil, known from history for its nutritional and medicinal benefits and applications, is one of the most important economies and industries in the MENA region. Olive oil production amounts to 2.7 million tons, of which 96% comes from the Mediterranean countries, especially from Italy, Greece, Spain, Tunisia, and Morocco. The extraction process...
Chapter
Personal protective clothing (PPC) protects healthcare workers from infectious diseases such as COVID-19; however, there are limited technologies regarding the production of breathable and adaptive thermo-responsive personal protective clothing, which can improve the wearers' comfort. In this chapter, the development of such breathable and adaptive...
Article
Tannic acid (TA), a natural polyphenol, is a hydrolysable amphiphilic tannin derivative of gallic acid with several galloyl groups in its structure. Tannic acid interacts with various organic, inorganic, hydrophilic, and hydrophobic materials such as proteins and polysaccharides via hydrogen bonding, electrostatic, coordinative bonding, and hydroph...
Article
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The fabrication of bio tissues using anisotropic constructs capable of repairing and/or replacing diseased bio tissues remains a significant challenge in tissue engineering. Therefore, this study investigated the fabrication of an anisotropic PLGA-microspheres/PVA-hydrogel composite using a novel directional freezing-thawing (DFT) technique. The DF...
Article
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In the current paper, we fabricated, characterized, and applied nanocomposite hydrogel based on alginate (Alg) and nano-hydroxyapatite (nHA) loaded with phenolic purified extracts from the aerial part of Linum usitatissimum (LOH) as the bone tissue engineering scaffold. nHA was synthesized based on the wet chemical technique/precipitation reaction...
Preprint
Full-text available
The global demand for acrylic acid (AA) is increasing due to its wide range of applications. Due to this growing demand, alternative AA production strategies must be explored to avoid the exacerbation of prevailing climate and global warming issues since current AA production strategies involve AA production using fossil resources. Investigations o...
Article
Full-text available
In line with the prevailing global interest in value extraction from biomass waste streams, the current study explored the technical feasibility of valorizing waste apple pomace (WAP) to produce high-value biochemicals of 5-hydroxymethylfurfural (HMF), lactic acid, and xylitol. Technical feasibility was demonstrated via a process simulation study t...
Article
Previous studies have explored the potential of pomace valorization, with an emphasis on the transformation of polysaccharide biopolymers of pomace-cellulose and hemicellulose to produce high-value bioproducts such as microcrystalline cellulose. Notably, opportunities for the exploration of the biopolymer of pomace-lignin for its employment in biom...
Article
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This study aims to assess kinetic modelling of the solid–liquid extraction process of total polyphenolic compounds (TPC) from apple pomace (AP). In this regard, we investigated the effects of temperature and solvent (i.e. water, ethanol, and acetone) on TPC extraction over various periods. The highest TPC yield of 11.1 ± 0.49 mg gallic acid equival...
Article
The development of biomineralized hydrogels with excellent cytocompatibility is of great importance for tissue engineering applications. Here, porous polyvinyl alcohol/alginate/biphasic calcium phosphate (BPS) hydrogels were fabricated via chemical and physical crosslinking methods, and the BPS hydrogels were in vitro biomineralized using urease in...
Article
The development of biomineralized hydrogels with excellent cytocompatibility is of great importance for tissue engineering applications. Here, porous polyvinyl alcohol/alginate/biphasic calcium phosphate (BPS) hydrogels were fabricated via chemical and physical crosslinking methods, and the BPS hydrogels were in vitro biomineralized using urease in...
Article
This paper demonstrates a new class of printable magnetic hydrogels that can be successfully used for multimaterial direct ink printing (4D printing) of soft actuators. To date, most reports on magnetic actuation have not considered biocompatibility issues associated with magnetic materials and synthetic polymers. For this reason, in this study, co...
Article
Cu-based nanostructures are a well-known class of antibacterial nanomaterials with broad antibacterial properties. In this study, a facile and one-pot solvosonication process is introduced to synthesize Cu-BTC/graphene oxide nanocomposites with controlled morphological and structural properties. The size range of synthesized Cu-BTC nanoparticles is...
Preprint
Full-text available
In this study, the solubilisation of waste coarse wool as a precursory step for the large scale valorisation of keratin was investigated using a green deep eutectic solvent (DES) based on L-cysteine and lactic acid. The investigation was undertaken via the response surface methodology and based on the Box-Behnken design for four process variables o...
Article
Full-text available
An artificial ovary is a promising approach for preserving fertility in prepubertal girls and women who cannot undergo current cryopreservation strategies. However, this approach is in its infancy, due to the possible challenges of creating a suitable 3D matrix for encapsulating ovarian follicles and stromal cells. To maintain the ovarian stromal c...
Article
Full-text available
Calcium phosphate compounds form the inorganic phases of our mineralised tissues such as bone and teeth, playing an important role in hard tissue engineering and regenerative medicine. In dentistry and oral care products, hydroxyapatite (HA) is a stable and biocompatible calcium phosphate with low solubility being used for various applications such...
Chapter
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Alginate has received much attention due to its biocompatibility. However, the properties of pure alginate are limited, such as weak mechanical strength, which limits its application. Alginate-based composite effectively overcomes the defect of pure alginate. The molecular weight and microstructure can be designed. More importantly, the essential p...
Article
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Considerable challenges in engineering the female reproductive tissue are the follicle's unique architecture, the need to recapitulate the extracellular matrix, and tissue vascularization. Over the years, various strategies have been developed for preserving fertility in women diagnosed with cancer, such as embryo, oocyte, or ovarian tissue cryopre...
Article
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Exopolysaccharides (EPSs) are important biopolymers with diverse applications such as gelling compounds in food and cosmetic industries and as bio-flocculants in pollution remediation and bioplastics production. This research focuses on enhancing crude EPS production from Rhodotorula mucilaginosa sp. GUMS16 using the central composite design method...
Article
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This article presents a thermal sintering method to fabricate porous bone tissue engineering scaffolds based on polycaprolactone (PCL), polylactic acid (PLA), and their composites. The mechanical properties, porous structure, biodegradability, and biocompatibility of sintered scaffolds were evaluated. The scaffolds showed a porosity in the range of...
Article
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Thermoresponsive hydrogel-based wound dressings with an incorporated antimicrobial agent can be fabricated employing 3D printing technology. A novel printable ink containing poly(N-isopropylacrylamide) (PNIPAAm) precursors, sodium alginate (ALG), methylcellulose (MC) that is laden with a mixture of octenidine dihydrochloride and 2-phenoxyethanol (O...
Article
Full-text available
Over the last decade, an important challenge in nanomedicine imaging has been the work to design multifunctional agents that can be detected by single and/or multimodal techniques. Among the broad spectrum of nanoscale materials being investigated for imaging use, iron oxide nanoparticles have gained significant attention due to their intrinsic mag...
Article
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Cancer is a major global health challenge for our health system, despite the important pharmacological and therapeutic discoveries we have seen since past 5 decades. The increasing prevalence and mortality of cancer may be closely related to smoking, exposure to environmental pollution, dietary and genetic factors. Despite significant promising dis...
Article
In this study, green tea waste (GTW) was used to synthesize the iron oxide (IO) nanoparticles ([email protected]) to facilitate the adsorption of heavy metals from wastewaters. To satisfy structural integrity needs, the synthesized [email protected] was incorporated into a polyvinyl alcohol (PVA)/alginate polymer network to obtain PVA/alginate/IO (...
Article
Alginate biopolymers are characterized by favorable properties, of biocompatibility, degradability, and non-toxicity. However, the poor stability properties of alginate have limited its suitability for diverse applications. Recently, click chemistry has generated significant research interest due to its high reaction efficiency, high selectivity fo...
Article
Full-text available
After tooth loss, bone resorption is irreversible, leaving the area without adequate bone volume for successful implant treatment. Bone grafting is the only solution to reverse dental bone loss and is a well-accepted procedure required in one in every four dental implants. Research and development in materials, design and fabrication technologies h...
Article
Calcium phosphate nanoparticles are suitable as scaffolds for bone regeneration; however, few reports on available calcium phosphate‐based biomaterials with an antibacterial property as drug carriers. Lei Nie and colleagues developed silver‐doped biphasic calcium phosphate/alginate microclusters using the double‐emulsions method. The cover image sh...
Article
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Protein/peptide-based hydrogel biomaterial inks with the ability to incorporate various cells and mimic the extracellular matrix’s function are promising candidates for 3D printing and biomaterials engineering. This is because proteins contain multiple functional groups as reactive sites for enzymatic, chemical modification or physical gelation or...
Article
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Electrospun poly (l-lactide-co-d, l-lactide) (PLDLLA)/poly (vinyl alcohol) (PVA) nanofibers were reinforced by various contents (0–1 wt%) of phospho-calcified cellulose nanowhiskers (PCCNWs) as scaffolds in bone applications. The hydrophilicity and rate of hydrolytic degradation of PLDLLA were improved by introducing 10 wt% of PVA. PCCNWs with inhe...
Article
This study aims to investigate the oxidative degradation of chitosan to produce chitooligosaccharides (CHOS) as a potential bioagent for biomaterials engineering. CHOS was produced via microwaved-assisted oxidative degradation of chitosan by using hydrogen peroxide in an acidic aqueous solution. The effects of the H2O2 concentration, reaction time,...
Article
Full-text available
Hydroxyapatite (HA) and HA-based nanocomposites have been recognized as ideal biomaterials in hard tissue engineering because of their compositional similarity to bioapatite. However, the traditional HA-based nanocomposites fabrication techniques still limit the utilization of HA in bone, cartilage, dental, applications, and other fields. In recent...
Article
Recognizing the importance of succinic acid as one of the most relevant platform molecules, the present study assesses the production of succinic acid from waste apple slurry/pomace as a sustainable and renewable feedstock. The assessment has been undertaken by incorporating technical and economic considerations in the analysis while also comparing...
Article
Keratin dissolution is the first step toward reusing protein-rich biomass such as waste wool, hair, and feather. This paper reports an efficient and environmentally friendly method for the complete recycling of waste wool using lactic acid and L-cysteine as a new green deep eutectic solvent for isolation of keratin. The dissolution time for 90% dis...
Article
Full-text available
Shortcomings related to the treatment of bone diseases and consequent tissue regeneration such as transplants have been addressed to some extent by tissue engineering and regenerative medicine. Tissue engineering has promoted structures that can simulate the extracellular matrix and are capable of guiding natural bone repair using signaling molecul...
Article
Full-text available
Biphasic calcium phosphate (BCP) based materials possessed with both excellent biocompatibility and antibacterial activity show potential advantages for biomedical applications. Here, the silver-doped BCP/Alginate (Ag BA) micro-clusters were first fabricated using the double-emulsions method. First, BCP nanoparticles were incorporated into the algi...
Article
Full-text available
While contraceptive drugs have enabled many people to decide when they want to have a baby, more than 100 million unintended pregnancies each year in the world may indicate the contraceptive requirement of many people has not been well addressed yet. The vagina is a well-established and practical route for the delivery of various pharmacological mo...
Chapter
Full-text available
Many soft tissues of the human body such as cartilages, muscles, and ligaments are mainly composed of biological hydrogels possessing excellent mechanical properties and delicate structures. Nowadays, bio-inspired hydrogels have been intensively explored due to their promising potential applications in tissue engineering. However, the traditional m...