Amin Saberi

Amin Saberi
Forschungszentrum Jülich · Institute of Neurosciences and Medicine (INM)

MD

About

39
Publications
4,936
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240
Citations
Introduction
I am a PhD student in the Cognitive Neurogenetics Lab at the MPI-CBS (Leipzig, Germany) and INM-7 (Jülich, Germany), under the supervision of Dr. Sofie Valk. My research is generally focused on using computational neuroscience techniques on neuroimaging data to study the low-dimensional structural and functional properties of the brain and their links to behavior and psychiatric disorders. I am also interested in open and reproducible science.
Education
September 2011 - March 2019

Publications

Publications (39)
Article
Full-text available
The human thalamus is a heterogeneous subcortical structure coordinating whole-brain activity. Investigations of its internal organization reveal differentiable subnuclei, however, a consensus on subnuclei boundaries remains absent. Recent work suggests that thalamic organization additionally reflects continuous axes transcending nuclear boundaries...
Article
Full-text available
The human cerebral cortex shows hemispheric asymmetry, yet the microstructural basis of this asymmetry remains incompletely understood. Here, we probe layer-specific microstructural asymmetry using one post-mortem male brain. Overall, anterior and posterior regions show leftward and rightward asymmetry respectively, but this pattern varies across c...
Preprint
Full-text available
The cerebellum plays important roles in motor, cognitive, and emotional behaviors. Previous cerebellar coordinate-based meta-analyses and mappings have attributed different behaviors to cerebellar subareas, but an accurate behavioral topography is lacking. Here, we show overrepresentation of superior activation foci, which may be exacerbated by his...
Article
Full-text available
Background Neuroimaging studies have provided valuable insights into the macroscale impacts of antidepressants on brain functions in patients with major depressive disorder. However, the findings of individual studies are inconsistent. Here, we aimed to provide a quantitative synthesis of the literature to identify convergence of the reported findi...
Article
Full-text available
Human brain morphology undergoes complex changes over the lifespan. Despite recent progress in tracking brain development via normative models, current knowledge of underlying biological mechanisms is highly limited. We demonstrate that human cortical thickness development and aging trajectories unfold along patterns of molecular and cellular brain...
Article
Full-text available
Determining sex-bias in brain structure is of great societal interest to improve diagnostics and treatment of brain-related disorders. So far, studies on sex-bias in brain structure predominantly focus on macro-scale measures, and often ignore factors determining this bias. Here we study sex-bias in cortical and hippocampal microstructure in relati...
Article
Full-text available
Study Objectives Insomnia symptoms are prevalent along the trajectory of Alzheimer’s disease (AD), but the neurobiological underpinning of their interaction is poorly understood. Here, we assessed structural and functional brain measures within and between the default mode network (DMN), salience network (SN), and central executive network (CEN)....
Preprint
Full-text available
The balance of excitation and inhibition is a key functional property of cortical microcircuits which changes through the lifespan. Adolescence is considered a crucial period for the maturation of excitation-inhibition balance. This has been primarily observed in animal studies, yet human in vivo evidence on adolescent maturation of the excitation-...
Preprint
Full-text available
While macroscale brain asymmetry and its relevance for human cognitive function have been consistently shown, the underlying neurobiological signatures remain an open question. Here, we probe layer-specific microstructural asymmetry of the human cortex using intensity profiles from post-mortem cytoarchitecture. An anterior-posterior cortical patter...
Preprint
Full-text available
The human thalamus is a bilateral and heterogeneous grey matter structure that plays a crucial role in coordinating whole-brain activity. Investigations of its complex structural and functional internal organization revealed to a certain degree overlapping parcellations, however, a consensus on thalamic subnuclei boundaries remains absent. Recent w...
Preprint
Full-text available
Background: Insomnia is prevalent along the trajectory of Alzheimer disease (AD), but the neurobiological underpinning of their interaction is poorly understood. Here, we assessed structural and functional brain measures within and between the default mode network (DMN), salience network (SN), and central executive network (CEN). Methods: We select...
Preprint
Full-text available
Background Neuroimaging studies have provided valuable insights into the macroscale impacts of antidepressants on brain functions in patients with major depressive disorder. However, the findings of individual studies are inconsistent. Here, we aimed to provide a quantitative synthesis of the literature to identify convergence of the reported findi...
Article
Full-text available
The human isocortex consists of tangentially organized layers with unique cytoarchitectural properties. These layers show spatial variations in thickness and cytoarchitecture across the neocortex, which is thought to support function through enabling targeted corticocortical connections. Here, leveraging maps of the 6 cortical layers based on 3D hu...
Preprint
Full-text available
Sex hormone receptors are expressed widely in both neurons and glial cells, which allows them to interact with the brains major cell groups via several molecular mechanisms. These mechanisms lead to sex differences in brain structure as well as hormone-induced plasticity in the female brain across the menstrual cycle. Adding to the literature on vo...
Preprint
Full-text available
Human brain morphology undergoes complex developmental changes with diverse regional trajectories. Various biological factors influence cortical thickness development, but human data are scarce. Building on methodological advances in neuroimaging of large cohorts, we show that population-based developmental trajectories of cortical thickness unfold...
Article
Introduction: Hippocampal local and network dysfunction is the hallmark of Alzheimer's disease (AD). Methods: We characterized the spatial patterns of hippocampus differentiation based on brain co-metabolism in healthy elderly participants and demonstrated their relevance to study local metabolic changes and associated dysfunction in pathologica...
Preprint
Full-text available
The human neocortex consists of tangentially organized layers with unique cytoarchitectural properties. These layers show spatial variations in thickness and cytoarchitecture across the neocortex, which is thought to support brain function through enabling targeted corticocortical connections. Here, leveraging maps of the six cortical layers in 3D...
Article
Schizophrenia is a highly heritable neuropsychiatric disorder, making it a good candidate for genetic inquiries on disease status and risk. However, it also shows strong clinical het- erogeneity reflected in interindividual differences in symp- toms and behavioral impairments, as well as patterns of brain alterations (1). Both the variety of pathop...
Conference Paper
Full-text available
Behavioral-variant frontotemporal dementia (bvFTD) is characterized by neurodegeneration in the frontal and anterior temporal lobes leading to insidious and progressive changes in behavior, personality and social functions. The individual neuroimaging studies in bvFTD point to divergent findings. Thus, quantitative assessment of neural abnormalitie...
Article
Full-text available
Introduction: Numerous studies have reported brain alterations in behavioral variant frontotemporal dementia (bvFTD). However, they pointed to inconsistent findings. Methods: We used a meta-analytic approach to identify the convergent structural and functional brain abnormalities in bvFTD. Following current best-practice neuroimaging meta-analys...
Article
Background and objective Preclinical studies suggest that curcumin might be a potential neuroprotective agent in Parkinson's disease (PD). This clinical trial aimed to evaluate the efficacy of adding nanomicelle curcumin on improving the motor and non-motor symptoms of PD patients and their quality of life. Material and methods Idiopathic PD patie...
Poster
Full-text available
Narcolepsy, as a second prevalent sleep disorder, is characterized by excessive daytime sleepiness, lack of muscle tone triggered by strong emotions (i.e., cataplexy), sleep paralysis, and hallucinations. Narcolepsy impairs quality of life and productivity of patients, and increases the risk of accidents. Several structural and functional neuroimag...
Article
Full-text available
Several neuroimaging studies have investigated localized aberrations in brain structure, function or connectivity in late-life depression, but the ensuing results are equivocal and often conflicting. Here, we provide a quantitative consolidation of neuroimaging in late-life depression using coordinate-based meta-analysis by searching multiple datab...
Article
Background Neutrophil to lymphocyte ratio (NLR) is a marker for many inflammatory diseases. Ankylosing spondylitis (AS) is among these inflammatory diseases, and many studies have compared the NLR ratio between patients with AS and healthy controls. Aim To systematically review and analyze the available evidence about the significance of NLR value...
Article
Full-text available
Background and aims: Visceral adiposity index (VAI) is a novel marker of fat distribution and function which incorporates both anthropometric and laboratory measures. Recently, several studies have suggested VAI as a screening tool for metabolic syndrome (MetS). Here, we aimed to consolidate the results of these studies by performing a systematic...
Article
Background The aim of this systematic review is to evaluate the chest computed tomography (CT) findings in infants with confirmed COVID-19 infection by providing a comprehensive review of the existing literature.Data sourcesA systematic search was conducted on PubMed and Embase from the onset of the COVID-19 outbreak to October 20, 2020, for studie...
Preprint
Full-text available
INTRODUCTION: Numerous studies have reported brain alterations in behavioral variant frontotemporal dementia (bvFTD). However, they pointed to inconsistent findings. METHODS: We used a meta-analytic approach to identify the convergent structural and functional brain abnormalities in bvFTD. Following the best-practice neuroimaging meta-analysis guid...
Article
Full-text available
Neuroimaging and genetics studies have advanced our understanding of the neurobiology of sleep and its disorders. However, individual studies usually have limitations to identifying consistent and reproducible effects, including modest sample sizes, heterogeneous clinical characteristics and varied methodologies. These issues call for a large‐scale...
Article
Thalamus plays an important role in the pathogenesis of multiple sclerosis-related fatigue (MSrF). However, the thalamus is a heterogeneous structure and the specific thalamic subregions that are involved in this condition are unclear. Here, we used thalamic shape analysis for the detailed localization of thalamic abnormalities in MSrF. Using the M...
Article
Full-text available
Background: Inflammatory processes have been proposed in the pathophysiology of ischemic stroke. The present study was designed to evaluate the relationship between tumor necrosis factor-alpha (TNF-α), interleukin 6 (IL-6), IL 1 beta (IL-1β), and high sensitivity C-reactive protein (hsCRP) with the prognosis and functional outcome in patients with...
Preprint
Full-text available
Several neuroimaging studies have investigated localized aberrations in brain structure, function or connectivity in late-life depression, but the ensuing results are equivocal and often conflicting. Here, we provide a quantitative consolidation of neuroimaging in late-life depression using coordinate-based meta-analysis by searching multiple datab...
Article
Full-text available
Background: Inflammatory processes have been proposed in the pathophysiology of ischemic stroke. The present study was designed to evaluate the relationship between tumor necrosis factor-alpha (TNF-α), interleukin 6 (IL-6), IL 1 beta (IL-1β), and high sensitivity C-reactive protein (hsCRP) with the prognosis and functional outcome in patients with...
Article
Full-text available
Background: Inflammatory processes have been proposed in the pathophysiology of ischemic stroke. The present study was designed to evaluate the relationship between tumor necrosis factor-alpha (TNF-α), interleukin 6 (IL-6), IL 1 beta (IL-1β), and high sensitivity C-reactive protein (hsCRP) with the prognosis and functional outcome in patients with...
Conference Paper
Late-life depression (LLD) is turning into a health concern with the aging of the population. Its unique presentation with somatic symptoms and cognitive dysfunction highlights the need to study LLD as a distinct disease process from depression in younger adults. Numerous functional and structural neuroimaging studies have investigated the neural c...
Article
Full-text available
Background: Red blood cell distribution width (RDW) is a quantitative measure of variability in the size of circulating erythrocytes. It has been recently identified as a prognostic marker in several diseases including acute pancreatitis (AP). In this systematic review the prognostic value of RDW in predicting mortality of AP patients will be asses...
Poster
Full-text available
Context: Bevacizumab is an FDA approved antiangiogenic agent for the treatment of recurrent glioblastoma. Patients have varied response to this treatment and it is important to identify biomarkers that can predict responders. Objective: To systematically review the prognostic value of cerebral blood volume (CBV) in glioblastoma patients treated wit...

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