Amin Abdullah Al-Doaiss

• Associate Professor of Histology and Cell Biology
• Professor (Associate) at King Khalid University

Background and Aim: Aluminum (AL) is commonly found in food, drinking, air, and soil and it can be a serious contaminant in varying amounts. Therefore, this study investigated the biochemical and histological hazardous reactions to aluminum chloride (AlCl3) and the efficiency of the methanol extract of Delonix regia aerial parts with gum Arabic (GA...

Quercetin is the most prevalent flavonoid; its bioactivities have a preventive role in helping protect cells against various damaging effects. Complex vitamin E and selenium help enhance the immune system and maintain brain and heart health, as well as keep normal cell division. Cadmium is a hazardous heavy metal that exists naturally, and both occ...

Abstact Copper oxide nanoparticles (CuO NPs) have wide range of application in many fields of industry, agriculture, cosmetics, and health care with probable risk to human health. The present study was conducted to find the chronic toxicity of these nanoparticles in the vital organs. Male healthy Wister Albino rats were subjected on daily bases to...

Background: Boswellia serrata (BS) is one of the medicinal plants that possess antioxidant and anti-inflammatory activities. This study aimed to investigate BS resin effect on cytokine levels, antioxidant status and NF-κB expression in the spleen and thymus of rats in a dose-dependent manner. Methods: Twenty male rats were divided equally into four...

Nanoparticles (NPs) are utilized in various applications, posing potential risks to human health, tissues, cells, and macromolecules. This study aimed to investigate the ultrastructural alterations in hepatocytes and renal tubular cells induced by metallic and metal oxide NPs. Adult healthy male Wistar albino rats ( Rattus norvegicus) were divided...

The duck industry is at high risk from duck viral hepatitis (DVH) and has the potential to cause substantial financial losses because of the high mortality rates observed in duck farming, even with continuous breeder duck flock vaccination. Among the different etiological agents of DVH, duck hepatitis A virus type-1 (DHAV-1) is the most common foll...

Background Melatonin is a peptide neurohormone naturally synthesized in the brain by the pineal gland. The basic function of melatonin is related to the causation and regulation of the sleep–wake cycle (circadian cycle). Cadmium (Cd) is a hazardous heavy metal and its toxic effects induce extensive tissue damage. The present study was undertaken to...

Objectives Majhool date (Phoenix dactylifera), renowned for its premium taste and texture, is extensively consumed in the Islamic world, particularly during Ramadan. Despite its popularity, concerns persist regarding its potential to induce diabetes in non-patients. This study aims to explore the diabetogenic effects of prolonged Majhool date (Phoe...

The liquid whey is a byproduct produced during cheese making. Cadmium is a highly hazardous heavy metal with cumulative toxic effects. The present research work was done to clarify the possible role of whey proteins in alleviating cadmium-induced oxidative stress. The used rats were allotted equally and randomly into three experimental groups; untr...

Background The present study was carried out to test the antioxidant activity of lactoferrin as a dietary supplement to alleviate the effects of oxidative stress induced by mercury toxicity. Hematological and biochemical assays were employed to evaluate the ameliorating effects of lactoferrin. Methods Sixty male Wistar rats were allotted randomly...

Helminths are considered a significant threat to the livestock industry, as they cause substantial economic losses in small and large ruminant farming. Their morbidity and mortality rates are also increasing day by day as they have zoonotic importance. Anthelmintic drugs have been used for controlling these parasites; unfortunately, due to the deve...

Epigenetics plays a vital role in the interaction between living organisms and their environment by regulating biological functions and phenotypic plasticity. Considering that most aquaculture activities take place in open or natural habitats that are vulnerable to environmental changes. Promising findings from recent research conducted on various...

Alcohol abuse is dangerous to one’s health and contributes to disorders such as neurotoxicity and hepatotoxicity worldwide. Twenty-five male albino rats, each weighing 200 ± 10 g, were divided into five groups. For 4 weeks, rats in the control group were given only a regular chow diet and ad libitum. Rats in the alcohol group received an oral gavag...

The aim of the present study was to identify and quantify the biochemical profile of Vaucheria karachiensis and to evaluate its nutritional, antioxidant, antimicrobial and hypoglycemic potential. The study revealed ash content of 34.98 %, followed by carbohydrates (20.37 %), crude protein (18.74 %), moisture (12.12 %), crude fat (11.20 %), crude fi...

Background: The level of fasting blood glucose (FBG) is influenced by several factors, including health status, genetics, and diet. Some studies have reported a beneficial effect of Ramadan Intermittent Fasting (RIF) on diabetic patients. However, clinical observations have shown that diabetes is exacerbated in some patients. Aim: This study aim...

Copper oxide nanomaterials (CuO NPs) have been widely utilized in many fields, including antibacterial materials, anti-tumor, osteoporosis treatments, imaging, drug delivery, cosmetics, lubricants for metallic coating, the food industry, and electronics. Little is known about the potential risk to human health and ecosystems. The present work was c...

Cystic echinococcosis (CE) is a parasite-borne disease caused by the larval stage of Echinococcus granulosus belonging to family Taeniidae, is an endemic disease, distributed worldwide as a neglected parasite with socioeconomic repercussions. It causes severe alterations in liver of infected host, and it could be fatal if untreated. The main object...

The livers of reptiles are being studied as a model for the link between the environment and hepatic tissue. There have been few investigations on the histology of reptile livers, and very few or no studies have examined the histology of liver of veiled chameleon (Chamaeleo calyptratus). This paper describes the histomorphological, histochemical an...

Sunbirds, as specialized nectarivores, have developed multiple lingual and oropharyngeal peculiarities imposed by this dietary specialization that particularly extract floral nectar. We have described the functional morphology of the tongues and palates of the shining sunbird, Cinnyris habessinicus, using gross anatomical, histological, and scannin...

The present study investigated the toxic action of acrylamide (ACR) and the abrogative effect of aqueous propolis extract on ACR-induced toxicity in male albino rats. Forty adult male albino rats were randomly divided into four groups and administered the treatment doses orally by gavage. Control, treated with a physiological solution (5.0 ml/rat)....

Quercetin is a naturally existing plant pigment belonging to the flavonoid group; it is contained in a wide range of vegetables and fruits. The accumulated evidence points to the potential uses of quercetin in protection of some disease conditions. Lead is one of the highly toxicant heavy metals that are widely spread in the environment and implica...

Compared to other mammals, Arabian camels are ideal models for exploring the structural adaptations that enable camels to survive in arid environments. Thus, this study aimed to explore how evolutionary adaptation to arid conditions modifies the characteristics of the kidneys in Arabian camels ( Camelus dromedarius ) compared to oxen. Urine samples...

[This corrects the article DOI: 10.3389/fvets.2022.1042640.].

Members of the order Trypanorhyncha are cestode parasites that are frequently found infecting the muscles of several marine fish species, affecting fish health, and resulting in consumers’ rejection of fish. Fifty-two specimens of marine fish were freshly caught throughout the year 2020 from boat landing sites at the Alexandria coast along the Medi...

Simple Summary Feline upper respiratory infection (FURI) is a frequent ailment in felines. It feels like a cold, but it has the potential to be far worse. Such infections in cats are most often caused by viruses, perhaps between 80% and 90%, while bacteria are responsible for the remaining 10% or so. Clinical sign analysis revealed that feline cali...

Since the duration of clinical signs could be used to identify cases of chronic constipation, in addition, prolonged duration is often associated with irreversible changes. Thus, the main objective of this study was to determine whether the duration of clinical signs of idiopathic megacolon in cats affected their diagnosis and prognosis after treat...

The study objective was to evaluate Allium sativum's potential and Nigella Sativa's combination's potential to reduce aluminum toxicity and return to the normal state. In the present study, a hundred albino rats were randomly divided into five equal groups. The first group was used as a control group; the other four groups were exposed to aluminum...

The oral intake of alcohol has become a widespread concern due to its high risk to body health. Therefore, our purpose in this study was to reveal the antioxidant efficacies of natural Commiphora myrrha on hepatotoxicity and oxidative stress induced by ethanol in adult male rats, especially because these were not adequately revealed by previous stu...

Gold nanoparticles (Au NPs) are used in diagnostic and therapeutic applications together with a variety of industrial purposes and in many biomedical sectors with potential risks to human health. The present study aimed to the histological, histochemical, and ultrastructural alterations induced by Au NPS in vital organs. Healthy male Wistar Albino...

This study aims to increase the aqueous solubility of ciprofloxacin (CPN) to improve oral bioavailability. This was carried out by formulating a stable formulation of the Self-Emulsifying Drug Delivery System (SEDDS) using various ratios of lipid/oil, surfactant, and co-surfactant. A pseudo-ternary phase diagram was designed to find an area of emul...

Members of the order Trypanorhyncha are cestode parasites that are frequently found infecting the muscles of several marine fish species, affecting fish health and resulting in consumers’ rejection. Seventy–five specimens of marine fish were freshly caught from boat landing sites at the Alexandria coast along the Mediterranean Sea in Egypt, includi...

Copper oxide nanomaterials are used in many biomedical, agricultural, environmental, and industrial sectors with potential risk to human health and the environment. The present study was conducted to determine the renal ultrastructural damage caused by 25 nm CuO nanoparticles in renal tissues. Adult healthy male Wister Albino rats ( Rattus norvegic...

Background: Jatropha variegata (family, Euphorbiaceae) is native to Yemen, where it is commonly known as the Ebki shrub. The fruits of the plant are traditionally ingested by local women as a natural method of contraception. This study was undertaken to investigate the phytochemical content of the methanol extract of J. variegata fruits and to eva...

[This corrects the article DOI: 10.1016/j.sjbs.2021.06.024.].

Objectives: The objectives of the study were to determine the phytochemical constituents and to assess the antibacterial, antioxidant, and wound-healing properties of the methanol extracts of Aloe irafensis. Methods: Methanol extracts of A. irafensis's latex, gel, and green skin were screened for their phytochemical constituents. All three extracts...

Breast cancer is one of the major causes of cancer deaths worldwide, and survival rate remains low even with the advancement of screening and treatment methods. Polyherbal medicines have been widely used for cancer treatment. CBBh and SNH are two new polyherbal formulations that showed anticancer effects. MDA-MB-231 and MCF-7 cells were used for in...

Objectives: The objectives of the study were to determine the phytochemical constituents and to assess the antibacterial, antioxidant, and wound-healing properties of the methanol extracts of Aloe irafensis. Methods: Methanol extracts of A. irafensis's latex, gel, and green skin were screened for their phytochemical constituents. All three extracts...

In this work, we investigated the larvicidal, ovicidal, and histopathological alterations induced by Lepidium sativum seed extracts in Culex pipiens. Hexane, chloroform, ethyl acetate, and methanol solvents were used for the seed extraction. Only ethyl acetate seed extract was active against the third instar mosquito larvae of Cx. pipiens. The ethy...

SUMMARY: This study aimed to describe the morphology, histology, and histochemistry of the kidneys and the sexual segment of the kidney (SSK) in Chamaeleo calyptratus (Yemen chameleons or veiled chameleons) collected during the active reproductive season. To achieve this objective, a total of 7 mature male Chamaeleo calyptratus were captured from t...

The present study focused on extracting green larvicides from extracts of the combination of Foeniculum vulgare and Matricaria chamomilla using different solvents of increasing polarity in a Soxhlet extractor and evaluating their ovicidal, larvicidal, and cytotoxic activities. The most promising among all tested extracts was hexane extract. The ovi...

Cancer is a universal health issue, and many anticancer therapeutic drugs have been isolated from natural products. This study analyzed the cytotoxic and apoptotic activity of Plectranthus amboinicus leaf hexane (PALH) extract in MDA-MB-231 (median inhibitory concentration [IC50] = 39.26 μg/mL) and MCF7 (IC50 = 89.05 μg/mL) breast cancer cell lines...

Abstract Silicon dioxide nanoparticles (SiO2 NPs) are widely invested in medicine, industry, agriculture, consuming products, optical imaging agents, cosmetics, and drug delivery. However, the toxicity of these NPs on human health and the ecosystem have not been extensively studied and little information is available about their behavioural toxicit...

Culex pipiens (Cx. pipiens) or common house mosquito is the most widely distributed species worldwide, including Saudi Arabia. The current study examined morphological, histological, and ultrastructural features of midgut epithelium of fourth instar larvae of Cx. pipiens. Findings provide a basis for research on insecticide resistance and mosquito...

The consumption of inadequately thermally treated fish is a public health risk due to the possible propagation of Anisakis larvae. The present study demonstrated the physiological and histopathological changes that accompanied an oral inoculation of crude extracts from fresh and thermally treated Anisakis Type II (L3) in rats. Worms were isolated f...

Background Atorvastatin (ATOR) is widely used for the treatment and prevention of hypercholesterolemia and various diseases, such as cardiovascular complication, with little data about the histopathological and ultrastructural renal alterations that might be induced by this drug. Objectives The present study was undertaken to investigate the poten...

Titanium dioxide nanoparticles (TiO2 NPs) have novel application and are used in many household application, nanomedicine, agriculture, industries and pharmaceutical products. These applications may be accompanied with potential risk in human health and the ecosystems. The current study was carried out to find out the acute damage that might be ind...

Background and objective: Jatropha variegata is traditionally used in Yemeni folk medicine for antiseptic and hemostatic purposes. In this study, the methanolic extract of the plant leaves was evaluated for its antioxidant, antibacterial and wound healing activity. Materials and methods: The antioxidant activity was assessed using 1,1-diphenyl-2...

Over dose or long-term clinical use of therapeutic doses of acetaminophen (APAP) causes hepatotoxicity. Various strategies attempted to ameliorate APAP-hepatotoxicity have been found to be unsuitable for clinical practice. This study was aimed to illustrate the histopathological changes induced by therapeutic dose of APAP and investigate the hepato...

Silver nanoparticles (Ag NPs) are invested in various sectors and are becoming more persistent in our ambient environment with potential risk on our health and the ecosystems. The current study aims to investigate the histological, histochemical and ultrastructural hepatic changes that might be induced by 10 nm silver nanomaterials. Male mice (BALB...

Silver nanoparticles (Ag NPs) are widely used in nanomedicine, pharmaceutical products, industry and other consumer products owing to their unique physiochemical properties with probable potential risk to human health and the ecosystems. The aim of this work was to investigate the in-life morphological effects, biochemical, histological and histoch...

The study aimed to clarify the characteristics of black tea (BTE) and/or curcumin (CMN) against aflatoxin‐B1 (AFB1). Forty eight adult male Sprague–Dawley rats were divided into eight groups. G1 was non‐treated control. G2, G3, and G4 were olive oil, BTE, and CMN, respectively. G5 was olive oil‐dissolved AFB1 (25 µg/kg b.w). G6, G7, and G8 were AFB...

Silver nanoparticles (Ag NPs) are invested in various sectors and are becoming more persistent in our ambient environment with potential risk on our health and the ecosystems. The current study aims to investigate the histological, histochemical and ultrastructural hepatic changes that might be induced by 10 nm silver nanomaterials. Male mice (BALB...

Metallic nanoparticles (NPs) are widely used in medical preparations. The present study aims to find out the influence of widely used five metallic NPs on the expression of major hepatic drug-metabolizing enzyme (DME) genes. Six groups of BALB/C mice, 7 mice each, were exposed to: Gold NPs, silver NPs, copper oxide NPs, silicon dioxide NPs and zinc...

A popular polyherbal formulation prepared from five plants (PHF5) may have anticancer effects. However, there is a lack of adequate scientific evidence. We assessed the anticancer, antioxidant, and acute toxicity effects of PHF5. Cancer cells were treated with 0 to 300 μg/mL PHF5 extract. Established assays were used to assess cytotoxicity, apoptos...

Diabetes mellitus is a serious disease with a high incidence of occurrence in our community. Gum Arabic (GA) is a branched-chain polysaccharide which has strong antioxidant properties, and has been used to reduce the experimental toxicity. Yet, the effects of GA on testicular tissue in type I diabetic rats have not been enough investigated. This st...

Avermectins are broad-spectrum antiparasitic drugs in veterinary and human medication. The current study aimed to examine the toxic effects of ivermectin (IVM) and doramectin (DRM), with or without co-treatment of vitamin E (Vit.E) and selenium (Se) on apoptosis, oxidative stress and male fertility in Wistar rats. Twenty five adult male animals wer...

A. niebuhriana is used in Yemeni folk medicine for treating various illnesses including liver or spleen enlargement. The aim of this study is to quantify the total phenolic content (TPC) of A. niebuhriana latex extract and validate its antioxidant, hepatoprotective and cytotoxic activity. The (TPC) of the extract was estimated spectrophotometricall...

Abstract Objective: To determine the phytochemical content and to evaluate the antibacterial, antioxidant, and wound healing activities of the methanol extracts of A. inermis. Material and Methods: The methanol extracts of the latex, gel and green skin of A. inermis were screened for their phytochemical content. The antibacterial activity of the ex...

Titanium dioxide nanoparticles (TiO2 NPs) are widely used in many commercial products, nanomedicine, agriculture, personal care products, different industries and pharmaceutical preparations with potential risk in human health and the environment. The current work was conducted to investigate the renal damage that might be induced by the acute toxi...

Purpose: To investigate the protective effect of vitamin E (Vit E) and selenium (Se) combination against gentamycin (GM)-induced renal and hepatic toxicity in rats. Methods: Forty-eight male Wistar albino rats were administrated GM at a dose of 80 mg/kg/day, with or without Se (1.5 mg/kg/day), and/or Vit E (250 mg/kg/day) for a period of 4 weeks. S...

Annona and ginger have prominent uses in traditional medicine; their therapeutic properties have not been sufficiently explored. The ameliorative effect of Annona or ginger extracts on hyperglycaemia associated with oxidative stress, inflammation, and apoptosis in experimentally induced diabetes was addressed. Type 1 diabetes in male rats was induc...

Abstract: Titanium dioxide (TiO2) nanoparticles are among the top five nanoparticles used in consumer products, paints, and pharmaceutical preparations. Given that exposure to such nanoparticles is mainly via the skin and inhalation, the present study was conducted in male Wistar albino rats (Rattus norvegicus). Our aim was to investigate the effec...

Titanium dioxide (TiO2) nanoparticles are among the top five nanoparticles used in consumer products, paints, and pharmaceutical preparations. Given that exposure to such nanoparticles is mainly via the skin and inhalation, the present study was conducted in male Wistar albino rats (Rattus norvegicus). Our aim was to investigate the effect of TiO2...

Titanium dioxide (TiO 2) nanoparticles are among the top five nanoparticles used in consumer products, paints, and pharmaceutical preparations. Given that exposure to such nanopar-ticles is mainly via the skin and inhalation, the present study was conducted in male Wistar albino rats (Rattus norvegicus). Our aim was to investigate the effect of TiO...

Summary Statins, such as atorvastatin (ATOR) and rosuvastatin (ROSU) are used as cholesterol-lowering drugs. Because statins widely used, commercially available and increasingly used day by day, with few studies and limited data existed on atorvastatin or rosuvastatin-induced histological, histochemical and ultrastructural changes, the present stud...

The aim of the present study is to determine the potential toxicity of the therapeutic doses of rosuvastatin in Wistar albino rats. A total of 80 adult Wistar male albino rats were divided randomly into 4 groups. The control group (group 1) received oral gavage administration of normal saline (1 ml /kg/day for 90 consecutive days) while group II an...

Gentamicin is an effective widely used antibiotic, but the risk of nephrotoxicity and oxidative damage limit its long-term use. Hence, the current study aims to elucidate such hazardous effects. To achieve the study aim male Wistar albino rats (Rattus norvegicus) were exposed to gentamicin to investigate the resultant blood chemical changes and ren...

The aim of this study was to investigate the effect of antibiotic gentamicin on the apoptotic pathway in rats liver cells. Gentamicin was administered intramuscularly (im) at a dosage of 80 mg kg-1 b. wt. once daily for 1, 2, 3, and 4 weeks. And then we have evaluated apoptosis induced by gentamicin in rats liver cells. Within 24 h, gentamicin star...

The aim of the present study was to investigate the effect of antibiotic gentamicin on the apoptotic pathway in rat liver cells. For this purpose, four groups of rats were injected intramuscularly (im) with gentamicin at a dosage of 80 mg kg-1 b.wt. once daily for 1, 2, 3 and 4 weeks successively. The induced apoptosis in hepatocytes was evaluated...