Ami Tsuchida

Ami Tsuchida
University of Bordeaux

Ph.D

About

27
Publications
3,324
Reads
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831
Citations
Citations since 2016
18 Research Items
527 Citations
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2016201720182019202020212022020406080100120
2016201720182019202020212022020406080100120
2016201720182019202020212022020406080100120
Introduction
My research interest is on structural and functional architecture of the brain and its relationship to individual differences in cognitive functions. My current work focuses on subtle white matter anomalies in relatively young subjects, and their impact of structural and functional connectivity of the brain, as well as how they may be related to cognitive decline and dementia caused by small cerebral vessel disease later in life.
Additional affiliations
May 2020 - present
University of Bordeaux
Position
  • Engineer
Description
  • Continuing my work from WAIMEA project, I will investigate the precursors of small cerebral vessel diseases by studying the impact of white matter anomalies, such as white matter hyperintensities and enlarged perivascular spaces, on functional architecture of the brain and cognition.
April 2016 - April 2020
University of Bordeaux
Position
  • PostDoc Position
Description
  • I worked on the WAIMEA project, which stands for White matter Anomalies Imaging Marker for Early Assessment. In this project, we identified and characterized subtle white matter anomalies in young adults using the MRiShare, a large multimodal neuroimaging database of a cohort of university students in Bordeaux.
June 2012 - March 2017
McGill University
Position
  • PostDoc Position
Description
  • I worked with Dr. Brenda Milner to investigate the hemispheric specialisations and the role of hemispheric interactions in memory function using neuropsychological approaches and functional neuroimaging methods.
Education
September 2006 - October 2012
McGill University
Field of study
  • Neuroscience
September 2000 - June 2004
McGill University
Field of study
  • Biology

Publications

Publications (27)
Preprint
Full-text available
Perivascular space burden (PVS) is an emerging and possibly the earliest magnetic resonance imaging (MRI)-marker of cerebral small vessel disease (cSVD), a leading cause of stroke and dementia. Its molecular underpinnings are unknown. Genome-wide and whole-exome association studies in 40,095 participants (21 population-based cohorts, 66.3±8.6 years...
Article
Background Subcortical brain structures play a key role in pathological processes of age-related neurodegenerative disorders. Mounting evidence also suggests that early-life factors may have an impact on the development of common late-life neurological diseases, including genetic factors that can influence both brain maturation and neurodegeneratio...
Article
Full-text available
We report on MRi-Share, a multi-modal brain MRI database acquired in a unique sample of 1870 young healthy adults, aged 18–35 years, while undergoing university-level education. MRi-Share contains structural (T1 and FLAIR), diffusion (multispectral), susceptibility-weighted (SWI), and resting-state functional imaging modalities. Here, we described...
Article
Full-text available
The relationship between hippocampal subfield volumetry and verbal list-learning test outcomes have mostly been studied in clinical and elderly populations, and remain controversial. For the first time, we characterized a relationship between verbal list-learning test outcomes and hippocampal subfield volumetry on two large separate datasets of 447...
Article
Full-text available
Human brain white matter undergoes a protracted maturation that continues well into adulthood. Recent advances in diffusion-weighted imaging (DWI) methods allow detailed characterizations of the microstructural architecture of white matter, and they are increasingly utilized to study white matter changes during development and aging. However, relat...
Article
Full-text available
We implemented a deep learning (DL) algorithm for the 3-dimensional segmentation of perivascular spaces (PVSs) in deep white matter (DWM) and basal ganglia (BG). This algorithm is based on an autoencoder and a U-shaped network (U-net), and was trained and tested using T1-weighted magnetic resonance imaging (MRI) data from a large database of 1,832...
Article
Full-text available
Background and Objectives: Young adults represent an increasingly large proportion of healthy volunteers in brain imaging research, but descriptions of incidental findings (IFs) in this age group are scarce. We aimed to assess the prevalence and severity of IFs on brain MRIs of healthy young research participants aged 18–35 years, and to describe t...
Preprint
Full-text available
Human brain white matter undergoes a protracted maturation that continues well into adulthood. Recent advances in diffusion-weighted imaging (DWI) methods allow detailed characterizations of the microstructural architecture of white matter, and they are increasingly utilised to study white matter changes during development and ageing. However, rela...
Article
Full-text available
White matter hyperintensities (WMH) are the most common brain-imaging feature of cerebral small vessel disease (SVD), hypertension being the main known risk factor. Here, we identify 27 genome-wide loci for WMH-volume in a cohort of 50,970 older individuals, accounting for modification/confounding by hypertension. Aggregated WMH risk variants were...
Preprint
Full-text available
We implemented a deep learning (DL) algorithm for the 3-dimensional segmentation of perivascular spaces (PVSs) in deep white matter (DWM) and basal ganglia (BG). This algorithm is based on an autoencoder and a U-shaped network (U-net), and was trained and tested using T1-weighted magnetic resonance imaging (MRI) data from a large database of 1,832...
Article
The frontal lobes have long been implicated in inhibitory control, but a full understanding of the underlying mechanisms remains elusive. The stop-signal task has been widely used to probe instructed response inhibition in cognitive neuroscience. The processes involved have been modelled and related to putative brain substrates. However, there has...
Preprint
Full-text available
The size of the human head is determined by growth in the first years of life, while the rest of the body typically grows until early adulthood. Such complex developmental processes are regulated by various genes and growth pathways. Rare genetic syndromes have revealed genes that affect head size, but the genetic drivers of variation in head size...
Preprint
We report on MRi-Share, a multi-modal brain MRI database acquired in a unique sample of 1,870 young healthy adults, aged 18 to 35 years, while undergoing university-level education. MRi-Share contains structural (T1 and FLAIR), diffusion (multispectral), susceptibility weighted (SWI), and resting-state functional imaging modalities. Here, we descri...
Article
Full-text available
Parameters of water diffusion in white matter derived from diffusion-weighted imaging (DWI), such as fractional anisotropy (FA), mean, axial, and radial diffusivity (MD, AD, and RD), and more recently, peak width of skeletonized mean diffusivity (PSMD), have been proposed as potential markers of normal and pathological brain ageing. However, their...
Article
Navigating our complex social world requires effective processing of subtle emotional signals, such as those conveyed by facial expressions. Failure to do so may underlie some of the disabling social-emotional deficits common in a range of neuropsychiatric and neurological conditions. Prefrontal cortex (PFC) has long been implicated in these proces...
Article
Adaptive decision making involves selecting the most valuable option, typically by taking an action. Such choices require value comparisons, but there is debate about whether these comparisons occur at the level of stimuli (goods-based) value, action-based value, or both. One view is that value processes occur in series, with stimulus value informi...
Article
Existing tools for rapid cognitive assessment in HIV-positive individuals with mild cognitive deficits lack sensitivity or do not meet psychometric requirements for tracking changes in cognitive ability over time. Seventy-five nondemented HIV-positive patients were evaluated with the Montreal Cognitive Assessment (MoCA), a brief battery of standard...
Conference Paper
Background / Purpose: This study attempts to clarify the precise roles played by right inferior frontal cortex (RIFC) and dorsomedial frontal cortex (DMF) in the performance of tasks requiring motor response inhibition.It has been proposed that these areas are important not for response inhibition per se, but for other aspects of the task, such a...
Article
Full-text available
Damage to the orbitofrontal cortex (OFC) has been linked to impaired reinforcement processing and maladaptive behavior in changing environments across species. Flexible stimulus-outcome learning, canonically captured by reversal learning tasks, has been shown to rely critically on OFC in rats, monkeys, and humans. However, the precise role of OFC i...
Article
Although prefrontal cortex is clearly important in executive function, the specific processes carried out by particular regions within human prefrontal cortex remain a matter of debate. A rapidly growing corpus of functional imaging work now implicates various areas within prefrontal cortex in a wide range of "executive" tasks. Loss-of-function stu...

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