Amee Krishnakumar

• Ph.D in life Sciences spclzn: Neurobiology
• Professor (Assistant) at Nirma University

Collagens constitute the major structural component of the extracellular matrix of every tissue and make up nearly one-third of the total human proteins. With a unique triple helical structure, and nearly 28 different types encoded by almost 43 genes, collagen constitutes its large family. Synthesized from its precursor procollagen molecules, these...

Since the turn of the century, biopolymer uses in the biomedical field have seen a tremendous rise owing to their abundance, biocompatibility, efficacy, minimal immunogenicity, and biodegradability. Biopolymer-based scaffolds - 2D films, hollow fibers, hydrogels, sponge, 2D/3D Electrospun fibers, microcarrier beads are used to produce prototypes to...

Glycemic regulation is important for maintaining critical physiological function. Extreme variation in levels of circulating glycemic levels are known to affect insulin secretion. Elevated insulin levels result in lowering of circulating glycemic levels culminating into hypoglycemia. Recurrence of hypoglycemia are often noted owing to fasting condi...

Meningitis creates a life-threatening clinical crisis. Moreover, the administered antibiotics result into multi-drug resistance, thereby necessitating development of alternative therapeutic strategies. This study aimed at identifying novel-drug targets in Neisseria meningitidis and therapeutic molecules which can be exploited for the treatment of m...

Neuronal regeneration is crucial for maintaining intact neural interactions for perpetuation of cognitive and emotional functioning. The NRG1-ErbB receptor signaling is a key pathway for regeneration in adult brain and also associated with learning and mood stabilization by modulating synaptic transmission. Extreme glycemic stress is known to affec...

Context: Regenerative endodontics uses the concept of tissue engineering to restore the diseased immature tooth, allowing for continued development of the root to a healthy state. For regenerative endodontics, the use of human dental pulp stem cells (HDPSCs) with appropriate scaffolds and growth factors is imperative. Aims: The aim of the study...

Hypoglycemia induced brain injury poses a major setback to optimal blood glucose regulation during diabetes. It causes irreversible injury in several brain regions culminating in improper function. Neuregulin 1 and ErbB receptors are involved in regeneration during adulthood as well as in glucose homeostasis. We intended to understand the influence...

ErbB receptors are involved in regulation of proliferation, differentiation and migration of oligodendrocytes. Oligodendrocytes are myelin producing cells of CNS which ensheaths multiple axons. Regeneration of oligodendrocytes in CNS fails due to its poor regenerative potential. ErbB 4 is involved in regeneration both during adult and developmental...

Bacopa monnieri is effective in stress management, brain function and a balanced mood. 5-HT2C receptors have been implicated in stress whereas NMDA receptors and mGlu5 play crucial role in memory and cognition. In the present study, we investigated the role of B. monnieri extract in ameliorating pilocarpine induced temporal lobe epilepsy through re...

Effect of Hypoglycemia on Motor Function, Malate Dehydrogenase and Arginase Activity in Streptozotocin Induced Diabetic Rats. Madhavi Joshi, Gokul M L Manickavachagam, Pooja Pathak, Rinal Maisuriya, Amee Krishnakumar Nair* Hypoglycemia is a common side effect of insulin treatment during diabetes which subsequently triggers cascade of events in vu...

Hypoglycemic brain injury is a common and serious complication of insulin therapy associated with diabetes. This study evaluated the effect of insulin-induced hypoglycemia and STZ-induced diabetes on striatal cholinergic receptors and enzyme expression and on motor function. Cholinergic enzymes: AChE and ChAT gene expression, radioreceptor binding...

Department of Biotechnology, Cochin University of Science and Technology

Emotional disturbances, depressive mood, anxiety, aggressive behavior, and memory impairment are the common psychiatric features associated with temporal lobe epilepsy (TLE). The present study was carried out to investigate the role of Bacopa monnieri extract in hippocampus of pilocarpine-induced temporal lobe epileptic rats through the 5-HT(2C) re...

We report here the regenerative cell proliferation and functional recovery of spinal cord injury after supplementation with neurotransmitter's combination and bone marrow cells. Monoplegia was induced in male Wistar rats by producing a wound between 12th and 13th vertebra and they were treated with neurotransmitter's combination and bone marrow cel...

Epilepsy is a syndrome of episodic brain dysfunction characterized by recurrent unpredictable, spontaneous seizures. Cerebellar dysfunction is a recognized complication of temporal lobe epilepsy and it is associated with seizure generation, motor deficits and memory impairment. Serotonin is known to exert a modulatory action on cerebellar function...

Hypoglycaemic coma and brain injury are potential complications of insulin therapy. Hippocampal neurons are particularly vulnerable to hypoglycaemic stress leading to memory impairment. In the present article, we have investigated the dopamine (DA) content, homovanillic acid (HVA)/DA turnover ratio, DA D(1) and DA D(2) receptors in the hippocampus...

Brain damage due to an episode of hypoxia remains a major problem in infants causing deficit in motor and sensory function. Hypoxia leads to neuronal functional failure, cerebral palsy and neuro-developmental delay with characteristic biochemical and molecular alterations resulting in permanent or transitory neurological sequelae or even death. Dur...

The potential for antiepileptic drugs to negatively impact cognitive abilities has generated renewed interest in herbal drugs and formulations in the treatment of epilepsy. Bacopa monnieri is one such widely used revitalizing herb that purportedly strengthens nervous function and also possesses memory-enhancing, antioxidative, antiepileptic, and an...

The experiments were designed to study the glutamate gene expression during epilepsy in adult and hypoxic insult to brain during the neonatal period and the therapeutic role of neuroprotective supplements. We investigated the role of metabotropic glutamate-8 receptor (mGluR8) gene expression in cerebellum during epilepsy and neuroprotective role of...

Neuroscience is the study of'tbe ne rvous system , including the i - ; . in, spinal cord and peripheral nerves . Neurons are the basic cells of the brain and nervous system which exerts its functional role through various neurotransmitters and receptor systems . The activity of a nen ren depends on the balance between the number of excitatory and i...

The recent developments in neurobiology have rendered new prominence and potential to study about the structure and function of brain and related disorders. Human behaviour is the net result of neural control of the communication between brain cells. Neurotransmitters are chemicals that are used to relay, amplify and modulate electrical signals bet...