Ambrish Singh

Ambrish Singh
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Ambrish verified their affiliation via an institutional email.
Verified
Ambrish verified their affiliation via an institutional email.
University of Tasmania · Menzie Institutue for Medical Research

Doctor of Medicine
Health Outcomes | COA | HEOR | Health Economics | PRO | Pharmacoepidemiology | Systematic Review

About

160
Publications
79,513
Reads
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29,727
Citations
Introduction
☆☆☆— Feel free to send a request if you need full-text of any of my research articles —☆☆☆ A researcher working in the field of primary medical research, evidence synthesis, and knowledge translation. I use Systematic Review, Meta-analysis, Health Economics & Outcomes Research (HEOR), and Health Technology Assessment (HTA) methodology to conduct research in various therapeutic areas. Open for paid consulting/research projects along with pro-bono research contributions. Expertise: Real World Evidence, Patient Outcomes, Systematic Review, Meta-analysis, HEOR, Market Access, Global HTA & Reimbursement, and Pharmacoeconomics. Disease areas: Cardiovascular, Renal, Oncology, Diabetes, Depression, Rheumatology, Parkinson's disease, Osteoarthritis, Alzheimer's disease, etc.
Additional affiliations
December 2022 - present
Eli Lilly and Company
Position
  • Scientist
June 2019 - March 2020
Freelance
Position
  • Consultant
January 2018 - July 2019
Eli Lilly and Company
Position
  • Manager
Education
July 2019 - December 2022
University of Tasmania
Field of study
  • Medical Studies
March 2014 - March 2015
Public Health Foundation of India
Field of study
  • Health Promotion
May 2009 - May 2011
Anna University, Chennai
Field of study
  • Biotechnology

Publications

Publications (160)
Article
Full-text available
Objectives Health state utilities (HSUs) are an input metric for estimating quality-adjusted life-years (QALY) in cost–utility analyses. Currently, there is a paucity of data on association of knee symptoms with HSUs for middle-aged populations. We aimed to describe the association of knee symptoms and change in knee symptoms with SF-6D HSUs and de...
Article
Objective To describe the associations between OA-related biochemical markers (COMP, MMP-3, HA) and MRI-based imaging biomarkers in middle-aged adults over 10-13 years. Methods Blood serum samples collected during the Childhood Determinants of Adult Health (CDAH)-1 study (year:2004-06;n=156) and 10-13 year follow-up at CDAH-3 (n=167) were analysed...
Article
Objective To describe the burden of osteoarthritis (OA) in India from 1990 to 2019. Design Data from Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019 were used. The burden of OA –knee OA, hip OA, hand OA, and other OA– was estimated for India and its states from 1990 to 2019 through a systematic analysis of prevalence, incide...
Article
Full-text available
Objectives Describe associations between MRI markers with knee symptoms in young adults. Methods Knee symptoms assessed using WOMAC scale during Childhood Determinants of Adult Health (CDAH)-knee study (year : 2008–10) and 6–9 year follow-up (CDAH-3; year : 2014–2019). Knee MRI scans, obtained at baseline, assessed for morphological markers (carti...
Article
Full-text available
Pain, particularly musculoskeletal (MSK) and multi-site pain, significantly impacts activities of daily living (ADL) in the elderly, leading to a decline in overall quality of life (QoL). This study, comprising 7490 participants, (mean age: 69 ± 10; females: 57%) from the sixth wave of the Korean Longitudinal Study of Aging (KLoSA), aimed to assess...
Article
Objectives: To describe the associations between OA-related biochemical markers and knee symptoms in middle-aged adults followed up over 10-13 years. Methods: Blood samples were collected during the Childhood Determinants of Adult Health (CDAH)-1 study (year: 2004-06) and 10-13 year follow-up at CDAH-3. Serum samples from baseline (n=156) and follo...
Article
Full-text available
Objectives: In this study, the trends and current situation of the injury burden as well as attributable burden to injury risk factors at global, regional, and national levels based on the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019 are presented. Study design: To assess the attributable burden of injury risk factors, th...
Article
Full-text available
Background: The Australian population aged 70 and above is increasing and imposing new challenges for policy makers and providers to deliver accessible, appropriate and affordable health care. We examine pre-COVID patterns of health loss between 1990 and 2019 to inform policies and practices. Methods: Using the standardised methodology framework an...
Article
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Background Estimates of demographic metrics are crucial to assess levels and trends of population health outcomes. The profound impact of the COVID-19 pandemic on populations worldwide has underscored the need for timely estimates to understand this unprecedented event within the context of long-term population health trends. The Global Burden of D...
Article
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Background Neck pain is a highly prevalent condition that leads to considerable pain, disability, and economic cost. We present the most current estimates of neck pain prevalence and years lived with disability (YLDs) from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) by age, sex, and location, with forecasted prevalence to...
Article
Introduction Hepatocellular carcinoma (HCC) is the most common form of liver cancer and the fourth leading cause of cancer-related death globally. There are unmet needs for effective systematic therapy. The findings of the RESORCE trial highlighted the improvement in overall survival with regorafenib in advanced HCC patients progressing on sorafeni...
Article
Introduction In the RESORCE trial, regorafenib was shown to provide overall survival (OS) benefit for patients with hepatocellular carcinoma (HCC) that has progressed on sorafenib treatment. Subsequently, it was approved by the Therapeutic Goods Administration for the treatment of patients with HCC who were previously treated with sorafenib; howeve...
Article
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https://pubmed.ncbi.nlm.nih.gov/38092509/#full-view-affiliation-41
Article
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Background Musculoskeletal disorders include more than 150 different conditions affecting joints, muscles, bones, ligaments, tendons, and the spine. To capture all health loss from death and disability due to musculoskeletal disorders, the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) includes a residual musculoskeletal category...
Article
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Abstract Objective Metabolic syndrome (MetS) is characterised by the clustering of central obesity with metabolic abnormalities. We aimed to describe the association of MetS and trajectories of MetS over 10–13 years with knee symptoms in general population-based middle-aged adults. Methods Fasting blood biochemistry, waist circumference and blood...
Article
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Background Rheumatoid arthritis is a chronic autoimmune inflammatory disease associated with disability and premature death. Up-to-date estimates of the burden of rheumatoid arthritis are required for health-care planning, resource allocation, and prevention. As part of the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2021, we...
Chapter
Cartilage diseases include a myriad of disorders ranging from genetic defects to articular cartilage abnormalities that are usually caused by traumatic injuries or result from chronic progressive degradation of articular cartilage. Osteoarthritis (OA) is the most prevalent cartilage disease. OA pathology involves the whole joint, but the change in...
Article
Full-text available
Background Osteoarthritis is the most common form of arthritis in adults, characterised by chronic pain and loss of mobility. Osteoarthritis most frequently occurs after age 40 years and prevalence increases steeply with age. WHO has designated 2021–30 the decade of healthy ageing, which highlights the need to address diseases such as osteoarthriti...
Article
Full-text available
Background: A comprehensive understanding of temporal trends in the disease burden in Australia is lacking, and these trends are required to inform health service planning and improve population health. We explored the burden and trends of diseases and their risk factors in Australia from 1990 to 2019 through a comprehensive analysis of the Global...
Article
Background Metabolic syndrome (MetS) is characterized by an increased waist circumference, dyslipidaemia (elevated triglycerides and reduced high-density lipoprotein (HDL)), hypertension and hyperglycaemia. MetS has been suggested as having a role in osteoarthritis (OA) pathogenesis. Few studies have described the association of MetS with joint pai...
Article
Full-text available
Background Low back pain is highly prevalent and the main cause of years lived with disability (YLDs). We present the most up-to-date global, regional, and national data on prevalence and YLDs for low back pain from the Global Burden of Diseases, Injuries, and Risk Factors Study 2021. Methods Population-based studies from 1980 to 2019 identified i...
Article
Full-text available
Background: Low back pain is highly prevalent and the main cause of years lived with disability (YLDs). We present the most up-to-date global, regional, and national data on prevalence and YLDs for low back pain from the Global Burden of Diseases, Injuries, and Risk Factors Study 2021. Methods: Population-based studies from 1980 to 2019 identified...
Article
Full-text available
Background Universal access to safe drinking water and sanitation facilities is an essential human right, recognised in the Sustainable Development Goals as crucial for preventing disease and improving human wellbeing. Comprehensive, high-resolution estimates are important to inform progress towards achieving this goal. We aimed to produce high-res...
Presentation
Title: Investigating Early Knee Osteoarthritis: Impact, Correlates, and Biomarkers Description: This presentation represents the final defense of my PgD thesis, focusing on the investigation of early knee osteoarthritis (OA). Osteoarthritis, particularly knee OA, is a prevalent condition affecting over 500 million people worldwide, with significa...
Article
Full-text available
Knee osteoarthritis (KOA) is a progressive joint disease and a leading source of chronic pain and disability. OA-bone marrow lesions (BMLs) are a recognised aetiopathological feature of KOA. Several intra-articular injectable therapies are recommended and used for management of KOA. This systematic review assessed the efficacy and safety of intra-a...
Article
Background: Curcuma longa (CL) extract is modestly effective for relieving knee symptoms in knee osteoarthritis (OA) patients; however, its mechanism of action is unclear. Purpose: We aimed to determine the effects of CL treatment on serum inflammatory markers over 12 weeks and to explore its potential effects on synovitis assessed by contrast-e...
Article
Full-text available
Introduction: Generic multiattribute utility instruments (MAUIs) are efficient tools for determining and enumerating health-related quality of life. MAUIs accomplish this by generating health state utilities (HSUs) via algorithms. Minimal important differences (MIDs) assist with the interpretation of HSUs by estimating minimum changes that are cli...
Article
Full-text available
Objective: Colchicine, an approved treatment for gout, has been trialed in many diseases including osteoarthritis (OA) due to its anti-inflammatory effects. However, its efficacy and safety remain unclear in OA. This systematic review and meta-analysis evaluated the efficacy and safety of colchicine for the treatment of OA. Methods: PubMed, Web...
Article
Full-text available
Osteoarthritis (OA) is a common joint disorder for which there is no cure. Current treatments are suboptimal. Exercise is a core treatment for knee OA, with muscle strengthening exercise commonly recommended. Yoga is a mind-body exercise intervention that can improve flexibility, muscle strength, balance, and fitness and potentially reduce symptoms...
Article
Full-text available
Background: Understanding the magnitude of cancer burden attributable to potentially modifiable risk factors is crucial for development of effective prevention and mitigation strategies. We analysed results from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019 to inform cancer control planning efforts globally. Methods:...
Article
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Evidence from preclinical studies suggests a preventive effect of proton pump inhibitors (PPIs) in preeclampsia. Recently, several epidemiological studies have described a conflicting association between the use of PPIs during pregnancy and preeclampsia risk. This study aimed to evaluate the association between PPI use and the risk of preeclampsia....
Patent
Full-text available
Can dowload from https://register.dpma.de/DPMAregister/pat/register?AKZ=2020221015201&CURSOR=0
Article
Background High prevalence of diabetes has been reported in the Americas, but no comprehensive analysis of diabetes burden and related factors for the region is available. We aimed to describe the burden of type 1 and type 2 diabetes and that of hyperglycaemia in the Americas from 1990 to 2019. Methods We used estimates from GBD 2019 to evaluate t...
Article
Background: Parkinson's Disease (PD) is a neurodegenerative disorder manifested by rest tremor, rigidity, bradykinesia, and postural instability. Recent pharmaco-epidemiological studies evaluating beta-adrenergic drug use and risk of PD have reported conflicting findings. Objectives: This systematic review and meta-analyses evaluate the associat...
Article
Background Few studies have reported the burden of osteoarthritis (OA) in different parts of India. However, no study has reported the detailed estimates of incidence, prevalence, and years lived with disability (YLDs) and its trends for OA (and its various sites) across the states of India over a long period of time. Objectives We aim to describe...
Article
Background Knee magnetic resonance imaging (MRI)-based morphological markers (quantitative biomarkers) and structural abnormalities (semi-quantitative biomarkers) are known to be associated with the progression of knee osteoarthritis (OA). However, there is conflicting evidence on the association between knee MRI-based morphological markers and kne...
Article
Background Colchicine, an approved treatment for gout, has been trialled in many diseases, including osteoarthritis (OA), due to its anti-inflammatory effects. However, its efficacy and safety remain unclear in OA. Objectives This systematic review and meta-analysis evaluated the efficacy and safety of colchicine for the treatment of OA. ¹ Method...
Presentation
Presentation on Integrated Evidence Plan (IEP): This presentation provided an overview of what an Integrated Evidence Plan (IEP) entails, outlining the key processes involved in its development, identifying the various stakeholders engaged throughout the process, and discussing the challenges faced in IEP formulation.
Article
Full-text available
Objectives To use data from the Global Burden of Diseases, Injuries, and Risk Factors Study 2019 (GBD 2019) to estimate mortality and disability trends for the population aged ≥70 and evaluate patterns in causes of death, disability, and risk factors. Design Systematic analysis. Setting Participants were aged ≥70 from 204 countries and terri...
Article
Full-text available
Background: Diabetes, particularly type 1 diabetes, at younger ages can be a largely preventable cause of death with the correct health care and services. We aimed to evaluate diabetes mortality and trends at ages younger than 25 years globally using data from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019. Methods: We...
Article
Full-text available
Background Diabetes, particularly type 1 diabetes, at younger ages can be a largely preventable cause of death with the correct health care and services. We aimed to evaluate diabetes mortality and trends at ages younger than 25 years globally using data from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019.
Article
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Background and Aim: A growing body of literature suggests the association between de-mentia risk and proton pump inhibitor (PPI) use. Therefore, we aimed to investigate the association between PPI use and dementia risk. Methods: An extensive literature search was performed in PubMed, Embase, and Cochrane till March 31, 2019. All the studies (cohort...
Article
Full-text available
Mucormycosis, a secondary fungal infection, gained much attention in the ongoing COVID-19 pandemic. This deadly infection has a high all-cause mortality rate and imposes a significant economic, epidemiological, and humanistic burden on the patients and healthcare system. Evidence from the published epidemiological studies showed the varying prevale...
Article
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Acute kidney injury (AKI) is associated with several adverse outcomes, including new or progressive chronic kidney disease, end-stage kidney disease, and mortality. Epidemiological studies have reported an association between AKI and dementia as a long-term adverse outcome. This meta-analysis was aimed to understand the association between AKI and...
Preprint
Full-text available
Preeclampsia is one of the common complications of pregnancy and is characterized by high blood pressure. Proton pump inhibitors (PPIs) are commonly used for the management of gastroesophageal reflux disease among pregnant women. Recently, multiple epidemiological studies suggested the association between PPIs use and the risk of preeclampsia. This...
Article
Full-text available
Background: Residual/reconverted red bone marrow (RBM) in adult knees is occasionally observed on routine knee magnetic resonance imaging (MRI). We aimed to identify its prevalence, distribution, and associations with lifestyle factors, knee structural abnormalities, and knee symptoms in young adults. Methods: Participants (n = 327; aged = 31-41...
Article
Full-text available
Background Measuring routine childhood vaccination is crucial to inform global vaccine policies and programme implementation, and to track progress towards targets set by the Global Vaccine Action Plan (GVAP) and Immunization Agenda 2030. Robust estimates of routine vaccine coverage are needed to identify past successes and persistent vulnerabiliti...
Preprint
Full-text available
Acute kidney injury (AKI) is a complex disorder characterized by an abrupt decline in kidney function over a short period of time. Published epidemiological studies linked AKI with the development of dementia. This meta-analysis aims to understand the pooled risk of dementia in AKI patients compared to non-AKI patients. MEDLINE and Embase databases...
Article
Full-text available
Osteoarthritis (OA) is the most common form of arthritis in adults that affects more than 500 million people globally [...]
Article
Aim: There is a lack of data on OA-related serum biomarkers’ (cartilage oligomeric matrix protein (COMP), matrix metalloproteinase (MMP)-3, and hyaluronan (HA)) association with MRI-markers in the middle-aged general population. Therefore, our aim was to investigate the association between OA-related biomarkers and MRI-markers in middle-aged adults...
Article
Background Serum levels of osteoarthritis (OA)-related cartilage and joint-specific biochemical markers – cartilage oligomeric matrix protein (COMP), matrix metalloproteinase (MMP)-3, and hyaluronan (HA) –are shown to be associated with cartilage degradation, joint tissue degradation, and synovitis in patients with OA. Although these OA-related bio...
Article
Background Serum levels of cartilage and joint-specific biochemical markers such as cartilage oligomeric matrix protein (COMP), matrix metalloproteinase (MMP)-3, and hyaluronan (HA) are associated with cartilage degradation, joint tissue degradation, and synovitis in patients with OA. Change in these biomarkers may precede the morphological and cli...
Preprint
Full-text available
Parkinsons disease (PD) is a progressive nervous system disorder characterised by the loss of dopaminergic neurons leading to motor and non-motor symptoms. Accumulation of α-synuclein protein (SNCA) in the form of Lewy bodies has been observed in dopaminergic neurons of PD patients. Potential relationships between β-adrenergic drugs (agonists and a...
Article
Introduction: Though cost-effectiveness analyses (CEAs) have evaluated continuous renal replacement therapy (RRTs) and intermittent RRTs in acute kidney injury (AKI) patients; it is yet to establish which RRT technique is most cost-effective. We systematically reviewed the current evidence from CEAs of CRRT versus IRRT in patients with AKI. Areas...
Article
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Background/aims: Conventional disease-modifying anti-rheumatic drugs have been trialed in osteoarthritis (OA). Hydroxychloroquine (HCQ), which has shown its effectiveness in rheumatoid arthritis, has been trialed for the treatment of OA; however, its efficacy and safety remain unclear. This systematic review and meta-analysis evaluate efficacy and...
Article
Background Non-alcoholic fatty liver disease (NAFLD) patients represent a vulnerable population that may be susceptible to more severe COVID-19. Moreover, not only the underlying NAFLD may influence the progression of COVID-19, but the COVID-19 may affect the clinical course of NAFLD as well. However, comprehensive evidence on clinical outcomes in...