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Publications
Publications (169)
In this article, we report on a pilot study consisting of an evaluation of the usability satisfaction and effectiveness of a preliminary telerobotic system to assist therapists of children with ASD. Unlike existing pre-programmed robotic systems, our solution beamed therapists in a humanoid robot (Pepper) to reproduce in real-time the therapist’s g...
Psychotropic drugs are often used to treat behavior problems in ASD with some evidence supporting efficacity (e.g.: risperidone and irritability) but also significant side effects at the short and longer-term. It is then essential to know better the factors associated with the prescription of these medications and potentially implement early behavi...
There are strong individual differences in adaptive behaviors (AB) in autism spectrum disorder (ASD) with conflicting results in literature about specific patterns and related factors. The present study aims to describe AB and identify related factors in terms of clinical and socio-familial characteristics in 875 children and adolescents with ASD i...
Background:
ASD in a child affects parental mental health, with elevated levels of stress, anxiety and depression reported in parents.
Method:
In this study, we examined mothers' and fathers' stress, anxiety and depression, as well as their coping strategies in a sample of 103 children and adolescents enrolled in the ELENA cohort study in France...
Introduction
The elevated rates of neurodevelopmental disorders (NDDs) among siblings of children with autism spectrum disorder (ASD) raise concerns about their developmental monitoring and development. The main aim of this study is to assess the feasibility and acceptability of a standardised screening process on a large sample of siblings.
Metho...
Autism spectrum disorder (ASD) is a neurodevelopmental disorder that results from a complex interaction between genes and environment. Breastfeeding (BF) is thought to promote healthy cognitive development, and a body of research has suggested that it may also protect against ASD. Our objectives were to identify the relationship between the initiat...
Background
The COVID-19 pandemic may affect the screen time of children and adolescents with Autism Spectrum Disorders (ASD). This study aimed to examine the screen time of children and adolescents with ASD during a discrete lockdown period in France and identify risk factors for excessive screen time.
Methods
The study sample consisted of 249 ASD...
Objective
The literature on sex related-clinical differences for children with autism spectrum disorder (ASD) is highly contradictory, whereas this topic has major clinical implications. We aimed to investigate sex-related clinical differences in children with ASD without intellectual disability (ID).
Materials and methods
We compared 319 boys and...
Multimorbidity relates to having multiple chronic health conditions. It is a risk factor for poor health and reduces life expectancy. Autistic people have multiple chronic health conditions and die prematurely, especially if they have an intellectual disability (autism spectrum disorder and intellectual disability). Certain pathophysiological proce...
There is a growing number of young people, diagnosed with an autism-spectrum disorder (ASD), transitioning to adulthood. Among this number, individuals without an intellectual disability have significant adaptive deficits and need individualized care and support services to better target vocational, social, and educational prospects and outcomes. G...
Atypical sensory processing (SP) is a diagnostic criterion of autism spectrum disorder (ASD). However, little is known about its course during development. In this exploratory longitudinal study, we aimed to investigate the course of SP among children with ASD and identify clinical variables associated with changes. We used a subsample of 51 childr...
Anxiety in children with autism spectrum disorder (ASD) negatively affects their social interactions, and quality of life. It is necessary to identify early risk factors for anxiety to tailor prevention and interventions. We aimed to examine the clinical level of anxiety in children with ASD from 5 to 10 years of age and identify potential early ri...
PurposeTo compare mothers and fathers perceptions of the impact of autism spectrum disorder on their Quality of Life (QoL), we used the Parental-Developmental Disorders-Quality of Life scale (Par-DD-QoL).Method
The perception of QoL of mothers and fathers was compared for 130 pairs of parents of children with ASD and the associated variables were i...
Objective
Autism Spectrum Disorder (ASD) is a chronic neurodevelopmental disorder. Living with ASD requires that individuals and parents develop skills in order to cope with daily life. Education interventions are recommended to support them. This study aims to get an overview of education and training interventions in ASD.
Methods
A scoping revie...
Objectives:
Autism spectrum disorder (ASD) has a major impact on caregivers. We aimed to describe caregivers' perceptions concerning their level of knowledge about ASD and their needs to better adapt education and training programs.
Methods:
This was a descriptive cross-sectional study conducted through a declarative and self-administered survey...
Lay abstract:
Autism spectrum disorder is an early onset neurodevelopmental disorder and diagnosis can be made as early as 18 months of age. Early diagnosis of autism spectrum disorder is critical as it leads to early intervention. Age of autism spectrum disorder diagnosis has been linked to the child profile as autism spectrum disorder is charact...
Introduction
Le trouble du spectre de l'autisme (TSA) est un trouble du neurodéveloppement apparaissant dans l'enfance et persistant toute la vie. Les parcours de soins sont très hétérogènes et très mal connus en France. La cohorte ELENA est une cohorte de 876 enfants et adolescents avec un diagnostic formel de TSA âgés de 2 à 16 ans. L'appariement...
Autism spectrum disorder (ASD) has a significant impact on the quality of life (QoL) of families. This study aimed to examine, for parents of children with ASD, the dyadic effect of each parent’s coping strategy on the perception of the impact of ASD on their QoL. In total, 164 couples completed self-report questionnaires, including the Par-DD-QoL,...
Inclusion of students with Autism Spectrum Disorder (ASD) in mainstream schools has a positive impact on their social and daily living behaviors. Our objective was to identify clinical and socio-demographic variables promoting or limiting inclusion in mainstream school through childhood and adolescence. The EpiTED study is a long-term, prospective,...
Influences of pesticide exposures on the clinical expression of children with ASD not known. The aim of this study was to analyze the associations between early residential proximity to agricultural crops, proxy of exposure to pesticides, and adaptive behaviors in children with ASD. Children with ASD were recruited within the Etude Longitudinale de...
Many scientific papers reported that an unbalanced gut microbiota could lead to or worsen neurodevelopmental disorders (NDD). A dysbiosis may then be observed in the course of development and mark a dysfunction within what is called the gut-brain axis. The aim of this systematic review is to investigate potential evidence of dysbiosis in children a...
Background
The Covid-19 pandemic had a strong impact on mental health in the general population. This study conducted during the first lockdown in France considered parents of children with Autism Spectrum Disorder (ASD) prospectively followed in the ELENA Cohort.
Objectives
We aimed to (1) compare the Anxiety and Depression (AaD) levels during th...
A Correction to this paper has been published: https://doi.org/10.1038/s41380-021-01056-7
Background
Direct support workers (DSWs) accompany adults with autism spectrum disorder (ASD) and intellectual disability (ID) in residential care homes. Such DSWs, without specialised ASD training, are exposed to chronic stress linked to supporting ASD-ID clients and must adjust by coping strategies adapted to the needs of the residents. Neverthel...
Background
Autism spectrum disorder (ASD) and attention-deficit hyperactivity disorder (ADHD) are frequently occurring conditions that are often associated (ASD + ADHD). However, there are few comparative studies concerning the clinical presentation in patients formally diagnosed with both ASD and ADHD. Here, we aimed to 1) compare social impairmen...
Introduction
Les expositions prénatales aux pesticides sont fréquemment associées à un risque élevé de trouble du spectre autistique (TSA) chez les enfants. À ce jour, aucune étude n’a investigué l’influence de ces expositions sur le pronostic clinique des enfants avec TSA. L’objectif de cette étude est donc d’analyser les associations entre la pro...
![The PRISMA Flow diagram [27] of the systematic review search strategy](publication/351132674/figure/fig1/AS:11431281130072799@1679712976087/The-PRISMA-Flow-diagram-27-of-the-systematic-review-search-strategy_Q320.jpg)
Autism Spectrum Disorder (ASD) is an early onset neurodevelopmental disorder in which the first signs generally emerge at approximately 12 months of age but its diagnosis is feasible only from the age of 18 months. According to the literature, the average age of diagnosis ranges from 2.7 to 7.2 years, which raises the question of factors associated...
Introduction Intervention in the preschool period is currently recommended for autism spectrum disorder. Therapies delivered by parents are particularly suitable for young children. Preschool Autism Communication Trial (PACT) is a parent-mediated therapy that has shown a significant and sustained impact on autism symptom reduction. However, access...
Autism-spectrum disorder (ASD) and attention-deficit hyperactivity disorder (ADHD) are early neurodevelopmental conditions that share clinical characteristics, raising important issues in clinical diagnosis. We aimed to compare (1) sensory processing in four groups of children: ASD alone, ASD + ADHD, ADHD alone, and typical development (TD) and (2)...
Background
Containment, involving separation and restriction of movement of people due to the COVID-19 pandemic, and mitigation, also referred to as lockdown, involving closure of schools, universities and public venues, has had a profound impact on people’s lives globally. The study focuses on the effects of containment and mitigation measures, on...
The early recognition of ASD in adults is challenging, in particular due to the lack of appropriate and robust diagnostic tools. We performed a psychometric validation and diagnostic accuracy study of the French version of the RAADS-R on a sample of 305 adults: 105 with ASD without ID, 99 with psychiatric disorders, and 103 non-psychiatric control...
Preprints!
https://authors.elsevier.com/c/1c2rW_WbmJ9-L
The intellectual functioning of people with autism spectrum disorder (ASD) without intellectual developmental disorder (IDD) has not been widely studied. However, marked heterogeneity in assessment measures, samples, and results has been an obstacle for the generalization of findings. We aimed to (a) describe WISC‐V intellectual functioning in a sa...
Atypical sensory processing is common in autism spectrum disorders (ASD), but their role in adaptive difficulties and problem behaviors is poorly understood. Our aim was to determine the prevalence and type of atypical sensory processing in children with ASD and investigate its impact on their adaptive functioning and maladaptive behaviors. We stud...
Background
A growing body of evidences suggests an association between early exposure to organophosphates (OPs), organochlorines (OCs), pyrethroids or carbamates and autism spectrum disorder (ASD). However, there are limited data about the other pesticide groups, especially in Europe.
Objectives
Based on a systematic review, we aimed to assess the...
Purpose
We examined whether long-term adherence to three diet quality scores—the Alternative Healthy Eating Index-2010 (AHEI-2010), Dietary Approach to Stop Hypertension (DASH) and transformed-Mediterranean Diet Score (tMDS), Alternative Healthy Eating Index-2010 (AHEI-2010) and Dietary Approach to Stop Hypertension (DASH) is associated with the ri...
This appendix formed part of the original submission and has been peer reviewed. We post it as supplied by the authors. Supplement to: Martínez-Leal R, Folch A, Munir K, et al. The Girona declaration on borderline intellectual functioning. Lancet Psychiatry 2020; 7: e8.
With the development of the latest DSM and ICD classifications, borderline intellectual functioning has ceased to be conceptualised as a diagnostic code and is increasingly less a focus of clinical attention. Even though DSM 5 does not provide a specific recommendation for identification of borderline intellectual functioning, unlike the ICD, it ad...
Children and adolescents with ASD are increasingly included in regular school settings, however little is known about how placement decisions are made. In the present study, we examined the types and duration of school attendance among children and adolescents in the ELENA Cohort, a multi-center study of children and adolescents with ASD, ages 2–16...
Background:
To examine whether Borderline Intellectual Functioning (BIF) and Adverse Childhood Experiences independently predict adult psychiatric morbidity.
Methods:
We performed a secondary analysis of longitudinal data derived from the 1970 British Birth Cohort Study to examine whether BIF and Adverse Childhood Experiences independently predi...
Background : To examine whether Borderline Intellectual Functioning (BIF) and Adverse Childhood Experiences independently predict adult psychiatric morbidity.
Methods : We performed a secondary analysis of longitudinal data derived from the 1970 British Birth Cohort Study to examine whether BIF and Adverse Childhood Experiences independently predic...
Poster presentation of our systematic review --> https://www.researchgate.net/publication/341259047_Is_there_a_dysbiosis_in_individuals_with_a_neurodevelopmental_disorder_compared_to_controls_over_the_course_of_development_A_systematic_review
This poster was presented during the last French Congress of Psychiatry and aim to synthesised limitations...
Background : To examine whether Borderline Intellectual Functioning (BIF) and Adverse Childhood Experiences independently predict adult psychiatric morbidity. Methods : We performed a secondary analysis of longitudinal data derived from the 1970 British Birth Cohort Study to examine whether BIF and Adverse Childhood Experiences independently predic...
Background: To examine whether Borderline Intellectual Functioning (BIF) and Adverse Childhood Experiences independently predict adult psychiatric morbidity. Methods: We performed a secondary analysis of longitudinal data derived from the 1970 British Birth Cohort Study to examine whether BIF and Adverse Childhood Experiences independently predict...
Background: Autism spectrum disorder (ASD) is an early-onset and lifelong neurodevelopmental condition frequently associated with intellectual disability (ID). Although emerging studies suggest that ASD is associated with premature ageing and various medical comorbidities, as described for ID, data are scarce. Objectives: To determine the comorbidi...
Purpose To examine whether Borderline Intellectual Functioning (BIF) and Adverse Childhood Experiences independently predict adult psychiatric morbidity. Methods We performed a secondary analysis of longitudinal data derived from the 1970 British Birth Cohort Study to examine whether BIF and Adverse Childhood Experiences independently predict adult...
Correction to: Molecular Psychiatry; https://doi.org/10.1038/s41380-018-0237-8; published online 26 September 2018.
To deal with stress, parents of children with ASD use coping strategies that help to tackle the challenging situations of raising their child. This systematic review examines parental coping strategy’s questionnaires, factors which influence these coping strategies, interactions between these strategies and perceived stress and their impact on pare...
There is limited data on long-term outcome of ASD with co-occurring intellectual disabilities (ID) and challenging behaviours in France. The EpiTED period cohort is a 15 years longitudinal study of the developmental trajectories of 281 children initially recruited at mean age of 5 years. Two contrasted developmental trajectories were identified. Lo...
The original version of this article unfortunately contained the following omissions.
Introduction
There is global concern about the increasing prevalence of autism spectrum disorders (ASDs), which are early-onset and long-lasting disorders. Although ASDs are considered to comprise a unique syndrome, their clinical presentation and outcome vary widely. Large-scale and long-term cohort studies of well-phenotyped samples are needed to...
Little is known about long‐term outcomes. We investigate the adaptive trajectories and their risk factors in ASD. Data were obtained from 281 children prospectively followed untill adulthood. The final sample consisted of 106 individuals. Vineland scores were collected at baseline (T1), 3 (T2), 10 (T3), and 15 (T4) years later. A group‐based method...
With depression being the psychiatric disorder incurring the largest societal costs in developed countries, there is a need to gather evidence on the role of nutrition in depression, to help develop recommendations and guide future psychiatric health care. The aim of this systematic review was to synthesize the link between diet quality, measured u...
Atypical sensory processing has been described in autism spectrum disorder. The goal of this systematic review is to investigate the links between sensory processing, adaptive behaviours, and attention skills in children with autism spectrum disorder. The PRISMA guidelines were followed and a search was conducted using electronic databases: Medline...
Résumé
Contexte
Le refus scolaire anxieux (RSA) est une pathologie sévère appartenant au spectre des troubles anxieux et un motif fréquent de consultations en milieu hospitalier. L’effet des TCC dont les bénéfices sont pourtant mis en avant dans le traitement des troubles anxieux, n’est pas étudié dans le RSA.
Méthode
Étudier l’efficacité d’un pr...
Background
Challenging behaviours are highly prevalent in children and adolescents with autism spectrum disorders (ASD), but little is known about the prevalence and course of these behaviours during adulthood. The aims of this study were to describe the topography of challenging behaviours in a cohort of 106 young adults with ASD and to identify t...
Résumé
Le handicap mental se caractérise par une déficience intellectuelle et du comportement adaptatif, liée à une altération du développement mental. Le vieillissement des personnes en situation de handicap mental est très peu étudié. Leur espérance de vie reste plus faible qu’en population générale, et de nombreuses comorbidités somatiques émerg...
Résumé
Le trouble du spectre autistique (TSA) est une pathologie fréquente touchant environ une naissance sur 100 et source de handicap mental. Il existe très peu de données sur le vieillissement des patients avec TSA. Cette question peut s’aborder de diverses façons : (i) en évaluant l’évolution des symptômes du TSA au cours du vieillissement, (ii...
The impact of ASD on parental QOL was evaluated in the EpiTED cohort study at early adulthood. Two-third of parents of young adults with ASD (66.7%) reported that their QoL was at least moderately altered. The perceived impact of ASD on parental QoL was related to the young adults' level of adaptive skills, as well as to symptom severity and the pr...
Background:
The autism spectrum (AS) is a multifaceted neurodevelopmental variant associated with lifelong challenges. Despite the relevant importance of identifying AS in adults for epidemiological, public health, and quality of life issues, the measurement properties of the tools currently used to screen and diagnose adults without intellectual...
Autism spectrum disorder (ASD) is defined as persistent deficits in social communication and social interaction, and restricted, repetitive patterns of behavior, interests or activities Diagnostic and Statistical Manual of Mental Disorders (5th ed., DSM-5; American Psychiatric Association, 2013). However, individuals with ASD show clearly atypical...
This study aims to broaden knowledge about pain expression and assessment in daily life situations in children with Autism Spectrum Disorder (ASD). The goals are to provide a description of the responses of the GED-DI, the French version of the NCCPC, and to test the internal structure validity of this scale. Thirty five children with ASD were incl...
Autism spectrum disorder (ASD) is defined as persistent deficits in social communication and social interaction, and restricted, repetitive patterns of behavior, interests or activities (DSM-5; APA, 2013). However, individuals with ASD show clearly atypical visual patterns. So far, indications of abnormal visual attention and oculomotor control con...
Anxiety disorders were long underestimated in children by healthcare professionals, but they are now better diagnosed. They account for the most frequent psychiatric diagnosis between 6 and 18 years of age, with differences in prevalence or risk factors related to the clinical forms. Different clinical subtypes of anxiety disorders are detailed in...
Les adolescents avec un trouble du spectre autistique sans déficience intellectuelle (TSA-SDI) ont une prévalence élevée de troubles anxieux (42 %). Par ailleurs, leur qualité de vie semble plus altérée que celle des sujets sans TSA. Nous pensons que les troubles anxieux pourraient être un facteur de risque d’altération de la qualité de vie dans ce...
Résumé
But de l’étude
Dans la littérature, les travaux concernant l’efficacité des interventions à destination des enfants avec troubles du spectre autistique (TSA) portent principalement sur les approches comportementales intensives, et les études de cohorte réalisées dans des conditions plus écologiques sont encore peu fréquentes. Cette étude a...
Introduction:
In some cases, cultural and social aspects are important determinants in health care access. Some authors have found that bilingualism and loss of cultural markers due to immigration or misunderstanding of the institutions of another country result in patients losing the opportunity to receive good care. In this article, we analyze t...
People with autism spectrum disorders (ASD) are likely to experience pain in a large variety of contexts because of challenging behaviors, medical comorbidities or life conditions. The assessment and treatment of pain in people with ASD is for those reasons a major issue. In this chapter, studies regarding pain expression in people with ASD are rev...
Introduction to Pain and its relation to Nervous System Disorders provides an accessible overview of the latest developments in the science underpinning pain research, including, but not limited to, the physiological, pathological and psychological aspects. This unique book fills a gap in current literature by focussing on the intricate relationshi...
Autism Spectrum Disorder (ASD) is an etiologically and clinically heterogeneous group of neurodevelopmental conditions, characterized by impairments in communication, social interaction and restricted repetitive and stereotyped behaviors. Ehlers-Danlos Syndrome hypermobility-type (EDS-HT; also known as Joint Hypermobility Syndrome), is the most com...
Résumé
Objectif
L’objectif de cette étude est d’évaluer les bénéfices de la participation à un groupe d’accompagnement parental sur le plan de la qualité de vie et du stress, chez des parents dont les enfants ont reçu récemment un diagnostic de TSA.
Matériel et méthode
Le programme comporte cinq séances d’une journée. Treize familles (18 parents...
Intellectual disability (ID) is a frequent feature but is highly clinically and genetically heterogeneous. The establishment of the precise diagnosis in patients with ID is challenging due to this heterogeneity but crucial for genetic counseling and appropriate care for the patients. Among the etiologies of patients with ID, apparently balanced de...