Amaresh Chaturbedi

Amaresh Chaturbedi
Cornell University | CU · Department of Molecular Biology and Genetics

PhD

About

20
Publications
796
Reads
How we measure 'reads'
A 'read' is counted each time someone views a publication summary (such as the title, abstract, and list of authors), clicks on a figure, or views or downloads the full-text. Learn more
84
Citations
Education
January 2008 - January 2016
Indian Institute of Technology Kanpur
Field of study
  • Molecular Genetics

Publications

Publications (20)
Article
Full-text available
Fatty acid desaturation is central to metazoan lipid metabolism and provides building blocks of membrane lipids and precursors of diverse signaling molecules. Nutritional conditions and associated microbiota regulate desaturase expression, but the underlying mechanisms have remained unclear. Here, we show that endogenous and microbiota-dependent sm...
Preprint
Full-text available
Fatty acid desaturation is central to metazoan lipid metabolism and provides building blocks of membrane lipids and precursors of diverse signaling molecules. Nutritional conditions and associated microbiota regulate desaturase expression 1–4 , but the underlying mechanisms have remained unclear. Here, we show that endogenous and microbiota-depende...
Preprint
Full-text available
Curtailed reproduction affects lifespan and fat metabolism in diverse organisms, suggesting a regulatory axis between these processes. In Caenorhabditis elegans , ablation of germline stem cells (GSCs) leads to extended lifespan and increased fat accumulation, suggesting GSCs emit signals that modulate systemic physiology. Previous studies mainly f...
Article
Full-text available
Epigenetic alterations occur as organisms age, and lead to chromatin deterioration, loss of transcriptional silencing and genomic instability. Dysregulation of the epigenome has been associated with increased susceptibility to age-related disorders. In this study, we aimed to characterize the age-dependent changes of the epigenome and, in turn, to...
Article
Full-text available
C. elegans SET-9 and SET-26 are highly homologous paralogs that share redundant functions in germline development, but SET-26 alone plays a key role in longevity and heat stress response. Whereas SET-26 is broadly expressed, SET-9 is only detectable in the germline, which likely accounts for their different biological roles. SET-9 and SET-26 bind t...
Data
Quantitative data for experiments reported. Table S1 (A) Lifespan data for Figure 1B were shown. (B) Heat stress resistance data for Figure 1C were shown. Table S2 (A) Brood size data for Figure 2A were shown. (B) Mortal germline assay data for Figure 2B were show. (C) Maternal and paternal effect on brood size for Figure 2C were shown. (D) Mitotic...
Data
Gene lists for comparison indicated gene list comparisons were shown.
Data
Fig. S1 CEH‐23 and CEP‐1 harbor putative AMPK phosphorylation sites.
Data
Table S2 Genes that are differentially expressed between isp‐1(qm150) and ceh‐23(ms23); isp‐1(qm150) (identified by Statistical Analysis of Microarray (SAM) 1 class analysis with false discovery rate (FDR) = 0.59%, 1.5 fold change cutoff).
Data
Table S4 Genes that are differentially expressed between aak‐2ca strain and transgenic control strain. (Data from Mair et al. and reanalyzed using SAM analysis. Gene list was identified by SAM 1 class analysis with FDR = 0, 1.5 fold change cutoff.)
Data
Table S5 Genes that are commonly regulated by CEH‐23, CEP‐1 and AAK‐2 (identified by overlap between gene lists in Table S3 and S4).
Data
Data S1 Supplemental experimental procedures.
Data
Fig. S3 CRTC‐1 antagonizes CEH‐23 and CEP‐1 to modulate the lifespan of isp‐1(qm150) mutant.
Data
Table S1 Quantitative data of individual lifespan experiments.
Data
Table S3 Genes that are commonly regulated by CEH‐23 and CEP‐1 in the isp‐1 mutant (identified by Statistical Analysis of Microarray (SAM) 1 class analysis with false discovery rate (FDR) = 0, 1.5 fold change cutoff).
Data
Fig. S2 (A) Wild‐type C. elegans lifespan was not altered by the combined loss of ceh‐23 and cep‐1. The ceh‐23(ms23) and cep‐1(gk138) single and double mutants were used in the lifespan analysis. (B) aak‐2 RNAi had little effect on the lifespan of the short‐lived gas‐1(fc21) and mev‐1(kn1) mutants. EV: empty vector RNAi control.
Article
Full-text available
A decline in mitochondrial electron transport chain (ETC) function has long been implicated in aging and various diseases. Recently, moderate mitochondrial ETC dysfunction has been found to prolong lifespan in diverse organisms, suggesting a conserved and complex role of mitochondria in longevity determination. Several nuclear transcription factors...

Network

Cited By