Amanpreet Badhwar

Amanpreet Badhwar
Université de Montréal | UdeM · Pharmacology and Physiology

PhD

About

131
Publications
15,827
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Introduction
AmanPreet Badhwar holds a PhD from McGill University, where she integrated brain imaging, mass spectrometry-based quantitative proteomics and in vivo measures of neurovascular coupling to study the interaction of neuronal and neurovascular damage in Alzheimer’s disease models, and the impact of therapeutics on these two components. Dr. Badhwar's current research focus is to determine how aspects of brain connectivity could be developed as biomarkers of progression in Alzheimer’s disease.
Additional affiliations
July 2020 - present
Université de Montréal
Position
  • Professor (Assistant)

Publications

Publications (131)
Article
Full-text available
The healthy adult brain demonstrates robust learning-induced neuroanatomical plasticity. While altered neuroanatomical plasticity is suspected to be a factor mitigating the progressive cognitive decline in Alzheimer's disease (AD), it is not known to what extent this plasticity is affected by AD. We evaluated whether spatial learning and memory-ind...
Article
Full-text available
Introduction We performed a systematic review and meta-analysis of the Alzheimer's disease (AD) literature to examine consistency of functional connectivity alterations in AD dementia and mild cognitive impairment, using resting-state functional magnetic resonance imaging. Methods Studies were screened using a standardized procedure. Multiresoluti...
Article
Full-text available
Studies using resting-state functional magnetic resonance imaging (rsfMRI) are increasingly collecting data at multiple sites in order to speed up recruitment or increase sample size. The main objective of this study was to assess the long-term consistency of rsfMRI connectivity maps derived at multiple sites and vendors using the Canadian Dementia...
Preprint
Full-text available
Etiological and clinical heterogeneity is increasingly recognized as a common characteristic of Alzheimer′s disease and related dementias. This heterogeneity complicates diagnosis, treatment, and the design and testing of new drugs. An important line of research is discovery of multimodal biomarkers that will facilitate the targeting of subpopulati...
Article
Introduction: Although age is a major risk factor for Alzheimer’s disease (AD), it is not an inevitable consequence of aging nor is it exclusively an old-age disease. Several other major risk factors for AD are strongly associated with metabolism and include lack of exercise, obesity, diabetes, high blood pressure and cholesterol, over-consumption...
Preprint
MRI-detected white matter hyperintensities (WMH) are often recognized as markers of cerebrovascular abnormalities and an index of vascular brain injury. The literature establishes a strong link between WMH burden and cognitive decline, and suggests that the anatomical distribution of WMH mediates cognitive dysfunction. Pathological remodeling of ma...
Preprint
MRI-detected white matter hyperintensities (WMH) are often recognized as markers of cerebrovascular abnormalities, an index of vascular brain injury, and are frequently present in individuals with Alzheimer disease (AD). Given the emerging bidirectional communication between the brain-body axis in both WMHs and AD, it is important to understand the...
Preprint
Oxidative stress, an imbalance between production and neutralization of reactive oxygen species, can damage brain cells and contribute to cognitive decline in Alzheimer disease (AD) continuum. Levels of glutathione (GSH), the most prevalent endogenous brain antioxidant, can be assessed with magnetic resonance spectroscopy (MRS) and serves as a brai...
Article
Full-text available
The initiative “Brain Mappers of Tomorrow” coordinated by the Organization for Human Brain Mapping (OHBM) Diversity and Inclusivity Committee (DIC) aims to make neuroscience accessible to children worldwide, particularly those from historically underrepresented backgrounds. Over the past several years, this successful initiative has grown and evolv...
Preprint
Full-text available
Living with dementia requires decision-making about numerous topics including daily activities, such as advance care planning (ACP). Both individuals living with dementia and care partners require informed support for decision-making. We conducted an umbrella review to assess knowledge translation (KT) interventions supporting decision-making for i...
Article
Diversity, equity, and inclusivity (DEI) are important for scientific innovation and progress. This widespread recognition has resulted in numerous initiatives for enhancing DEI in recent years. Although progress has been made to address gender and racial disparities, there remain biases that limit the opportunities for historically underrepresente...
Article
Full-text available
INTRODUCTION Brain‐derived extracellular vesicles (BEVs) in blood allows for minimally‐invasive investigations of central nervous system (CNS) ‐specific markers of age‐related neurodegenerative diseases (NDDs). Polymer‐based EV‐ and immunoprecipitation (IP)‐based BEV‐enrichment protocols from blood have gained popularity. We systematically investig...
Preprint
Full-text available
The initiative "Brain Mappers of Tomorrow" coordinated by the Organization for Human Brain Mapping (OHBM) Diversity and Inclusivity Committee (DIC) aims to make neuroscience accessible to children worldwide, particularly those from historically underrepresented backgrounds. Over the past several years, this successful initiative has grown and evolv...
Article
Full-text available
As adults get older, their body functions decline. This can cause a build up of harmful substances, called reactive oxygen species, which can damage the cells: the process is called oxidative stress. Luckily, the body uses superhero chemicals called antioxidants to fight against oxidative stress, with the most common being a chemical called glutath...
Article
Full-text available
Cerebrovascular pathology that involves altered protein levels (or signaling) of the transforming growth factor beta (TGFβ) family has been associated with various forms of age-related dementias, including Alzheimer disease (AD) and vascular cognitive impairment and dementia (VCID). Transgenic mice overexpressing TGFβ1 in the brain (TGF mice) recap...
Preprint
INTRODUCTION: Brain-derived extracellular vesicles (BEVs) in blood allows for minimally-invasive investigations of CNS-specific markers of age-related neurodegenerative diseases (NDDs). Polymer-based EV- and immunoprecipitation (IP)-based BEV-enrichment protocols from blood have gained popularity. We systematically investigated protocol consistency...
Preprint
A cerebrovascular pathology that involves altered protein levels or signaling of the transforming growth factor beta (TGFβ) family has been associated with various forms of dementia, including Alzheimer disease (AD) and vascular cognitive impairment and dementia (VCID). Transgenic mice overexpressing TGFβ1 in the brain (TGF mice) recap VCID-associa...
Article
Full-text available
With the increase in large multimodal cohorts and high‐throughput technologies, the potential for discovering novel biomarkers is no longer limited by data set size. Artificial intelligence (AI) and machine learning approaches have been developed to detect novel biomarkers and interactions in complex data sets. We discuss exemplar uses and evaluate...
Article
Artificial intelligence (AI) and machine learning (ML) approaches are increasingly being used in dementia research. However, several methodological challenges exist that may limit the insights we can obtain from high‐dimensional data and our ability to translate these findings into improved patient outcomes. To improve reproducibility and replicabi...
Article
Full-text available
Introduction: Artificial intelligence (AI) and neuroimaging offer new opportunities for diagnosis and prognosis of dementia. Methods: We systematically reviewed studies reporting AI for neuroimaging in diagnosis and/or prognosis of cognitive neurodegenerative diseases. Results: A total of 255 studies were identified. Most studies relied on the...
Book
Full-text available
Art Catalogue for the Exhibition held during the 2022 Annual Meeting of the Organization for Human Brain Mapping - OHBM (Glasgow, UK)
Preprint
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Introduction: Machine learning (ML) has been extremely successful in identifying key features from high-dimensional datasets and executing complicated tasks with human expert levels of accuracy or greater. Methods: We summarize and critically evaluate current applications of ML in dementia research and highlight directions for future research. Resu...
Article
Full-text available
Introduction: Machine learning (ML) has been extremely successful in identifying key features from high-dimensional datasets and executing complicated tasks with human expert levels of accuracy or greater. Methods: We summarize and critically evaluate current applications of ML in dementia research and highlight directions for future research....
Article
Full-text available
Alzheimer’s disease and related dementias is a major public health burden–compounding over upcoming years due to longevity. Recently, clinical evidence hinted at the experience of social isolation in expediting dementia onset. In 502,506 UK Biobank participants and 30,097 participants from the Canadian Longitudinal Study of Aging, we revisited trad...
Article
The Comprehensive Assessment of Neurodegeneration and Dementia (COMPASS‐ND) cohort of the pan‐Canadian Consortium on Neurodegeneration in Aging (CCNA) provides imaging on participants following a standardized protocol. This imaging contribution to deep phenotyping is done to study the full spectrum of age‐related dementias in more than 1,100 indivi...
Article
Full-text available
Alzheimer’s disease is marked by intracellular tau aggregates in the medial temporal lobe (MTL) and extracellular amyloid aggregates in the default network (DN). Here, we examined codependent structural variations between the MTL’s most vulnerable structure, the hippocampus (HC), and the DN at subregion resolution in individuals with Alzheimer’s di...
Article
Importance Several ocular biomarkers have been proposed for the early detection of Alzheimer disease (AD) and mild cognitive impairment (MCI), particularly fundus photography, optical coherence tomography (OCT), and OCT angiography (OCTA). Objective To perform an umbrella review of systematic reviews to assess the diagnostic accuracy of ocular bio...
Article
Full-text available
Science and art have been intertwined for centuries, as both embody means for humans to represent, communicate, and interpret our external and internal worlds. The collective effort to gather and organize knowledge about the brain blends well with a wide array of human creative activities, from visual and performing arts to interactive media. It th...
Preprint
Alzheimer's disease and related dementias (ADRD) are marked by intracellular tau aggregates in the medial-temporal lobe (MTL) and extracellular amyloid aggregates in the default network (DN). Here, we sought to clarify ADRD-related co-dependencies between the MTL's most vulnerable structure, the hippocampus (HC), and the highly associative DN at a...
Preprint
Alzheimer's disease and related dementias is a major public health burden - compounding over upcoming years due to longevity. Recently, clinical evidence hinted at the experience of social isolation in expediting dementia onset. In 502,506 UK Biobank participants and 30,097 participants from the Canadian Longitudinal Study of Aging, we revisited tr...
Preprint
Science and art have been intertwined for centuries, both representing means for humans to represent, communicate and interpret our external and internal worlds. Our collective effort to gather and organize knowledge about the brain blends well with a wide array of human creative activities, from visual and performing arts to interactive media. It...
Article
Full-text available
Early career researchers (ECRs) are faced with a range of competing pressures in academia, making self-management key to building a successful career. The Organization for Human Brain Mapping undertook a group effort to gather helpful advice for ECRs in self-management. Bielczyk et al.
Article
Brainhack is an innovative meeting format that promotes scientific collaboration and education in an open, inclusive environment. This NeuroView describes the myriad benefits for participants and the research community and how Brainhacks complement conventional formats to augment scientific progress.
Preprint
Full-text available
Brainhack is an innovative meeting format that promotes scientific collaboration and education in an open and inclusive environment. Departing from the formats of typical scientific workshops, these events are based on grassroots projects and training, and foster open and reproducible scientific practices. We describe here the multifaceted, lasting...
Article
Full-text available
Scientific research aims to bring forward innovative ideas and constantly challenges existing knowledge structures and stereotypes. However, women, ethnic and cultural minorities, as well as individuals with disabilities, are systematically discriminated against or even excluded from promotions, publications, and general visibility. A more diverse...
Article
Full-text available
Alzheimer’s disease (AD) is a complex disease that attacks the brain that mostly affects people 65 years and older. AD affects more and more people each year. A major problem with AD is that it is diagnosed too late. A big goal is to find ways to help doctors identify the disease early, so they can better help AD patients. Biomarkers are something...
Preprint
Scientific research aims to bring forward innovative ideas and constantly challenges existing knowledge structures and stereotypes. However, women, ethnic and cultural minorities, as well as individuals with disabilities, are systematically discriminated against or even excluded from promotions, publications, and general visibility. A more diverse...
Preprint
Many imaging and genetics studies have aimed to clarify whether the brain acts as an intermediate phenotype mediating the influence of genes in human behaviour. Brain activations in response to task demands are heterogeneous at the individual level, but also follow common patterns at the group level. Some studies have addressed this tension between...
Article
Full-text available
The impact of multisite acquisition on rsfMRI connectivity has recently gained attention. We provide consistency values (Pearson's correlation) between resting-state fMRI (rsfMRI) connectivity maps of an adult volunteer (Csub) scanned 25 times over 3.5 years at 13 sites using the Canadian Dementia Imaging Protocol (CDIP, www.cdip-pcid.ca). This dat...
Article
Early career researchers (ECRs) are faced with a range of competing pressures in academia, making self-management key to building a successful career. The Organization for Human Brain Mapping undertook a group effort to gather helpful advice for ECRs in self-management. Keywords: ECRs; career development; early career researchers; mentoring; networ...
Article
Full-text available
Introduction: Brain cells secrete extracellular microvesicles (EVs) that cross the blood-brain barrier. Involved in cell-to-cell communication, EVs contain surface markers and a biologically active cargo of molecules specific to their tissue (and cell) of origin, reflecting the tissue or cell's physiological state. Isolation of brain-secreted EVs...
Article
Full-text available
Automatic alignment of brain anatomy in a standard space is a key step when processing magnetic resonance imaging for group analyses. Such brain registration is prone to failure, and the results are therefore typically reviewed visually to ensure quality. There is however no standard, validated protocol available to perform this visual quality cont...
Article
Full-text available
Aetiological and clinical heterogeneity is increasingly recognized as a common characteristic of Alzheimer's disease and related dementias. This heterogeneity complicates diagnosis, treatment, and the design and testing of new drugs. An important line of research is discovery of multimodal biomarkers that will facilitate the targeting of subpopulat...
Article
Full-text available
We present MRI data from a single human volunteer consisting in over 599 multi-contrast MR images (T1-weighted, T2-weighted, proton density, fluid-attenuated inversion recovery, T2* gradient-echo, diffusion, susceptibility-weighted, arterial-spin labelled, and resting state BOLD functional connectivity imaging) acquired in over 73 sessions on 36 di...
Preprint
Automatic alignment of brain anatomy in a standard space is a key step when processing magnetic resonance imaging for group analyses. Such brain registration is prone to failure, and the results are therefore typically reviewed visually to ensure quality. There is however no standard, validated protocol available to perform this visual quality cont...
Article
Full-text available
The idea that intelligence is embedded not only in a single brain network, but instead in a complex, well-optimized system of complementary networks, has led to the development of whole brain network analysis. Using graph theory to analyze resting-state functional MRI data, we investigated the brain graph networks (or brain networks) of high intell...
Preprint
Full-text available
This is a working paper for a project launched and managed by the members of the OHBM Student and Postdoc Special Interest Group (SP-SIG, www.ohbmtrainees.com), in collaboration with two guest early career researchers, Dan Kessler from University of Michigan and Daniel Lurie from University of Berkeley. We would like to further develop the manuscri...
Article
Full-text available
Mentorship in academia facilitates personal growth through pairing trainees with mentors who can share insight and expertise. Expertise can be purely academic, on work‐life balance, personal branding and networking, or general career advice. Mentoring has been shown to be beneficial for mentees, both in terms of objective research productivity (Mus...
Preprint
Full-text available
Studies using resting-state functional magnetic resonance imaging (rsfMRI) are increasingly collecting data at multiple sites in order to speed up recruitment or increase sample size. Multisite studies potentially introduce systematic biases in connectivity measures across sites, which may negatively impact the detection of clinical effects. Long-t...
Article
Full-text available
Early prognosis of Alzheimer's dementia is hard. Mild cognitive impairment (MCI) typically precedes Alzheimer's dementia, yet only a fraction (30%-50%) of MCI individuals will progress to dementia. Even when a prognosis of dementia is established using machine learning models and biomarkers, the fraction of MCI progressors remain limited (50%-75%)....
Preprint
Full-text available
Highlights Reliable functional brain network subtypes accompany cognitive impairment in AD Symptom-related subtypes exist in the default-mode, limbic and salience networks A limbic subtype is associated with a familial risk of AD in healthy older adults Limbic subtypes also associate with beta amyloid deposition and ApoE4 In Brief We found reliabl...
Article
Full-text available
Calibrated fMRI based on arterial spin-labeling (ASL) and blood oxygen-dependent contrast (BOLD), combined with periods of hypercapnia and hyperoxia, can provide information on cerebrovascular reactivity (CVR), resting blood flow (CBF), oxygen extraction fraction (OEF), and resting oxidative metabolism (CMRO2). Vascular and metabolic integrity are...
Preprint
Full-text available
INTRODUCTION We performed a systematic review and meta-analysis of the Alzheimer’s disease (AD) literature to examine consistency of functional connectivity alterations in AD dementia and mild cognitive impairment (MCI), using resting-state functional magnetic resonance imaging (rsfMRI). METHODS Studies were screened using a standardized procedure...
Conference Paper
Full-text available
Table of contents I1 Introduction to the 2015 Brainhack Proceedings R. Cameron Craddock, Pierre Bellec, Daniel S. Margules, B. Nolan Nichols, Jörg P. Pfannmöller A1 Distributed collaboration: the case for the enhancement of Brainspell’s interface AmanPreet Badhwar, David Kennedy, Jean-Baptiste Poline, Roberto Toro A2 Advancing open science through...
Article
Full-text available
We present group eight resolutions of brain parcellations for clusters generated from resting-state functional magnetic resonance images for 99 cognitively normal elderly persons and 129 patients with mild cognitive impairment, pooled from four independent datasets. This dataset was generated as part of the following study: Common Effects of Amnest...
Conference Paper
Full-text available
One key objective of team 9 (Developing New Biomarkers) is to extract standardized and sensitive markers of neurodegeneration from MRI data acquired on the COMPASS-ND sample following the Canadian Dementia Imaging Protocol (CDIP). For each CDIP featured acquisition technique, we include multiple analytical pipelines to cater to different philosophi...
Preprint
Full-text available
We present group brain parcellations for clusters generated from resting-state functional magnetic resonance images for 99 cognitively normal elderly persons and 129 patients with mild cognitive impairment, pooled from four independent datasets. The brain parcellations have been registered to both symmetric and asymmetric MNI brain templates and ge...
Article
Cerebrovascular insufficiency appears years prior to clinical symptoms in Alzheimer's disease. The soluble, highly toxic amyloid-β species, generated from the amyloidogenic processing of amyloid precursor protein, are known instigators of the chronic cerebrovascular insufficiency observed in both Alzheimer's disease patients and transgenic mouse mo...
Data
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About the Mouse Hippocampal Atlas Weblink: https://scalablebrainatlas.incf.org/mouse/BLHS13 Anatomical images (T2-weighted 3D fast spin-echo) of adult C57Bl/6J mouse brains were acquired on a 7.0 Tesla scanner at an isotropic resolution of 32 μm. The hippocampus proper was manually segmented into the CA1, CA2, and CA3 subfields using the average v...