Amani Meaidi

University of Copenhagen

This study uses data from nationwide Danish registries to assesses breast cancer risk with continuous use of levonorgestrel-releasing intrauterine systems, accounting for other hormonal exposures.

Objectives Whether vaginal estradiol use is associated with an increased risk of recurrent venous thromboembolism (VTE) in women with prior VTE is unknown. We sought to evaluate the association between vaginal estradiol use and recurrent VTE in women with prior VTE. Methods We performed a nationwide nested case–control study among 44 024 women age...

Background Use of the high-dose levonorgestrel-releasing intrauterine system (LNG-IUS) has been associated with increased risk of incident depression. Evidence is lacking on the influence of use of two recently marketed low-dose LNG-IUS on risk of depression. This study aims to examine associations between use of different doses of LNG-IUS and risk...

Objective To estimate the rate of breast cancer associated with use of vaginal oestradiol tablets according to duration and intensity of their use. Design Registry based, case-control study, nested in a nationwide cohort. Setting Based in Denmark using the civil registration system, the national registry of medicinal product statistics, the Danis...

Background Use of estrogen-containing menopausal hormone therapy has been shown to influence the risk of central nervous system (CNS) tumors. However, it is unknown how the progestin-component affects the risk and whether continuous versus cyclic treatment regimens influence the risk differently. Methods and findings Nested case-control studies wi...

This study examines the association between use of estrogen-only therapy for perimenopausal and menopausal women and risk of dementia.

Background In-hospital cardiac arrest is a life-threatening event, often leading to poor outcomes and high mortality rates. There is limited research investigating how the time and day of arrest might impact long-term outcomes, such as mortality and functional status. Purpose To investigate the relationship between time and day of arrest and long-...

Objective To study the influence of concomitant use of hormonal contraception and non-steroidal anti-inflammatory drugs (NSAIDs) on the risk of venous thromboembolism. Design: Nationwide cohort study. Setting: Denmark through national registries. Participants: All 15-49-year-old women living in Denmark between the years 1996-2017 with no medical hi...

Background: Hormonal contraception and nonsteroidal antiinflammatory drugs (NSAIDs) have individually been positively associated with venous thromboembolism. Little is known about the influence of concomitant use. Methods: We assessed associations between concomitant use of hormonal contraception and NSAIDs and rate of venous thromboembolism in a...

Objectives: To assess the association between use of menopausal hormone therapy and development of dementia according to type of hormone treatment, duration of use, and age at usage. Design: Nationwide, nested case-control study. Setting: Denmark through national registries. Participants: 5589 incident cases of dementia and 55 890 age matche...

Background: It is currently unknown whether cumulative use of vaginal oestradiol is associated with development of meningioma and glioma. Methods: We conducted a nested case-control study within a nationwide cohort of Danish women followed from 2000 to 2018. The cohort consisted of 590,676 women aged 50-60 years at study start, without prior can...

Background: Use of exogenous female sex hormones is associated to development of asthma, but the question of whether the effect is protective or harmful remains unresolved. Objective: To investigate whether initiation of hormonal contraception was associated with development of asthma. Methods: We performed a register-based, exposure-matched c...

This study assesses the association between use of levonorgestrel intrauterine systems containing 52, 19.5, and 13.5 mg of hormone and ectopic pregnancy in a nationwide cohort study.

Objective Ultrasonographic features of the endometrium are often assessed when deciding the necessity of surgical intervention following early medical abortion. Knowledge is therefore needed on the ultrasonographic appearance of the endometrium following successful medical abortion in order to avoid unnecessary surgical interventions. We aimed to a...

Purpose: To describe the use of hormonal contraceptives in Danish breast cancer patients. Methods: Nationwide drug utilization study in Danish women diagnosed with breast cancer at ages 13-50 years during 2000-2015. User proportions were estimated in 6-months intervals from two years before to two years after diagnosis. Results: Use of hormona...

Research question Does menopausal hormone therapy with exogenous estrogens and progestogens change the use of inhaled anti-asthma medications in women with asthma? Methods In a population-based, matched cohort study using the Danish registries, we included women with asthma aged 45–65 years from June 1, 1995 to June 30, 2018. We investigated wheth...

Introduction: Use of systemic hormone therapy has been positively associated with development of dementia. Little is known about the dose-dependent effect of vaginal estradiol on dementia risk. Methods: We assessed associations between cumulative dose of vaginal estradiol tablets and dementia in a case-control study nested in a nationwide Danish...

Background Oral tranexamic acid is effective for heavy menstrual bleeding, but the thrombosis risk with this treatment is largely not studied. Methods Using nationwide registries, we assessed associations between use of oral tranexamic acid and risk of deep-vein thrombosis or pulmonary embolism and arterial thrombosis in heart or brain in a nation...

Objective To evaluate the time trend in risk of surgical intervention following early medical abortion. Study Design We conducted a retrospective observational study including all medical abortions induced before a gestational age of 63 days during the period 2008-2012 in a Danish gynecology clinic with a single provider deciding the necessity of...

Objective The primary objectives were to 1) identify risk factors for surgical evacuation following medical termination of second-trimester pregnancies in Denmark and 2) assesses if these risk factors were able to explain the a priori observed variation in risk of surgical evacuation among Danish hospitals and the a priori observed decline in risk...

Objective: To characterize ovarian cancer patients who die within 6 months of diagnosis and to identify prognostic factors for these early deaths. Methods: A nationwide cohort study covering ovarian cancer in Denmark in 2005-2016. Tumor and patient characteristics including comorbidity and socioeconomic factors were obtained from the comprehensi...

Objective: To study patterns of oral tranexamic acid use among pre- and perimenopausal Danish women following the introduction of the levonorgestrel-releasing intrauterine system. Study design: We conducted a nationwide descriptive drug utilization study including all 15-54-year-old Danish women during the period 1996-2017. National health regis...

Introduction/Background Denmark has, along with the UK, for many years ranked at the bottom of the statistics regarding ovarian cancer survival. Considering ovarian cancer survival curves, Denmark distinguishes itself by having a steep fall in survival during the first 0–6 months, after which the survival curve is parallel to the curves of the othe...

Background: By being noninvasive, medical termination of pregnancy has increased worldwide access to abortion and improved safety of unsafe abortion. However, secondary surgical intervention is the most frequent complication to medical abortion. Objective: We aimed to identify and quantify risk factors for surgical intervention in women undergoi...

Introduction: We know little about the use of vaginal estrogen in peri- and postmenopausal women. We aimed to assess the prevalence of vaginal estrogen use in Denmark. Material and methods: The study was designed as a nationwide cross sectional study of all Danish women aged 40-79 years, living in Denmark during the period 2007-2013. The Danish...