Amani Al-Khaifi

Amani Al-Khaifi
Sultan Qaboos University | SQU · College of Medicine and Health Sciences

Doctor of Philosophy

About

6
Publications
504
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75
Citations
Introduction
Amani Al-Khaifi currently works at the Department of Biochemsitry, College of Medicine and Health Sciences , Sultan Qaboos University in Oman. Amani does research in human metabolism. Their most recent publication is 'Asynchronous rhythms of circulating conjugated and unconjugated bile acids in the modulation of human metabolism'.

Publications

Publications (6)
Article
Full-text available
Background and Aim Disturbances of the enterohepatic circulation of bile acids (BAs) are seen in a number of clinically important conditions, including metabolic disorders, hepatic impairment, diarrhea and gallstone disease. To facilitate the exploration of underlying pathogenic mechanisms, we developed a mathematical model built upon quantitative...
Article
FGF21 is a circulating protein of hepatic origin proposed to be involved in the regulation of lipid and glucose metabolism. Increased levels have been reported in conditions of metabolic overload. Recent animal studies have also suggested that FGF21 levels may be influenced by modulation of bile acid metabolism, but knowledge about the human situat...
Article
Full-text available
Background and Objectives Bile acids (BAs) traversing the enterohepatic circulation (EHC) influence important metabolic pathways. By determining individual serum BAs in relation to markers of metabolic activity, we explored how diurnal variations in their EHC relate to hepatic metabolism in normal humans. Methods Serum BAs, fibroblast growth facto...
Article
Full-text available
Bile acid (BA) synthesis is regulated through suppression of hepatic cholesterol 7α-hydroxylase via FXR activation in hepatocytes and/or enterocytes; in enterocytes, this process requires FGF19 signaling. To study these pathways, we quantified markers of BA synthesis (7α-hydroxy-4-cholesten-3-one;C4) and cholesterol production (lathosterol), FGF19,...
Poster
Objectives: Regulation of bile acid (BA) synthesis is mediated through the farnesoid X receptor (FXR), which is predominantly expressed in the liver and intestine (1). The role of direct interaction of BAs with hepatic FXR versus the influence of FGF19 which is secreted from the small intestine after BA-mediated FXR activation is still unclear (2,...
Poster
Bile acids (BAs) are formed from cholesterol in the liver, excreted into the bile after conjugation, stored in the gallbladder and released into the intestine where they promote the absorption of dietary lipids. Over 95% of BAs are then reabsorbed, mainly by active transport in the lower small intestine. Further metabolism, mainly in the large inte...

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