Amandeep Jutla

• MD
• Whitaker Scholar in Developmental Neuropsychiatry at Columbia University

16p11.2 copy number variation (CNV) is implicated in neurodevelopmental disorders, with the duplication and deletion associated with autism spectrum disorder (ASD) and the duplication associated with schizophrenia (SCZ). The 16p11.2 CNV may therefore provide insight into the relationship between ASD and SCZ, distinct disorders that co-occur at an e...

Severe mental illness among adolescents with existing intellectual or developmental disability is common and persists into adulthood. In New York State, this “dually diagnosed” population’s access to psychiatric care is managed by two separate agencies, which requires either the mental illness or the developmental disability to be considered the “p...

Although the clinical phenotypes of autism and schizophrenia spectrum disorders are considered distinct, there are substantial areas of overlap between both diagnoses. The two conditions co-occur disproportionately often, and research has begun to explore the impact of their simultaneous occurrence on clinically relevant outcomes such as depression...

The field of psychiatry is hampered by a lack of robust, reliable and valid biomarkers that can aid in objectively diagnosing patients and providing individualized treatment recommendations. Here we review and critically evaluate the evidence for the most promising biomarkers in the psychiatric neuroscience literature for autism spectrum disorder,...

Although the schizophrenia (SCZ) rate is increased in autism spectrum disorder (ASD), it is difficult to identify which ASD youth will develop psychosis. We explored the relationship between ASD and emerging psychotic-like experiences (PLS) in a sample of 9127 youth aged 9–11 from the Adolescent Brain Cognitive Development (ABCD) cohort. We predict...

Autism spectrum disorder (ASD) and schizophrenia (SCZ) are separate disorders, with distinct clinical profiles and natural histories. ASD, typically diagnosed in childhood, is characterized by restricted or repetitive interests or behaviors and impaired social communication, and it tends to have a stable course. SCZ, typically diagnosed in adolesce...

Although the schizophrenia rate is increased in autism spectrum disorder (ASD), it is difficult to identify which youth with ASD will go on to develop psychosis. We explored the relationship between ASD and emerging psychotic-like experiences in the Adolescent Brain Cognitive Development (ABCD) cohort of school-aged children. We predicted that ASD...

16p11.2 copy‐number variation (CNV) is implicated in neurodevelopmental disorders, with the duplication and deletion associated with autism spectrum disorder (ASD) and the duplication associated with schizophrenia (SCZ). The 16p11.2 CNV may therefore provide insight into the relationship between ASD and SCZ, distinct disorders that co‐occur at an e...

Decades of research have implicated both genetic and environmental risk factors for autism spectrum disorder (ASD). However, only in recent years have population-based studies been able to place risk in a broader context, allowing the relative influence of these factors on ASD liability to be better estimated. In this issue of JAMA Psychiatry, Bai...

Poster

Poster

People with autism spectrum disorder (ASD) are over three times more likely to develop schizophrenia (SCZ) than the general population, but identifying ASD youth with emerging psychosis who may be at risk of SCZ is difficult. Augmenting the traditional identification of categorical symptoms with multimodal phenotypic data could improve risk assessm...

16p11.2 copy number variation (CNV) is rare in the general population but enriched in individuals with developmental delay or psychiatric illness, with 16p11.2 duplication and deletion associated with autism spectrum disorder (ASD) and 16p11.2 duplication associated with schizophrenia (SCZ). The 16p11.2 CNV may therefore provide insight into the re...

Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental syndrome affecting about 5% of children worldwide. Like many behavioral disorders, ADHD is a phenotypically heterogeneous construct. The type and severity of symptoms present can vary across cases, as can age of onset. Gender, intelligence, and co-occurring autism spectrum diso...

Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental syndrome a ing about 5% of children worldwide. Like many behavioral disorders, ADHD is a phenotypically heterogeneous construct. The type and severity of symptoms present can vary across cases, as can age of onset. Gender, intelligence, and co-occurring autism spectrum disorder...

Psychogenic nonepileptic seizures (PNES) in children are associated with high rates of psychiatric and medical comorbidities, including epilepsy. Early PNES diagnosis leads to timely psychiatric treatment and improved outcomes. The gold standard approach to diagnosis includes a comprehensive history, a psychiatric assessment, and a video-EEG record...

Catatonia is most often associated with psychotic or mood disorders. Obsessive-compulsive disorder presenting with catatonia (catatonic OCD) has never been systematically studied, and in over 50 years has only been reported in one adolescent. We identify common factors across descriptions of catatonic OCD, present a case younger than any previously...

Psychosis-associated creatine kinase (CK)-emia, the so- called “PACK” phenomenon, has been consistently described in acutely psychotic patients. Although PACK can be the result of antipsychotic exposure, other causes are possible. For example, physical restraints, intramuscular injections, or intense physical activity can elevate CK by causing musc...

Psychogenic nonepileptic seizures (PNES), a conversion disorder, is highly comorbid with anxiety disorders, but its mechanism is unknown. Neuroimaging studies of pediatric anxiety have found altered resting-state connectivity within and between the default mode network (DMN) and salience network (SN) and altered hippocampal structure. Similar studi...

Copy number variations (CNVs) are genetic deletions and duplications that involve at least 50 nucleobase pairs. Once thought rare, they have in recent years been recognized as the most common cause of structural variation in the human genome. As associations have repeatedly been found between specific CNVs and atypical neurodevelopmental phenotypes...

There is great need for improved pediatric training in child and adolescent psychiatry (CAP) to meet the growing mental health concerns of youth patients. This preliminary study surveys pediatrician trainees to determine 1) the extent of their education in children and adolescent psychiatry; 2) whether the type of psychiatry exposure residents rece...

Serotonin has a well­-established role in the development of the mammalian central nervous system, and abnormalities in the serotonin system are a consistent finding in autism spectrum disorder (ASD). As the most commonly prescribed antidepressants alter serotonergic activity, prenatal exposure to them may influence ASD risk. Several recent studies...

We present a case of neuroleptic malignant syndrome, or NMS, in an adolescent with intellectual disability who had been given antipsychotic medication for behavioral control in a psychiatric ER setting. His case is notable because while his clinical course is consistent with NMS, it was not consistent with the ”classic” form of the syndrome, and th...