Amanda Burls

Amanda Burls
City, University of London · Division of Health Services Research and Management

BA MSc (Neuroscience) MBBS MSc (Public Health)

About

160
Publications
42,652
Reads
How we measure 'reads'
A 'read' is counted each time someone views a publication summary (such as the title, abstract, and list of authors), clicks on a figure, or views or downloads the full-text. Learn more
6,354
Citations
Additional affiliations
April 2008 - July 2013
University of Oxford
Position
  • Director of Postgraduate Programmes in Evidence-Based Health Care
Description
  • Director of the Oxford International Programme in Evidence-Based Health Care which included short courses, an MSc and a DPhil Programme in EBHC and a Certificate and a Diploma course in Health Services Research.

Publications

Publications (160)
Article
Research objective To determine if Muscle Response Testing (MRT) can be used to distinguish lies from truths using blind test patients. Design A prospective study of diagnostic test accuracy was carried out using MRT to distinguish lies from truth. Methods Twenty practitioners who routinely practised MRT were paired with 20 blind test patients (T...
Article
Full-text available
Background: The prevalence and consequences of obesity among children and adolescents remain a leading global public health concern, and evidence-based, multidisciplinary lifestyle interventions are the cornerstone of treatment. Mobile electronic devices are widely used across socioeconomic categories and may provide a means of extending the reach...
Preprint
BACKGROUND The prevalence and consequences of obesity among children and adolescents remain a leading global public health concern, and evidence-based, multidisciplinary lifestyle interventions are the cornerstone of treatment. Mobile electronic devices are widely used across socioeconomic categories and may provide a means of extending the reach a...
Article
Full-text available
Introduction: Muscle response testing (MRT) is an assessment method used by 1 million practitioners worldwide, yet its usefulness remains uncertain. The aim of this study, one in a series assessing the accuracy of MRT, was to determine whether emotionally arousing stimuli influence its accuracy compared to neutral stimuli. Methods: To assess dia...
Article
Full-text available
Background: Utility scores are integral to health economics decision-making. Typically, utility scores have not been scored or developed with mental health service users. The aims of this study were to i) collaborate with service users to develop descriptions of five mental health states (psychosis, depression, eating disorder, medication side eff...
Article
Background: The Self-Management Open Online Trials in Health (SMOOTH) survey reports methods as well as researcher preferences in online trials and explores to what extent public and participant involvement in online trials occurs. This survey queried researchers’ experience in online trials and their perceived value in terms of public and patient...
Article
Background: The growth of trials conducted over the internet has increased, but with little practical guidance for their conduct and it is sometimes challenging for researchers to adapt the conventions used in face-to-face trials and maintain the validity of the work. Aim: To systematically explore existing self-recruited online randomized trial...
Article
Full-text available
Background: Intermittent locking of central venous catheters (CVCs) is undertaken to help maintain their patency. There are systematic variations in care: some practitioners use heparin (at different concentrations), whilst others use 0.9% NaCl (normal saline). This review looks at the effectiveness and safety of intermittent locking with heparin...
Article
Full-text available
Research Objective: To investigate if grip strength via dynamometric muscle testing (DMT) could be used to distinguish lies from truth. Rationale: Although DMT is primarily used in the diagnosis of neuromusculoskeletal (NMS) disorders, previous studies have attempted to use other forms of muscle testing to detect conditions other than NMS. For ins...
Article
Background: Funders encourage lay-volunteer inclusion in research. There are controversy and resistance, given concerns of role confusion, exploratory methods, and limited evidence about what value lay-volunteers bring to research. This overview explores these areas. Methods: Eleven databases were searched without date or language restrictions f...
Article
Full-text available
Background: Tumour necrosis factor (TNF)-alpha inhibitors are beneficial for the treatment of rheumatoid arthritis (RA) for reducing the risk of joint damage, improving physical function and improving the quality of life. This review is an update of the 2014 Cochrane Review of the treatment of RA with certolizumab pegol. Objectives: To assess th...
Article
Full-text available
Background People are frequently confronted with untrustworthy claims about the effects of treatments. Uncritical acceptance of these claims can lead to poor, and sometimes dangerous, treatment decisions, and wasted time and money. Resources to help people learn to think critically about treatment claims are scarce, and they are widely scattered. F...
Data
Selection criteria for learning-resources. (DOCX)
Data
Selection criteria for evaluations of learning-resources. (DOCX)
Conference Paper
Background The appearance of tumor necrosis factor-alpha (TNFalpha) inhibitors dramatically changed the prognosis of rheumatoid arthritis. Certolizumab pegol (CZP) is a human Fab fragment of anti-TNFalpha monoclonal antibody which is approved for the treatment of rheumatoid arthritis. We performed a systematic review and meta-analysis, with Cochran...
Article
Full-text available
BACKGROUND The use of public engagement and self-management in online clinical trials is growing with benefits, boundaries and minimal methodological guidance. This analysis explores whether running self-recruited online trials can provide trustworthy and useful answers to research questions. AIM To systematically explore existing self-recruited...
Preprint
Full-text available
BACKGROUND: The use of public engagement and self-management in online clinical trials is growing with benefits, boundaries and minimal methodological guidance. This analysis explores whether running self-recruited online trials can provide trustworthy and useful answers to research questions. AIM: To systematically explore existing self-recruited...
Article
Background Oxygen (O2) is widely used in people with acute myocardial infarction (AMI). Previous systematic reviews concluded that there was insufficient evidence to know whether oxygen reduced, increased or had no effect on heart ischaemia or infarct size. Our first Cochrane review in 2010 also concluded there was insufficient evidence to know whe...
Article
Full-text available
The ECRAN (European Communication on Research Awareness Needs) project was initiated in 2012, with support from the European Commission, to improve public knowledge about the importance of independent, multinational, clinical trials in Europe. Participants in the ECRAN consortium included clinicians and methodologists directly involved in clinical...
Article
Full-text available
Background Manual muscle testing (MMT) is a non-invasive assessment tool used by a variety of health care providers to evaluate neuromusculoskeletal integrity, and muscular strength in particular. In one form of MMT called muscle response testing (MRT), muscles are said to be tested, not to evaluate muscular strength, but neural control. One establ...
Chapter
Full-text available
This is the protocol for a review and there is no abstract. The objectives are as follows: To assess the effects of drinking extra water or other non-caloric beverages for promoting weight loss or preventing weight gain.
Article
Objective To review the evidence for the efficacy and safety of colchicine in children with pericarditis. Design Systematic review. Search strategy The following databases were searched for studies about colchicine in children with pericarditis (June 2015): Cochrane Central, Medline, EMBASE and LILACS. Eligibility criteria All observational and exp...
Article
Full-text available
Background: Many new clinical prediction rules are derived and validated. But the design and reporting quality of clinical prediction research has been less than optimal. We aimed to assess whether design characteristics of validation studies were associated with the overestimation of clinical prediction rules' performance. We also aimed to evalua...
Data
Systematic reviews of clinical prediction rule studies included in analysis. (PDF)
Data
Search strategies for systematic reviews of clinical prediction rule studies. (PDF)
Data
Dataset for multivariable model. (XLSX)
Data
Flow diagram. Selection of (a) systematic reviews and (b) validation studies. (PDF)
Data
Univariable analysis. Influence of design characteristics on the performance of clinical prediction rule. (PDF)
Article
Full-text available
Background: Online trials are rapidly growing in number, offering potential benefits but also methodological, ethical and social challenges. The International Network for Knowledge on Well-being (ThinkWell™) aims to increase public and patient participation in the prioritisation, design and conduct of research through the use of technologies. Obj...
Article
Full-text available
Rationale, aims and objectives: Evidence-based practice (EBP) is widely promoted, but does EBP produce better patient outcomes? We report a natural experiment when part of the internal medicine service in a hospital was reorganized in 2003 to form an EBP unit, the rest of the service remaining unchanged. The units attended similar patients until 2...
Article
Full-text available
Water intake is a cost effective, non-invasive and low-risk intervention to reduce or prevent headache pain. Chronic mild dehydration may trigger headache. Increased water intake could help. A small trial shows modest benefit; however, a larger methodologically sound randomized controlled trial is needed to confirm efficacy. Spigt, M., Weerkamp, N....
Article
Full-text available
Pericarditis is inflammation and swelling of the pericardium, the fluid-filled sac surrounding the heart, and causes chest pain. Most acute pericarditis is either idiopathic or follows a viral infection. Acute pericarditis is not usually life threatening and is normally treated medically on an outpatient basis with non-steroidal anti-inflammatory d...
Conference Paper
Full-text available
TITLE PLOT-IT Public Led Online Trials-Infrastructure and Tools INTRODUCTION PLOT is a pragmatic "Does it Work" innovation for putting public led online clinical trials into practice. It is the clinical trials arm of the ThinkWell1 the not-for-profit organization where people can become engaged partners in healthcare through responsible, informe...
Article
Full-text available
Most information about clinical trials sites contains advice for patients to make sure the trials they choose to be a part of are registered. The WHO’s decision to adopt a statement on clinical trial reporting reflects the Declaration of Helsinki which states that “every research study involving human subjects must be registered in a publicly acces...
Article
Background: Heparin intermittent flushing is a standard practice in the maintenance of patency in central venous catheters. However, we could find no systematic review examining its effectiveness and safety. Objectives: To assess the effectiveness of intermittent flushing with heparin versus 0.9% sodium chloride (normal saline) solution in adult...
Article
Background Tumour necrosis factor (TNF)-alpha inhibitors are beneficial for the treatment of rheumatoid arthritis (RA) in terms of reducing the risk of joint damage, improving physical function and improving quality of life. This Cochrane review is an update of a review of the treatment of RA with certolizumab pegol that was first published in 2011...
Article
Background: Pericarditis is the inflammation of the pericardium, the membranous sac surrounding the heart. Recurrent pericarditis is the most common complication of acute pericarditis, causing severe and disabling chest pains. Recurrent pericarditis affects one in three patients with acute pericarditis within the first 18 months. Colchicine has be...
Article
Full-text available
Background: Obesity is a global epidemic. Behavioral change approaches towards improving nutrition, increasing physical activity level, improving sleep, and reducing sitting time are recommended as best practices in adolescent obesity management. However, access to evidence-based treatment is limited and portable technologies such as mobile apps m...
Article
Objective: To evaluate the effectiveness of uterine-sparing interventions for women with symptomatic uterine fibroids who wish to preserve their uterus. Design: Systematic review and indirect comparison meta-analysis. Methods: MEDLINE, EMBASE, CENTRAL, conference proceedings, trial registers and reference lists were searched up to October 2013...
Article
Full-text available
Introduction Practitioners have used manual muscle testing (MMT) to assess neuromusculoskeletal integrity since early last century [1]. Since the 1960’s, chiropractors began using MMT to detect various other target conditions such as organ, endocrine or immune dysfunction [2]. Subsequently, a third distinct type of MMT has evolved, kinesiology-styl...
Article
Full-text available
There are few evidence-based mobile health solutions for treating adolescent obesity. The primary aim of this parallel non-inferiority trial is to assess the effectiveness of an experimental smartphone application in reducing obesity at 12 months, compared to the Temple Street W82GO Healthy Lifestyles intervention.Methods/design: The primary outcom...
Conference Paper
Full-text available
Background / Purpose: ThinkWELL provides interactive learning where the public can learn by doing and engage as informed stakeholders. Citizens will choose to work with experts on systematic reviews, life sciences projects or clinical trials. Scientists, students, and the public, working together will form a synergy that will be solution-based an...
Conference Paper
Full-text available
Background / Purpose: When we use words in healthcare they may not communicate a clear meaning. Data shows that it is not only patients and the public who read the same words to have different meanings and this has implication for medical communications. Main conclusion: Words alone do not carry the clarity to deliver important healthcare deci...
Article
Oxygen (O₂) is widely used in people with acute myocardial infarction (AMI) although it has been suggested it may do more harm than good. Previous systematic reviews have concluded that there was insufficient evidence to know whether oxygen reduced, increased or had no effect on heart ischaemia or infarct size, as did our original Cochrane review o...
Article
Background: Etanercept is a soluble tumour necrosis factor alpha-receptor disease-modifying anti-rheumatic drug (DMARD) for the treatment of rheumatoid arthritis (RA). Objectives: The purpose of this review was to update the previous Cochrane systematic review published in 2003 assessing the benefits and harms of etanercept for the treatment of...
Article
Full-text available
Interventions to promote mental well-being can bring benefits to the individual and to society. The Internet can facilitate the large-scale and low-cost delivery of individually targeted health promoting interventions. To evaluate the effectiveness of a self-directed Internet-delivered cognitive-behavioral skills training tool in improving mental w...
Article
Interventions to promote mental wellbeing can bring benefits both to the individual, improving mood and psychological functioning, and to society, in terms of economic prosperity and social cohesion. An approach using the principles of cognitive behavioural therapy to encourage healthier patterns of thinking and behaviour could offer an individual-...
Article
Total pancreatectomy and islet autotransplantation (TP/IAT) is a treatment option in a subset of patients with chronic pancreatitis. A systematic review of the literature was performed to evaluate the outcome of this procedure, with an attempt to ascertain when it is indicated. MEDLINE (1950 to present), Embase (1980 to present) and the Cochrane Li...
Article
The aim of this systematic review was to assess the evidence on tumour downstaging before liver transplantation in patients with hepatocellular carcinoma (HCC) initially staged beyond the Milan criteria. MEDLINE (from 1952), Embase (from 1980) and the Cochrane Library were searched. The review included cohort studies that reported the outcomes of p...
Article
Full-text available
Values are intrinsic to the use of health technology assessments (HTAs) in health policy, but neglecting value assumptions in HTA makes their results appear more robust or normatively neutral than may be the case. Results of a 2003 survey by the International Network of Agencies for Health Technology Assessment (INAHTA) revealed the existence of di...
Article
Full-text available
Research evidence is insufficient to change physicians' behaviour. In 1996, Pathman developed a four step model: that physicians need to be aware of, agree with, adopt, and adhere to guidelines. To review evidence in different settings on the patterns of 'leakage' in the utilisation of clinical guidelines using Pathman's awareness-to-adherence mode...
Article
Full-text available
Informed consent is a requirement for all research. It is not, however, clear how much information is sufficient to make an informed decision about participation in research. Information on an online questionnaire about childhood development was provided through an unfolding electronic participant sheet in three levels of information. 552 participa...
Article
TNF-alpha inhibitors have been shown to reduce the risk of joint damage and improve physical function and quality of life in people with rheumatoid arthritis (RA). This is the first Cochrane review of certolizumab pegol, a new TNF-alpha inhibitor. To assess the effectiveness and safety of certolizumab pegol (CDP870) in patients with RA who have not...
Article
Full-text available
Oxygen (O(2)) is widely recommended in international guidelines for treatment of acute myocardial infarction (AMI), but there is uncertainty about its safety and benefits. A systematic review and meta-analysis were performed to determine whether inhaled O(2) in AMI improves pain or the risk of death. Cochrane CENTRAL Register of Controlled Trials,...