Amaia Alquiza

• Bachelor of Pharmacy
• University of the Basque Country

Purpose Kv1.3 channel regulates the activity of lymphocytes, macrophages, or adipose tissue and its blockade reduces inflammatory cytokine secretion and improves insulin sensitivity in animals with metabolic syndrome and in genetically obese mice. Thus, Kv1.3 blockade could be a strategy for the treatment of type 2 diabetes. Elevated circulating le...

Diabetes is a chronic metabolic disease characterized by hyperglycemia in the absence of treatment. Among the diabetes-associated complications, cardiovascular disease is the major cause of mortality and morbidity in diabetic patients. Diabetes causes a complex myocardial dysfunction, referred as diabetic cardiomyopathy, which even in the absence o...

Background: Diabetic patients have prolonged cardiac repolarization and higher risk of arrhythmia. Besides, diabetes activates the innate immune system, resulting in higher levels of plasmatic cytokines, which are described to prolong ventricular repolarization. Methods: We characterize a metabolic model of type 2 diabetes (T2D) with prolonged card...

Diabetesa gaixotasun kronikoa da, prebalentzia handikoa, zeinen pankreak ez duen behar adina intsulina sortzen edo organismoak sortzen duen intsulina ez duen eraginkortasunez erabiltzen. Kontrolatu gabeko diabetesaren ondorioa hipergluzemia da, denborarekin organo eta sistema asko larriki kaltetzen dituena, nerbioak eta odol-hodiak batez ere. 2 mot...

Hypothyroidism, the most common endocrine disease, induces a cardiac electrical remodeling, creates a proarrhythmic substrate and facilitates the occurence of ventricular arrhythmias including torsades de pointes. Recent studies highlight the importance of Thyroid-Stimulant Hormone (TSH) levels in the mortality of both hypothyroid patients and euth...

Background: Hypothyroidism (HT), the most common endocrine disease, induces cardiac electrical remodeling that creates a substrate for ventricular arrhythmias. Recent studies report that high thyroid stimulating hormone (TSH) levels are related to cardiac electrical abnormalities and increased mortality rates. The aim of the present work was to inv...