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Alvaro Antonio Jerez

Alvaro Antonio Jerez
CITACA, EDIF SIXTINO II, GUATEMALA. OF 904 ALA 2 · GENERAL DIRECTOR

MD MS

About

36
Publications
69,754
Reads
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302
Citations
Additional affiliations
March 2013 - present
Texas Tech University Health Sciences Center
Position
  • Member of the Sibpair Publications Committee
January 2013 - present
HUMANA (Centro de Tratamiento de la Epilepsia)
Position
  • Jefe del Departamento de Docencia e Investigación
January 2013 - November 2015
Humana, Centro de Epilepsia
Humana, Centro de Epilepsia
Position
  • Research Director
Education
March 2008 - August 2008
Favaloro University
Field of study
  • Bipolar Disorders

Publications

Publications (36)
Article
We previously identified bipolar disorder (BD) susceptibility loci on 8q24, 14q32, and 2q12‐14 in a genome‐wide nonparametric linkage screen in a Latino cohort. We now perform a fine mapping analysis using a dense map of additional SNPs to identify BD susceptibility genes within these regions. One thousand nine hundred and thirty‐eight individuals...
Book
Full-text available
Estimado lector, en esta oportunidad, el Centro de Epilepsia y Neurocirugía Funcional, “HUMANA”, se ha propuesto llevar a sus manos una obra centrada en un tema de mucha actualidad sobre el cual recién se ha comenzado a dar la importancia que merece aún falta mucho por escribir, la “neurocognición” y el impacto de amplia variedad de patologías psi...
Article
Personality traits have been suggested as potential endophenotypes for Bipolar Disorder (BP), as they can be quantitatively measured and show correlations with BP. The present study utilized data from 2,745 individuals from 686 extended pedigrees originally ascertained for having multiplex cases of BP (963 cases of BPI or schizoaffective BP). Subje...
Book
Full-text available
Compilación de aspectos relevantes de la epilepsia en la infancia y la adolescencia. La epilepsia es un trastorno del cerebro que se caracteriza por una predisposición duradera para generar ataques epilépticos (Fisher et al. 2005). 1-2 % de la población sufre epilepsia, y en Guatemala este índice representa aproximadamente 300,000 personas, que a...
Chapter
Full-text available
Crisis psicogénicas no epilépticas (Pseudocrisis). Generalidades. La convulsión no es una enfermedad en sí, sino un signo que puede tener va-riados orígenes a nivel cerebral: un traumatismo, una alteración anatómica, un desequilibrio en su homeostasis, etc. Una crisis epiléptica es una descarga eléctrica, súbita, que se origina en un punto del cere...
Article
Full-text available
Objectives: Recent genome-wide association studies (GWASs) have identified numerous putative genetic polymorphisms associated with bipolar disorder (BD) and/or schizophrenia (SC). We hypothesized that a portion of these polymorphisms would also be associated with BD in the Latino American population. To identify such regions, we tested previously...
Chapter
Full-text available
El sueño es una función fisiológica esencial para la salud física y mental del individuo, su horario, duración y calidad constituyen aspectos críticos para mantenernos física y men-talmente saludables. El sueño normal es una función crítica del sistema nervioso central, que reviste la misma importan-cia de otras funciones vitales del organismo. Est...
Chapter
Full-text available
En este capítulo presentamos los resultados de una encuesta prelimi-nar de la situación de la investigación y desarrollo de la medicina del sueño (MS) en la región centroamericana. El desarrollo de la MS en la región ha sido importante en la última década, cuando más especialistas y tecnologías están disponibles para los pacientes aquejados por tra...
Chapter
Full-text available
lo largo de la historia de la humanidad siempre han estado presentes dos interrogantes:  ¿Por qué dormimos?.. y,  ¿Para qué dormimos? Hoy en día, gracias a los grandes avances logrados en el campo de las neurociencias contamos con muy buenas respuestas para la primera pregunta, incluso, desde una perspectiva molecular, hemos llegado a comprender...
Chapter
Full-text available
Los trastornos del sueño son un problema frecuente en to-dos los grupos de población, e impactan negativamente la calidad de vida de la persona afectada. En los países desarrollados, los hipnóticos son uno de los grupos farma-cológicos más prescritos, la situación en Centroamérica es muy similar. Gran cantidad de drogas se utilizan como inductores...
Chapter
Full-text available
Los trastornos del sueño constituyen un verdadero problema de Salud Pública que requiere de un meticuloso diagnóstico para brindar el tratamiento más adecuado. Por definición, los trastornos del sueño involucran diversas alte-raciones que impactan negativamente en el proceso fisiológico del dormir; pueden afectar tanto el proceso de conciliación de...
Chapter
Full-text available
El estudio de los trastornos del sueño debería ser materia obligada en los pensum de pregrado de nuestros centros de estudio debido a varias razones: 1. La alta incidencia de los mismos, que los convierte en un verdadero problema sanitario. 2. El impacto de los mismos sobre la salud global de la persona afectada. 3. El impacto sobre el funcionamien...
Article
Full-text available
Variations in circadian genes can impact biological rhythms. Given the rhythm disturbances that characterize bipolar disorder (BD), genes encoding components of molecular clocks are good candidate genes for the illness. A family based association analysis of circadian gene single nucleotide polymorphisms (SNPs) and BD was conducted in Latino pedigr...
Data
Supplemental Figure S1: The DNA methylation landscape of bipolar disease. Supplemental Figure S2: Genomic distribution of DMRs in bipolar disease. Supplemental Figure S3: Ultra DMRs are associated with gene- and CGI-related regions. Supplemental Figure S4: Ultra DMRs are associated with gene- and CGI-related regions in BP. Supplemental Figure S5: U...
Article
Full-text available
Schizophrenia (SZ) and bipolar disorder (BP) are complex genetic disorders. Their appearance is also likely informed by as yet only partially described epigenetic contributions. Using a sequencing-based method for genome-wide analysis, we quantitatively compared the blood DNA methylation landscapes in SZ and BP subjects to controls both in an under...
Article
A genome-wide nonparametric linkage screen was performed to localize Bipolar Disorder (BP) susceptibility loci in a sample of 3757 individuals of Latino ancestry. The sample included 963 individuals with BP phenotype (704 relative pairs) from 686 families recruited from the US, Mexico, Costa Rica, and Guatemala. Non-parametric analyses were perform...
Chapter
Full-text available
Revisión de los aspectos más relevantes de la interacción entre la epilepsia y sus dos comorbilidades más frecuentes (depresión y ansiedad). Se destaca el impacto bidireccional de esa interacción, los problemas diagnósticos y se proponen pautas terapéuticas para el manejo adecuado de las mismas.
Article
Translational Psychiatry explores the more translational area between the research in neuroscience and conceptually novel treatments
Article
Full-text available
Objectives: Through recent genome-wide association studies (GWASs), several groups have reported significant association between variants in the calcium channel, voltage-dependent, L-type, alpha 1C subunit (CACNA1C) and bipolar disorder (BP) in European and European-American cohorts. We performed a family-based association study to determine whethe...
Article
Full-text available
Objectives: Through recent genome-wide association studies (GWASs), several groups have reported significant association between variants in the calcium channel, voltage-dependent, L-type, alpha 1C subunit (CACNA1C) and bipolar disorder (BP) in European and European-American cohorts. We performed a family-based association study to determine whethe...
Article
Full-text available
Bipolar disorder (BPD) has been associated with variations in personality dimensions, but the nature of this relationship has been unclear. In this study, the heritabilities of BPD and the Big Five personality factors and the genetic correlations between BPD and personality factors are reported. The participants in this study were 1073 individuals...
Article
The aims of this study were to estimate the frequency and course of substances use disorders in Latino patients with schizophrenia and to ascertain risk factors associated with substance use disorders in this population. We studied 518 subjects with schizophrenia recruited for a genetic study from the Southwest United States, Mexico, and Central Am...
Article
Methionine sulfoxide reductase (MSRA) is an antioxidant enzyme implicated in protection against oxidative stress and protein maintenance. We have previously reported the association of marker D8S542, located within the MSRA gene, with schizophrenia in the Central Valley of Costa Rica (CVCR). By performing fine mapping analysis, we have now identifi...
Article
The present study investigated a new set of families of Latin American ancestry in order to detect the location of genes predisposing to schizophrenia and related psychotic disorders. A genome-wide scan was performed for 175 newly recruited families with at least two siblings suffering from a psychotic disorder. Best-estimate consensus procedures w...
Article
Schizophrenia is a genetically complex illness with heterogeneous clinical presentation, including variable age of onset. In this study, the heritability, or proportion of variation in age of onset of psychotic symptoms due to genetic factors, was estimated using a maximum likelihood method. The subjects were 717 members of families with more than...
Article
This study attempted to replicate evidence for association of the Epsin 4 gene (which encodes enthoprotin, a protein involved in vesicular transport) to schizophrenia in a new sample of families segregating schizophrenia drawn from the Latin American population. 1,423 subjects (767 with a history of psychosis) from 337 Latino families were genotype...

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Projects

Projects (2)
Project
Write a book focus on cognition and epilepsy including several authors of America.