Alon Kahana

Alon Kahana
Oakland University William Beaumont School of Medicine · Ophthalmology

MD, PhD

About

203
Publications
67,225
Reads
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6,817
Citations
Introduction
Dr. Alon Kahana is a Professor and Vice Chair for Academic Affairs in the Department of Ophthalmology at Oakland University William Beaumont School of Medicine. Dr. Kahana has pursued research in the fields of Tissue Regeneration, Cancer Stem Cells, Cell Biology, Molecular Biology, and Orbital Inflammation. His primary focus is on orbital biology and cancer.
Additional affiliations
July 2007 - present
University of Michigan
Position
  • Professor (Associate)
July 2002 - June 2007
University of Wisconsin–Madison
Position
  • Instructor

Publications

Publications (203)
Article
Purpose: In response to the coronavirus (COVID-19) pandemic, teprotumumab production was temporarily halted with resources diverted toward vaccine production. Many patients who initiated treatment with teprotumumab for thyroid eye disease were forced to deviate from the standard protocol. This study investigates the response of teprotumumab when p...
Article
Full-text available
Intra-tumoral heterogeneity is a hallmark of glioblastoma that challenges treatment efficacy. However, the mechanisms that set up tumor heterogeneity and tumor cell migration remain poorly understood. Herein, we present a comprehensive spatiotemporal study that aligns distinctive intra-tumoral histopathological structures, oncostreams, with dynamic...
Article
Glioblastomas multiforme (GBMs) are the most lethal tumors of the brain. Tumoral mesenchymal transformation is a hallmark of GBMs associated with alterations in cellular morphology and dynamic organization. However, little is known about the mechanisms that control this pathological process. Here, we report a comprehensive spatiotemporal study inte...
Article
Full-text available
Purpose: Open-air motor vehicles present unique trauma risks to the eyes and face. We describe two patients who suffered a crash while riding an all-terrain vehicle (ATV), leading to globe dislocation with optic nerve avulsion in order to raise awareness about the risks associated with ATV accidents. Observations: In both cases, the injury was c...
Article
A young, morbidly obese woman with recent SARS-CoV-2 infection requiring hospitalization presented with visual and neurologic complications secondary to bilateral cerebral venous sinus thromboses. With elevated intracranial pressure and severe papilledema, she rapidly progressed to complete bilateral vision loss despite anticoagulation, therapeutic...
Chapter
Ultrasound is a noninvasive, first-line imaging method for orbital disease, providing accurate detection and tissue differentiation of orbital and periorbital pathologies. The dynamic nature of the exam allows to establish the kinetic characteristics of the lesions such as its consistency and vascularity. Moreover, ultrasound is a nonionizing, cost...
Chapter
Computed tomography angiography (CTA) and venography (CTV) provide a noninvasive approach to evaluating arterial and venous blood flow in the characterization of normal and abnormal tissue vascular beds. The use of these imaging modalities has become more powerful over the years, providing not only outstanding resolution of vascular channels but al...
Chapter
Magnetic resonance angiography (MRA) and magnetic resonance venography (MRV) enable noninvasive imaging of vascular structures without using ionizing radiation. Pulse sequences are constructed to generate signal from blood flow by taking advantage of variable magnetic relaxation properties and magnetic susceptibilities. MRA/MRV in conjunction with...
Chapter
Intraoperative imaging is a cornerstone of interventional vascular procedures and is becoming increasingly important in functional neurosurgery and tumor excision surgery. Dynamic intraoperative imaging is particularly useful for vascular procedures, enabling a real-time delineation of vascular channels and blood flow characteristics. Because of th...
Chapter
Computed tomography (CT) is a noninvasive, diagnostic imaging modality with high spatial resolution. It is rapid, amenable to claustrophobic patients, and provides excellent examination of bone anatomy with adequate soft tissue evaluation.
Article
Full-text available
Purpose To date, there are no studies on healthcare resource utilization (HRU) and costs for treating periocular basal cell carcinoma (pBCC). We investigated real-world HRU and costs of patients with limited vs extensive pBCC. Design Retrospective cost analysis. Methods Administrative claims database was mined for BCC-related claims from January...
Article
Full-text available
Background: Basal cell carcinoma (BCC) is a common skin cancer often curable by excision; however, for patients with BCC around the eye, excision places visual organs and function at risk. Here we test the hypothesis that use of the hedgehog inhibitor vismodegib will improve vision-related outcomes in patients with orbital and extensive periocular...
Article
Magnetic resonance imaging (MRI) is increasingly used by the orbital surgeon to aid in the diagnosis, surgical planning, and monitoring of orbital disease. MRI provides superior soft tissue detail compared with computed tomography or ultrasound, and advancing techniques enhance its ability to highlight abnormal orbital pathology. Diffusion-weighted...
Article
Intratumoral heterogeneity is a hallmark of high grade gliomas. However, whether heterogeneity is static or dynamic remains unknown. Here we demonstrate that gliomas’ core and border regions display areas of self-organized collective motion, which we have termed oncostreams. Histologically oncostreams appear as multicellular fascicles of elongated...
Article
Purpose of review: This review aims to bring together recent advances in basic, translational and clinical research on the pathogenesis and treatment of orbital inflammatory conditions. Recent findings: Basic science studies provide mechanistic insights into why the orbit is targeted for inflammation by autoimmune inflammatory disorders. Using G...
Article
Full-text available
In 2008, we published the first set of guidelines for standardizing research in autophagy. Since then, this topic has received increasing attention, and many scientists have entered the field. Our knowledge base and relevant new technologies have also been expanding. Thus, it is important to formulate on a regular basis updated guidelines for monit...
Preprint
Full-text available
In 2008, we published the first set of guidelines for standardizing research in autophagy. Since then, this topic has received increasing attention, and many scientists have entered the field. Our knowledge base and relevant new technologies have also been expanding. Thus, it is important to formulate on a regular basis updated guidelines for monit...
Article
The orbit houses and protects the ocular globe and the supporting structures, and occupies a strategic position below the anterior skull base and adjacent to the paranasal sinuses. Its embryologic origins are inextricably intertwined with those of the central nervous system, skull base, and face. Although the orbit contains important contributions...
Preprint
Full-text available
the PDF can be download freely on pubmed. https://pubmed.ncbi.nlm.nih.gov/33634751/
Cover Page
Full-text available
In 2008, we published the first set of guidelines for standardizing research in autophagy. Since then, this topic has received increasing attention, and many scientists have entered the field. Our knowledge base and relevant new technologies have also been expanding. Thus, it is important to formulate on a regular basis updated guidelines for monit...
Chapter
Surgical management of thyroid eye disease (TED) has two general aims: (1) relieve symptoms of orbital congestion and fibrosis, including possibly compressive optic neuropathy, and (2) reconstruct the periocular region to reduce deformity and renormalize appearance. Surgical management follows a sequence that is tailored to individual patient needs...
Chapter
Vascular anomalies are classified into vascular tumors and vascular malformations based on the classification system of the International Society for the Study of Vascular Anomalies (ISSVA). Vascular tumors are characterized by proliferation and tumor enlargement, and the most common vascular tumor is infantile hemangioma, while a less common vascu...
Article
We describe a case of an 18-year-old male who developed a supraorbital neuroma following facial trauma that occurred 2 years earlier. He presented with complaints of persistent facial pain and migraines despite successful laceration repair and removal of foreign bodies at the time of injury. A non-contrast computed tomography (CT) scan of the orbit...
Conference Paper
Glioblastoma multiforme (GBM) is the most frequent and lethal tumor of the central nervous system. GBM are characterized by diffuse invasion and cellular heterogeneity which challenges treatment efficacy. Tumors with mesenchymal properties display the most aggressive phenotype. However, the biological function and molecular mechanisms underlying GB...
Chapter
Inflammation, from the Latin inflammare (to set on fire), represents a complex biological reaction to stimuli of endogenous or exogenous origin. Inflammation of periocular tissues is common and may have local and systemic implications. The varied etiologies of orbital inflammations can make diagnosis and treatment difficult because appropriate trea...
Chapter
Thyroid eye disease (TED) is caused by an inflammatory process involving the orbit and periorbital tissues in the setting of autoimmune thyroiditis. TED has been shown not only to impact visual and social functioning but also to reduce patients’ quality of life. Thyroid dysfunction in TED most frequently involves hyperthyroidism secondary to Graves...
Chapter
The transcranial approach to the orbit requires specialized knowledge, skill, and instrumentation. It can be performed by neurosurgeons but is commonly approached collaboratively, with an orbital, skull base, and/or craniofacial plastic surgeon joining the neurosurgical team to provide specialized skills. The role of the ophthalmic plastic surgeon,...
Chapter
Orbital exenteration is defined as the surgical excision of the ocular globe, orbital soft tissues, and ocular adnexa. Total exenteration entails removing the orbital contents in their entirety, whereas a subtotal exenteration spares some portion of the posterior orbital soft tissues. In extended exenteration, removal of bone and/or adjacent struct...
Chapter
Stereotaxy involves the use of computerized technology to identify a point in three dimensions using a Cartesian coordinate system, which can be used for preoperative surgical planning and intraoperative computer-assisted surgical navigation. Stereotactic technology allows for the visualization of surgical anatomy and instrument placement intraoper...
Article
Full-text available
Purpose: The orbit displays unique vulnerability to inflammatory conditions. The most prevalent of these conditions, thyroid eye disease (TED), occurs in up to 50% of patients with Graves' disease (GD). Whereas the pathology of both TED and GD is driven by autoantibodies, it is unclear why symptoms manifest specifically in the orbit. Methods: We...
Article
Full-text available
Zebrafish have the ability to regenerate damaged cells and tissues by activating quiescent stem and progenitor cells or reprogramming differentiated cells into regeneration-competent precursors. Proliferation among the cells that will functionally restore injured tissues is a fundamental biological process underlying regeneration. Midkine-a is a cy...
Article
Purpose: To determine the efficacy of a frontalis muscle flap eyelid reanimation technique for correction of severe congenital ptosis and associated amblyopia in infants. Methods: The authors performed a retrospective chart review of patients 12 months of age or younger with unilateral or bilateral congenital ptosis and associated amblyopia or d...
Article
10069 Background: LA BCC of the eye/lacrimal drainage system most often requires disfiguring radical surgery, possibly including exenteration. As an alternative to radical surgery, we evaluated ophthalmologic outcomes following treatment with V using a novel Visual Assessment Weighted Score (VAWS) in patients (pts) with locally advanced periocular...
Article
Purpose: Conjunctival cicatrizing conditions are vision threatening, with poor outcomes despite aggressive systemic therapy. This study tests the utility of serial injections of 5-fluorouracil (5-FU) into the fornices to treat conjunctival scarring in patients with ocular cicatricial pemphigoid or Stevens-Johnson syndrome/toxic epidermal necrolysi...
Article
Full-text available
Severely damaged adult zebrafish extraocular muscles (EOMs) regenerate through dedifferentiation of residual myocytes involving a muscle-to-mesenchyme transition. Members of the Twist family of basic helix-loop-helix transcription factors (TFs) are key regulators of the epithelial-mesenchymal transition (EMT) and are also involved in craniofacial d...
Preprint
Full-text available
Zebrafish have the ability to regenerate damaged cells and tissues by activating quiescent stem and progenitor cells or reprogramming differentiated cells into regeneration-competent precursors. Proliferation among the cells that will functionally restore injured tissues is a fundamental biological process underlying regeneration. Midkine-a is a cy...
Article
Periocular skin is highly prone to malignancies, especially basal cell and squamous cell carcinomas. Because of the complex anatomy and eye-protecting functions of the periocular tissues, treatment of these cancers requires special considerations. Mohs micrographic surgery is usually the treatment of choice, whenever possible, in order to enhance m...
Article
Purpose: To test whether intraoperative stereotactic navigation during orbital decompression surgery resulted in quantifiable surgical benefit. Methods: This retrospective cohort study examined all consecutive patients who underwent primary orbital decompression surgery for thyroid associated orbitopathy performed by a single surgeon (A.K.) duri...
Article
Purpose: To perform a comprehensive review of dermis fat graft (DFG) in socket reconstruction and illustrate the technical nuances and outcomes using a retrospective case review. Methods: A literature search of 143 texts was reviewed. A retrospective case series of 34 patients following primary or secondary DFG after enucleation at a single inst...
Article
Full-text available
Purpose: Genomic reprogramming and cellular dedifferentiation are critical to the success of de novo tissue regeneration in lower vertebrates such as zebrafish and axolotl. In tissue regeneration following injury or disease, differentiated cells must retain lineage while assuming a progenitor-like identity in order to repopulate the damaged tissue...
Article
Mesenchymal gliomas are the most aggressive tumors that carry the worst prognosis. The origins of mesenchymal cells within brain tumors, remains poorly understood. They could originate either from invading mesenchymal cells, from perivascular smooth muscle actin+ cells, or from a mesenchymal transformation of tumor cells. Identifying the origin and...
Article
The development of orbit-eroding mucocele associated with inverted papilloma has been rarely reported. Here, the authors present a case and surgical management of a patient with orbit-eroding mucocele associated with inverted papilloma who declined craniotomy. A combined approach utilizing frontal endoscopic sinus surgery and external sub-brow ante...
Article
Rationale and objectives: Surgical repair of an isolated orbital fracture requires anatomically accurate implant shape and placement. We describe a three-dimensional (3D) printing technique to customize the shape of commercially available absorbable implants. Materials and methods: We reviewed our early experience with three cases in which 3D pr...
Article
Purpose: Thyroid eye disease (TED) is an inflammatory orbitopathy with significant impact on visual function and quality of life. Although studies have shown that patients who are deficient in vitamin D are more likely to develop autoimmune conditions, there are no studies demonstrating a definitive correlation between serum 25-hydroxyvitamin D (2...
Article
Purpose: Congenital ptosis can threaten visual function and is usually treated with surgical correction. This study tests the hypothesis that congenital ptosis involves not only the levator muscle but also the orbital septum, which may tether the eyelid in the primary position. Methods: A retrospective chart review was performed on 30 patients (...
Article
Full-text available
OBJECTIVES/SPECIFIC AIMS: Oncostreams represent a novel growth pattern of GBM. In this study we uncovered the cellular and molecular mechanism that regulates the oncostreams function in GBM growth and invasion. METHODS/STUDY POPULATION: We studied oncostreams organization and function using genetically engineered mouse gliomas models (GEMM), mouse...
Article
Full-text available
A 64-year-old man presented to the emergency department with 2 months of progressively worsening vision in both eyes. The worsening vision was preceded by binocular diplopia, which was intermittent at first and then became constant. He had no relevant ocular or other medical history. A review of systems was notable for a 2-month history of progress...
Article
Full-text available
GBM remains the deadliest primary malignant brain tumor. Given the importance of invading cells, less attention has been paid to the tumor mass, even if such a mass eventually kills the patient. We previously demonstrated that human and mouse transplantable or GEMM gliomas display regular anatomical multicellular structures containing elongated cel...
Article
Full-text available
Thyroid-associated orbitopathy (TAO) is a disfiguring periocular connective tissue disease associated with autoimmune thyroid disorders. TAO is a potentially blinding eye condition, for which no effective pharmacological treatment has been established. Despite a suggested role played by autoimmune thyrotropin receptor activation in the pathogenesis...
Article
Poly-DL-lactide polymer implants absorb over a period of 6 to 12 months and have been used with increasing frequency for repair of orbital fractures. The authors describe the case of a 7-year-old boy who presented with orbital inflammation 10 months following repair of a white-eyed blowout fracture with a poly-DL-lactide implant. Rapid improvement...
Article
Microphthalmia is defined by a globe axial length greater than or equal to 2 standard deviations below the age-adjusted mean and can occur as part of a broader syndrome. The presence of a colobomatous cyst with microphthalmia signifies failure of the embryonic neuroectodermal fissure to close appropriately during development of the globe, creating...
Article
Background Advanced basal cell carcinomas (BCCs) suffer from a scarcity of effective treatment options. Previously, we found that the targetable histone methyltransferase EZH2 was upregulated in aggressive BCC subtypes, suggesting that epigenetics may play a role in BCC progression. The purpose of this study was to determine whether EZH2-associated...
Chapter
Zebrafish extraocular muscles regenerate after severe injury. Injured myocytes dedifferentiate to a mesenchymal progenitor state and reenter the cell cycle to proliferate, migrate, and redifferentiate into functional muscles. A dedifferentiation process that begins with a multinucleated syncytial myofiber filled with sarcomeres and ends with prolif...
Article
Full-text available
Purpose To describe the clinical course of a patient with a retrobulbar orbital tumor causing myopic shift and macular pucker. Observation Following complete surgical removal of a retrobulbar orbital cavernous hemangioma, the myopic shift improved but the macular pucker persisted even 3 years after orbital surgery, with no sign of tumor recurrence...
Article
Full-text available
Insulin-like growth factors (Igfs) are key regulators of key biological processes such as embryonic development, growth, and tissue repair and regeneration. The role of Igf in myogenesis is well documented and, in zebrafish, promotes fin and heart regeneration. However, the mechanism of action of Igf in muscle repair and regeneration is not well un...
Article
Purpose: To review physician-based clinical surveys published in Ophthalmic Plastic and Reconstructive Surgery. Methods: Complementary Ovid and PubMed searches of Ophthalmic Plastic and Reconstructive Surgery journal content were performed for the term "survey." Results were narrowed to studies that specifically addressed physicians' clinical pr...
Article
Full-text available
Background Tissue regeneration requires a series of steps, beginning with generation of the necessary cell mass, followed by cell migration into damaged area, and ending with differentiation and integration with surrounding tissues. Temporal regulation of these steps lies at the heart of the regenerative process, yet its basis is not well understoo...