Alok Chakrabarti

Alok Chakrabarti
Indian Council of Medical Research | ICMR · Microarray Division

PhD

About

40
Publications
3,714
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1,076
Citations
Citations since 2017
7 Research Items
563 Citations
2017201820192020202120222023020406080100120
2017201820192020202120222023020406080100120
2017201820192020202120222023020406080100120
2017201820192020202120222023020406080100120

Publications

Publications (40)
Article
Full-text available
In addition to the ongoing global problem of healthcare-acquired infections, the COVID-19 pandemic continues to pose a serious threat to the health of the global population. This unprecedented pandemic situation has reinforced the need for the development of technologies that can curb the transmission of viruses among human beings and help to contr...
Article
Full-text available
Cholera continues to be a major burden for developing nations, especially where sanitation, quality of water supply, and hospitalization have remained an issue. Recently, growing antimicrobial-resistant strains of Vibrio cholerae underscores alternative therapeutic strategies for cholera. Bacteriophage therapy is considered one of the best alternat...
Article
Full-text available
Purpose We describe here a multicentric community- dwelling cohort of older adults (>60 years of age) established to estimate incidence, study risk factors, healthcare utilisation and economic burden associated with influenza and respiratory syncytial virus (RSV) in India. Participants The four sites of this cohort are in northern (Ballabgarh), sou...
Article
Full-text available
Coronavirus disease 2019 (COVID-19) is considered as the most dreaded disease that has spread all over the world in the recent past. Despite its outbreak in December 2019–January 2020, a few continents and countries such as India started to experience a significant number of COVID-19-positive cases from March 2020. GISAID clade variation analysis i...
Article
The last century has witnessed several assaults from RNA viruses, resulting in millions of death throughout the world. The 21st century appears no longer an exception, with the trend continued with escalated fear of SARS coronavirus in 2002 and further concern of influenza H5N1 in 2003. A novel influenza virus created the first pandemic of the 21st...
Article
Annual flu led by influenza viruses is contemplated to be one of the foremost global health challenges due to its rapid spread leading to the life-threatening epidemic or pandemic. An enormous number of people die due to flu and its associated intricacies every year. Annual vaccination is considered to be the gold standard strategy to protect the i...
Article
Full-text available
PB1-F2 is a multifunctional protein and contributes to the pathogenicity of influenza A viruses. PB1-F2 is known to have strain and cell specific functions. In this study we have investigated the apoptotic and inflammatory responses of PB1-F2 protein from influenza viruses of diverse pathogenicities in A549 lung epithelial cells. Overexpression of...
Article
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High-fat diet (HFD) elevates circulatory fatty acids and influences glucose and fat metabolism. Azelaic acid (AzA), a naturally occurring α,ω-dicarboxylic acid in wheat, rye, barley, oat seeds and sorghum, has been reported to exert antidiabetic effects in HFD-induced type 2 diabetes mellitus (T2DM) C57BL/6J mice. The present study was undertaken t...
Article
Full-text available
Aim: H7 avian influenza viruses pose a major public health threat raising concerns regarding their pandemic potential, especially after the recent outbreak in China of H7N9 subtype viruses. The objective was to gain insight into the geographical and host-wise distribution of H7 subtype viruses, and to understand molecular determinants responsible f...
Article
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Background: Replication of influenza virus in the host cells results in production of immune mediators like cytokines. Excessive secretion of cytokines (hypercytokinemia) has been observed during highly pathogenic avian influenza virus (HPAI-H5N1) infections resulting in high fatality rates. Objective: The exact mechanism of hypercytokinemia dur...
Article
PB1F2 is the 11th protein of the influenza A virus. The protein has variable sizes with truncations either at the C- or N-terminal ends. The most recent example being the 2009 pandemic H1N1 virus which codes for only 11 amino-acids of the C-terminus. A review of the reports since the discovery of PB1F2 in 2001 suggests a multifunctional role for th...
Article
Full-text available
Background The Non-Structural (NS1) protein of Influenza A viruses is an extensively studied multifunctional protein which is commonly considered as key viral component to fight against host immune responses. Even though there has been a lot of studies on the involvement of NS1 protein in host immune responses there are still ambiguities regarding...
Article
Background: PB1F2 is the 11th protein of influenza A virus translated from +1 alternate reading frame of PB1 gene. Since the discovery, varying sizes and functions of the PB1F2 protein of influenza A viruses have been reported. Selection of PB1 gene segment in the pandemics, variable size and pleiotropic effect of PB1F2 intrigued us to analyze ami...
Article
Full-text available
The world has recently overcome the first influenza pandemic of the 21st century caused by a novel H1N1 virus (pH1N1) which is a triple reassortant comprising genes derived from avian, human, and swine influenza viruses and antigenically quite different from seasonal H1N1 strains. Although the case fatality rates have decreased in many developed co...
Article
Full-text available
To understand the molecular mechanism of host responses to highly pathogenic avian influenza virus infection and to get an insight into the means through which virus overcomes host defense mechanism, we studied global gene expression response of human lung carcinoma cells (A549) at early and late stages of infection with highly pathogenic avian Inf...
Data
Full-text available
Figure S1. Genes involved in chemokine & cytokine mediated signaling in highly-pathogenic and RG modified H5N1 infected A549 cell lines (16 h post infection time point). Red arrow indicates expression in highly-pathogenic H5N1 infected A549 cells and Blue arrow indicates expression in RG modified H5N1 infected A549 cells. Up- arrow indicates up-reg...
Data
Table S2. List of significantly up- and down-regulated genes in A549 cell lines infected with RG modified H5N1 at different post-infection time points. Genes showing increase or decrease in expression by ≥ 1.5 folds (Significant, p-value < 0.05) compared to controls at different post infection time points studied with RG modified H5N1 have been enl...
Data
Table S1. List of significantly up-regulated and down-regulated genes in A549 cells infected with HPAI-H5N1 at different post-infection time points. Genes showing increase or decrease in expression by ≥ 1.5 folds (Significant, p-value < 0.05) compared to controls at different post infection time points studied with HPAI-H5N1 have been enlisted.
Data
Full-text available
Figure S2. Genes involved in p53 signaling pathway in highly-pathogenic and RG modified H5N1 infected A549 cell lines (16 h post infection time point). Red arrow indicates expression in highly-pathogenic H5N1 infected A549 cells and Blue arrow indicates expression in RG modified H5N1 infected A549 cells. Up- arrow indicates up-regulation and down-a...
Article
Influenza surveillance in different wild bird populations is critical for understanding the persistence, transmission and evolution of these viruses. Avian influenza (AI) surveillance was undertaken in wild migratory and resident birds during the period 2007–2008, in view of the outbreaks of highly pathogenic AI (HPAI) H5N1 in poultry in India sinc...
Article
Past literature on the development of new technology-based firms (NTBF) within business incubators suggests that the incubation process of these ventures includes both business and technical assistance. In addition, past literature suggests that this assistance is accessible through direct and networking interactions with the incubator management....
Data
Details of viruses isolated and analysed during January 2008 - May 2009. (0.04 MB DOC)
Article
Full-text available
Widespread infection of highly pathogenic avian influenza A H5N1 was reported from backyard and commercial poultry in West Bengal (WB), an eastern state of India in early 2008. Infection gradually spread to Tripura, Assam and Sikkim, the northeastern states, with 70 outbreaks reported between January 2008 and May 2009. Whole genome sequence analysi...
Article
Full-text available
India reported outbreaks of Highly Pathogenic Avian Influenza (HPAI) H5N1 in poultry in the states of Maharashtra, Gujarat and Madhya Pradesh (February-April 2006); Manipur (July 2007); West Bengal (January 2008) and Tripura (April 2008). The role of migratory birds in the transmission of the HPAI H5N1 remains a subject of debate. Avian Influenza (...
Article
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A focal H5N1 outbreak in poultry was reported from Manipur, a north-eastern state, of India, in 2007. The aim of this study was to genetically characterize the Manipur isolate to understand the relationship with other H5N1 isolates and to trace the possible source of introduction of the virus into the country. Characterization of the complete genom...
Article
New product development often incorporates a multitude of individual technologies. Research and experience show that even very large firms have resource limitations that prevent them from maintaining and developing all of the necessary technologies in-house. We explore how the value of a technology is related to whether a firm develops a technology...
Article
We compare some EU countries with China and India in terms of IPR development trends and inflows and outflows. We examined the trends in production of patents, the trend in ownership pattern and the impact of the globalisation of science and technology. We have obtained patent-related data from the website of the United States Patent and Trademark...
Article
Technology incubators are newer organizational forms that are created to support and accelerate the development and success of affiliated ventures, particularly new technology-based ventures. Current literature regarding incubators has suggested that an understanding of the incubation process is important when seeking to understand how affiliated v...
Article
There are currently three divergent views regarding the sources of beneficial social capital within collectivities or networks: historical ties, organisational facilitation, and trust-based shared pursuit of common goals. Technology incubators are newer organisational forms that are created to support and accelerate the development and success of a...
Article
Full-text available
Influenza virus neuraminidase (NA), a type II transmembrane glycoprotein, possesses receptor-destroying activity and thereby facilitates virus release from the cell surface. Among the influenza A viruses, both the cytoplasmic tail (CT) and transmembrane domain (TMD) amino acid sequences of NA are highly conserved, yet their function(s) in virus bio...
Article
Full-text available
The scenario of cholera that existed previously changed in 1992 and 1993 with the emergence of toxigenic Vibrio cholerae O139 in India. The genesis of the new serogroup formed the impetus to search for O139 phages in and around the country. A total of five newly isolated phages lytic to V. cholerae O139 strains were used for the development of this...
Article
During the period 1991-98, distribution of biotype, serotype and phage type of V. cholerae O1 strains isolated from different parts of the country and referred to the National Institute of Cholera and Enteric Diseases, Calcutta were studied. Of the 8101 strains received, 5613 (69.2%) were subjected to phage typing. All these strains belonged to the...
Article
A total of 196 Vibrio cholerae O1 strains isolated between 1970 and 1996 were biotyped by multiplex PCR, susceptibility to polymyxin B and sensitivity to biotype specific phages. We modified the multiplex PCR by increasing the primer concentration of tcpA to improve the results. Comparison of the results of modified multiplex PCR and sensitivity to...
Article
Five V. cholerae 0139 phages isolated from different parts of India have been used for phage typing study. A strain isolated from Nagpur city (NPR-4) was used as the host for phage propagation. All but one of the 260 strains of V. cholerae 0139 were found to be typeable and could be clustered into 8 distinct phage types as revealed by lytic pattern...
Article
A set of ten V. cholerae EITor phages is in routine use for phage typing of V. cholerae O1 biotype EITor strains. These phages were used in rabbit ileal loop experiment to investigate whether these phages have any prophylactic value as regards their lytic capability on V. cholerae strains. The phages were found to have no prophylactic use as they w...

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Projects (3)
Project
Isolation and purification of novel bacteriophage and their probable therapeutic efficacy by in vivo and in vitro.