Allison M Weis

Allison M Weis
University of Utah | UOU · Department of Pathology

Ph.D.

About

117
Publications
5,874
Reads
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856
Citations
Introduction
Allison M Weis currently works at the Department of Pathology, University of Utah.
Additional affiliations
May 2017 - September 2020
University of Utah
Position
  • PostDoc Position
Description
  • Dr. June Round lab
August 2013 - April 2017
University of California, Davis
Position
  • PhD Student
Description
  • Ph.D. lab
June 2008 - June 2009
Lewis & Clark College
Position
  • Research Assistant

Publications

Publications (117)
Article
Full-text available
Recent studies have suggested a potential role for wild birds in zoonotic transmission of Campylobacter jejuni, the leading cause of gastroenteritis in humans worldwide. In this study, we detected Campylobacter spp. in 66.9% (85/127) of free-ranging American crows (Corvus brachyrhyncos) sampled in the Sacramento Valley of California in 2012 and 201...
Article
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Complex glycans cover the gut epithelial surface to protect the cell from the environment. Invasive pathogens must breach the glycan layer before initiating infection. While glycan degradation is crucial for infection, this process is inadequately understood. Salmonella contains 47 glycosyl hydrolases (GHs) that may degrade the glycan. We hypothesi...
Article
Full-text available
Importance: This study examined the link between public health and genomic variation of Campylobacter in relation to disease in humans, primates, and livestock. Use of large-scale whole genome sequencing enabled population level assessment to find new genes that are linked to livestock disease. With 184 Campylobacter genomes we assessed virulence...
Article
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Immunoglobulin A (IgA) is the most abundant antibody at mucosal surfaces and has been the subject of many investigations involving microbiota research in the last decade. Although the classic functions of IgA include neutralization of harmful toxins, more recent investigations have highlighted an important role for IgA in regulating the composition...
Article
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The commensal microbiota influences many aspects of immune system regulation, including T cells, but molecular details of how this occurs are largely unknown. Here we review our findings that the microbiota regulates Erdr1, a secreted apoptotic factor, to control T cell survival. Erdr1 is highly upregulated in CD4+ T cells from germfree mice and an...
Article
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Intestinal epithelial cells (IECs) have long been understood to express high levels of major histocompatibility complex class II (MHC class II) molecules but are not considered canonical antigen-presenting cells, and the impact of IEC-MHC class II signaling on gut homeostasis remains enigmatic. As IECs serve as the primary barrier between underlyin...
Article
Vibrio parahaemolyticus is the most common cause of seafood-borne illness reported in the United States. Draft genomes of 132 North American clinical and oyster V. parahaemolyticus isolates were sequenced to investigate their phylogenetic and biogeographic relationships. The majority of oyster isolate sequence types (STs) were from a single harvest...
Article
Full-text available
Traditional taxonomy in biology assumes that life is organized in a simple tree. Attempts to classify microorganisms in this way in the genomics era led microbiologists to look for finite sets of 'core' genes that uniquely group taxa as clades in the tree. However, the diversity revealed by large-scale whole genome sequencing is calling into questi...
Article
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Infectious diseases can have devastating impacts on wildlife populations and are of particular concern for small, inbred populations. Identifying specific pathogens that are linked to morbidity and mortality in inbred individuals is a priority for the conservation of small populations, but opportunities to examine them in the wild are rare. Here, w...
Article
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Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) was compared to conventional biochemical testing methods and nucleic acid analyses (16S rDNA sequencing, hippurate hydrolysis gene testing, whole genome sequencing [WGS]) for species identification of Campylobacter isolates obtained from chickens (Gallus gal...
Article
Full-text available
Salmonella is a common food-associated bacterium that has substantial impact on worldwide human health and the global economy. This is the public release of 1,183 Salmonella draft genome sequences as part of the 100K Pathogen Genome Project. These isolates represent global genomic diversity in the Salmonella genus.
Article
Full-text available
Sialidases, which are widely distributed in nature, cleave the α-ketosidic bond of terminal sialic acid residue. These emerging virulence factors degrade the host glycan. We report here the release of seven sialidase and one sialic acid transporter deletion in Salmonella enterica serovar Typhimurium strain LT2, which are important in cellular invas...
Poster
Full-text available
The PacBio RS II provides for single molecular, real-time (SMRT) DNA technology to sequence genomes and detect DNA modifications. The quality control methods from gDNA input to the final library using the Agilent BioanalyzerSytem and Agilent TapeStation System were evaluated. Automated protocols of PacBio 10 kb library preparation produced librarie...
Article
Full-text available
Shigella is a major foodborne pathogen that infects humans and non-human primates and is the major cause of dysentery and reactive arthritis worldwide. This is the initial public release of 16 Shigella genome sequences from four species sequenced as part of the 100K Pathogen Genome Project.
Article
Full-text available
Campylobacter jejuni is an enteric bacterium that can cause abortion in livestock. This is the release of a multidrug-resistant Campylobacter jejuni genome from an isolate that caused an abortion in a cow in northern California. This isolate is part of the 100K Pathogen Genome Project.
Article
Full-text available
The diversity revealed by large scale genomics in microbiology is calling into question long held beliefs about genome stability, evolutionary rate, even the definition of a species. MacArthur and Wilson's theory of insular biogeography provides an explanation for the diversity of macroscopic animal and plant species as a consequence of the associa...
Article
Full-text available
Many bacterial genomes are highly variable but nonetheless are typically published as a single assembled genome. Experiments tracking bacterial genome evolution have not looked at the variation present at a given point in time. Here, we analyzed the mouse-passaged Helicobacter pylori strain SS1 and its parent PMSS1 to assess intra- and intergenomic...
Poster
Full-text available
The placenta is a functionally complex temporary organ of fetal origin, which among many roles serves as an immunological barrier, protecting the developing fetus from the maternal immune system. Due to its central role in fetal development and maintenance of pregnancy, placental pathology is implicated in several disorders and long-term health eff...
Article
Full-text available
Many bacterial genomes are highly variable but nonetheless are typically published as a single assembled genome. Experiments tracking bacterial genome evolution have not looked at the variation present at a given point in time. Here, we analyzed the mouse-passaged Helicobacter pylori strain SS1 and its parent PMSS1 to assess intra-and intergenomic...
Article
Full-text available
Background The PacBio RS II provides for single molecule, real-time DNA technology to sequence genomes and detect DNA modifications. The starting point for high-quality sequence production is high molecular weight genomic DNA. To automate the library preparation process, there must be high-throughput methods in place to assess the genomic DNA, to e...
Article
Full-text available
Campylobacter is a food-associated bacterium and a leading cause of foodborne illness worldwide, being associated with poultry in the food supply. This is the initial public release of 202 Campylobacter genome sequences as part of the 100K Pathogen Genome Project. These isolates represent global genomic diversity in the Campylobacter genus.
Article
Full-text available
Campylobacter jejuni is an intestinal bacterium that can cause abortion in livestock. This publication announces the public release of 15 Campylobacter jejuni genome sequences from isolates linked to abortion in livestock. These isolates are part of the 100K Pathogen Genome Project and are from clinical cases at the University of California (UC) Da...
Data
Full-text available
Supplemental Material for Weis et al 2016
Article
Full-text available
BACKGROUND: Helicobacter pylori, a gram-negative bacterium associated with a spectrum of benign and malignant gastric conditions, is one of the most genetically variable pathogens. Its genome encodes a large number of DNA methyltransferases targeting specific motif sequences of ∼4-15 bp. DNA base modifications epigenetically regulate gene expressio...
Article
Full-text available
Importance: Campylobacter jejuni is the most common cause of gastroenteritis in industrialized countries. Despite efforts to reduce colonization of poultry flocks and eventual infection of humans, the incidence of human C. jejuni infection has remained high. Because wild birds can harbor strains of C. jejuni that eventually infect humans, there ha...
Poster
Full-text available
The host gut epithelial membrane is shielded by complex glycans to protect the cell. Gastroenteritis begins when invasive pathogens bind and degrade the glycans at the epithelial barrier to gain access of host membrane. While glycan degradation is crucial for infection, this process is poorly understood. We hypothesized that Salmonella deploys its...
Poster
Full-text available
Campylobacter jejuni is the leading cause of gastroenteritis in humans worldwide with recent studies indicating wild birds as zoonotic vectors. American crows, abundant in urban, suburban, and agricultural settings, carry C. jejuni as a commensal organism. Studies demonstrating that the crow is a Campylobacter zoonotic reservoir are lacking, and no...
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