Allan Böhm

Premedix Academy & Clinic

Background More than 64 million patients with heart failure (HF) are burdened with poor quality of life, frequent hospitalizations, and high readmission rates. While HF with reduced ejection fraction (HFrEF) accounts for approximately half of these patients, there is currently no effective tool for performing cost-effective and reliable early-stage...

Background and objectives: The relevance of the use of intra-aortic balloon pump (IABP) in cardiogenic shock (CS) has been discussed over the past years. The aim of this study is to describe a single-centre 10-year experience with IABP and analyse the risk factors for 30-day mortality. Methods: The data for this single-centre, observational, ret...

Mobile health (mHealth) solutions have the potential to improve self-management and clinical care. For successful integration into routine clinical practice, healthcare professionals (HCPs) need accepted criteria helping the mHealth solutions’ selection, while patients require transparency to trust their use. Information about their evidence, safet...

Background: Cardiogenic shock (CS) complicating acute coronary syndrome (ACS) is a life-threatening condition with mortality reaching 50% despite the use of mechanical circulatory support devices (MCS). It is hypothesized that early implantation of MCS before hemodynamic deterioration could prevent CS. For this purpose, we have developed and extern...

Purpose: The incidence of acute myocardial infarctions (AMI) shows circadian variation typically peaking during morning hours with a decline at night. However, this variation does not occur in patients with diabetes mellitus (DM). The night's decline of AMI may be partially explained by melatonin-related platelet inhibition. Whether this effect is...

Introduction Recent advances in machine learning provide new possibilities to process and analyse observational patient data to predict patient outcomes. In this paper, we introduce a data processing pipeline for cardiogenic shock (CS) prediction from the MIMIC III database of intensive cardiac care unit patients with acute coronary syndrome. The a...

Objectives: Purpose of this study was to evaluate properties of apelin, a peptide detectable in peripheral blood, for atrial fibrillation (AF) detection in a diverse population of patients covering a broad spectrum from healthy to polymorbid patients. Background: AF is the most common cardiac arrhythmia with constantly increasing incidence and p...

Left ventricular hypertrophy (LVH) refers to a complex rebuilding of the left ventricle that can gradually lead to serious complications—heart failure and life-threatening ventricular arrhythmias. LVH is defined as an increase in the size of the left ventricle (i.e., anatomically), therefore the basic diagnosis detecting the increase in the LV size...

Objectives: The aim of this study was to investigate bleeding risk in patients treated with VKAs after ground-level falls, considering the type and severity of bleeding. Methods: The study was designed as a retrospective cohort study and included a total of 204 elderly patients aged > 65 years treated for AF continuously with warfarin for more t...

Purpose Oxidative stress is an important contributor to the etiology of atrial fibrillation (AF). Our aim was to study oxidative stress biomarkers in patients undergoing pulmonary vein isolation (PVI) for paroxysmal AF with radiofrequency catheter ablation and to assess its prognostic value in predicting long-term PVI outcome. Methods In this pros...

Funding Acknowledgements Type of funding sources: Public grant(s) – National budget only. Main funding source(s): Ministry of Education, Science, Research and Sport of the Slovak Republic VEGA Background Cardiogenic shock (CS) is a serious life-threatening condition affecting almost 10% of patients suffering from acute coronary syndrome (ACS). Des...

Artificial intelligence (AI) is here to stay. It is not a future anymore, and there are many particular problems in cardiology that are already being solved via machine learning (ML), and many more are to come. AI cannot solve complex tasks yet, and probably this will not change in the upcoming years. Therefore, cardiologists do not have to be afra...

Background: Catecholamines are recommended as first-line drugs to treat hemodynamic instability after out-of-hospital cardiac arrest (OHCA). The benefit-to-risk ratio of catecholamines is dose dependent, however, their effect on metabolism and organ function early after OHCA has not been investigated. Methods: The Post-Cardiac Arrest Syndrome (PCA...

Background: Atrial fibrillation (AF) is associated with high risk of stroke preventable by timely initiation of anticoagulation. Currently available screening tools based on ECG are not optimal due to inconvenience and high costs. Aim of this study was to study the diagnostic value of apelin for AF in patients with high risk of stroke. Methods: We...

Background and aim There are differences in the training programs among European Countries and some sub-specialities are not even recognized in all the training programs. However, discrepancies amongst the Countries and the needs of the trainees are not well known. As such, a survey on the experience of Cardiovascular Professional Training across E...

Background: Concurrent evidence about cardiogenic shock (CS) characteristics, treatment and outcome does not represent a global spectrum of patients and is therefore limited. The aim of this study was to investigate these regional differences. Methods: To investigate regional differences in presentation characteristics, treatments and outcomes o...

In this prospective cohort study, 62 patients (mean age 55±8 years, 12 females and 50 males) with paroxysmal atrial fibrillation (AF) and implanted ECG loop recorders who underwent PVI were included. Plasmatic concentrations of advanced glycation end-products (AGEs), fructosamine, advanced oxidation protein products and thiobarbituric-acid reacting...

Aims The implementation of the 2013 European Society of Cardiology (ESC) Core Curriculum guidelines for acute cardiovascular care (acc) training among European countries is unknown. We aimed to evaluate the current status of acc training among cardiology trainees and young cardiologists (<40 years) from ESC countries. Methods and results The surve...

Introduction: Data describing contemporary profile of infective endocarditis (IE) in the Czech Republic are lacking. The aim of this study was to describe the current profile and outcomes of IE patients. Methods: Prospectively collected data on consecutive patients admitted for IE diagnosis between April 2016 and March 2018 to 11 main tertiary c...

Aim: Asymptomatic atrial fibrillation (AF) detection and pulmonary veins isolation (PVI) outcome prediction remain challenging. Our aim was to study the association between apelin and paroxysmal AF in patients undergoing radiofrequency catheter PVI. Methods: Sixty-three consecutive patients (55 ± 8years, 12 females) with paroxysmal AF without a...

Social media increasingly impact both the private and professional lives of the majority of the population, including individuals engaged in cardiovascular healthcare and research. Healthcare providers across the world use social media platforms such as Twitter or Facebook to find medical and scientific information, to follow scientific meetings, t...

Background and Objectives Potential of using the T-peak to T-end (TpTe) interval as an electrocardiographic parameter reflecting the transmural dispersion of ventricular repolarization (TDR) to identify patients (pts.) with higher risk of malignant ventricular arrhythmias (MVA) for better selection of candidates for implantable cardioverter-defibri...

Aims The aim of this pilot study was to compare selected three‐dimensional speckle tracking echocardiography (3D STE) parameters in patients with ischaemic and non‐ischaemic aetiology of heart failure (HF) and to identify indices that can differentiate the two pathologies. Methods and results Forty patients with left ventricular ejection fractio...

Micro ribonucleic acids (miRNAs) are short non-coding RNA molecules responsible for regulation of gene expression. They are involved in many pathophysiological processes of a wide spectrum of diseases. Recent studies showed their involvement in atrial fibrillation. They seem to become potential screening biomarkers for atrial fibrillation and even...

Background: Previous studies showed an association between apelin and atrial fibrillation (AF). The aim of this study was to analyse the effect of pulmonary vein isolation (PVI) in patients with paroxysmal AF on plasmatic apelin concentrations. Methods: Nine consecutive patients (aged from 43 to 69 years, 3 females and 6 males) with documented p...

In our paper, we continue with our research and in cooperation with Faculty of Medicine and Research Institute called Academy. In this paper, we would like to present our knowledge about the identification of KDD (Knowledge discovery in database) problems from medical data. Our research is focused on medical data from the field of cardiology. We ar...

Cardiovascular disease is one of the main causes of morbidity and mortality worldwide. Despite the availability of highly effective treatments, the contemporary burden of disease remains huge. Digital health interventions hold promise to improve further the quality and experience of cardiovascular care. This position paper provides a brief overview...

In the original version of the book, acknowledgement should be included in chapter “Computing Importance Value of Medical Data Parameters in Classification Tasks and Its Evaluation Using Machine Learning Methods”. The correction chapter and the book have been updated with the change.

This paper aims to evaluate the importance values of medical data parameters for further classification tasks. One of the steps of proposed methodology for analyzing medical data is initial data analysis. One part of the initial data analysis is to determine the importance rate of parameters in given data set. The reason behind this step is to prov...

In this paper a classification model is proposed to predict a future state of patient’s cardiac diagnosis based on a large amount of medical data. The methodology of building a prediction model can be applied also to the other areas, such as industrial processes. In our research, we focus on cardiologic datasets of selected patients who were indica...

Introduction: There is a well-known relation between oxidative stress and atrial fibrillation. The aim of our research was to study the relation between the percentage of time spent in atrial fibrillation (AF burden) and concentrations of oxidative stress biomarkers, before and after pulmonary veins isolation (PVI). Methodology: We included 19 pati...

Introduction: Patients with atrial fibrillation have a five-fold increased risk of stroke, which can be effectively reduced with oral anticoagulant therapy. However, elderly patients with atrial fibrillation and tendency to ground-level falls are often deprived of the treatment for fear of bleeding. Clinicians prescribing oral anticoagulants often...