Alkesh Khurana

Alkesh Khurana
AIIMS Bhopal All India Institute of Medical Sciences · Pulmonary Medicine

MD,DNB,FCCP

About

61
Publications
5,921
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285
Citations
Additional affiliations
May 2013 - present
AIIMS Bhopal All India Institute of Medical Sciences
Position
  • Professor (Associate)

Publications

Publications (61)
Article
Co-infection with Pneumocystis jirovecii and Mycobacterium tuberculosis is rarely reported in patients without human immunodeficiency virus (HIV) infection. We describe the case of a 33-year-old HIV-negative female patient who was on long-term oral corticosteroids for rheumatoid arthritis and admitted with for respiratory distress and diffuse infil...
Article
Ewing's sarcoma (ES) is a small round cell sarcoma arising in the bone or soft tissue. Ewing's sarcoma/primitive neuroectodermal tumours (PNET) of the thoracopulmonary region is called Askin's tumour. The common clinical presentations described for this extrapulmonary tumour are fever, chest wall mass with or without pain, dyspnea, and cough. Very...
Article
Full-text available
Background: Tracheostomy is integral in long-term intensive care of coronavirus disease-2019 (COVID-19) patients. There is a paucity of studies on weaning outcomes and mortality after tracheostomy in COVID-19 in Indian scenario. Materials and methods: We conducted a retrospective, single-center, observational study of severe COVID-19 patients wh...
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IntroductionPositional therapy has been described as add-on therapy to a mandibular advancement device, but the efficacy of combination of positional therapy and positive airway pressure (PPAP) has not been documented. We have found PPAP therapy as an effective method of titration in patients with difficult to treat OSA (obstructive sleep apnea).Me...
Article
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Background: Coronavirus disease-2019 (COVID-19) commonly presents with respiratory symptoms. However, symptoms involving the digestive system may be present, significance of which is not well studied in the Indian scenario. Methods: This prospective observational cohort study included consecutive patients with severe COVID-19 admitted to intensi...
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Objectives: Some patients with obstructive sleep apnea (OSA) do not respond to Continuous Positive Airway Pressure (CPAP) and for these patients, Bi-level PAP is the next level modality. This study by a theory driven hierarchical approach, tries to identify the predictors for CPAP failure among OSA patients. Methodology: The potential predictors...
Article
Plasma cell myeloma is a hematologic malignancy characterized by multifocal clonal proliferation of plasma cells usually associated with M protein secretion in serum and/or urine and evidence of organ damage. Generally, the presenting features are related to anemia, bone lesions, and renal failure. Pleural effusion is rare in multiple myeloma and w...
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To evaluate the benefit of pulmonary rehabilitation, a control group is a must to mitigate the effect of confounding factors like spontaneous resolution of lung damage, learning effect and better mental status https://bit.ly/3qy5sfe.
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Study objectives: Studies have found Obstructive Sleep Apnea (OSA) as a risk factor for increased risk for COVID19 Acute respiratory Distress Syndrome (ARDS); but most of the studies were done in already known patients of OSA. This study was done to find prevalence of OSA in patients with COVID-19 related acute respiratory distress syndrome. Method...
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Lung cancer is the leading cause of cancer-associated mortality, with a 5-year survival of 19% for all types of lung cancer. Lymphoid malignancies of the lung have a significantly better prognosis, with 5-year survival approaching 90%, making it very important to identify these patients. As the signs and symptoms, laboratory investigations, and rad...
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Thromboelastography (TEG) and rotational thromboelastometry (ROTEM) are viscoelastic point of care (POC) devices that use whole blood samples to assess coagulation and fibrinolysis. These devices give information from initiation of coagulation cascade, activation of clotting factors to fibrin cross-linking, contribution of fibrinogen and platelet t...
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We report a case of 65-year-old sorcerer, who presented with COPD exacerbation. Patient used to see vivid images of beasts and he also had history of loud snoring. On diagnostic polysomnography, patient was diagnosed as having severe OSA and REM without Atonia (RWA). RWA was abolished while manual titration, proving that it was secondary to OSA. Th...
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Introduction OSA has been postulated to be associated with mortality in COVID-19, but studies are lacking thereof. This study was done to estimate the prevalence of OSA in patients with COVID-19 using various screening questionnaires and to assess effect of OSA on outcome of disease. Methodology In this prospective observational study, consecutive...
Article
Full-text available
Study Objectives Studies have found Obstructive Sleep Apnea (OSA) as a risk factor for increased risk for COVID19 Acute respiratory Distress Syndrome (ARDS); but most of the studies were done in already known patients of OSA. This study was done to find prevalence of OSA in patients with COVID-19 related acute respiratory distress syndrome. Method...
Preprint
Full-text available
Study Objectives- Studies have found Obstructive Sleep Apnea (OSA) as a risk factor for increased risk for COVID19 Acute respiratory Distress Syndrome (ARDS); but most of the studies were done in already known patients of OSA. This study was done to find prevalence of OSA in patients with COVID-19 related acute respiratory distress syndrome. Method...
Article
Small-cell lung cancer (SCLC) is a very fast growing form of cancer and is characterised by early metastasis. As a result, chemotherapy is the mainstay of treatment. Platinum-containing combination regimens are the current treatment of choice for limited stage-SCLC and extensive stage SCLC. Various adverse effects after cisplatin and etoposide chem...
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Chronic eosinophilic pneumonia (CEP) is a rare disorder of unknown aetiology which comes under the class of diffuse parenchymal lung diseases with eosinophilia. It is classically characterised by blood and pulmonary eosinophilia, peripheral consolidation on chest radiograph and prompt response to corticosteroid therapy. We report a case of CEP in a...
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Bartter syndrome is a very rare and heterogeneous disease with variable age of onset and symptom severity. Genotypically they have inherited disorders of the thick ascending limb in the renal tubular system, which manifest phenotypically as electrolyte imbalance due to loss of sodium, chloride and potassium. Gain of function mutations in the calciu...
Preprint
Full-text available
Introduction OSA has been postulated to be associated with mortality in COVID19, but studies are lacking thereof. This study was done to estimate prevalence of OSA in patients with COVID-19 using various screening questionnaires and to assess effect of OSA on outcome of disease. Methodology In this prospective observational study, consecutive pati...
Preprint
Full-text available
Introduction: Steroids have shown its usefulness in critically ill COVID19 patients. However time of starting steroid and dose tailored to severity remains a matter of inquiry due to still emerging evidences and wide-ranging concerns of benefits and harms. We did a retrospective record analysis in an apex teaching hospital ICU setting to explore op...
Preprint
Full-text available
Introduction: Steroids have shown its usefulness in critically ill COVID19 patients. However time of starting steroid and dose tailored to severity remains a matter of inquiry due to still emerging evidences and wide-ranging concerns of benefits and harms. We did a retrospective record analysis in an apex teaching hospital ICU setting to explore op...
Preprint
Full-text available
Abstract : Introduction: Steroids have theoretically seems useful in critically ill patients of COVID-19 . However the time of starting steroid and dose remains a matter of concern due to still emerging evidences and wide-ranging concerns of benefits and harms. We did a retrospective record analysis in an apex teaching hospital ICU setting to explo...
Article
Introduction The variable course of illness in patients of Tubercular lymphadenitis remains a therapeutic challenge to treating physicians in a significant proportion of patients. This study was aimed to explore the possible determinants which could predict the outcome of this subgroup of patients. Methodology This was a prospective cohort study w...
Article
Background: Recently, new classification criteria for obesity hypoventilation syndrome (OHS) have been described. OHS prevalence according to new criteria has not been reported in obstructive sleep apnea (OSA). Prevalence of OHS has not been previously reported from India. Methods: Retrospective study was carried out in OSA patients for whom bot...
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A 4-year-old boy presented with community acquired pneumonia, hepatosplenomegaly and bilateral cervical lymphadenopathy. The peripheral blood film showed significant monocytosis and bone marrow examination revealed multiple histiocytic granulomas. Presence of CD 68 positive granulomas supported by cytological findings enabled us to make a diagnosis...
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Tuberculosis continues to haunt mankind since its discovery more than a century ago. Although commendable advancements have been made in the diagnosis as well as treatment, especially in the last couple of decades, the healthcare burden of this disease worldwide is immense. Continuously evolving medical science has provided recent changes in nation...
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Background Asthma and chronic obstructive lung disease (COPD) together constitute a huge burden on healthcare all around the world. Treatment of these patients is largely dependent on the way the inhalation devices are used. This study aimed at measuring the impact of rectification of inhalation technique on quality of life and severity of obstruct...
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Background Ethnic craniofacial morphology differences significantly affect upper airway caliber and thus apnea–hypopnea index (AHI). As there is very limited data available from India regarding factors influencing severity of obstructive sleep apnea (OSA), we tried to explore whether anthropometric and craniofacial variable predict severity of OSA....
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Diffuse alveolar hemorrhage (DAH) has been rarely reported with pulmonary infections and even rarer with pulmonary tuberculosis (PTB). We hereby report the case of a 31-year-old male, a known case of ankylosing spondylitis, who presented with clinical and radiological features consistent with DAH. Initial partial improvement with steroids was follo...
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A 36-year-old woman was admitted to the All India Institute of Medical Sciences, Bhopal, Madhya Pradesh, India, in 2018 with complaints of breathlessness upon exertion and a dry cough of one week's duration. She had been previously diagnosed with recurrent right-sided hydropneumo-thorax and one episode of left-sided hydropneumo-thorax over the cour...
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Pulmonary alveolar microlithiasis (PAM) is an uncommon entity which can pose a diagnostic challenge. We report a 45-year-old female who was referred to the All India Institute of Medical Sciences, Bhopal, India, in 2017 with a two-year history of progressively worsening dyspnoea and dry coughing. She had been previously diagnosed with pulmonary tub...
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RBD (REM behavior disorder) is a type of parasomnia in which voluntary muscle atonia is abolished during REM sleep and is associated with complex motor behavior and/or sleep-related vocalization while dreaming. RBD can also be due to other sleep disorders including OSA (obstructive sleep apnea) and this scenario is termed as pseudo-RBD. We are here...
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We hereby present a case of a 62-year-old man who presented with tracheostomy in situ for the last two years and unexplained etiology for the life-threatening airway compromise. Thorough work up revealed tracheal amyloidosis as the cause for airway obstruction. This case describes not only the uncommon presentation of the disease but also the isola...
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We report a case of an elderly male with predominant obstructive sleep apnea and who developed or complex sleep apnea (CxSA) at the start of continuous positive airway pressure (CPAP) titration. This CxSA was more prominent in supine position, and he was not settling with either CPAP/bilevel positive airway pressure (PAP) in supine position. He fin...
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Complex sleep apnea (CxSA) is commonly seen during PAP therapy and it is often difficult to treat. Here we are reporting a case of positional complex sleep apnea in which CxSA was more prominent in supine position and it was treated with Bilevel PAP-S/T mode along with position therapy. This case highlights that postural therapy can be tried along...
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Background: Dermatoglyphics and bronchial asthma (BA) are both influenced by genetic factors. Hence, we assessed the diagnostic potential of correlation between fingerprint pattern and BA. Materials and methods: The study was carried out in out-patient Department of Pulmonary Medicine of All India Institute of Medical Sciences Bhopal. It include...
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Sarcoidosis is a chronic multisystem inflammatory disease of unknown etiology characterized by widespread noncaseating granulomas in various organs. The diagnosis of sarcoidosis is based on cytological, clinicolaboratory, and radiological findings, and requires careful exclusion of other granulomatous diseases especially tuberculosis. Involvement o...
Article
We read with interest the article by Esposito et al. [1], whereby they emphasised the role of the European Respiratory Society (ERS)/World Health Organization (WHO) Tuberculosis (TB) Consilium [2–4] in the management of an extensively drug-resistant (XDR)-TB case. The creation of this e-platform brings together many brains and aims at improving tre...
Article
We read with great interest the article by Tan et al,1 whereby they have discussed the occurrence of exacerbation-like events in patients without COPD. The basic concept of the study needs debate and clarification. The authors have used the terms ‘non-COPD patients’ and ‘exacerbation like event’ to mention the group of patients who didn't fulfil t...
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Differentiation between tuberculosis (TB) and sarcoidoisis is sometimes extremely difficult. Sequential occurrence of sarcoidosis and TB in the same patient is uncommon. We present the case of a young man, with a proven diagnosis of sarcoidosis who later developed TB after completion of treatment for sarcoidosis. A 32-year-old male patient presente...
Article
Countries with a high burden of TB are still struggling to pick up MDR TB cases at an early phase of treatment because of a lack of adequate resources (ie, widespread availability of drug culture and sensitivity methods).² Hence, by carrying out drug susceptibility testing at the start of treatment (ie, ruling out MDR TB at the outset), the practic...
Article
PURPOSE: The World Health Organization - Government of India (WHO-GOI) Guidelines - 2003 for management of chronic obstructive pulmonary diseases (COPD) is a consensus statement. However, the outcome and impact of its implementation on quality of life (QOL) among COPD patients has not been studied so far. Present study evaluated the same. METHODS:...
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A middle aged male presented to us with right side pneumothorax. Two hours after insertion of intercostals tube he felt discomfort and increased breathlessness. His chest examination showed crepitations. Chest radiograph showed partial expansion of right lung with opacity in right lower zone consistent with unilateral pulmonary edema. He was manage...

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Project (1)
Project
This study intends to Determine Safety and Effectiveness and Client satisfaction and Cost Aversion with the use of a NewThree Tier Telephone Triage Guideline