Aliyu Muhammad

Aliyu Muhammad
Ahmadu Bello University | ABU · Department of Biochemistry

NCE. BSc. MSc. Ph.D.
Translational research in prostate and breast cancer epigenetics in relation to racial disparity

About

151
Publications
62,641
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1,072
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Introduction
Additional affiliations
February 2022 - present
Tuskegee University
Position
  • Fulbright Senior Visiting Scholar
Description
  • Translational research on prostate and breast cancer epigenetics
January 2016 - March 2022
German Cancer Research Center
Position
  • DKFZ guest scientist
March 2012 - September 2012
University of Karachi
Position
  • Researcher

Publications

Publications (151)
Article
Full-text available
Environmental contamination with Cr (VI) has recently attracted public attention because of its high concentration in soil and wastewater originating majorly from anthropogenic activities and natural processes. Reduction of Cr (VI) to Cr (III) is a feasible method for minimizing chromium pollution. This work aimed at characterizing the effects of C...
Article
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Background Probiotics are beneficial microorganisms that alter microbial flora to promote human and animal health by ameliorating the physiological and psychological hitches and distress. The aim of the study was to investigate the protective effect of probiotic (protexin) in sucrose induced hyperglycaemia in Harwich strain Drosophila melanogaster...
Preprint
Full-text available
Background: We previously found that QNBC tumors are more frequent in African Americans compared to TNBC tumors. To characterize this subtype further, we sought to determine the miRNA-mRNA profile in QNBC patients based on race. Methods: Both miRNA and mRNA expression data were analyzed from TCGA and validated using datasets from the METABRIC, TCGA...
Preprint
This study investigates the effects of Flavokawain B (FKB) on the growth and development of metastatic hepatocellular carcinoma. HepG2 cells were used in this study and a neutral red assay was performed to determine the anti-proliferation effects of FKB at varying concentrations. Cell scratch and exclusion zone assays were performed to assess the i...
Preprint
Hepatocellular carcinoma (HCC) is currently the third most common cancer-related death worldwide. HCC is associated with a high mortality rate due to early recurrence and its distant metastasis to the nearby organs. Current treatment options include surgical removal and transplantation as well as chemotherapy, which remains a major challenge to pat...
Article
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Due to the challenges associated with breast cancer prognosis, this study examined sialic acid levels based on subtypes, grades and therapeutic courses among breast cancer patients presenting at Ahmadu Bello University Teaching Hospital (ABUTH) in North-Western Nigeria between June 2019 and December 2020. This was a cross-sectional study. Sociodemo...
Article
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Cytokine storm is a phrase used to refer to an abrupt upsurge in the circulating levels of various pro-inflammatory cytokines, causing increased stimulation and activity of immune cells during disease conditions. The binding of pattern recognition receptors to pathogen-associated molecular patterns during COVID-19 infection recruits response machin...
Article
Current research on triple-negative breast cancer (TNBC) has resulted in delineation into the quadruple-negative breast cancer (QNBC) subgroup. Epigenetic modifications such as DNA methylation, histone posttranslational modifications and associated changes in chromatin architecture have been implicated in breast cancer pathogenesis. Herein, the aut...
Article
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Background: The presence of diabetes mellitus (DM) among COVID-19 patients is associated with increased hospitalization, morbidity, and mortality. Evidence has shown that hyperglycemia potentiates SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) infection and plays a central role in severe COVID-19 and diabetes comorbidity. In this revi...
Article
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Due to the need to develop locally available, cheaper, and efficacious treatment regimens for breast cancer, the chemopreventive effect of kolaviron (KV), an extract of Garcinia kola seeds was examined. Fifty (50) female Wistar rats (120–180 g) were assigned to five groups (control group, 7, 12 dimethylbenzanthracene [DMBA] groups, tamoxifen group)...
Article
Introduction: For decades, viral diseases have been treated using medicinal plants and herbal practices in the northern part of Nigeria. Though scarcely investigated, these medicinal plants could serve as potential sources for novel antiviral drugs against emerging and remerging viral diseases. Therefore, this study is aimed at investigating the me...
Article
Introduction: For decades, viral diseases have been treated using medicinal plants and herbal practices in the northern part of Nigeria. Though scarcely investigated, these medicinal plants could serve as potential sources for novel antiviral drugs against emerging and remerging viral diseases. Therefore, this study is aimed at investigating the me...
Article
Full-text available
ABSTRACT: Paraoxonase and aryl-esterase-1 (PON-1) in serum of rats intoxicated with lead then administered Folic acid and Vitamin-C was investigated in forty male albino rats (160-190 g) randomly separated into 2 groups of 20 rats each namely: Lead acetate (60 mg kg-1) and normal saline was given to each group for 6 weeks and there after administer...
Article
Selective permeability of biological membranes represents a significant barrier to the delivery of therapeutic substances into both microorganisms and mammalian cells, restricting the access of drugs into intracellular pathogens. Cell-penetrating peptides usually 5–30 amino acids with the characteristic ability to penetrate biological membranes hav...
Article
The open reading frame 8 (ORF8) protein of SARS-CoV-2 has been implicated in the onset of cytokine storm which is responsible for the pathophysiology of COVID-19 infection. The present study investigated the potentials of isolated compounds from Clerodendrum volubile leaves to stall oxidative burst in vitro and interact with ORF8 mRNA segments of S...
Article
Full-text available
The possible evolutionary trend of COVID-19 in South Africa was investigated by comparing the genome of SARS-CoV-2 isolated from a patient in KwaZulu-Natal, South Africa with those isolated from China, Spain, Italy, and USA, as well as the genomes of Bat SARS CoV, Middle East Respiratory Syndrome Coronavirus (MERS-CoV), Mouse Hepatitis Virus (MHV),...
Article
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Glucocorticoid therapy has been linked with several of adverse effects which ultimately lead to diabetics, hyperlipidemia and osteoporosis. The aim of this study is to investigate the effect of N-acetylcysteine (NAC) against dexamethasone-induced renal dysfunction alteration of hematological and bone minerals indices in rats. The animals were divid...
Article
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Hexavalent chromium has been widely distributed in the environment by natural and anthropogenic sources characterized by higher toxicological and solubility properties than the trivalent form. Remediation-by-reduction of chromium(VI) to chromium(III) through the use of chemicals has offered an environmental and cost-effective approach for chromate...
Article
Full-text available
Sickle cell disease (SCD) treatment and management remain a challenging puzzle especially among developing Nations. Chrysin's sickling-suppressive properties in human sickle (SS) erythrocytes in addition to its effect on AA-genotype erythrocytes were evaluated. Sickling was induced (76%) with 2% sodium metabisulphite at 3 h. Chrysin prevented (81.1...
Article
Full-text available
COVID-19 is a zoonotic disease with devastating economic and public health impacts globally. Being a novel disease, current research is focused on a clearer understanding of the mechanisms involved in its pathogenesis and viable therapeutic strategies. Oxidative stress and inflammation are intertwined processes that play roles in disease progressio...
Article
Full-text available
The 2019 coronavirus disease (COVID-19) is a potentially fatal multisystemic infection caused by the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). Currently, viable therapeutic options that are cost effective, safe and readily available are desired, but lacking. Nevertheless, the pandemic is noticeably of lesser burden in African an...
Article
Background Kolaviron (KV) is a flavonoid rich portion obtained from Garcinia kola seeds with a number of reported pharmacological effects. However, its ameliorative effects on 7,12-Dimethylbenzanthracene (DMBA)-induced mammary damage has not been fully investigated, despite the reported use of the seeds in the treatment of inflammatory related diso...
Article
The antihyperlipidemic and antioxidant effects of Mentha piperita leaves extracts in Poloxamer 407-induced hyperlipidemic rats were investigated. Antihyperlipidemic activities of hexane, ethyl acetate, and methanol extracts (100, 200, or 300 mg kg−1 b.w.) were evaluated by lipid profile analysis. Twelve (12) fractions (F1 to F12) were collected fro...
Article
Full-text available
In most parts of West Africa and other developing countries, herbal medicines are sometimes used by patients concomitantly receiving conventional drugs, which can result in potentially serious adverse effects. This study examined in vivo cytotoxic effects of Azadirachta indica extracts followed by artesunate administration on some markers of liver...
Article
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This study was carried out to formulate rice and pigeon pea flour blend with the aim of providing nutrient‐enriched and inexpensive food for developing countries where the raw materials are found in abundance. Three factors (screw speed, feed moisture content and feed blend composition) affecting the extrusion cooking process were subjected to face...
Preprint
Full-text available
Bioreduction of certain environmental toxic metals using plant-derived antioxidants has been proven effective and promising bioremediation approach. The Redox state of specific metals, in particular chromium, determines its environmental solubility and toxicity. Antioxidant-rich extract of tamarind leaves was extracted and its Cr(VI) reduction pote...
Article
Full-text available
Malaria and toxoplasmosis are two important parasitic diseases with significant public health concerns in the Sub-Saharan African countries. Some aspects of pathogenesis of the two parasitic diseases involve the central nervous system manifesting neuropsychiatric disorders. Studies have implicated the single infection by Plasmodium spp. and Toxopla...
Article
Full-text available
Access to potable water is a major problem confronting most developing nations particularly with the overwhelming health burden posed by polluted water and its sources. In this review, studies on the level of contamination of drinking water sources in different geopolitical zones in Nigeria were assessed. The anthropogenic activities eliciting the...
Article
Full-text available
Breast cancer is one of the leading causes of death among women. We employed in silico model to predict the mechanism of actions of selected novel compounds reported against breast cancer using ADMET profiling, drug likeness and molecular docking analyses. The selected compounds were andrographolide (AGP), dipalmitoylphosphatidic acid (DPA), 3-(4-B...
Article
Breast cancer is one of the leading causes of death among women. We employed in silico model to predict the mechanism of actions of selected novel compounds reported against breast cancer using ADMET profiling, drug likeness and molecular docking analyses. The selected compounds were andrographolide (AGP), dipalmitoylphosphatidic acid (DPA), 3-(4-B...
Article
Full-text available
The global spread of the coronavirus infections disease � 2019 (COVID-19) and the search for new drugs from natural products particularly from plants are receiving much attention recently. In this study, the therapeutic potential of a new iridoid glycoside isolated from the leaves of Clerodendrum volubile against COVID-19 was investigated. Harpagid...
Article
Full-text available
Objective: People's compliance to control measures is dependent on their perception, attitudes and practices towards COVID-19. This survey evaluated the perception, attitude and practice of personal protective measures by Nigerians during the COVID-19. Methods: This was a cross-sectional study using an internet-based survey/questionnaire. A total o...
Article
Full-text available
Background: Wuchereria bancrofti is the major cause of lymphatic filariasis transmitted by mosquito vectors. In the vector-parasite interaction and among other proteins, actin-1 has been implicated for successful transmission of the pathogen in laboratory-controlled experiments. However, validation of this finding from the pathogen's natural envir...
Article
Full-text available
Malaria and toxoplasmosis are two important parasitic diseases with significant public health concerns in the Sub‐Saharan African countries. Some aspects of pathogenesis of the two parasitic diseases involve the central nervous system manifesting neuropsychiatric disorders. Studies have implicated the single infection by Plasmodium spp. and Toxopla...
Article
Cancer is a rapidly growing non-communicable disease worldwide that is responsible for high mortality rates, which account for 9.6 million death in 2018. Dihydroartemisinin (DHA) is an active metabolite of artemisinin, an active principle present in the Chinese medicinal plant Artemisia annua used for malaria treatment. Dihydroartemisinin possesses...
Article
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This study was designed to explore and record various medicinal plants integrated into the traditional system of medicine for the treatment of cancer. The traditional system of medicine is a routine practiced among the indigenous ethnic groups of Sokoto state. A semi-structured questionnaire was designed and used for data collection around the sele...
Article
Full-text available
Malnutrition is a major health problem worldwide and causes about 2.3 million deaths among under-5 children in low-and middle-income countries annually including Nigeria. Therefore, the present study was designed to assess the nutritional status of under-five children (0-59 months) and associated factors in Danko-Wasagu. The socio-demographic chara...
Article
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As feared and deadly human diseases globally, Rabies virus contrived mechanisms to escape early immune recognition via suppression of the interferon response. This study, preliminarily investigated whether Rabies virus employs epigenetic mechanism for the suppression of the interferon using the Challenge virus standard (CVS) strain and Nigerian str...
Article
Full-text available
Rabies virus infection is an endemic disease which remains central to public health issues. The presence of epigenetics associated with the over-expression of B7-H1 in mice brain infected with rabies virus was investigated for the first time. A significant increase (p < 0.05) in mRNA level of B7-H1 as the disease progressed was observed. The percen...
Article
Vitex doniana leaves are used traditionally in West Africa for the treatment of swellings and cancer. We investigated if Vitex doniana leaves extract could ameliorate 7, 12-dimethylbenz[a]anthracene (DMBA)-induced mammary damage. Female Wistar rats aged 52 ± 2 day were administered 80 mg/kg DMBA. After monitoring for 150 day, rats were administered...
Article
Kebbi state is endowed with medicinal plants that have been used by different tribes especially the Hausa-Fulani, Dakarkari and Gungawa to treat different ailments such as cancer for decades. Therefore, this study is aimed at documenting the medicinal plants used for treating cancer in Kebbi state. Demographic data, personal information of willing...
Article
Abstract Introduction The southwestern and northcentral parts of Nigeria are highly endowed with medicinal plants that have been used for decades to cancer. However, the herbal recipes and traditional medicinal practices used in treating cancer have been scarcely investigated and documented. New uninvestigated plants could serve as potential source...
Article
Full-text available
Under-utilized and abundant plants found in Africa have been endowed with a lot of potentials. These potentials can be coupled and channeled to aid environmental, economic and social development. Tamarind (Tamarindus indica) is one of the most commonly under-utilized plant materials with a number of reported biological and environmental relevance....
Article
Full-text available
Sickle cell disease (SCD) is a medical condition caused by mutation in a single nucleotide in the β-globin gene. It is a health problem for people in sub-Saharan Africa, the Middle East and India. Orthodox drugs developed so far for SCD focus largely on symptomatic respite of pain and crisis mitigation. We investigated the antisickling effects of c...
Article
Full-text available
A mutation in p53 is frequently reported in nearly 50% of all of human cancers arising from DNA-binding core domain of p53. DNA-contact mutant R273H rendered p53 at dysfunctional state due to the substitution of single residue Arg273 for His273. Here, natural bioactive compounds curcumin, alpinetin and flavokawain B were investigated for possible s...
Article
Background Honey is used for nutritional, medicinal and industrial purposes and maintenance of the requisite quality is of great importance. Objective This study distinctively aimed to portray twelve randomly selected profitable honeys accessible in the North West Nigerian market with regards to floral nectar origin, physicochemical factors, antim...
Article
Full-text available
Sickle cell anaemia is a hereditary disease branded by an upsurge in generation of ROS, irregular iron release and little or no antioxidant activity which can lead to cellular injuries due to oxidative stress resulting in severe symptoms including anaemia and pain. The disease is caused by a mutated version of the gene that helps make haemoglobin,...
Article
Full-text available
It is now glaring that sickle cell anaemia is still one of the highest leading inbred hemoglobinopathy amongst Africans. This study examined the antisickling effects of quercetin via modulation of deoxy-haemoglobin, redox homeostasis and alteration of functional chemistry in human sickle erythrocyte using in silico and in vitro models while espousi...
Article
Full-text available
Poor understanding of the clinicopathological features of prostate cancer (CaP) in Black men (BM) is one of the major challenges implicated in the management and prevention of the disease. The development of CaP involves an accumulation of multiple oncogenic events with associated increase in prostate specific antigen (PSA) and stress related hormo...
Article
Full-text available
Lead induced oxidative stress is the chief mechanism by which lead affects every part of the body, especially the liver. This study examined the liver oxidative stress status of sub-chronic lead intoxicated rats supplemented with folic acid and/or vitamin C. Forty (40) male albino rats weighing 160-190g were randomly divided into eight groups conta...
Article
Breast cancer as a multifactorial disease has been classified among the major causes of morbidity and mortality in women across the world, with a higher prevalence among post-menopausal women. Osteoporosis, a condition characterized by altered bone mineralization is also commonly found among post-menopausal women. Consequently, post-menopausal wome...
Article
Full-text available
Environmental lead pollution is a continuous public health concern in Nigeria and the world at large. Exposure to lead results in toxicological complications, which range from brain disorders, decreased organ functions, and increased risk of chronic diseases especially in the elderly. Oxidative stress is the chief pathophysiologic mechanism by whic...
Conference Paper
Prostate cancer (CaP) is the most common male gender cancer and present with a 5-year prevalence, incidence and mortality rate in Nigerian Black men. There is disproportionate prevalence and poor understanding of CaP in Black men globally. The Prostate Cancer Transatlantic Consortium (CaPTC) has documented significant CaP burden among Nigerian blac...
Article
Full-text available
Biodiesel is becoming prominent among the alternative sources of energy due to its economic, environmental and social values. This work investigated the possibility of using calcium alginate immobilized lipase from Pseudomonas aeruginosa for the production of biodiesel from Acacia nilotica seed oil. The physico-chemical properties of Acacia nilotic...
Article
Full-text available
The aim of this study was to evaluate the potentials of rutin on 2,5-hexanedione-induced toxicities. Two successive phases were involved using in silico and in vivo approaches. The in silico was adopted for potential oral toxicity and docking. The in vivo was carried-out in two stages for two weeks; the ameliorative (stage 1, first week), preventiv...