Alireza Poshtkohi- Doctor of Philosophy
- Lecturer at University of Hertfordshire
Alireza Poshtkohi
- Doctor of Philosophy
- Lecturer at University of Hertfordshire
Applied Mathematics, Biophysics, Neuroimmunology,Theoretical Physics, High-Performance Computing, Modelling & Simulation
About
22
Publications
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Introduction
Over the course of his career, Alireza has taken a truly interdisciplinary approach to tackling grand challenges in engineering, physics and medicine. Most importantly, he incorporates a wide diversity of principles and tools from applied mathematics and computer science into his research.
Current institution
Publications
Publications (22)
The motility of microglia involves intracellular signaling pathways that are predominantly controlled by changes in cytosolic Ca²⁺ and activation of PI3K/Akt (phosphoinositide-3-kinase/protein kinase B). In this letter, we develop a novel biophysical model for cytosolic Ca²⁺ activation of the PI3K/Akt pathway in microglia where Ca²⁺ influx is media...
Regulation of cytosolic calcium (Ca²⁺) dynamics is fundamental to microglial function. Temporal and spatial Ca²⁺ fluxes are induced from a complicated signal transduction pathway linked to brain ionic homeostasis. In this paper, we develop a novel biophysical model of Ca²⁺ and sodium (Na⁺) dynamics in human microglia and evaluate the contribution o...
System-level description languages in electronic system level are domain-specific sequential simulation languages using the shared-everything model in discrete-event modeling and simulation terminology. They implement sequential process-interaction worldview to take advantage of event partitioning for ease of programming and modularity. Therefore,...
The large size and complexity of the modern digital hardware impose great challenges to design and validation. Hardware Description Languages (HDLs) and System-Level Description Languages (SLDLs) rely on sequential discrete event semantics. Parallel Discrete Event Simulation (PDES) has recently gained extensive attention for parallelizing these lan...
During the past decades, different variants of technology solutions have emerged to eliminate the restrictions on the processing power of computers in solving various problems. Grid and Cloud computing patterns are among the most important of them. In this paper, we introduce a new infrastructure referred to as Parvicursor based on the distributed...
Grid infrastructures that have provided wide integrated use of resources are becoming the de-facto computing platform for solving large-scale problems in science, engineering and commerce. In this evolution, desktop grid technologies allow the grid communities to exploit the idle cycles of pervasive desktop PC systems to increase the available comp...
DotGrid platform is a Grid infrastructure integrated with a set of open and standard protocols recently implemented on the top of Microsoft .NET in Windows and MONO .NET in UNIX/Linux. DotGrid infrastructure along with its proposed protocols provides a right and solid approach to targeting other platforms, e.g., the native C/C++ runtime. In this pa...
Resource discovery is one of the most important services that significantly affects the efficiency of grid computing systems. The inherent dynamic and large-scale characteristics of grid environments make their resource discovery a challenging task. In recent years, different approaches have been proposed for resource discovery, attempting to tackl...
Resource discovery is one of the most important services that significantly affects the efficiency of grid computing systems. The inherent dynamic and large-scale characteristics of grid environments make their resource discovery a challenging task. In recent years, different approaches have been proposed for resource discovery, attempting to tackl...
DotGrid platform is a Grid infrastructure integrated with a set of open and standard protocols recently implemented on the top of Microsoft .NET in Windows and MONO .NET in UNIX/Linux. DotGrid infrastructure along with its proposed protocols provides a right and solid approach to targeting other platforms, e.g., the native C/C++ runtime. In this pa...
Grid infrastructures that have provided wide integrated use of resources are becoming the de facto computing platform for solving large-scale problems in science, engineering and commerce. In this evolution, desktop grid technologies allow the grid communities to exploit the idle cycles of pervasive desktop PC systems to increase the available comp...
Recently, Grid infrastructures have provided wide integrated use of resources. DotGrid intends to introduce required Grid services and toolkits that are implemented as a layer wrapped over the existing operating systems. Our DotGrid has been developed based on Microsoft .NET in Windows and MONO .NET in Linux and UNIX. Using DotGrid APIs, Grid middl...
