Alireza Lashay

Alireza Lashay
Tehran University of Medical Sciences | TUMS · Department of Ophthalmology (Farabi)

professor

About

69
Publications
13,787
Reads
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661
Citations
Education
October 1991 - October 1993
Tehran University of Medical Sciences
Field of study
  • Vitreoretinal
October 1984 - October 1988
Tehran University of Medical Sciences
Field of study
  • Ophthalmology
October 1974 - October 1981
Tehran University of Medical Sciences
Field of study
  • General practice

Publications

Publications (69)
Article
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To present long-term visual and structural outcome of treatment in two forms of flat irregular pigment epithelial detachment (FIPED): avascular (aFIPED) and vascularized (vFIPED) in eyes within pachychoroid spectrum. Prospective interventional case series. FIPED were classified into two subgroups; aFIPED and vFIPED based on OCTA. aFIPED underwent P...
Article
This is an Erratum to "Biodistribution of Cy5-labeled Thiolated and Methylated Chitosan-Carboxymethyl Dextran Nanoparticles in an Animal Model of Retinoblastoma" [J Ophthalmic Vis Res 2021;17(1):58–68] and does not have an abstract. Please download the PDF or view the article HTML.
Article
Purpose: The use of more potent medicine for local chemotherapy of retinoblastoma in order to minimize local and systemic adverse effects is essential. The main goal of this investigation was to assess the biodistribution of thiolated and methylated chitosan-carboxymethyl dextran nanoparticles (CMD-TCs-NPs and CMD-TMC-NPs) following intravitreal (...
Article
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Purpose: To estimate the prevalence, burden of refractive errors and their associated trend from 1990 to 2018 and geographic inequalities in Iran. Methods: Data regarding the epidemiology of refractive errors was extracted from three different sources: systematic review of published literature, data from visual school screening programs, and dat...
Article
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Purpose: To assess the safety of biosimilar intravitreal aflibercept (CinnaGen Co., Iran) compared to the reference product (Eylea®; Bayer Schweiz AG, Zurich, Switzerland) in rabbit eyes through functional and histologic studies. Methods: Forty New Zealand albino rabbits were recruited to the study and were divided into four groups to be sacrifi...
Article
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Background and objective: To evaluate the efficacy of intravitreal ziv-aflibercept (IVZ) in patients with diabetic macular edema (DME) resistant to intravitreal bevacizumab (IVB). Patients and methods: This prospective study was conducted in patients with persistent DME. Patients were switched to IVZ no longer than 6 weeks after the last three c...
Article
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Background: Due to lack of information about ophthalmic economics in Iran, health policy makers unable to distribute resources optimally in terms of efficiency and equity. Therefore, we estimated the total and eye care utilization, out-of-pocket expenditures, and its association with social determinants of health in Iran in 2015. Methods: A mult...
Article
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Purpose: To determine the magnitude and causes of blindness and visual impairment (VI) in Kurdistan, using the Rapid Assessment of Avoidable Blindness methodology. Methods: In this population-based cross sectional study, 99 clusters were selected through probability proportional to size sampling. Visual acuity (VA) was measured using a standard tum...
Article
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PURPOSE The purpose of this study is to provide a pooled estimate of moderate-to-severe visual impairment (MSVI) and blindness in Iran for people 50 years and over and to identify the major causes through systematic review. MATERIALS AND METHODS International (PubMed, ISI Web of Science, and Scopus) and national databases (Scientific Information D...
Article
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Purpose: To evaluate the frequency of 12 single nucleotide polymorphisms (SNPs) of complement factor H (CFH) and LOC387715/ARMS2/HRTA1 and their association with some of the presenting clinical features of neovascular age-related macular degeneration (AMD). Methods: In this prospective non-comparative case series forty four naïve patients with n...
Article
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Purpose: To compare the outcomes of photodynamic therapy (PDT) combined with intravitreal bevacizumab (IVB) with versus without intravitreal triamcinolone (IVT) in neovascular age-related macular degeneration (AMD). Methods: Eighty-four eyes with active CNV secondary to AMD with no prior treatment were enrolled and followed for 1-year. Eligible eye...
Article
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Although Visual impairment (VI) and its prevention is a public health issue, sub-optimal information about its magnitude in national level and its distribution is one of the impediments for visual health advocacy. In this article, we are detailing the approaches which will be taken to estimate the magnitude (prevalence, incidence, and burden), dist...
Article
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Millions of patients are either slowly losing their vision or are already blind due to retinal degenerative diseases such as retinitis pigmentosa (RP) and age-related macular degeneration (AMD) or because of accidents or injuries. Employment of artificial means to treat extreme vision impairment has come closer to reality during the past few decade...
Article
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The World Sight Day (WSD) is held on the 2nd Thursday of October to emphasize the importance of sight and impact of vision impairment. This observance is a joint initiative of the International Agency for the Prevention of Blindness (IAPB), the World Health Organization (WHO) and other international non-governmental organizations.1 The celebration...
Article
Purpose: To describe the macular thickness map of Iranian adult with normal retinal status as measured by Cirrus' optical coherence tomography (OCT) instrument. Methods: In this cross-sectional study, one eye of subjects with normal ocular examination and retinal status of at least one eye were recruited. The 512×128-scan pattern and scan area of 6...
Article
Background: To compare pain score of single spot short duration time (20 milliseconds) panretinal photocoagulation (PRP) with conventional (100 milliseconds) PRP in diabetic retinopathy. Methods: Sixty-six eyes from 33 patients with symmetrical severe non-proliferative diabetic retinopathy (non-PDR) or proliferative diabetic retinopathy (PDR) we...
Article
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Data suggest that the multifocal electroretinography (mfERG) may have a role in the assessment of patients with central retinal vein occlusion (CRVO). To explore the mfERG responses in patients with CRVO. mfERG responses were recorded at 61 discrete retinal locations from both eyes of 25 patients diagnosed with retinal vein occlusions within 3 week...
Article
To study predisposing factors of endophthalmitis in patients with open-globe injury. All 2,340 patients with open-globe injury admitted to our center over 5 years were studied retrospectively, and patients with endophthalmitis were compared with other patients. The number of endophthalmitis cases among patients with open-globe injury was 117 eyes,...
Article
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To present ultrasound biomicroscopic (UBM) findings and their clinical correlations in people with optically hazy media after injury at the Persian Wednesday Eve fireworks festival. Ultrasound biomicroscopy was performed on a series of 32 eyes with severe closed-globe injuries by P40 ultrasound biomicroscope. The median age of the participants was...
Article
It has been suggested that nitric oxide (NO) has a role in ischemic retinopathies. Since retinal ischemia may develop in retinal vein occlusion, we investigated the presence of nitric oxide in the pathogenesis of central retinal vein occlusion (CRVO). Eighteen consecutive patients with CRVO were included in this study. Aqueous humor specimens were...
Article
To evaluate the efficacy and safety of combined intravitreal triamcinolone acetonide (IVTA) injection plus panretinal photocoagulation (PRP) and macular photocoagulation (MPC) in comparison with PRP and MPC in eyes with coexisting high-risk proliferative diabetic retinopathy (PDR) and clinically significant macular edema (CSME). Twenty-three patien...
Article
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Purpose: Cataract is one of the most common diseases of older ages and, at present, the leading cause of avoidable blindness in the world. Along with the population growth, the rate of cataract surgeries is increasing in most countries worldwide. The number of cataract operations per million population per year is known as the cataract surgery rate...
Article
Purpose: The objective of this study was to investigate the causes, the clinical presentation, and treatment modalities in patients with valsalva premacular hemorrhage. Methods: This case series study included 21 eyes of 21 patients referred to retina clinic of Farabi eye hospital and two private eye clinics during 2001-2006 with sudden loss of vis...
Article
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To describe the clinical features and surgical outcomes of rhegmatogenous retinal detachment (RRD) following myopic laser in situ keratomileusis (LASIK). In a retrospective, non-comparative case series, 46 eyes that had undergone vitreoretinal surgery for management of RRD following myopic LASIK were identified. Data was reviewed with emphasis on c...
Article
Purpose: To evaluate the anatomical and functional outcomes of surgical management of retinal detachments associated with choroidal colobomas. Methods: In this retrospective study, 31 eyes of 31 patients with coloboma-related retinal detachments enrolled. All the eyes underwent standard three-port pars plana vitrectomy with internal tamponade with...
Article
Purpose: To evaluate the anatomical and functional outcomes of using heavy silicone oil as an internal tamponade for complicated cases of retinal detachment associated with proliferative vitreoretinopathy involving inferior retinal quadrants Methods: 55 eyes from 55 patients with complicated retinal detachments enrolled in this interventional case...
Article
Full-text available
Purpose: To evaluate the anatomical and functional outcomes of surgical management of retinal detachments associated with choroidal colobomas Methods: In this retrospective study, 31 eyes of 31 patients with coloboma-related retinal detachments enrolled. All the eyes underwent standard three-port pars plana vitrectomy with internal tamponade with n...
Article
Full-text available
Purpose: To evaluate the anatomical and functional outcomes of using heavy silicone oil as an internal tamponade for complicated cases of retinal detachment associated with proliferative vitreoretinopathy involving inferior retinal quadrants Methods: 55 eyes from 55 patients with complicated retinal detachments enrolled in this interventional case...
Article
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!--[if gte mso 9]> Normal 0 false false false MicrosoftInternetExplorer4 PURPOSE: To evaluate the anatomic and visual results and complications of vitrectomy in eyes with diffuse refractory diabetic macular edema associated with a taut posterior hyaloid. METHODS: This prospective interventional case series was conducted on 25 eyes of 22 patients w...
Article
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To evaluate the additive effect of triamcinolone to bevacizumab in comparison to standard macular laser photocoagulation versus bevacizumab in the management of diabetic macular edema (DME). In a prospective, randomized clinical trial, 130 eyes of 110 patients with type 2 diabetes with DME were included. Eligible eyes were randomly assigned to 1.25...
Article
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Purpose To compare the short-term outcomes of intravitreal bevacizumab (IVB) with the combination of IVB and intravitreal triamcinolone acetonide (IVB/IVT) for treatment of neovascular age-related macular degeneration (AMD). Methods This randomized clinical trial was performed on 92 eyes of 90 patients with subfoveal and juxtafoveal choroidal neov...
Article
Pharmacologic preconditioning with morphine has been shown to protect several kinds of tissues against ischemia-reperfusion injury. The aim of the present study was to investigate whether intravitreal administration of morphine induces structural protection against ischemic damage in a rabbit model of ischemic retinopathy. Twenty-eight male white N...
Article
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To evaluate the additional therapeutic effect of single intravitreal bevacizumab injection on standard laser treatment in the management of proliferative diabetic retinopathy. A prospective, fellow-eye sham controlled clinical trial was conducted on 80 eyes of 40 high-risk characteristic proliferative diabetic retinopathy type II diabetics. All cas...
Article
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Contrast sensitivity is an important aspect of visual function and is even more important for ordinary daily tasks than visual acuity. Contrast sensitivity function may be deteriorated to a significant level in diabetic retinopathy, especially in diabetic macular edema. The objective of this study was to determine the impact of macular laser photoc...
Article
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Purpose: To investigate the risk factors and causes for blindness in Behcet's disease (BD). Methods: In this preliminary retrospective case series we have investigated 27 BD patients (54 eyes), legally blind (vision 0.1 or less) at least in one eye at the last visit (2006), and compared them with 54 eyes of 27 non-blind patients (control group), ma...
Article
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Export Date: 17 March 2010, Source: Scopus, PubMed ID: 18988166, Correspondence Address: Roohipdor, R.; Eye Research Center, Farabi Eye Hospital, Oazvin Square, 1336616351 Tehran, Iran; email: hbenvidi@razi.tums.ac.ir
Article
Purpose: To compare the success rate of adjunctive 5-fluorouracil (5-FU) and low molecular weight heparin (LMWH), and daunomycin in combination with triamcinolone during vitrectomy in eyes with retinal detachment (RD) and proliferative vitreoretinopathy (PVR). Methods: In this prospective randomized clinical trial, 69 eyes from 69 patients with RD...
Article
Full-text available
To evaluate the efficacy of triple therapy consisting of single-session photodynamic therapy (PDT), intravitreal bevacizumab (IVB) and intravitreal triamcinolone (IVT) as initial pulse therapy followed by repeat intravitreal bevacizumab injections for maintenance treatment in neovascular age-related macular degeneration (AMD). In a prospective inte...
Article
Full-text available
Purpose: To evaluate the efficacy of pars plana vitrectomy (PPV) in treating patients with rhegmatogenous retinal detachment (RRD) Methods: In a retrospective study, we reviewed hospital records of patients with RRD operated by PPV at Farabi Eye Hospital between 2002 and 2004. The indications for PPV were proliferative vitreoretinopathy (PVR) grade...
Article
PurposeIt has been suggested that nitric oxide (NO) has a role in ischemic retinopathies. Since retinal ischemia may develop in retinal vein occlusion, we investigated the presence of nitric oxide in the pathogenesis of central retinal vein occlusion (CRVO).
Article
Full-text available
Purpose: To compare the effect of tissue plasminogen activator (TPA) and aspirin in patients with central retinal vein occlusion. Methods: A prospective interventional study was conducted on patients with central retinal vein occlusion of less than 28 days' duration. Patients in the TPA group received 100 μ g intravitreal tissue plasminogen activat...
Article
A young woman with severe visual loss, diplopia, bilateral optic nerve swelling, subhyaloid hemorrhage, and vasculitis was diagnosed with brucellosis. Clinical and ocular findings, except optic disc atrophy, improved within 3 months after antibrucellar treatment. These findings expand the ocular manifestations of brucellosis, and should be consider...
Article
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Although uncommon, traumatic optic neuropathy (TON) is an important cause of visual loss. Different therapeutic approaches including different dosages of steroids, surgical decompression of optic canal and observation alone have been suggested but there has been no conclusive evidence to establish a standard approach to this devastating cause of vi...
Article
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To evaluate the safety and efficacy of surgical induction of chorioretinal venous anastomosis in the management of ischaemic central retinal vein occlusion (CRVO). In a comparative clinical trial, 28 patients with ischaemic CRVO were included, of whom 18 who declined surgery were considered as controls. The 10 surgical cases underwent standard vitr...
Article
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The purpose of this study was to compare the anatomic and visual outcome of primary vitrectomy with scleral buckling in patients with retinal detachment following cataract surgery. Fifty-six consecutive patients with retinal detachment after cataract surgery were randomly assigned to two treatment groups: standard scleral buckling and standard thre...
Article
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To study the effect of acetazolamide on cystoid macular oedema (CMO) in patients with Behcet's disease. A total of 67 eyes of 35 Behcet's patients with chronic, but well-controlled uveitis, and CMO were randomised into a double-masked, crossover trial comparing the effect of acetazolamide vs placebo. The patients received an initial 4-week course o...
Article
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Twenty six patients with double elevator palsy (DEP) (ranging from 25-90 PD), who had undergone either Callahan or Knapp-Modified-Kanpp Procedure from February, 1981 to February, 1994, were reviewed. We achieved acceptable results in correction of hypotropia in primary position. Three patients gained peripheral fusion and after reviewing the result...

Projects

Projects (7)
Project
To evaluate the safety and efficacy of intravitreal injection of these drugs
Project
As a clinical professor in Ophthalmology!
Project
Evidence Generation, Policy Analysis, Outreach, Public Eye Health Education...