Alireza Hasaninejad

Alireza Hasaninejad
Texas A&M University | TAMU · Department of Chemistry

Full Professor

About

144
Publications
24,485
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3,724
Citations
Citations since 2016
20 Research Items
1685 Citations
2016201720182019202020212022050100150200250300
2016201720182019202020212022050100150200250300
2016201720182019202020212022050100150200250300
2016201720182019202020212022050100150200250300

Publications

Publications (144)
Article
Full-text available
The objective of this study was to design new polysubstituted pyrrole derivatives as selective acetylcholinesterase (AChE) inhibitors to target Alzheimer's disease. In this context, a highly efficient, one-pot, sequential, multi-component synthesis of a diverse range of polysubstituted pyrroles was developed through a sequential domino strategy by...
Article
Full-text available
A green and efficient one-pot multi-component protocol was developed for the synthesis of some novel dihydrochromeno[4,3-b]pyrrol-3-yl derivatives through the reaction of arylglyoxals, malono derivatives, and different 4-amino coumarins in ethanol at reflux condition. In this method, all products were obtained in good to excellent yield. Next, all...
Article
When CDCl3 solutions of chiral racemic molecules containing moderately Lewis basic functional groups are treated with the chiral solvating agent (CSA) Λ-[Co((S,S)-dpen)3]3+ 2I-B(C6F5)4- (Λ-(S,S)-13+ 2I-B(C6F5)4-), baseline resolved NMR signals are observed for the enantiomers (29 diverse analytes). Only 0.62-100 mol% loadings are required (avg 14.5...
Article
Novel pyrimidine derivatives were prepared from the reaction of 2‐substituted 1,3‐bis(dimethylamino)‐trimethinium salts with thiourea or guanidine in the presence of ethyl‐diisopropylamine in ethanol at reflux, and also some 5‐substituted pyrimidine‐2‐thiols has been used for the synthesis of novel disulfane compounds. Infrared, 1H NMR, 13C NMR, an...
Article
Full-text available
An efficient synthesis of propellane derivatives is described by the condensation reaction between acenaphthenequinone, malono derivatives, primary amines and β-ketoesters or β-diketones in the presence of triethylamine in ethanol at room temperature.
Article
A novel, green and high yielding preparation of poly substituted pyrazolyl-1,2-diazepine derivatives is described via a one-pot pseudo seven-component condensation reaction under catalyst-free conditions in EtOH at room temperature. For this synthesis, at first, 1,1-bis(methylthio)-2-nitroethylene (BMTNE) reacted with NH2NH2.H2O to form 1,1-dihydra...
Article
A simple and elegant synthesis of some novel bis‐spiro pyranopyrazoles has been achieved via the condensation reaction between bis‐isatins, malononitrile, hydrazine hydrate and ß‐ketoester derivatives in the presence of a catalytic amount of 1, 4‐diazabicyclo [2.2.2] octane (DABCO) in ethanol at reflux conditions. The significant features of the pr...
Article
Full-text available
PEG-400 has been used for the synthesis of novel asymmetrical bis-spirooxindoles by the reaction of N -alkyl isatin, isatin derivatives, alkylmalonates and C–H activated carbonyl compounds in the presence of K 2 CO 3 at room temperature.
Article
In this study, a green and high yielding synthesis of novel pyrazoline‐containing Schiff bases via a one‐pot pseudo five‐component condensation reaction under catalyst‐free conditions in EtOH at room temperature is described. Initially, the reaction of 1,1‐bis(methylthio)‐2‐nitroethylene (BMTNE), with NH2NH2.H2O is used for situ preparation of 1,1‐...
Article
Full-text available
A green and efficient one-pot, sequential, multi-component protocol has been developed for the synthesis of some novel symmetrical bis-spirooxindole derivatives from the reaction of isatins, dihalides, malono derivatives and C–H activated carbonyl compounds or ketene aminal derivatives in the presence of potassium carbonate (K2CO3) in polyethylene...
Article
An operationally simple and high yielding procedure for the synthesis of spirooxindole and spiroacenaphthylene derivatives is described by the condensation reaction between isatin/acenaphthenequinone derivatives, malono derivatives, and C−H activated carbonyl compounds in the presence of a catalytic amount of 1,4-Diazabicyclo[2.2.2]octane (DABCO) i...
Article
An efficient, one-pot, two-step, four-component reaction for the synthesis of spiroindoloquinazoline derivatives in the presence of 1,4-diazabicyclo[2.2.2]octane (DABCO) is described. The syntheses are achieved by the condensation reaction of isatin derivatives, isatoic anhydride, malononitrile and carbonyl compounds under reflux in acetonitrile. S...
Article
The simple synthesis of 1,2,3,5-substituted pyrroles from α-bromoacetophenones and 2-nitroethene-1,1-diamines in the presence of K2CO3 in DMF at 120 °C is described. A range of fused and non-fused polysubstituted pyrroles were prepared in high yields with short reaction times.
Article
The one-pot, three-component synthesis of spiroindoloquinazoline derivatives in good to excellent yields via the condensation reaction of tryptanthrin, C-H activated carbonyl compounds and malononitrile under solvent-free conditions in the presence of ammonium acetate is reported.
Article
A convenient synthesis of substituted spiroindenoquinoxalines at mild and green conditions was developed. Multicomponent reaction of substituted phenylene diamines, ninhydrin, malononitrile and N,N’-substituted-2-nitroethene-1,1-diamines produced the target compounds. Twelve new spiroindenoquinoxalines were obtained, and their ability in inhibition...
Article
The title compounds are prepared by condensation of pyrazolecarbaldehydes, hydrazines, and β-ketoesters in high yields.
Article
Full-text available
A new micelle-mediated extraction method for the pre-concentration of trace amounts of Cu2+ and Zn2+ as a prior step to their simultaneous spectrophotometric determination has been developed in various samples. The analytes were complexed with new synthesized ligand 4,4′-((4-chlorophenyl)methylene)bis(1,3-diphenyl-1H-pyrazol-5-ol) (CPBMPY) and Trit...
Article
Nanomagnetite-Fe3O4 is used as a highly efficient, mild, green and recyclable nanomagnetite catalyst for the synthesis of 4,4'-(arylmethylene)-bis(3-methyl-1-phenyl-1H-pyrazol-5-ol) derivatives in solvent-free conditions. The condensation of 3-methyl-1-phenyl-1H-pyrazol-5(4H)-one with aromatic aldehydes affords the title compounds in high yields an...
Article
Full-text available
An efficient synthesis of 1, 8-dioxo-octahydroxanthens and 1, 8-dioxo-decahydroacridines from the reaction of 5,5-dimethyl-1,3-cyclohexanedione (dimedone) with aromatic aldehydes bearing electron-donating or withdrawing substituents either in the presence or absence of primary amines has been described in a single pot using a catalytic amounts of a...
Article
In this work, a green, simple and highly efficient procedure for the preparation of 1,8-dioxo-octahydroxanthene and 1,8-dioxo-decahydroacridine derivatives [as biologically active heterocycles, fluorescence materials and Pharmaceutical compounds] is described. Sulfonated Polyethylene glycol (PEG-SO3H) has been used as an efficient and reusable cata...
Article
We report a novel nanostructured organosalt, based on sulfonic acid functionalized pyrazinium {[H-pyrazine–SO3H]Cl2} that was synthesized and characterized by several techniques including Fourier transform infrared (FT-IR) spectroscopy, X-ray diffraction (XRD), thermal gravimetric analysis (TGA), differential thermal gravimetric (DTG) analysis, tra...
Article
In this work, novel ionic liquid 1-sulfopyridinium chloride {[Pyridine–SO3H]Cl} is synthesized, and characterized by IR, 1H and 13C NMR, UV as well as mass spectra. The ionic liquid is used as an efficient, homogeneous and reusable catalyst for the synthesis of 4,4′-(arylmethylene)-bis(3-methyl-1-phenyl-1H-pyrazol-5-ol)s by tandem Knoevenagel–Micha...
Article
The reaction of 3-chloropropyl silica (SilprCl) with 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU) in dry acetone affords silica-bonded 5-n-propyl-octahydro-pyrimido[1,2-a]azepinium chloride (SB-DBU)Cl as a new silica-supported ionic liquid catalyst. Afterward, (SB-DBU)Cl is used for the efficient synthesis of 4H-benzo[b]pyran derivatives via the one-po...
Article
A novel, domino, multi-component reaction for the synthesis of polyfunctionalized spiro[benzo[c]pyrano[3,2-a]phenazine] derivatives has been established. l-Proline has been used as a bifunctional catalyst for the one-pot condensation of 2-hydroxy-1,4-naphthoquinone with aromatic 1,2-diamines to form the corresponding quinoxalines and then cyclo-con...
Article
Full-text available
1,4-Diazabicyclo[2.2.2]octane (DABCO) has been used as an efficient and reusable solid base catalyst for the one-pot, two-step, four-component synthesis of pyrano[3,2-a]phenazine derivatives by the condensation reaction of 2-hydroxy-1,4-naphthoquinone, 1,2-diamines, carbonyl compounds and alkylmalonates under conventional heating as well as microwa...
Article
A green and convenient approach for the synthesis of 4,4-(arylmethylene)bis (3-methyl-1-phenyl-1H-pyrazol-5-ols) by the reaction of aromatic aldehydes, phenylhydrazine derivatives, and ethyl acetoacetate in water/ethanol (1/1) under ultrasound irradiation is described. This method provides several advantages such as environmental friendliness, shor...
Article
A one-pot, four-component reaction for the efficient synthesis of novel spiro[indeno[2,1-b]quinoxaline-11,4′-pyran]-2′-amines by using InCl3 is described. The syntheses are achieved by reacting ninhydrin with 1,2-diaminobenzenes to give indenoquinoxalines, which are trapped in situ by alkyl malonates and various α-methylencarbonyl compounds through...
Article
An efficient, one-pot, three-component synthesis of various biologically important heterocyclic compounds is described via a tandem Knoevengel-cyclo condensation reaction of aromatic aldehydes, malono derivatives, and phenyl hydrazine derivatives in water and ethanol at room temperature.
Article
Organocatalyst trityl chloride (Ph3CCl), by in situ formation of trityl carbocation with inherent instability, efficiently promotes the cross-aldol condensation reaction between cycloalkanones and arylaldehydes in solvent-free and homogeneous media to afford α,α′- bis(arylidene)cycloalkanones in high yields. Moreover, an attractive and plausible me...
Article
Full-text available
Brønsted acidic ionic liquid triethylamine-bonded sulfonic acid {[Et3N-SO3H]Cl} efficiently catalyzes the one-pot multi-component condensation of 2-naphthol with arylaldehydes and dimedone (5,5-dimethylcyclohexane-1,3-dione) under solvent-free conditions to afford 12-aryl-8,9,10,12-tetrahydrobenzo[a]xanthen-11-ones in high yields and relatively sho...
Article
3-Aminopropylated silica gel is introduced as an efficient, reusable, and thermally stable heterogeneous catalyst for tandem Knoevenagel–Michael reaction of 1-phenyl-3-methyl-5-pyrazolone with aldehydes. Short reaction times, mild reaction conditions, ease of recovery, and catalyst reusability make this method a new, economical, and waste-free chem...
Article
Novel ionic liquid 1,3-disulfonic acid imidazolium hydrogen sulfate {[Dsim]HSO4} efficiently catalyzes the synthesis of 1,2,4,5-tetrasubstituted imidazoles via the one-pot multi-component condensation of benzyl with aldehydes, primary amines and ammonium acetate at 90 ºC under solvent-free conditions. Dual hydrogen-bond donors can be used to dire...
Article
Full-text available
In this work, a green, simple and efficient method for the synthesis of 4,4′-(arylmethylene)-bis(3-methyl-1-phenyl-1H-pyrazol-5-ol)s by the condensation of 1-phenyl-3-methylpyrazol-5-one with aromatic aldehydes using 1,3-disulfonic acid imidazolium tetrachloroaluminate {[Dsim]AlCl4} as a new, heterogeneous and reusable catalyst is reported.
Article
Full-text available
A simple, efficient procedure for the synthesis of 11-(1H-pyrrol-1-yl)-11H-indeno[1,2-b]quinoxaline and 3-(1H-pyrrol-1-yl)indolin-2-one derivatives in aqueous media is described. The condensation reaction between 4-hydroxyproline and isatin derivatives or 11H-indeno[1,2-b]quinoxalin-11-ones, using a catalytic amount of Zr(NO3)4 as a water tolerant...
Article
An efficient and simple solvent-free procedure for the synthesis of 12-aryl-8,9,10,12-tetrahydrobenzo[ a ]-xanthen-11-one derivatives via the one-pot multi-component condensation of dimedone with aromatic aldehydes and β-naphthol in the presence of protic acidic ionic liquid pyrazinium di(hydrogen sulfate) {Py(HSO<sub>4</sub>)<sub>2</sub>} as a gre...
Article
Full-text available
Synthesis of 1,8-dioxo-octahydroxanthene derivatives from dimedone and aldehydes using silica-supported phosphorus pentoxide (P 2 O 5 /SiO 2) or Silicaphosphine (Silphos, [PCl 3-n (SiO 2) n ]) as efficient and heterogeneous catalysts is described in this paper. The reactions were completed in relatively short reaction times under solvent-free condi...
Article
Export Date: 28 July 2012, Source: Scopus, CODEN: JCCTA, doi: 10.1002/jccs.201100372, Language of Original Document: English, Correspondence Address: Zare, A.; Department of Chemistry, Payame Noor University, PO BOX 19395-3697, Tehran, Iran; email: abdolkarimzare@yahoo.com, References: Qiao, Y.F., Okazaki, T., Ando, T., Mizoue, K., Kondo, K., Eguch...
Article
In this work, some novel sulfonic acid functionalized imidazolium salts (SAFIS), as a new category of ionic liquids, are synthesized by eco-friendly and simple procedures, and used as highly efficient and reusable catalysts to promote the following one-pot multicomponent organic transformations under solvent-free conditions: (i) the synthesis of 14...
Article
Ionic liquid triethylamine-bonded sulfonic acid ([Et 3N–SO 3H]Cl, N,N-diethyl-N-sulfoethanammonium chloride) is utilized as a highly efficient, inexpensive and homogeneous catalyst to promote the following one-pot multi-component organic transformations under solvent-free conditions: (i) the condensation of 2-naphthol with arylaldehydes and amides...
Article
Full-text available
In this work, highly efficient, green and inexpensive procedures for the preparation of quinoxaline and quinoline derivatives as attractive aza-polycyclic compounds are described. Silicananoparticles-catalyzed condensation of 1,2-diamines with 1,2-diketones under solvent-free conditions at room temperature affords high yields of quinoxalines with s...
Article
Full-text available
A highly efficient and simple procedure for the synthesis of 4H-benzo[b]pyrane derivatives is described. The reaction of 5,5-dimethylcyclohexane-1,3-dione or cyclohexane-1,3-dione with aromatic aldehydes and malononitrile using catalytic amount of alumina supported KF in reflux ethanol affords the title compounds in high to excellent yields and in...
Article
Full-text available
Saccharin sulfonic acid (SaSA) is utilized as a highly efficient, green and inexpensive sulfonic acid-containing catalyst for the following one-pot multi-component organic transformations: (i) the condensation of dimedone (2 eq.) with aromatic aldehydes (1 eq.) leading to 1,8-dioxo-octahydroxanthenes, and (ii) the reaction of 2-naphthol (2 eq.) wit...
Article
Full-text available
Silica-functionalized sulfonic acid (SFSA) and sulfuric acid-modified polyethylene glycol-6000 (PEG-OSO3H) efficiently catalysed one-pot multi-component condensation of enolizable ketones or alkyl acetoacetates with arylaldehydes, acetonitrile and acetyl chloride to afford the corresponding β-acetamido ketone or ester derivatives in high to excelle...
Article
In this work, the efficiency, generality and applicability of novel Brønsted acidic ionic liquid triethylamine- bonded sulfonic acid {[Et3N–SO3H]Cl, N,N-diethyl-N-sulfoethanammonium chloride} as homogeneous and green catalyst for organic transformations under various conditions are studied. Herein, the following one-pot multi-component reactions in...
Conference Paper
Full-text available
Export Date: 28 July 2012, Source: Scopus, Article in Press, CODEN: CRCOC, doi: 10.1016/j.crci.2012.05.003, Language of Original Document: English, Correspondence Address: Zolfigol, M.A.; Faculty of Chemistry, Bu-Ali Sina University, Hamedan 6517838683, Iranemail: zolfi@basu.ac.ir
Article
Cited By (since 1996): 3, Export Date: 28 July 2012, Source: Scopus, CODEN: JMLID, doi: 10.1016/j.molliq.2011.12.012, Language of Original Document: English, Correspondence Address: Zare, A.; Department of Chemistry, Payame Noor University, PO BOX 19395-3697, Tehran, Iran; email: abdolkarimzare@yahoo.com, References: Wasserscheid, P., Keim, W., (20...
Article
Full-text available
In this work, highly efficient, green and inexpensive procedures for the preparation of quinoxaline and quinoline derivatives as attractive aza-polycyclic compounds are described. Silica nanoparticles-catalyzed condensation of 1,2-diamines with 1,2-diketones under solvent-free conditions at room temperature affords high yields of quinoxalines with...
Article
Saccharin sulfonic acid (SaSA) is used as a highly efficient and recyclable catalyst for the one-pot multicomponent condensation of 2-naphthol with arylaldehydes and amides (thioamides or alkyl carbamates) under green, mild (70 °C), and solvent-free conditions. In this reaction, 1-amidoalkyl-2-naphthols, 1-thioamidoalkyl-2-naphthols, 1-carbamatoalk...
Article
A sequential one-pot four-component reaction for the efficient synthesis of novel 2′-aminospiro[11H-indeno[1,2-b]quinoxaline-11,4′-[4H]pyran] derivatives 5 in the presence of AcONH4 as a neutral, inexpensive, and dually activating catalyst is described (Scheme 1). The syntheses are achieved by reacting ninhydrin (1) with benzene-1,2-diamines 2 to g...
Article
Cited By (since 1996): 3, Export Date: 28 July 2012, Source: Scopus, doi: 10.1016/j.scient.2011.09.016, Language of Original Document: English, Correspondence Address: Khazaei, A.; Faculty of Chemistry, Bu-Ali Sina University, P.O. Box 6517838683, Hamedan, Iran; email: Khazaei1326@yahoo.com, References: Spasov, A.A., Yozhitsa, I.N., Bugaeva, L.I.,...
Article
Full-text available
Sulfuric acid-modified polyethylene glycol 6000 (PEG-OSO3H) is applied as an efficient and eco-friendly polymeric catalyst for Friedländer synthesis of poly-substituted quinolines from 2-aminoaryl ketones (or anthranilonitrile) and carbonyl compounds possessing a reactive methylene group under microwave irradiation and solvent-free conditions. The...
Article
A catalyst-free one-pot four component methodology for the synthesis of 2H-indazolo[2,1-b]phthalazine-triones under ultrasonic irradiation at room temperature using 1-butyl-3-methylimidazolium bromide, [Bmim]Br, as a neutral reaction medium is described. A broad range of structurally diverse aldehydes (aromatic aldehydes bearing electron withdrawin...
Article
The reaction of 3-chloropropyl silica with diazabicyclo[2.2.2]octane in dry acetone affords silica bonded n-propyl-4-aza-1-azoniabicyclo[2.2.2]octane chloride (SB-DABCO) as a new basic catalyst. The catalyst is used for the efficient synthesis of 4H-benzo[b]pyran derivatives via one-pot three-component reaction of cyclic ketones/1,3-diketones with...
Article
In this work, a green, simple and highly efficient procedure for the synthesis of bis(indolyl)methanes and 4,4′- (arylmethylene)-bis(3-methyl-1-phenyl-1H-pyrazol-5-ol)s [as an important class of bis(pyrazolyl)methanes] is described. The condensation of indoles or 1-phenyl-3-methylpyrazol-5-one with carbonyl compounds catalyzed by poly(ethylene glyc...
Article
An efficient and simple new method for the preparation of l-amidoalkyl-2-naphthols as biologically interesting compounds is described. The one-pot multi-component condensation of βnaphthol, aromatic aldehydes and acetamide/urea in ionic liquid l-butyl-3-methylimidazolium bromide ([Bmim]Br) under microwave and catalyst-free conditions affords the ti...
Article
A new, convenient, and high yielding procedure for the synthesis of triazolo[1,2-a]indazole-triones by the condensation reaction between dimedone, aryl aldehydes, and ueazoles in the presence of a catalytic amount of sulfonated polyethylene glycol (PEG-SO3H) as a highly stable and reusable eco-friendly degradable polymeric catalyst is described und...
Article
A simple and efficient solvent-free procedure for the preparation of bis(indolyl)methanes via electrophilic substitution reactions of indoles with aldehydes and ketones is described. The reactions took place in the presence of a catalytic amount of silica chloride at room temperature. The advantages of this method are high yields, short reaction ti...
Article
Full-text available
An efficient procedure for the synthesis of carboacyclic nucleosides via microwave-assisted Michael addition of pyrimidine and purine nucleobases to α,β-unsaturated esters in the presence of catalytic amounts of zinc oxide (ZnO) and tetrabutylammonium bromide (TBAB) is described. The reactions proceed rapidly in good to excellent yields.Key words:...
Article
Full-text available
A highly efficient procedure for the preparation of N-sulfonyl imines via condensation of sulfonamides with aldehydes as well as ketones in the presence of triarylmethyl chlorides as metal-free organo-catalysts at 40 °C is described. The advantages of this class of catalysts over the reported ones are their efficiency and possibility of running rea...