Aliasghar Behnamghader

Aliasghar Behnamghader
Materials and Energy Research Center | MERC · Department of Nanotechnology and Advanced Materials

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38
Publications
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Introduction
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Publications

Publications (38)
Article
Hydrogels play a key role in cartilage tissue engineering (CTE) and cell transplantation. Idealy, the hydrogels designed for CTE should facilitate the formation of cartilage ECM, cilinically. However, challenges remain to engineer hydrogels with controllable responses, fast‐self recovery, and high stability. In the present study, a dual crosslinked...
Article
In this study, a group of injectable composite pastes with a novel formulation consisting of two inorganic components: α-calcium sulfate hemihydrate (α-CSH, P/L = 1.8–2.1 g/ml) and calcium-deficient hydroxyapatite (CDHA, P/L = 0.1 g/ml) nanoparticles; and three biopolymers: gelatin (2, 4 wt. %), alginate (1, 1.5 wt. %), and chondroitin sulfate (0.5...
Article
In this study, the chondrogenic potential of hyaluronic acid/chondrotin sulfate/carboxymethyl chitosan hydrogels with adipose‐derived mesenchymal stem cells (ADMSCs) was evaluated. Here, hyaluronic acid, chondrotin sulphate and carboxymethyl chitosan were used as the substrate for cartilage tissue engineering in which the hydrogel is formed due to...
Article
Full-text available
Over the last years, three-dimensional (3D) printing has been successfully applied to produce suitable substitutes for treating bone defects. In this work, 3D printed composite scaffolds of polycaprolactone (PCL) and strontium (Sr)- and cobalt (Co)-doped multi-component melt-derived bioactive glasses (BGs) were prepared for bone tissue engineering...
Article
In this study, hyaluronic acid-pullulan injectable hydrogels were incorporated with biomimetic hydroxyapatite spheres and were modified using silane coupling agents in order to improve the physicochemical, mechanical, and biological performance of hydrogels. So the biomimetic hydroxyapatite spheres were synthesized through immersion of gelatin-silo...
Article
The incorporation of antibiotics in glass ionomer cements (GICs) for the treatment of periodontal diseases has been considered as an effective therapeutic strategy. In this research, metronidazole was added to silanized glass fiber‐reinforced GICs. The fiber‐reinforced cements containing antibiotic were made by adding 6.0 w% silanized E‐glass fiber...
Chapter
Metal implants have a wide range of therapeutic uses in orthopedic surgery, cardiac devices, dentistry, and gynecological implants. Deleterious immune responses to implanted devices can possibly result in implant failure. Furthermore, due to an increase in joint replacements, revision surgeries are supposed to have a sevenfold increase in the next...
Article
The purpose of this study is to evaluate the general function and properties of a new class of reinforced glass-ionomer cements (GICs). In this regard, GIC powders based on a molar composition of 4.5SiO2.3Al2O3.1.5P2O5.3CaO.2CaF2 were synthesised via a melt-quenching method. The cement reinforced with silanized fibers (CSFs) were made by adding sil...
Article
During the past few years, invasive surgery operations using injectable systems, have been applied for the treatment of osteoporosis bone defects. In this research, different injectable pastes made from natural polymer such as gelatin (Ge), carboxymethyl cellulose (CMC), alginate (Alg) and inorganic materials containing hydroxyapatite (HA) and biph...
Article
The degradation behavior of poly(lactic‐co‐glycolic acid) (PLGA) is important for its application as a biomaterial. In this work, the influence of nano‐hydroxyapatite (nano‐HA) on the degradation behavior of PLGA matrix was studied. PLGA‐based in situ forming system containing nano‐HA was prepared using the immersion precipitation method and the po...
Article
In this study, mussel-inspired polydopamine nanospheres (∼400nm) were synthesized via spontaneous oxidative polymerization of dopamine hydrochloride. The creation of bioactive template provided an opportunity for the biomimetic formation of hydroxyapatite layers through soaking of polymeric samples in 10 × -simulated body fluid (10 × -SBF) solution...
Article
In this study, Mussel-inspired polydopamine (PDA) nanospheres were synthesized via spontaneous oxidative polymerization of dopamine hydrochloride (dopa-HCl) in a deionized water-alcohol mixed solvent at room temperature and atmospheric air, under alkaline condition. Field-emission scanning electron microscopy (FE-SEM) demonstrated production of sph...
Article
Background: Bioactive glasses with different compositions have been extensively used as bone tissue engineering. Preparation, development and characterization of alginate pastes containing bioglass for bone repair applications were the purpose of this study. Objective: The injectable bone pastes were produced from sol-gel derived bioactive glass...
Article
This study investigated the fabrication and modification of gelatin microspheres via single emulsion method and silane coupling agents, respectively. Herein, the influence of oil phase and washing procedure on morphology and uniformity of microspheres was evaluated. The results of field emission scanning electron microscopy indicated a positive eff...
Article
Bioactive materials can attract calcium and phosphate ions in simulated body fluid (SBF) solution to mimic the composition of extracellular matrix (ECM). Rapid biodegradation rate of natural polymers in contact with water-based solutions and time-consuming process of mineralization in SBF led to using concentrated simulated media. Herein, gelatin-s...
Cover Page
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COVER ILLUSTRATION: Bioactive materials can attract calcium and phosphate ions in simulated body fluid (SBF) solution to mimic the composition of extracellular matrix (ECM). Rapid biodegradation rate of natural polymers in contact with water-based solutions and timeconsuming process of mineralization in SBF led to using concentrated simulated media...
Article
Background: It is well known that the properties of polymers can be altered by exposure to γ- ray. γ-irradiation has been used as a sterilization method for polymeric drug delivery devices, and its drug release profile must not be significantly changed. In this study, the effect of γ-irradiation on the release profile of leuprolide acetate from PL...
Article
Full-text available
Magnetic nanoparticles attracted a great deal of attention in the medical applications due to their unique properties. The most exceptional property of magnetic particles is their response to a magnetic force, and this property has been utilized in applications such as drug targeting, bioseparation, contrast agents in magnetic resonance imaging (MR...
Article
Drug release mechanism of in situ-forming implants (ISIs) based on poly(lactic acid-co-glycolic acid) (PLGA) loaded with leuprolide acetate/β-cyclodextrin (LA/β-CD) complexes via fitting with four diffusion-based semi-empirical models were studied. The release rate constants and release exponent of ISIs were calculated. The main drug release mechan...
Article
Full-text available
In situ forming implants (ISIs) based on poly(lactic acid-co-glycolic acid) (PLGA) containing leuprolide acetate/β-cyclodextrin (LA/β-CD) complexes were prepared. Incorporation of LA or complexes did not change Tg values of ISIs (48.4-49.6°C). ISIs containing complexes with more β-CD content showed higher surface and bulk porosity. Higher β-CD port...
Article
Full-text available
In the present research, the aqueous stability of leuprolide acetate (LA) in phosphate buffered saline (PBS) medium was studied (pH = 2.0–7.4). For this purpose, the effect of temperature, dissolved oxygen and pH on the stability of LA during 35 days was investigated. Results showed that the aqueous stability of LA was higher at low temperatures. D...
Article
Full-text available
Collagen and noncollagenous proteins have an important role in the formation of mineral constituent of bone matrix. In this research, the morphology and phase characteristics of calcium phosphate nanoparticles in presence of collagen were investigated. The synthesis reaction was initiated by mixing H3PO4 as phosphorous source and CaCl2 as calcium s...
Article
Full-text available
Nanocomposites have recently been identified as a useful scaffolding material in tissue engineering applications. Poly (3-hydroxybutyrate)/hydroxyapatite nanoparticles (P3HB)/(nHA) porous scaffolds were successfully fabricated through a solvent casting and particulate leaching technique. P3HB/nHA and P3HB scaffolds were prepared by the same techniq...
Article
Full-text available
The purpose of this research was to study the effect of zeolite powder, with particles size range between 53 and 1180 μm, on the stability and release of vitamins A, D3 and E. Zeolite type, chemical and morphological features were studied using SEM and XRF. High performance liquid chromatography was used to investigate the extracted vitamins from z...
Article
Full-text available
In This study, hydroxyapatite nanoparticles (nHA) was synthesized via sol-gel method and then poly 3-hydroxybutyrate\Hydroxyapatite Nanocomposite scaffolds (PHB/nHA) prepared by solvent casting and particulate leaching Technique. The scaffolds were prepared from 0.4-0.8 gr PHB in 10mm choloroform. nHA weight percent was 0-10 and the ratio of PHB:Na...
Article
Full-text available
The purpose of this research was to study the effect of zeolite powder, with particles size range between 53 and 1180 μm, on the stability and release of vitamins A, D 3 and E. Zeolite type, chemical and morphological features were studied using SEM and XRF. High performance liquid chromatography was used to investigate the extracted vitamins from...
Article
In this study, different concentrations of Li2O (0–12wt.%) were substituted for Na2O in 45S5 bioglass® and the effect of these substitutions on both in vitro apatite formation ability and osteoblastic cell responses was studied. For these purposes, the structural and topographical properties of the glasses were studied using, XRD, FTIR, SEM/EDXA an...
Article
Surface degradation and cracking of dense hydroxyapatite were evaluated through Vickers micro indentation using indentation loads ranged from 25 gf to 2000 gf. Crack lengths, imprint diameters and the number of lateral cracks and chips were measured using SEM. The crack length-indentation load data were analyzed with regard to the specific relation...
Article
Full-text available
In this research hydroxyapatite powder was synthesized by wet chemical method using calcium nitrate and diammonium hydrogen phosphate precursors at 2, 20, 50 and 90⁰ C. Phase composition, morphological aspects and particle size have been investigated using X-ray diffraction method (XRD), Fourier transform infra red spectroscopy (FTIR) and scanning...
Article
Full-text available
In this study, hydroxyapatite was coated on titanium substrates by plasma spraying process. A well-known porous and lamellar microstructure was found in the lateral and outer surface of coating. The phase composition was studied by XRD and the morphological and the microstructural aspects were investigated by scanning electron and optical microscop...
Conference Paper
Full-text available
In recent years, wide investigations were done about the use of natural Zeolites in biomedical engineering. There is a lot of researches have been done about the interaction between some drugs and natural Zeolites. The cancer therapy and drug delivery are some of the most important application of natural Zeolite. Because of some complications and s...
Conference Paper
Full-text available
The purpose of this research was to study the effect of fine Zeolite powder with a size lower than 50 μm on the stability of vitamin E. The powder emanating from natural Iranian Zeolite was first plunged in a saturated solution of vitamin E. The solutions were then taken in laboratory condition at room temperature for 2 hours, 3 and 10 days in room...
Article
Full-text available
Objective-To determine the effect of selected bone graft on the compression properties of radial bone in rabbit. Design-Experimental in vivo study. Animals-A total of 45 adult male New Zealand white rabbits. Procedures-The rabbits were anesthetized and a one-cm-full thickness piece of radial bone was removed using oscillating saw in the all rabbit....
Chapter
Nanocrystalline hydroxyapatite (HAP) powder was synthesized by a non-alkoxide sol-gel method. The prepared powder was characterized with STA, X-ray diffraction, Zetasizer and SEM microscopy. The effect of aging for 24h and heating time at 550°C on crystallity, crystallite and particle size were studied through XRD, zetasizer and SEM. Results showed...
Chapter
The extensive use of appropriate coatings to improve wear resistance, friction coefficient, electrical properties, corrosion resistance and biomedical application has stimulated a growing interest in their mechanical properties and especially hardness testing that is routinely used for coating evaluation. In this study Jönsson and Hogmark model is...
Article
Full-text available
L’objectif de cette étude est de caractériser le comportement fragile de l’hydroxyapatite (HAP) par évaluation de sa ténacité. Cette ténacité a été estimée pour des d’échantillons sous forme massive et pour des revêtements par indentation Vickers. Pour les échantillons d’HAP sous forme massive, des fissures de type Médian sont visibles à chaque coi...

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