Ali Reza Safarpour

Ali Reza Safarpour
Shiraz University of Medical Sciences | SUMS · Gastroenterohepatology Research Center

MD, MPH, PhD

About

119
Publications
18,714
Reads
How we measure 'reads'
A 'read' is counted each time someone views a publication summary (such as the title, abstract, and list of authors), clicks on a figure, or views or downloads the full-text. Learn more
739
Citations
Introduction
Ali Reza Safarpour,MD,MPH,PhD Shiraz University of medical Sciences Manager in chief of Gastroenterohepatology Research Center
Additional affiliations
June 2015 - August 2018
Shiraz University of Medical Sciences
Position
  • MD, MPH, PhD
June 2013 - present
Shiraz University of Medical Sciences
Position
  • Manager of gastroenterohepatology Research Center

Publications

Publications (119)
Article
Full-text available
Background MicroRNAs (miRNAs) are non-coding, endogenous, single-stranded, small (21–25 nucleotides) RNAs. Various target genes at the post-transcriptional stage are modulated by miRNAs that are involved in the regulation of a variety of biological processes such as embryonic development, differentiation, proliferation, apoptosis, inflammation, and...
Article
Full-text available
Background Colorectal cancer (CRC) is the second most common cancer in women and the third most common cancer in men worldwide, with an increasing trend in its incidence in Asian countries. In the present study, we aimed to describe the 13-year results of patients with CRC based on the Shiraz Colorectal Cancer Surgery (SCORCS) registry system in pa...
Article
Background: Anal fistulas are one of the interactable cases in proctologic clinics. Managing these patients has the major risk of recurrence and incontinence. Objectives: In this retrospective cohort study, we compared the results of three sphincter saving procedures during a two-year follow-up phase. Methods: A total of 87 patients who underwent e...
Article
Full-text available
Findings on the association of sodium with nonalcoholic fatty liver disease (NAFLD) are conflicting. The present systematic review and meta‐analysis study aimed to assess the association between salt or sodium intake or serum sodium levels and NAFLD risk. Relevant articles were identified by searching PubMed, Web of Knowledge, Scopus, Proquest, and...
Article
Full-text available
The PERSIAN Kavar cohort study (PKCS) aims to investigate the prevalence, trends, and relevant prognostic risk factors of non-communicable diseases in participants aged 35–70 years living in the urban area of Kavar County. Kavar County is located at the center of Fars province in the southwest of Iran. Overall, 5236 adults aged 35–70 years old were...
Article
Full-text available
Objectives: Post-dural Puncture Headache (PDPH) is prevalent among individuals undergoing lumbar punctures. The non-invasive effect of some drugs, such as aminophylline on PDPH has been investigated in several clinical studies. As there is no comprehensive systematic review and meta-analysis about the preventive and therapeutic effects of aminophy...
Article
Full-text available
IntroductionOver the past decades prevalence of diabetes has increased in Iran and other countries. This study aimed to update the prevalence of diabetes and prediabetes in Iran and to determine associated sociodemographic risk factors, as well as diabetes awareness and control.Methods This is a nationally representative cross-sectional survey that...
Article
Full-text available
Cholangiocarcinoma (CCA) is a type of cancer with increasing prevalence around the world that originates from cholangiocytes, the epithelial cells of the bile duct. The tumor begins insidiously and is distinguished by high grade neoplasm, poor outcome, and high risk for recurrence. Liver transplantation has become broadly accepted as a treatment op...
Article
Full-text available
It is hypothesized that liver impairment caused by coronavirus disease 2019 (COVID-19) infection might play a central role in severe clinical presentations. Liver injury is closely associated with severe disease and, even with antiviral drugs, have a poor prognosis in COVID-19 patients. In addition to the common hepatobiliary disorders caused by CO...
Article
Full-text available
Background: Genetic variation in immune regulatory genes might influence the HBV infection outcome. Objective: This study aimed to determine the association of IL-17A rs2275913 (G197A), IL-17F rs763780 (A7488G), and IL-23R rs10889677 (C2370A) gene polymorphisms, as well as the emerged haplotypes in the individual infected by HBV and to investiga...
Article
Full-text available
Background Neuroendocrine tumors (NETs), as a rare and heterogeneous category of solid tumors, feature various morphologies and behaviors. In recent years, the incidence of NETs has continued to increase. Endoscopic mucosal resection (EMR) is one of the therapeutic modalities for the treatment of gastric and rectal NETs. Methods We evaluated patie...
Preprint
Full-text available
Introduction: The most kind of dementia is Alzheimer's disease. Alzheimer’s is a type of degenerative cerebrovascular disorder which exacerbates over time. Meanwhile, anticholinergic drugs can potentially modify the risk factors. As different studies have achieved different results and the clinical findings of these interventions have not been conc...
Article
Full-text available
Recently, the novel coronavirus disease 2019 (COVID-19), has attracted the attention of scientists where it has a high mortality rate among older adults and individuals suffering from chronic diseases, such as chronic kidney diseases (CKD). It is important to elucidate molecular mechanisms by which COVID-19 affects the kidneys and accordingly devel...
Preprint
Full-text available
Background Recently, massive open online courses (MOOCs) have received increasing popularity throughout the world. Regardless of the subject taught and the university providing the course, the dropout rate of MOOCs is one of the most important challenges ahead. Methods This systematic review will search MEDLINE/PubMed, Scopus, Web of Science (Clari...
Preprint
Full-text available
Background Primary sclerosing cholangitis (PSC) is an uncommon chronic and progressive cholestatic liver disease . There is a robust association between PSC and Inflammatory Bowel Disease (IBD), usually Ulcerative Colitis (UC) . According to the review of literature, the incidence of de novo IBD after solid organ transplantation (SOT) is found to b...
Article
Full-text available
Background: Centers of excellence are organizations with prominent activities in a specific field and are capable of delivering quality services using specialized equipment, innovative techniques, and modern technologies. They can also bring financial benefits and cost recovery to their organizations. So, promoting the independence of these organiz...
Article
Full-text available
Background: Drug use can lead to several psychological, medical and social complications. The current study aimed to measure and decomposes socioeconomic-related inequalities in drug use among adults in Iran. Methods: This was a cross-sectional study The PERSIAN Cohort is the largest and most important cohort among 18 distinct areas of Iran. Thi...
Article
Full-text available
Background: Changes in the enteric microbiota have been suggested to contribute to gastrointestinal diseases, including irritable bowel syndrome. Most of the published work is on bacterial dysbiosis with meager data on the role of the virome in irritable bowel syndrome and other gastrointestinal diseases. In the current study, we therefore aimed t...
Article
PURPOSE: The objective of this study is to evaluate the effect of the topical interferon α2b (IFNα2b) as an adjunctive therapy in the treatment of diabetic macular edema. METHOD: This was a randomized controlled clinical trial performed on patients with diabetic macular edema. Fifty eyes of 50 patients (one eye/patient) who were receiving treatment...
Preprint
Full-text available
Background Increasing breastfeeding rates around the world is one of the most important goals of the World Health Organization. Self-efficacy is a modifying and predictive factor for initiation and continuation of breastfeeding. This study was conducted to investigate the impact of mobile-based education and regular delivery of designed messages on...
Article
Full-text available
Background: Hepatitis C virus (HCV) infection is an important public health hazard, with approximately 71 million chronically HCV-infected individuals around the world. Objectives: This study was designed to provide epidemiologic information on HCV, evaluate the possible route of transmission and its associated risk factors, and characterize the pr...
Article
Full-text available
Background Overweight and obesity are major health concerns worldwide, with adverse health consequences during the life span. This study measured socioeconomic inequality in overweight and obesity among Iranian adults. Methods Data were extracted from 129,257 Iranian adults (aged 35 years and older) participated in the Prospective Epidemiologic Re...
Article
Full-text available
Introduction Inflammatory bowel diseases, including ulcerative colitis (UC), Crohn’s disease (CD) and inflammatory bowel disease type unclassified (IBDU), are debilitating conditions that are rapidly growing in developing countries. Given the absence of a comprehensive systematic review and meta-analysis containing a rigorous pooled estimate of inc...
Article
Full-text available
Abstract Background The level of socioeconomic-related inequality in physical activity in Iran is largely unknown. This study investigates socioeconomic-related inequality in poor-physical activity (PPA) among Iranian adults. Methods A total of 129,257 adult participants enrolled in the PERSIAN (Prospective Epidemiological Research Studies in IrAN...
Article
Full-text available
BACKGROUND Hepatic dysfunction has been associated with poor prognosis in critically ill patients. We aimed to investigate the incidence of early liver dysfunction and its association with probable predictive variables in a group of Iranian patients. METHODS The study was conducted on 149 pediatric patients referred to the pediatric intensive care...
Article
Objective To find the relationship between Helicobacter pylori infection and iron deficiency anemia in school-aged children. Methods 71 children with dyspepsia, epigastric and vague abdominal pain attending a tertiary medical center in Iran underwent upper gastrointestinal endoscopy and were investigated for H. Pylori infection. Hemoglobin, mean c...
Article
Background: Gastric cancer (GC) is the first leading cause of cancer-related deaths in Iran. GC is a multifactorial disease and is caused by the interaction of genetic and environmental factors. The aim of this study was to assess the exposure and risk of nitrate intake through fruits and vegetables (F&V) in high-risk area (HRA) and low-risk area...
Article
Full-text available
Background: Self-management (SM) as a dynamic process enables Ulcerative colitis (UC) patients to live with this chronic illness. The present study aimed to investigate the effect of SM education on self-efficacy (SE) and quality of life (QoL) in patients with UC. Methods: This randomized controlled clinical trial study was conducted on 64 patie...
Article
Background: Self-management (SM) as a dynamic process enables Ulcerative colitis (UC) patients to live with this chronic illness. The present study aimed to investigate the effect of SM education on self-efficacy (SE) and quality of life (QoL) in patients with UC. Methods: This randomized controlled clinical trial study was conducted on 64 patients...
Article
Full-text available
Introduction: Patients with drug addiction have high risk for hepatitis C virus (HCV). Effective treatment response is essential to optimize treatment for drug abusers infected by hepatitis C virus. Aim: The aim of this present study was to show that hepatitis C treatment in patients with drug addiction is effective like patients without drug ad...
Article
Full-text available
Inflammatory bowel disease (IBD) that include Crohn´s Disease (CD) and Ulcerative colitis (UC) are types of digestive system disease that steel have not been properly identified as their original causes. Our goal was to evaluation of lower infection with H.pylori in patients suffer from IBD in compete with the normal population. Method: IN this cas...
Article
Full-text available
Background: There are clear variations between andwithin countries regarding the prevalence of Helicobacter pylori. In addition, there are no estimations of its prevalence in the general population in the south of Iran. Objectives: We aimed to evaluate the prevalence of H. pylori in the rural population of Kavar, a southern city of Iran. Methods: A...
Article
Full-text available
Background: Constipation is one of the most common Gastrointestinal (GI) symptoms among children. The present study aimed to identify the demographic and clinical characteristics of the children suffering from constipation. Methods: This descriptive-analytical study was conducted on 987 children with constipation in Fars province from March 2015 to...
Article
Full-text available
The aim of the present study was to evaluate the gastrointestinal and hepatobiliary manifestation of cytomegalovirus. In a retrospective study, demographic and clinical information of patients with gastrointestinal or hepatobiliary manifestations and histologically confirmed cytomegalovirus infection was investigated among pathological records. The...
Article
Full-text available
Objectives: The study aimed to compare tubeless, totally tubeless, and standard percutaneous nephrolithotomy (PNL) in a tertiary center with selected patient population. Methods: Between September 2013 and March 2015, percutaneous nephrolithotomy was performed on 216 patients in our center. Patients without massive bleeding, calyceal perforation, a...
Article
Full-text available
PURPOSE: Next-generation sequencing (NGS) is currently used to establish mutational profiles in many multigene diseases such as colorectal cancer (CRC) which is on the rise in many parts of the developing World including in the Middle East. Little is known about its genetic hallmarks in these populations. AIM: To identify variants in 15 CRC-associa...
Article
Full-text available
Purpose Anal sphincter injury after delivery is the main factor in the pathogenesis of fecal incontinence. Clinical obvious and specific injury to anal canal sphincter is seen in 3% of vaginal deliveries. There are many women who do not have a clear and specific laceration but they are damaged by sphincter muscles of anal canal. The purpose of the...
Article
Background: The natural history of ulcerative colitis (UC) after liver transplantation (LT) for primary sclerosing cholangitis (PSC) remains ill defined. This study aimed to evaluate the course of UC after LT for PSC. Methods: The course of UC, including the clinical colitis severity index, was evaluated in patients with concomitant PSC and UC w...
Article
Full-text available
Objective Human amniotic membrane (HAM) used as a wound coverage for more than a century. The aim of this study is to evaluate the efficacy of amniotic membrane on wound healing and reduce post-operative complication. Study design Randomized clinical trial study. Place and duration of study Surgery Department, Shahid Faghihi Hospital, Shiraz, in...
Article
Full-text available
Introduction Resection of the prostate is one of the standard surgical treatments for symptomatic Benign Prostatic Hyperplasia (BPH). To evaluate minimally invasive treatments, intraprostatic injections of ethanol and bleomycin were compared with oral finasteride administration in rats with BPH. Material and methods The rats were divided into six g...
Article
Full-text available
Objective To determine the applicability of urinary caspase 3 enzyme and TNF-α as biomarkers in children with ureteropelvic junction obstruction (UPJO). Methods In this study, 31 unilateral UPJO patients and 33 age- and sex-matched healthy childrens were enrolled. The patients with UPJO consisted of 11 female and 20 male children between the ages...
Article
Full-text available
Dear Editor, Small bowel bleeding accounts for 5% of all gastrointestinal bleeding cases. Vascular lesions of the gastrointestinal tract include hemangioma, telangiectasia, angiodysplasia and phlebectasia 1 and they account for 5-10% of all benign neoplasms of the small bowel. 2 The diagnosis of small bowel hemangioma is not easy and different moda...
Article
Full-text available
Background: Inflammatory bowel diseases(IBDs), including ulcerative colitis(UC) and Crohn’s disease (CD), are chronic inflammatory disorders of the gastrointestinal tract. A combination of environmental factors and interactions with a genetic predisposition are suggested to play an important role in the etiology and pathogenesis of the IBD. Glutath...
Article
Full-text available
Background: Ulcerative colitis (UC) is a form of inflammatory bowel disease (IBD). There are several chemical and herbal drug regimens for treatment of UC. Objectives: The aims of this study were to investigate the effects of Hypericum perforatumon histopathological and tissue malondialdehyde (MDA) level of colonic tissue in rat with induced UC....
Article
Full-text available
Background: Drug abusers are one of the most at risk populations for hepatitis C virus (HCV) transmission worldwide. The aims of this study were to measure the seroprevalence of HCV and to compare certain related risk factors in participants who were referred to drug rehabilitation centers affiliated to Shiraz University of Medical Sciences, Shiraz...
Article
Full-text available
Gastric malignancies are the third most common causes of cancer-related death in the world. Here, we aimed to compare brush cytology before and after biopsy in the diagnosis of gastric malignancies. This prospective study included 74 cases referred to endoscopy clinic for suspected gastric lesions during 1 year. In 38 cases, brush cytology was done...
Article
Full-text available
Background: Non-alcoholic fatty liver disease (NAFLD) is the most common form of liver disease in many parts of the world. Objectives: The aim of the present study was to identify the most important factors influencing NAFLD using a classification tree (CT) to predict the probability of NAFLD. Patients and methods: This cross-sectional study w...
Article
Full-text available
BACKGROUND Some evidence, not in large study populations, suggests that nonalcoholic fatty liver disease (NAFLD) and metabolic syndrome (MetS) share common interactions. We aimed to determine the prevalence of NAFLD and MetS in a large population registered to Kavar Cohort Study center. We also assessed the role of each component of MetS in NAFLD e...
Article
Full-text available
Objective: Self-medication is common among patients with gastrointestinal (GI) symptoms. This study was performed to evaluate self-medication among patients who fulfilled irritable bowel syndrome (IBS) and dyspepsia diagnostic criteria and to investigate the appropriateness of self-medication with chemical and herbal drugs. Methods: A prospectiv...
Article
Full-text available
Background: The epidemiology of inflammatory bowel disease (IBD) is changing globally and there is disagreement between studies about the prevalence of relapse of ulcerative colitis (UC) as a type of IBD.
Article
Full-text available
Background: Hepatitis C virus (HCV) infection is a major blood-borne infection which imposes high economic cost on the patients. Objectives: The current study aimed to evaluate the total annual cost due to chronic HCV related diseases imposed on each patient and their family in Southern Iran. Patients and methods: Economic burden of chronic he...
Article
Full-text available
PURPOSE: Sphincter repair is the primary management for fecal incontinence especially in traumatic causes. Regardless of progression in the method and material of sphincter repair, the results are still disappointing. This study evaluates the efficacy of using amniotic membrane during sphincteroplasty regarding its effects in healing of various tis...
Article
Full-text available
Background: The burden of inflammatory bowel disease (IBD) hasn’t been reported in Iran. We aimed to estimate the prevalence and incidence of IBD and itstrend in Iran at national and subnational level from 1990 to 2012. Methods: We conducted a systematic review of English and Persian databases about the epidemiology of IBD. We also collected outpat...
Article
Full-text available
Background Inflammatory bowel diseases (IBDs), including ulcerative colitis (UC) and Crohn's disease (CD), are chronic inflammatory disorders of the gastrointestinal tract. A combination of environmental factors and interactions with a genetic predisposition are suggested to play an important role in the etiology and pathogenesis of the IBD. Glutat...
Poster
Introduction: Metabolic syndrome (MetS) and gallstone disease (GSD) are common problems and shared some common pathophysiological mechanisms. The aim of this study was to investigate the association between MetS and its components with the GSD. Methods: In a retrospective case-control study, 59 patients with GSD and 177 controls without gallstones...
Poster
Introduction: Helicobacter pylori, is a Gram-negative, microaerophilic bacterium found in the stomach. It has been reported that more than 50% of the world’s population harbor H. pylori in their upper gastrointestinal tract. However, there are no such estimations from rural population in Iran. The aim of the present study was to evaluate the preval...
Poster
Introduction: Both non-alcoholic fatty liver disease (NAFLD) and metabolic syndrome (MetS) are important metabolic disorders especially in developing and developed countries. Also, it has been reported that NAFLD and MetS share common interactions. We aimed to determine the NAFLD and MetS prevalence in a large population and find the prevalence of...
Poster
Introduction: Drug abuser is one of the most at risk population for HCV transmission worldwide. The aims of this study were to measure the sero-prevalence of HCV and compare some related risk factors in participants who referred to drug rehabilitation centers affiliated to Shiraz University of Medical Sciences, Shiraz, Iran. Methods: Blood samples...