Ali Ramazani

University of Zanjan · Department of Chemistry

Due to the importance of energy storage systems based on supercapacitors, various studies have been conducted. In this research CuO, NCNO and the flower like CuO/NCNO have been studied as a novel materials in this field. The resulte showed that the synthesized CuO nanostructutes have flower like morphology which studied by FE-SEM analisis. Further,...

Background: Thiazole ring is one of the most important heterocycle scaffolds in organic and medicinal chemistry due to this scaffold being the backbone of numerous drugs and their significant activities against various diseases have made it one of the best candidates for industrial production. According to the literature, the number of drugs that h...

Over the past few decades, studies on bone tissue engineering have inspired innovation in novel materials, processing methods, performance evaluations, and applications. Nanomaterials have great promise for the creation of novel treatment solutions, such as bone regeneration and repair, as well as the replacement of organs and tissues. Bone tissue...

Recent advances in nanotechnology have gained remarkable attention to nanodiamonds (NDs) in both research and industrial areas thanks to their promising intrinsic properties such as large specific area, poor cytotoxicity, high biocompatibility, facile surface functionalization, chemical resistance, optical and biological properties, inexpensive lar...

Since aniline is a persistent pollutant, a cost‐effective and efficient removal method is urgently needed. This study evaluates the synergistic effect of nickel doping in spinel zinc ferrite to enhance the photocatalytic performance of magnetic nanoparticles. Herein, XRD, FTIR, BET, DRS, TEM, FESEM, EDX/Map, and VSM techniques were used to evaluate...

The use of biomarkers as early warning systems in the evaluation of disease risk has increased markedly in the last decade. Biomarkers are indicators of typical biological processes, pathogenic processes, or pharmacological reactions to therapy. The application and identification of biomarkers in the medical and clinical fields have an enormous imp...

In this study, phytochemicals extracted from three different Achillea genera were identified and analyzed to be screened for their interactions with the SARS-CoV-2 main protease. In particular, the antiviral potential of these natural products against the SARS-CoV-2 main protease was investigated, as was their effectiveness against the SARS-CoV-1 m...

This study aimed to prepare a novel organic-mineral nanofiber/hydrogel of chitosan-polyethylene oxide (CS-PEO)/nanoclay-alginate (NC-ALG). The effects of NC particles on the mineralization and biocompatibility of the scaffold were investigated. A layer-by-layer scaffold composed of CS-PEO and NC-ALG was prepared. The morphological properties, swell...

Development of novel antimicrobial phytochemical-bearing nanofibrous mats could be considered as a promising strategy to overcome against antibiotic resistance in wound healing. In this work, the electrospinning process was used to successfully create novel antimicrobial nanofiber mats made of a blend of electrospun chitosan/polycaprolactone (CS/PC...

A new PEGylated redox/pH dual‐responsive dendritic prodrug (H40‐SS‐PTX/PEG) based on commercially available dendritic polyester, boltorn® H40 (H40), as starting core template was developed and characterized for tumor triggered paclitaxel delivery. The size of the nanocarrier was determined 100 nm by TEM. The results of in vitro drug release study s...

Unlabelled: Glycyrrhiza glabra L., Fabaceae, or licorice has shown potential therapeutic effects on fever, gastric ulcers, hepatic disorders, and malaria. This study aimed to assess the antimalarial activity of different fractions of root extract from twelve ecotypes from Iran. In this regard, mice were then randomly divided into 8 groups of 5 mic...

This study aimed to directly detect the V617F point mutation of the Janus kinase 2 (JAK2) gene in the target DNA using a FRET-based biosensor. The water-soluble GSH-CdTe-QDs were synthesized by a one-step process, then GSH-QD conjugated to the termini amino-modified oligonucleotides target via carboxylic groups on the QD surface. The prepared QDs-D...

In this study, the synthesis of lenalidomide nitro precursor was investigated, which is helpful in the production of active pharmaceutical ingredients of the anticancer drug lenalidomide (IV). The cyclization of methyl 2-(bromomethyl)-3-nitrobenzoate (I) with 3-aminopiperidine-2,6-dione hydrochloride (II) was performed to prepare (3RS)-3-(7-nitro-3...

In current research, we focused on the an eco-friendly and efficient procedure for the coating of Copper(II) on the surface of Schiff base complex immobilized on Fe3O4@SiO2 MNPs to synthesize a Core/shell nanostructure Fe3O4@SiO2@GPTMS/Schiff base-Cu(II) nanocatalyst. Then, the as-prepared nanocatalyst was characterized various analyses such as FT-...

Silicone oil nanoemulsion softeners with different particle sizes can be prepared using different surfactants with various ratios aminosilicone oil, surfactants concentration and time of mixing. The silicone oil nanoemulsion softeners could penetrate well into the polyester fibers; therefore, they can induce desirable physicochemical properties in...

Periodontal disease is a set of inflammatory conditions affecting the tissues surrounding the teeth, which can be fairly preventable. In this research, antibacterial polymeric nanofibers were prepared for the management of periodontal disease treatment. New hybrid organic/inorganic nanofibers of chitosan/polyethylene oxide (CS/PEO) contains doxycyc...

In this current study, the picolylamine copper complex immobilized on the core-shell Fe3O4 nanomagnetic particles [Fe3O4@SiO2@GP/Picolylamine-Cu(II)] has been easily prepared via a multistep procedure from the reaction between 2-picolylamine and GPTMS to give GP/picolylamine. Then, the as-prepared GP/picolylamine materials can be immobilized with c...

In this research, we successfully designed and synthesized a new core-shell-structured inorganic-organic hybrid magnetic nanocatalyst via the ethylene diamine immobilized to the core-shell Fe3O4 nanomagnetic particles (Fe3O4@SiO2@(CH2)3/EDA). A variety of analyses such as fourier-transform infrared spectroscopy (FT-IR), energy-dispersive X-ray spec...

5H-Chromeno[2,3-b]pyridine derivatives are a series of the most important compounds of chromenes with industrial, biological, and medicinal properties. These compounds are known as the privileged medicinal scaffold and can be synthesized by different methods such as multicomponent reactions (MCRs), Multicomponent coupling reactions (MCCRs), pot, at...

To study the influence of pore structural properties of metal-organic frameworks (MOFs) on drug adsorption and delivery, we synthesized two MOF termed TMU-6(RL1) {[Zn(oba)(RL1)0.5]n·(DMF)1.5} and TMU-21(RL2) {[Zn(oba)(RL2)0.5]n·(DMF)1.5} with amine basic N-donor pillars containing phenyl or naphthyl cores with various hydrophilic properties around...

Application of conventional chemotherapy regardless of its unique effectiveness have been gradually being edged aside due to limited targeting capability, lack of selectivity and chemotherapy-associated side effects. To this end, colon-targeted nanoparticles via combination therapy have shown great therapeutic potential against cancer. Herein, pH/e...

The Ni0.5Zn0.5AlFeO4 magnetic nanoparticles (MNPs) were synthesized using Plantago major seed extract via an environmentally friendly, efficient, low-cost, and simple process. The nanoparticles were characterized by FTIR, XRD, SEM, EDS, TEM, VSM, DRS, DLS, zeta potential analysis, and BET surface area analysis. The Ni0.5Zn0.5AlFeO4 MNPs were examin...

Janus heterostructures based on bimetallic nanoparticles have emerged as effective radiosensitizers owing to their radiosensitization capabilities in cancer cells. In this context, this study aims at developing a novel bimetallic nanoradiosensitizer, Bi2S3-Fe3O4, to enhance tumor accumulation and promote radiation-induced DNA damage while reducing...

Malaria and cancer have been considered deadly diseases around the world. Cancer and malaria both have high incidence rates despite numerous research efforts to develop effective strategies for mitigating the burden of these two distinct ailments. Herein, pH-responsive nanogel based on methacrylic acid-functionalized with bovine serum albumin (PMAA...

The attachment of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike to angiotensin-converting enzyme 2 (ACE-2) leads the cell fusion process, so spike blockade may be a promising therapy combating COVID-19. Bee pollen bioflavonoids with intrinsic bioactivities are of outmost importance to block SARS-CoV-2-ACE-2 interaction. Herein,...

Background: The application of plumbagin (PLN), with a wide use in pharmaceutical science, is limited due to its low water solubility and poor bioavailability. Micelles can encapsulate hydrophobic drugs due to their hydrophobic core. The aim of this study was to develop and characterize a polymeric micelle formulation of PLN and evaluate its in viv...

Coumarins and their derivatives are becoming a potential source for new drug discovery due to their vast array of biological activities. The present study was designed to investigate the cardioprotective effects of a newly synthesized coumarin, symbolized as 5,6‐PhSHC, against cardiac remodeling process in isoproterenol (ISO) induced myocardial inf...

This study focused on developing a superparamagnetic graphene oxide-based nanocomposite consisting of iron oxide (IO) and gold nanoparticles for quercetin delivery. For this purpose, the structure and morphology of the designed nanocomposite (GO/IO/Au) were investigated by several characterization methods such as fourier-transform infrared (FT-IR)...

Synthesis and Structural analysis of a Novel Stable Quinoline Dicarbamic Acid: X-Ray Single Crystal Structure of (2-((4-((2-(Carboxy (Methyl) Amino) Ethoxy) Carbonyl) Quinoline-2-yl) oxy) Ethyl) (Methyl)-Carbamic Acid and Molecular Docking Assessments to Test Its Inhibitory Potential against SARS-CoV-2 Main Protease

In the present study, a green and ecofriendly nanocatalyst was synthesized through functionalization of 2,4,6-trichloro-1,3,5-triazine (TCT) and mesalamine on silica-coated magnetic nanoparticles (MNPs), then coordination with Cu2+ without agglomeration, consecutively. The silica-coated MNPs functionalized with the Cu(*II)-mesalamine complex was (F...

The aim of the current work was to study for the first time the phytochemical profile of Ephedra alata subsp. alenda seeds extract (ESS). The extract was characterized using high-performance liquid chromatography coupled to electrospray ionization quadropole time-of-flight mass spectrometry (HPLC–ESI–QTOF/MS). The antioxidant and antihemolytic prop...

One of the foremost inescapable impediments that industrial sectors face is to remove organic pollutants, which affected nature and threatened the existence of species per se. Nanoscale magnetic ferrites are considerable materials for removing the majority of organic dyes due to their unique properties and high potential photocatalytic activity. Th...

Single crystal X-ray structure analyses of 3-Hydroxyl-1,7,7-trimethyl-3-[5-(4-methyl phenyl)-1,3,4-oxadiazol-2-yl]bicycle [2.2.1] heptan-2-one was performed. In addition, the computational investigations such as optimization energy, infrared spectra, the frontier orbitals of HOMO, LUMO, HOMO-1, and LUMO+1 analysis, molecular electrostatic potential...

The synthesis of gold nanoparticles (AuNPs) using plant extracts has gained significant attention owing to their potential properties. We have applied the green synthetic approach to preparing AuNPs using an aqueous extract from the fruit of the Rhamnus cathartica plant. In the present investigation, the main reaction parameters affecting the synth...

An eco-friendly, highly efficient, and novel sulfonic acid functionalized imidazolium thiocyanate (Imidazole-SO3H)/SCN and sulfonic acid functionalized imidazolium chloride (Imidazole-SO3H)/Cl solid acid catalyst were successfully synthesized. The structure of catalyst was characterized by various analyses such as FT-IR, ¹H NMR and ¹³C NMR spectros...

The idea of applying ultrasound (US) as a green activation method in chemical transformations, especially in catalytic alcohol oxidations, technically and ecologically appeals to chemists. In the present work, as an attempt to fulfill the idea of designing an eco-friendly system to oxidize alcoholic substrates into corresponding aldehydes, we devel...

Carbon nanotube (CNT)-based hydrogels have recently found a wide variety of applications due to the unique physical and chemical properties of CNTs. CNTs can be used as a nanofiller and/or crosslinker to produce nanocomposite hydrogels with good mechanical and structural properties. In this research, a novel method was reported for producing polyac...

In this study, we synthesized the GPTMS‐guanidine attached to the magnetic nanoparticles (Fe3O4@SiO2@GPTMS@guanidine) as a novel and efficient heterogeneous nanocatalyst through cheap and available materials. Then, the Fe3O4@SiO2@GPTMS@guanidine nanoparticles were characterized by various analyses such as fourier transform infrared spectroscopy (FT...

A new, facile, low-cost, and green sol-gel route for the synthesis of the MgFe2O4@CoCr2O4 magnetic nanocomposite is reported. The photocatalytic performances of the prepared magnetic nanocomposite was investigated for the degradation of organic dye under visible light irradiation. The synthesized magnetic photocatalyst depicted high degradation per...

Although graphene oxide (GO) nanosheets are widely used in different fields, the mechanism of their toxicity remains relatively unknown. NMR‐based metabolomics was used to study in vivo time and dose‐dependent toxicity of GO nanosheets in mice. Sixty serum samples from mice in four different time intervals including 24 and 72 h and 7 and 21 days af...

An ecofriendly inorganic–organic hybrid and novel Schiff base complex of copper coated on epoxy-modified Fe3O4@SiO2 MNPs was successfully designed and prepared from readily available chemicals. In this method, a Schiff base complex as a linker is utilized to protect copper nanoparticles to the core–shell Fe3O4 exterior without agglomeration. The re...

This research investigates antiviral potential of extracted honeybee products against COVID-19 main protease (Mpro) by computational methods. The crystal structure of COVID-19 Mpro was obtained from the protein data bank. Six synthetic drugs with antiviral properties were used as control samples in order to compare the results with those of natural...

Using magnetic and recyclable catalysts to promote selective C–C bond formation could help in the design of safer and ‘‘greener’’ chemical manufacturing process. This work describes the preparation of magneto Ni(II) complex (Fe3O4@PCAPic/NiII) as a novel semi-heterogeneous system and the evaluation of their potential catalytic activity towards the...

Malaria, as one of the most common human infectious diseases, remains the greatest global health concern, since approximately 3.5 billion people around the world, especially those at subtropical areas, are at the risk of being infected by malaria. Due to the emergence and spread of drug resistance to the current antimalarials, malaria-related morta...

The ascending concentration of atmospheric carbon dioxide resulting from fossil fuel combustions causes global climate change and a significant environmental problems in our lives. The increased forthcoming requisite for fossil fuel consumption followed by the resulting subsequent increase in global CO2 level reveals the need for carbon dioxide cap...

During the past decades, Amphiphilic hydrogels found versatile applications in biomaterial field due to their suitable mechanical properties and control on releasement of hydrophobic substrates. Polyethylene glycol (PEG) and polycaprolactone (PCL) are FDA approved polymers that were used together in lots of research articles due to their complement...

In the present study, isoquinoline sulfonic acid thiocyanate (isoquinoline-SO3H)SCN and isoquinoline sulfonic acid chloride (isoquinoline-SO3H)Cl as a novel and heterogeneous catalyst were designed and synthesized by a simple and inexpensive procedure. The prepared heterogeneous catalyst was characterized by FT-IR, ¹H NMR, and ¹³C NMR techniques. T...

Herein, a robust Pd(II)-based polyfunctional magnetic amphiphilic artificial metalloenzyme was prepared by anchoring a Pd(2,2′-dipyridylamine)Cl2 bearing hydrophilic monomethyl ether poly(ethylene glycol) (mPEG) chains on the surface of amino-functionalized silica-coated magnetic nanoparticles. The 2,2′-dipyridylamine (dpa) has shown excellent comp...

The bimetallic nanocatalysts with improved catalytic activity and selectivity has emerged as an important class of nanocatalysts. Herein, a highly efficient Ag–Pd alloy-based semi heterogeneous magnetic nanocatalyst has been developed. The catalyst exhibits enzyme-like catalytic efficiency for the reduction of nitro functional group of 4-nitro phen...

The widespread transmission of SARS-CoV-2 has sparked alarm worldwide. Attaining the best drugs to treat COVID-19 at the shortest possible time is one of the most critical issues in this urgent situation. Molecular docking investigation of the therapeutic potential of marketed drugs is a fast and cost-effective approach to provide a solution to thi...

In the present study, with the aim of improving the permeability of methotrexate (MTX) to the brain, the lipophilic MTX prodrugs containing the ester functional moiety were synthesized. The chemical structure of synthesized prodrugs was characterized and confirmed by FT-IR, NMR and mass spectral studies. Based on the results of in vitro cytotoxic s...

The very important psychoactive phytocannabinoid from Cannabis Δ9 tetrahydrocannabinol (Δ9-THC) and its non-psychotropic member is cannabidiol (CBD). These compounds have a variety of pharmacological activities. THC has been approved for the treatment of nausea caused by chemotherapy, multiple sclerosis and chronic and neuropathic pain and research...

Herein, we present an interesting role of tungstate-decorated amphiphilic carbon quantum dots (A-CQDs/W) in the selective oxidative cleavage of alkenes to aldehydes. In this work, for the first time, we disclose an unprecedented tungstate-based oxidative system incorporating A-CQDs as a bridge to the homogeneous catalyst for selective and efficient...

The Ni0.5Zn0.5Fe2O4 magnetic nanoparticles (MNPs) were synthesised using Plantago major seed extract through an environment-friendly, economic, and easy procedure. The nanoparticles were characterised by FTIR, XRD, SEM, TEM, EDX, BET surface area analysis, and VSM. The Ni0.5Zn0.5Fe2O4 MNPs were investigated as a nanoadsorbent for removal of reactiv...

Cancer is the second leading cause of death in Iran next to heart disease. Current therapy suffers from the major limitations of side effects and drug resistance, so characterization of new structures that can be power-selective and less-toxic anticancer agents is the main challenge to medicinal chemistry research. Furoxan (1,2,5-oxadiazole-2-oxide...

A new serise of 7-hydroxy-chromone derivatives bearing pyridine moiety were synthesized, and evaluated as multifunctional agents against Alzheimer’s disease (AD). Most of the compounds were good AChE inhibitors (IC50=9.8-0.71 µM) and showed remarkable BuChE inhibition activity (IC50=1.9-0.006 µM) compared with donepezil as the standard drug (IC50=...

Fullerene, a new allotrope of carbon with a spherical-shaped molecular structure, draws substantial attention of nano-scientists nowadays because of having numerous applications in different industrial fields such as materials science, building nano-sensors, modified composites, molecular drug containers, etc. This is the reason why having knowledg...

An efficient method for the synthesis of a new highly substituted pyrrolidinone derivative is developed via a three-component one-pot reaction of aniline, diethyl acetylenedicarboxylate, and 4-anisaldehyde. The structure of ethyl 4-hydroxy-2-(4-methoxyphenyl)-5-oxo-1-phenyl-2,5-dihydro-1H-pyrrole-3-carboxylate is confirmed by FTIR, 1H and 13C NMR s...

The crystal structure of 2-amino-4-(2,4-dichlorophenyl)-6 phenylnicotinonitrile (ADPN) was determined by single crystal X-ray diffraction. The crystal structure showed two independent molecules with very similar geometric parameters and different environments. Density functional theory (DFT) and DFT dispersion corrected (DFT-D3) calculations were a...

This chapter briefly reviews current progress in the investigation of magnon-electron interaction and its effects in various compounds, such as ferromagnetic and antiferromagnetic semiconductors, doped and undoped molecular magnets, and supermagnetic compounds. Several aspects in relation to importance of advanced physical processes, including magn...

Lithium sulfur (Li-S) batteries have been considered as next-generation rechargeable batteries beyond lithium-ion batteries owing to high capacity, high energy density and low cost. However, this battery suffers from poor cycle life that is major technical barrier because of shuttling of soluble polysulfide intermediates and volume expansion of S c...

Water pollution is one of the main global concerns affecting humans and numerous people die annually because of the diseases inflicted by contaminated water. Due to the toxicity and carcinogenic potential of the dyes in effluent, it is necessary to attain an efficient method for wastewater treatment using the highly active and reusable photocatalys...

Many drug molecules that are currently in the market suffer from short half-life, poor absorption, low specificity, rapid degradation, and resistance development. The design and development of lipophilic prodrugs can provide numerous benefits to overcome these challenges. Fatty acids (FAs), which are lipophilic biomolecules constituted of essential...

Ni0.5Cu0.5Fe2O4 magnetic nanoparticles using Arabic gel (AG) as a reducing and stabilizing agent was prepared by the sol-method. The catalyst identification was performed using fourier transform infrared spectroscopy (FT-IR), powder X-ray diffraction (PXRD), scanning electron microscopy (SEM), and vibrating sample magnetometer (VSM). Magnetic analy...

This study centers on the controllable synthesis, characterization, and application of a novel magnetic bio-metal-organic framework (Bio-MOF) for the adsorption and subsequent removal of arsenic from aqueous solutions. Zinc ions and carnosine (Car) were exploited to construct the Car-based MOF on the surface of magnetite (Fe 3 O 4 NPs). The Magneti...

A simple and efficient method has been developed for the synthesis of thioesters from carboxylic acids and thiols using N,N'-diisopropylcarbodiimide (DIC). The reactions were carried out in water as an environmentally friendly and green solvent. The developed procedure presents an economic, efficient, mild, and very simple protocol for thioesterifi...