Ali A Moosavi-Movahedi

• Ph.D.
• Professor at University of Tehran

This article explores tardigrades, microscopic invertebrates renowned for their resilience to extreme environmental conditions and examines parallels to human resilience and the Human Development Index (HDI). Tardigrades use unique mechanisms like cryptobiosis to survive harsh conditions, including extreme temperatures, dehydration, radiation, and...

Lawrence Berkeley National Laboratory is recognized as one of the world's leading research laboratories. sixteen elements of the periodic table were introduced to the world by the scientists of this laboratory. Scientists from this renowned laboratory have won 14 Nobel Prizes. The presence of interested and dynamic scientists, professors, and stude...

The membrane potential is a critical aspect of cellular physiology, essential for maintaining homeostasis, facilitating signal transduction, and driving various cellular processes. While the resting membrane potential (RMP) represents a key physiological parameter, membrane potential fluctuations, such as depolarization and hyperpolarization, are e...

Microfluidic chips are powerful tools for investigating numerous variables including chemical and physical parameters on protein aggregation. This study investigated the aggregation of bovine serum albumin (BSA) in two different systems: a vial-based static system and a microfluidic chip-based dynamic system in which BSA aggregation was induced suc...

Neurodegenerative diseases, particularly Alzheimer's disease and Parkinson's disease, present formidable challenges in modern medicine due to their complex pathologies and the absence of curative treatments. Despite advances in symptomatic management, early diagnosis remains essential for mitigating disease progression and improving patient outcome...

Parkinson’s disease (PD), a chronic and common neurodegenerative disease, is characterized by the progressive loss of dopaminergic neurons in the dense part of the substantia nigra and abnormal aggregation of alpha-synuclein. Type 2 diabetes mellitus (T2DM) is a metabolic disease characterized by chronic insulin resistance and deficiency in insulin...

Human serum albumin (HSA), a crucial plasma protein, plays a significant role in drug interactions within the bloodstream, bearing considerable clinical relevance. Bortezomib (BTZ) is a potent anti-cancer drug for multiple myeloma (MM) and mantle cell lymphoma (MC). The mechanism of BTZ transfer in the blood remains undetermined. This study aims to...

Luteolin (Lut) is a flavonoid compound with antioxidant, anti-inflammatory and other biological properties. Lut has been used in many fields such as biomedicine and food safety. Therefore, the quantitative measurement of Lut is of great significance. In this study, an electrochemical sensor based on aminated multi-walled carbon (NH2-MWCNTs), sodium...

Triple-negative breast cancer (TNBC) presents a significant challenge due to its heterogeneous and aggressive nature. Human serum albumin (HSA) offers a promising drug delivery platform due to its high binding capacity and biocompatibility, reducing toxicity and enhancing efficacy. Lapatinib (LAP), a tyrosine kinase inhibitor effective against TNBC...

The importance of amyloid nanofibrils made from food proteins is rising in diverse fields such as biomedicine and food science. These protein nanofibrils (PNFs) serve as versatile and sustainable building blocks for biomaterials, characterized by their high β-sheet content and an ordered hydrogen bond network. These properties offer both stability...

Antibiotic resistance is a critical global health concern, necessitating innovative approaches to combat this challenge. Researchers have explored natural materials as potential solutions. One intriguing candidate is the coelomic fluid of earthworms. Earthworms’ coelomic fluid (CF) contains a diverse array of bioactive compounds. These include anti...

Bacteriophage endolysins are potential alternatives to conventional antibiotics for treating multidrug-resistant gram-negative bacterial infections. However, their structure–function relationships are poorly understood, hindering their optimization and application. In this study, we focused on the individual functionality of the C-terminal muramida...

A revolution in chemical biology occurred with the introduction of click chemistry. Click chemistry plays an important role in protein chemistry modifications, providing specific, sensitive, rapid, and easy-to-handle methods. Under physiological conditions, click chemistry often overlaps with bioorthogonal chemistry, defined as reactions that occur...

The substitution of leucine to proline at position 39 (p.P39L) in human αB-crystallin (αB-Cry) has been associated with conflicting interpretations of pathogenicity in cataracts and cardiomyopathy. This study aimed to investigate the effects of the p.P39L mutation on the structural and functional features of human αB-Cry. The mutant protein was exp...

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In pulmonary inflammation diseases, like COVID-19, lung involvement and inflammation determine the treatment regime. Respiratory inflammation is typically arisen due to the cytokine storm and the leakage of the vessels for immune cells recruitment. Currently, such a situation is detected by the clinical judgment of a specialist or precisely by a ch...

Microfluidic chips are powerful tools for investigating protein aggregation. They can be used to study the effects of various variables on protein aggregation, including chemical and physical properties. This study investigated the aggregation of bovine serum albumin (BSA) in two different systems: a bulk system (vial) and a microfluidic chip in wh...

By providing a suitable platform that accelerates early-stage occurrences needed for triggering protein aggregation, liquid-liquid phase separation (LLPS) has the potential to promote this phenomenon. Among different proteins which their condensation propensity has been investigated, bovine serum albumin (BSA) has attracted attentions because of it...

Tau cleavage has been shown to have a significant effect on protein aggregation. Tau truncation results in the formation of aggregation-prone fragments leading to toxic aggregates and also causes the formation of harmful fragments that do not aggregate. Thus, targeting proteolysis of tau would be beneficial for the development of therapeutics for A...

This paper focuses on the synthesis of nano-oxali-palladium coated with turmeric extract (PdNPs) using a green chemistry technique based on the reduction in the Pd (II) complex by phytochemicals inherent in turmeric extract. PdNPs were examined and characterized using Field Emission Scanning Electron Microscopy (FESEM), Dynamic Light Scattering (DL...

Today, with the increase in health concerns among the people of the world, the Halal food business has a high capacity. The concept of Halal indicates the health, cleanliness, and quality of consumed food, which improves the health of consumers. Therefore, knowing the science and knowledge of Halal products and the chemistry of Halal compounds are...

Colorectal cancer (CRC) continues to pose a significant challenge to healthcare systems, despite considerable advancements in the fields of medicine and pharmaceuticals. Palladium complexes, considered potential alternatives to platinum-based drugs for treating CRC, are being explored. Additionally, green chemistry, which enables the safe, reproduc...

Triboelectric nanogenerators (TENG) have gained significant attention for their unique advantages such as self-powering, lightweight, and flexibility, leading to their applications in various fields like industry, blue energy, power sources, and biomedical applications. However, the potential application of TENG devices in cancer treatment has rece...

Angiotensin-converting enzyme 2 (ACE2) has a specific interaction with the coronavirus spike protein, enabling its entry into human cells. This membrane enzyme converts angiotensin II into angiotensin 1–7, which has an essential role in protecting the heart and improving lung function. Many therapeutic properties have been attributed to the human r...

The exploration of the chiral configurations of enantiomers represents a highly intriguing realm of scientific inquiry due to the distinct roles played by each enantiomer (D and L) in chemical reactions and their practical utilities. This study introduces a pioneering analytical methodology, termed fast Fourier transform capacitance voltammetry (FF...

Cytochrome c (Cyt c) is a key molecule involved in mitochondria-mediated apoptosis. Cyt c is released into the cytoplasm to bind to apoptotic enzyme activating factor 1 (Apaf-1) and then forms an apoptotic complex and activated Caspase-9 to further activate Caspase-3/6/7, thereby inducing apoptosis. Among them, the caspase-activated deoxyribonuclea...

In this work, we have performed an alternative analytical process including the transformation of few biological molecules’ frequencies data obtained by 13CNMR spectroscopy into sounds characterized with their frequencies, intensities, and time durations. As a main point, we have relied on the “magnetic behavior of proton” as a positively charged s...

The substitution of leucine to proline at position 39 (P39L) in human αB-crystallin (αB-Cry) has been associated with conflicting interpretations of pathogenicity in cataracts and cardiomyopathy. This study aimed to investigate the effects of the P39L mutation on the structural and functional features of human αB-Cry. The mutant protein was express...

The development of a glucose sensor that can monitor blood glucose levels is particularly important with the increasing number of diabetes patients. Here, a glucose biosensor based on Nafion (NF), glucose oxidase (GOx), multi-walled carbon nanotubes (MWCNTs), hydroxy fullerene (HFs) composite modified glassy carbon electrode (GCE) is presented. The...

Angiotensin-converting enzyme 2 (ACE2) has a specific interaction with the coronavirus spike protein, enabling its entry into human cells. This membrane enzyme converts angiotensin II into angiotensin 1–7, which has an essential role in protecting the heart and improving lung function. Many therapeutic properties have been attributed to the human r...

Type 2 diabetes mellitus (T2DM) is a challenging and progressive metabolic disease caused by insulin resistance. Skeletal muscle is the major insulin-sensitive tissue that plays a pivotal role in blood sugar homeostasis. Dysfunction of muscle metabolism is implicated in the disturbance of glucose homeostasis, the development of insulin resistance,...

Crystallins are the major soluble lens proteins, and α-crystallin, the most important protective protein of the eye lens, has two subunits (αA and αB) with chaperone activity. αB-crystallin (αB-Cry) with a relatively wide tissue distribution has an innate ability to interact effectively with the misfolded proteins, preventing their aggregation. Mel...

Titanium dioxide nanotubes (TNT) are widely researched materials for the photocatalytic genera-tion of free radicals, which are useful in wastewater treatment. We aimed to prepare Mo-doped TNT sheets, covered with a cellulose membrane to avoid TNT surface inactivation by protein ad-sorption. We studied the susceptibility of serum albumin (SA) bound...

Glucose sensors based blood glucose detection are of great significance for the diagnosis and treatment of diabetes because diabetes has aroused wide concern in the world. In this study, bovine serum albumin (BSA) was used to cross-link glucose oxidase (GOD) on a glassy carbon electrode (GCE) modified by a composite of hydroxy fullerene (HFs) and m...

Oxidative stresses (OSs) are considered a pivotal factor in creating various pathophysiological conditions. Cells have been able to move forward by modulating numerous signaling pathways to moderate the defects of these stresses during their evolution. The company of Kelch-like ECH-associated protein 1 (Keap1) as a molecular sensing element of the...

Rutin is a natural antioxidant flavonoid compound with anti-inflammatory, antioxidant, and antiviral effects that is used to prepare drugs with wide application in clinical treatment. Therefore, the quantitative detection of rutin has important practical significance. In this work, a novel electrochemical sensor based on glassy carbon electrodes (G...

A520 as a member of metal organic frameworks (MOFs) family is a new porose material with diverse applications such as biosensing and drug delivery. Doxorubicin (DOX) as a dangerous chemotherapy drug can generate harms for patients bodies. Our results shown DOX disturbing hemoglobin functional species to methemoglobin as a radical source 3. In this...

In this study, the chitin of adult Mediterranean flour moth (Ephestia kuheniella) (Cht) was extracted and then converted to chitosan by deacetylation process to achieve the chitosan derived from E. kuheniella (Chsfm). The new chitosan-based scaffold was produced using the polyvinyl alcohol (PVA) co-electrospinning technique. The degree of deacetyla...

Protein oligomerization has two notable aspects: it is crucial for the performing cellular and molecular processes accurately, and it produces amyloid fibril precursors. Although a clear explanation for amyloidosis as a whole is lacking, most studies have emphasized the importance of protein misfolding followed by formation of cytotoxic oligomer st...

As an active ingredient in its derivative products, glyphosate has emerged as the most widespread herbicide in recent decades. Bovine serum albumin (BSA) as a carrier protein may be adversely affected by structural changes due to binding affinity with glyphosate, which may lead to dysfunctionality or metabolic disorders. This study aimed to investi...

Artificial enzymes were developed as alternatives to natural enzymes. Considering the unique characteristics of periodic mesoporous organosilica (PMO) materials, a rational design approach was investigated to simulate the coordination sphere around the iron active center in natural horseradish peroxidase (HRP) and fabricate a new peroxidase-like na...

Reactive oxygen species (ROS) are identified to control the expression and activity of various essential signaling intermediates involved in cellular proliferation, apoptosis, and differentiation. Indeed, ROS represents a double-edged sword in supporting cell survival and death. Many common pathological processes, including various cancer types and...

Yousefpour P, Atyabi F, Vasheghani-Farahani E, Movahedi M, Dinarvand R. Int J Nanomedicine. 2011;6:1977—1990. The authors have advised Figure 9D on page 1986 is incorrect. Due to an error at the time of figure assembly Figure 9B and D were duplicated. The correct Figure 9 is shown below. Figure 9 Fluorescence microscopy of cellular uptake of (A)...

Insulin and its homologous are the most utilized protein drugs due to their role in diabetic patients' treatment. Insulin forms amyloid-like fibrils in vivo at the injection site. Therefore, the study of its fibrillation mechanism and designing efficient inhibitors have high importance in the pharmaceutical industry. Insulin fibrils are formed at b...

Rutin is a flavonoid glycoside compound, which is mainly transported via the blood circulation system in the human body. The monitoring of the blood concentration of rutin is of great significance in many fields such as pharmacology and pharmacokinetics. In this work, a biosensor based on multi-walled carbon nanotubes (MWCNTs), cetyltrimethylammoni...

Acetylshikonin (ASK), as a privileged naphthoquinone derivative with unique spectroscopic properties, is considered an effective substance in biomedical areas. This manuscript was purposefully undertaken for systematic characterization of ASK-bovine serum albumin (BSA) binding to best understand the pharmaceutics properties of ligand, and deep illu...

Sturgeons are living fossils and among the oldest surviving vertebrate species, and Caspian Sea is habitat of the vast majority of sturgeon species. It is tempting to assume that speciation of sturgeons occurred in response to the severe environmental changes during the formation of Caspian Sea from the ancient Paratethys Sea. Hemoglobin (Hb) refle...

Nowadays, a small number of incretin mimics are used to treat type 2 diabetes mellitus (T2DM) due to their longer half-life. The present study aimed to introduce a novel method for producing the liraglutide precursor peptide (LPP) and developing a potentially new incretin mimic. Here, human αB-crystallin (αB-Cry) was ligated to the LPP at the gene...

As alternatives to natural enzymes, nanostructured materials with enzyme catalytic properties named “nanozymes” have attracted a great deal of attention with widespread usage in industrial, medical, and biological fields. Focusing on the design of enzyme models based on supramolecular scaffolds provides new perspectives towards artificial enzyme re...

Laccases have been broadly applied as a multitasking biocatalyst in various industries, but their applications tend to be limited by easy deactivation, lack of adequate stability, and susceptibility under complex conditions. Identifying stable laccase as a green-biocatalyst is crucial for developing cost-effective biorefining processes. In this dir...

A functionalized nanocomposite composed of multi-wall carbon nanotubes (MWCNTs), Fe3O4 nanoparticles (Fe3O4), and β-cyclodextrin (CD) was prepared. The MWCNTs-CD-Fe3O4 modified glassy carbon electrode (GCE) displayed good electrochemical response toward rutin (Ru). The detection linear range and the detection limit of the electrochemical sensor for...

Serum albumin (SA) exists in relatively high concentrations, in close contact with most cells. However, in the adult brain, except for cerebrospinal fluid (CSF), SA concentration is relatively low. It is mainly produced in the liver to serve as the main protein of the blood plasma. In the plasma, it functions as a carrier, chaperon, antioxidant, so...

Metal Organic Frameworks (MOF) are novel careers in Drug Delivery Systems (DDS) that they are prevised to have a good ability for selective transfer to cancerous mass. MOFs are nano porous materials that have important role in DDS. These materials have high porosity level to keep of drugs in the optimum possible way because of van der Waals interac...

The study was aimed to evaluate the impact of peroxynitrite (PON, oxidative stress agent in diabetes), methylglyoxal (MGO, diabetes-associated reactive carbonyl compound), and their simultaneous application on the structural and functional features of human αA-crystallin (αA-Cry) using various spectroscopy techniques. Additionally, the surface tens...

Alzheimer’s disease is characterized by the presence of extraneuronal amyloid plaques composed of amyloid-beta (Aβ) fibrillar aggregates in the brains of patients. In mouse models, it has previously been shown that atorvastatin, a cholesterol-lowering drug, has some reducing effect on the production of cerebral Aβ. A meta-analysis on humans showed...

The aim of this study was to investigate the antioxidant activity and phenolic compounds of propolis and to evaluate the possibility of encapsulation of propolis extract in the nanoparticles of whey protein (WPN) to increase protein's functionality and physicochemical characteristics. Nanoparticles were produced through freeze-drying. According to...

در برخی از کشورهای جهان پیشینه ایجاد شبکه آزمایشگاه های ملی ماموریت گرا و پیشرو در قلمرو های کلیدی که محل تلاقی علم و فناوری و جایگاه استقرارامکانات بزرگ پژوهشی و فعالیت دانشمندان و مهندسان برجسته می باشد به بیش از نیم قرن می رسد. چنین آزمایشگاه هایی هم افزایی قابل توجهی با دانشگاه ها در گسترش مرزهای علوم فاخر و فناوری های نافذ دارند. امکانات بزرگ...

In today's world, many problems, such as the deadly pandemics that science seeks to solve, are borderless in nature, and overcoming such challenges goes through the international scientific cooperation between scientists and policymakers working across geopolitical boundaries. Over the past few decades, in parallel with traditional diplomacy, a new...

Science diplomacy as important opportunity for development of international scientific cooperation and strategic relations Abstract In today's world, many problems, such as the deadly pandemics that science seeks to solve, are borderless in nature, and overcoming such challenges goes through the international scientific cooperation between scienti...

Oxidative stress is the leading player in the onset and development of various diseases. The Keap1-Nrf2 pathway is a pivotal antioxidant system that preserves the cells’ redox balance. It decreases inflammation in which the nuclear trans-localization of Nrf2 as a transcription factor promotes various antioxidant responses in cells. Through some oth...

Quinoa (Chenopodium quinoa Willd) is a potential source of protein with ideal amino acid profiles which its bioactive compounds can be improved during germination and gastrointestinal digestion. The present investigation studies the impact of germination for 24 hr and simulated gastrointestinal digestion on α-glucosidase inhibitory activity of the...

The health effects of ambient air particulate matter with a diameter of ≤2.5 μm (PM2.5) on the central nervous system are well known and the induced oxidative stress has been shown as their main neuropathologic outcome. Ambient air PM2.5 sampling methods mostly use air sampler systems that collect PM2.5 on filters, which is followed by a PM2.5 extr...

Glycine to serine substitution at position 154 of human αB-crystallin (αB-Cry) is behind the development of cardiomyopathy and late-onset distal myopathy. The current study was conducted with the aim to investigate the structural and functional features of the G154S mutant αB-Cry using various spectroscopic techniques and microscopic analyses. The...

αB-crystallin (heat shock protein β5/HSPB5) is a member of the family of small heat shock proteins that is expressed in various organs of the human body including eye lenses and muscles. Therefore, mutations in the gene of this protein (CRYAB) might have many pathological consequences. A new mutation has recently been discovered in the α-crystallin...

Hemoproteins play important roles in physiological activities in animals and plants. The research on the structures and properties of hemoproteins can better understand the relationship between structure and function of hemoproteins and expand the application fields and scopes of hemoproteins. In this report, the peroxidase activity, stability and...