Ali Ibeabuchi Jude

• Enugu State University of Science and Technology

The significance of medicinal plants such as Terminalia pennyana (Combretaceae) in the management of parasitic infections has continued to sustain the healthcare system of many developing countries. Aside from antimicrobial and antioxidant activities, ethnopharmacological data have shown the use of the stem bark as mosquito repellent. The study eva...

The significance of medicinal plants such as Terminalia pennyana (Combretaceae) in the management of parasitic infections have continued to sustain the healthcare system of many developing countries. Aside antimicrobial and antioxidant activities, ethnopharmacological data have shown the use of the stem bark as mosquito repellent. The study evaluat...

Epilepsy is a neurological condition that affects the central nervous system and is characterized by strange emotions and actions. Antioxidants are believed to play a very vital role in the body defense system against reactive oxygen species (ROS). ROS, is a basal cause of aging as well as various degenerative and chronic diseases in human. In Nige...

Authors' contributions This work was carried out in collaboration among all authors. Author CCA conceptualized and designed the work, wrote the introduction and the reference list and sourced the reagents and chemicals used for the study. Authors IJA and RCO carried out plant extractions and conducted the various anti-inflammatory test studies and...

Background: Due to high frequency of use, many kinds of microbes may contaminate the ATM device resulting in the emergence and spread of infectious agents especially multi-antibiotic resistant (MAR) bacteria. Aim: This study was conducted to isolate and phenotypically characterize bacteria isolates from ATM devices in Enugu State, Nigeria. Study De...

Medicinal herb-infused oil is utilized in folkloric medicine due to its efficacy in ameliorating various diseases of humans; even with this evidence, most herbs are still underutilized and poorly investigated. This prompted the investigation of ginger-infused virgin coconut oil's chemical composition and antimicrobial and antiulcer activities (GIVC...

Microorganisms in any ecological niche exhibit some characteristics that contribute to their survival in the ecosystem. A good example of such survival strategies is the production of antibiotic hydrolyzing enzymes such as ESBL and MBL enzymes in Gram negative bacteria. The study was conducted to isolate, and characterize by phenotypic methods, bac...

Background: Numerous diseases related to diarrhea are the primary cause of morbidity and mortality in underdeveloped countries, accounting for hundreds of thousands of deaths annually. Polyalthia longifolia, the false ashoka, commonly referred to as Monoon longifolium is a tree species from Asia. It is commonly found in southern india, Sri Lanka an...

Morinda lucida Benth is a common Nigerian medicinal plant generally used to cure malaria parasite infection, though there is a lack of scientific reports on its capacity to treat diarrhea. The current study evaluated the effect of extract and fractions of stem bark of Morinda lucida Benth (Rubicaceae) on castor-oil-induced diarrhea in mice. The gro...

ARTICLE INFO This research work is aimed at evaluating the phytochemicals, antibacterial potentials of the Chrysophyllum albidum stem bark extracts. The ethyl acetate and methanol extracts were obtained using soxhlet extraction method. The extracts obtained were screened for the presence of phytochemicals by standard methods. Agar diffusion and aga...

Anaemia is a leading cause of morbidity and mortality in both males and females of all ages. Anaemia was induced by intraperitoneal (i.p.) administration of phenylhydrazine (60 mg/kg) for a period of 3 days. Anaemic rats were allotted to five (5) groups; group I served as the negative control, group II served as the positive control received Astyfe...

Background of the Study: The response of the body to harmful stimuli, such as tissue damage or a pathogenic infection is known as inflammation. Rauwofia vomitera is a medicinal plant that is native to large areas of tropical Africa and it belongs to the family of Apocynaceae. It is a medicinal herb used in traditional Nigerian medicine to treat a v...

Infections due to antimicrobial-resistant microorganisms have become widespread in recent years. Thus, searching for novel antimicrobial agents to combat such pathogens has become crucial. The current study aimed to evaluate the antimicrobial, antiplasmodial, and immunomodulatory activities of the extracts of endophytic fungi isolated from Psidium...

Infections due to antimicrobial-resistant microorganisms have become widespread in recent years. Thus, searching for novel antimicrobial agents to combat such pathogens has become crucial. The current study aimed to evaluate the antimicrobial, antiplasmodial, and immunomodulatory activities of the extracts of endophytic fungi isolated from Psidium...

Many diseases are treated using medicinal plants because they contain components that have therapeutic properties. The prevention and treatment of diseases linked to oxidative stress depend heavily on antioxidants. With over 20 genera and 600 species, the Combretaceae family is a vast group of plants that is distributed tropically throughout the wo...

Hemorrhoids (Piles) are an inflammation of blood vessels around the anal canal. When the anal cushions are displaced during defecation, piles are formed. The purpose of this study is to document traditional knowledge and medicinal plants used in pile therapy in Nigeria. This study is to establish the usage of beneficial medicinal herbs to cure hemo...

Chrysophyllum albidum is a tropical plant commonly found in different parts of Sub-Saharan Africa used in folklore for the treatment of yellow fever, toothache, malaria, diarrhea, vaginal and dermatological infections. This study investigated the phytochemical constituents and antibacterial and antipyretic activities of the methanol, ethyl acetate,...

Chrysophyllum albidum is a tropical plant commonly found in different parts of Sub-Saharan Africa used in folklore for the treatment of yellow fever, toothache, malaria, diarrhea, vaginal and dermatological infections. This study investigated the phytochemical constituents and antibacterial and antipyretic activities of the methanol, ethyl acetate,...

The synthetic process, type of precursor material, and the phytochemical materials involved in the biological synthesis of metal nanoparticles influence the properties of the resulting nanoparticles. The physicochemical attributes of synthesized nanoparticles, in turn, influence their applicability for various purposes, hence the need to standardiz...

Peptic ulcer has been a ravaging gastrointestinal disorder in clinical practice. The symptomatic effect is the perforation of the stomach lining. The study was aimed at evaluating the anti-ulcer activity and phytochemical constituents of the leaves of Ocimum gratissimum The powdered leaves were macerated in 95%v/v of methanol for 72 h, and the drie...

Inflammatory diseases such as arthritis, rheumatoid or non-rheumatoid joint inflammations are dominant among people all around the world. Plant-derived anti-inflammatory drugs are widely used against these disease conditions. This study investigated the in-vitro anti-inflammatory activity of the aqueous methanol and butanol extracts of Persea ameri...

Lagenaria breviflora (LB) seeds were modified with acid (AMLB) and base (BMLB) for the sorption of Ni2+ from an aqueous solution. It was characterized by Fourier transformation infrared spectroscopy (FTIR), scanning electron microscope (SEM), X-ray diffraction (XRD), thermogravimetric analyzer (TGA), and Brunauer–Emmett–Teller (BET). Kinetic, isoth...

The unmodified and modified Irvingia gabonensis (IG) were characterized with Fourier transform infrared (FTIR), X-ray diffraction (XRD), Brunauer–Emmett–Teller (BET), thermogravimetric analyzer (TGA), and scanning electron microscope (SEM). The experimental conditions revealed that the optimum adsorption efficiency was achieved at pH 6 within 30 mi...

Background: The body uses inflammation as a defence mechanism to eliminate harmful stimuli like germs, damaged cells, or irritants and to initiate the healing process. However, the ongoing discovery of several medicinal plants and the testing of their bioactivity to produce information that will assist doctors and patients in making informed decisi...

Background: Essential oil (EO) of Cymbopogon citratus has been demonstrated to have antibacterial activities against both Gram negative and Gram positive bacteria. The study was, therefore, conducted to evaluate the effects of combined use of C. citratus and ciprofloxacin against fluoroquinolone-resistant Staphylococcus aureus (FQRSA) and Escherich...

Background: Chrysophyllum albidum is widely used by African people for the treatment of various types of diseases such as ear infection, sore throat, typhoid, cellulites, septicaemia, bactericemia, abscesses and tooth infections. Aim: The study was conducted to investigate the chemical components and antibacterial activity of the extract and fracti...

Peptic ulcer disease has remained a global threat due to several complications such as perforation, gastrointestinal obstruction and organ penetration associated with the disease. This study evaluated the phytochemical composition and anti-ulcer activity of crude extract and fractions of Acanthus montanus on an indomethacin-induced ulcer in a mouse...

Background: Different parts of Anacardium occidentale (Cashew) are used in folk medicine to treat dysentery, diarrhea piles, toothache and sore gums. Evaluation of phytoconstituents or novel compounds from the plant is highly needed to authenticate these claims. Aim: The aim of the research was to conduct phytochemical analysis and antibacterial ev...

Investigation of microorganisms for natural product is the new paradigm in drug discovery research. Microorganisms are obtained from different sources for this purpose, and plants are one of these sources. Endophytes usually present in the plant's cell walls have been confirmed to synthesize secondary metabolites similar or sometimes different from...

The objective of the current work was to design and characterize aceclofenac-loaded breadfruit seed oil-based self-emulsifying drug delivery systems (SEDDS) with intent to improve the gastrointestinal fluid solubility of the drug. The breadfruit oil was extracted by the soxhlet solvent extraction technique. The oil was then characterized for acid,...

Diabetes mellitus is a long term, diverse metabolic illness with a complex pathophysiology. Hyperglycemia, which stems from anomalies in either insulin secretion or insulin action or both, is its defining feature. Metabolic dysfunctions involving proteins, carbohydrates, and fats originate from hyperglycemia, which can express itself in a variety o...

Aim: The study's objective was to examine the anti-inflammatory activity and leucocyte mobilization of a methanol extract of leaves from Acalypha ciliata in adult Wistar rats. Study Design: Egg albumin-induced edema was used for anti-inflammatory test and leucocyte mobilization test was carried out to check for total leucocyte cout and differential...

Highlights ➢ Extraction of oil from breadfruit seeds by a cold maceration and by soxhlet methods resulted in oil yields of 13.69 % and 23.54 % respectively. ➢ Fatty acid determination showed that the oil contained predominantly poly unsaturated long chain fatty acids. ➢ Values obtained for most of the determined physicochemical parameters were sugg...

Evaluation of the anti-inflammatory effect of methanol, ethylacetate and N-hexane fraction extract of combretum Obanense stem bark plant using experimentally induced inflammatory models in rats. Inflammation (oedema) of the hind paw was induced by injecting 0.1 mL of fresh egg-albumin into the subplantar surface of the left hind paw.After 30 minute...

Aim: The phytochemicals, antioxidant and antimicrobial investigations of Combretum bauchiense leaves used in folkloric medicine to treat majorly infectious diseases were explored in the present study. Methodology: The methanol extract (MECB), n-hexane fraction (HFCB), ethyl acetate fraction (EFCB) and n-butanol fraction of C. bauchiense (BFCB) were...

Background and Purpose: Medicinal plants are used for the treatment of diseases because of the presence of therapeutic phytochemical constituents. Antioxidants play important roles in preventing and mitigating diseases. The plant Cola rostrata K. Schum (Sterculiaceae) is used in traditional medicine for pain relief, diabetes, erectile dysfunction,...

Epilepsy is a central nervous system (neurological) disorder characterized by a bizarre feelings, sensations, and behaviors. Muscle spasms, convulsions, and loss of consciousness occasionally from epileptic seizures. Neuronal dependent on neurotransmitters in the central nervous system. In this review, we discussed epilepsy and its therapies, placi...

Background: Epilepsy is a neurological illness that affects people of all ages and is characterized by excessive electric activity in the brain. This causes social embarrassment coupled with side effect of orthodox medication; hence, the needs to search for plant with antiepileptic agent. Aims: This study aimed at investigating the anticonvulsive e...

Background: Diabetes mellitus is a metabolic disorder characterized by chronic hyperglycaemia with disturbances of carbohydrate, fat and protein metabolism resulting from impairments in insulin secretion, insulin action or both. The side effect of orthodox is alarming and expensive. This prompted a search for a cheaper and reliable alternative drug...

Background: The leaves of Tapinathus bangwensis have been used in the treatment of infectious and non-infectious diseases by the herbalist. This instigated evaluation of extract and fractions of Tapinathus bangwensis leaves for antimicrobial activity against some pathogenic organisms and identifications of the phytoconstituents. Methods: The standa...

Spenostylis stenocarpa popularly known as African yam bean is a neglected legume despite its nutritional potentials. The seeds are consumed in the southeastern parts of Nigeria either cooked as porridge or roasted as snacks. In traditional medicine, the powdered seeds are reported to be used in the management of high blood pressure diabetes, high c...

Objective: Combretum bauchiense as claimed in folkloric medicine is used for treatment of infectious diseases, feverish condition and as a tonic. There is no documented scientific report on its biological activity as at the time of this research. This research work evaluates the phytochemical constituents and antibacterial activity of extract and f...

Background: Newbouldia leavis have been used in folkloric medicine

Many therapeutically important drugs experience quick passage through the stomach either due to the nature of the drug or the presence of some pathological conditions. Rapid transit through the stomach limits the effectiveness of drugs in treating local stomach lesions/diseases and prevents optimum concentration of such drugs in the gastric fluid....

The rapid spread of microbial infections and effort by scientists to identify novel antimicrobial agents from natural products has necessitated further search for antimicrobial agents from medicinal plants of Annonaceae family. This study was, therefore, designed to evaluate the phytochemical constituents and antimicrobial activities of Pachypodant...

Triclisia marcrophylla is a climbing plant used in Nsukka in the treatment of gastrointestinal disorder. This research was designed to study the phytochemical constituents and antibacterial activity of T. macrophylla ethanol leaf extract. Cold maceration method was used to get the ethanol extract. Standard qualitative and quantitative phytochemical...

The phytochemical screening and antimicrobial activities of the methanol extract of Garcinia kola fruit mesocarp were investigated against four bacteria and two fungi in the study. The extract was investigated for the presence of phytochemicals using standard phytochemical screening methods. The results revealed the presence of flavonoids, tannins,...

This study was designed to ascertain the safety profile as well as explore new antimicrobial agents from the methanol leaf extract of Stachytarpheta indica. The methanol extract was prepared and screened for its phytochemical composition, oral acute toxicity profile as well as challenged with common pathogenic microorganisms for its antimicrobial a...

Herbal medicine despite its increase usage globally is being plagued by inadequate research on their effectiveness. Stachytarpheta indica commonly known as snakeweed is used locally in the management of asthma, headache, alopecia, bronchitis, bruise, chest cold, constipation, itch, diarrhea, skin sore, vermifuge, dysentery, dysmenorrhea among other...