Ali Gholamrezaei

Ali Gholamrezaei
The University of Sydney · Pain Management Research Institute (PMRI)

MD PhD
Digital Health in Pain Management

About

122
Publications
308,951
Reads
How we measure 'reads'
A 'read' is counted each time someone views a publication summary (such as the title, abstract, and list of authors), clicks on a figure, or views or downloads the full-text. Learn more
950
Citations
Introduction
My main research interests and goals are 1) development of self-management mental health interventions and delivering them via digital/mobile health technologies, 2) biomedical signal processing via wearable health technologies, and 3) combining these two in a comprehensive psychophysiological digital/mobile health package. I have worked on step 1 and 2 for over 15 years, and I'm focusing now on step 3.
Additional affiliations
September 2020 - present
The University of Sydney
Position
  • Research Associate
March 2020 - September 2020
Liverpool Hospital
Position
  • Project Manager
May 2015 - May 2019
KU Leuven
Position
  • PhD Student
Education
May 2015 - May 2019
KU Leuven
Field of study
  • Biomedical Science
September 2002 - November 2010
September 2001 - August 2002
National Organization for Development of Exceptional Talents
Field of study
  • Experimental Sciences

Publications

Publications (122)
Article
BACKGROUND: Antidepressants are effective in adults with pain-related functional gastrointestinal disorders. We investigated the effectiveness of citalopram in the treatment of childhood functional abdominal pain (FAP). METHODS: Children with FAP, based on the Rome III criteria (n = 115, aged 6-18 years), were randomized to receive either citalopra...
Article
Full-text available
We evaluated the effectiveness of an antispasmodic, mebeverine, in the treatment of childhood functional abdominal pain (FAP). Children with FAP (, aged 6–18 years) received mebeverine (135 mg, twice daily) or placebo for 4 weeks. Response was defined as ≥2 point reduction in the 6-point pain scale or “no pain.” Physician-rated global severity was...
Article
Background and study aim: Diagnostic esophagogastroduodenoscopy (EGD) is uncomfortable for most patients. We determined the efficacy of alprazolam, administered orally or sublingually, as premedication for sedation during EGD. Patients and methods: Adult EGD candidates were randomly allocated to four groups (n=55, each group) and received alprazola...
Article
Evidence has shown benefits of single-strain probiotics for Helicobacter pylori eradication. We investigated the effects of adding a multistrain probiotic compound on bismuth-containing quadruple therapy for H. pylori infection. Adult patients with peptic ulcer disease and confirmed H. pylori infection (n = 180) were randomized to receive bismuth-c...
Article
Irritable bowel syndrome (IBS) is a gastrointestinal disorder characterized by chronic abdominal pain and altered bowel habits in the absence of any organic cause. Despite its prevalence, there remains a significant lack of efficient medical treatment for IBS to date. However, according to some previous research studies, hypnosis has been shown to...
Article
Full-text available
Introduction: Opioid medications are no longer recommended as long-term therapy for chronic non-cancer pain, and many patients are advised to reduce or discontinue opioid medications. Many patients report difficulties in tapering opioid medications, necessitating supporting interventions. This protocol describes a pilot randomised controlled trial...
Article
Objective To review interventions to reduce long term opioid treatment in people with chronic non-cancer pain, considering efficacy on dose reduction and discontinuation, pain, function, quality of life, withdrawal symptoms, substance use, and adverse events. Design Systematic review and meta-analysis of randomised controlled trials and non-random...
Article
Full-text available
Past research links depression and blunted cardiac vagal reactivity to chronic stress. Yet, to our knowledge no experiment investigates heart rate (variability) responses to a repeated laboratory stressor in patients with depression. Repeated exposure may provide valuable information on stress reactivity in depression. Fifty-nine women (30 inpatien...
Article
Background: Postoperative atrial fibrillation (AF) is a common complication after cardiac surgery. We investigated whether perioperative cardiac troponin T (cTnT) is associated with the risk of AF after coronary artery bypass grafting (CABG). Methods: Two thousand four hundred twenty-one patients with isolated CABG were studied. High sensitivity...
Article
Neuroimaging studies have revealed important pathomechanisms related to disorders of brain-gut interactions, such as irritable bowel syndrome and functional dyspepsia. More detailed investigations aimed at neural processing in the brainstem, including the key relay station of the nucleus of the solitary tract (NTS), have hitherto been hampered by t...
Article
Full-text available
Parasympathetic nervous system innervates peripheral organs including pancreas, hepatic portal system, and gastrointestinal tract. It thereby contributes to the regulation of whole-body glucose metabolism especially in the postprandial state when it promotes secretion of insulin and enhances its action in major target organs. We now aimed to evalua...
Article
Background: Studies using somatic pain models have shown the hypoalgesic effects of slow, deep breathing. We evaluated the effect of slow, deep breathing on visceral pain and explored putative mediating mechanisms including autonomic and emotional responses. Methods: Fifty-seven healthy volunteers (36 females, mean age = 22.0 years) performed co...
Article
Full-text available
Introduction Perianal fistulising Crohn’s disease (pfCD) can be somewhat treatment refractory. Higher infliximab trough levels (TLIs) may improve fistula healing rates; however, it remains unclear whether escalating infliximab therapy to meet higher TLI targets using proactive, or routine, therapeutic drug monitoring (TDM) improves outcomes. This r...
Article
Slow, deep breathing (SDB) is a common pain self‐management technique. Stimulation of the arterial baroreceptors and vagal modulation are suggested, among others, as potential mechanisms underlying the hypoalgesic effects of SDB. We tested whether adding an inspiratory load to SDB, which results in a stronger baroreceptor stimulation and vagal modu...
Article
Full-text available
Background: Colonoscopy plays a vital role for the diagnosis and treatment of colonic diseases but can be associated with anxiety and discomfort or pain. We tested whether unsedated colonoscopy impacts quality indicators and investigated predictors of pain during colonoscopy. Materials and methods: This randomized controlled trial was performed...
Article
Full-text available
Objective: Primary dysmenorrhea is believed to be common and associated with reduced quality of life among menstruating women. Recent studies have shown a possible association between vitamin D deficiency and the severity of primary dysmenorrhea. The present study aimed to investigate the effect of vitamin D supplementation on pain and systemic sy...
Article
We read with great interest Giusti et al.'s systematic review and meta-analysis of psychological and psychosocial predictors of chronic postsurgical pain (CPSP). 1 The prevalence and societal burden of CPSP is escalating. We agree with the authors that identification is the key to managing risk, and this involves understanding not only the biologic...
Article
Full-text available
Objective: Patients’ beliefs and emotions toward an illness can influence their coping responses, illness behaviors, adherence to treatment, quality of life, and even the psychoneuroimmune responses. The aim of present study was to develop and validate a novel questionnaire assessing both rational and irrational beliefs of patients regarding their...
Article
Deep breathing exercises are commonly used for several health conditions including pain and hypertension. Various techniques are available to practice deep breathing, whereas possible differential psychophysiological effects have not been investigated. We compared four deep breathing techniques and examined outcomes in blood pressure variability, r...
Thesis
Pain is the most common symptom for which people seek medical care. Chronic pain is common worldwide, and often not treated adequately, thereby leading to reduced quality of life and high healthcare costs. Recently, there has been increasing attention toward the complexity and biopsychosocial nature of pain, and the need for multidisciplinary pain...
Article
Slow deep breathing (SDB) is commonly employed in the management of pain, but the underlying mechanisms remain equivocal. This study sought to investigate effects of instructed breathing patterns on experimental heat pain and to explore possible mechanisms of action. In a within-subject experimental design, healthy volunteers (n = 48) performed fou...
Article
The aim of the study reported in this paper is to investigate the effect of slow-deep breathing (SDB) on self-reported pain, heart rate variability (HRV) and baroreflex sensitivity (BRS). These effects are examined in three separate experiments, each using a different phasic pain modality. For each experiment, different subjects were recruited. Eig...
Article
Objective: We assessed mean heart rate (HR) and heart rate variability (HRV) across wake, rapid eye movement (REM) and non-rapid eye movement (NREM) sleep, and across varying levels of NREM sleep depth in individuals with depression and sleep complaints. Methods: Retrospective polysomnographic data were obtained for 25 individuals diagnosed with...
Article
Slow, deep breathing is being used as a self-management intervention for various health conditions including pain and hypertension. Stimulation of the arterial baroreceptors and increased vagal modulation are among the proposed mechanisms for the therapeutic effects of slow, deep breathing. We investigated whether adding inspiratory threshold load...
Article
Purpose: We investigated the effect of vitamin D therapy on sexual function in women with low vitamin D levels and sexual dysfunction. Materials and methods: We performed this randomized, double-blind, placebo controlled trial in women 18 to 45 years old with sexual dysfunction, defined as a FSFI (Female Sexual Functioning Index) score less than...
Article
Full-text available
Background: Premedication with orally administered benzodiazepines is effective in reducing anxiety and discomfort related to endoscopic procedures. We evaluated the efficacy and safety of oral midazolam in comparison to sublingual alprazolam as premedication for esophagogastroduodenoscopy (EGD). Materials and Methods: Adult candidates for diagnos...
Poster
Background: Baroreceptors are assumed to be involved in interoception, but neurophysiological evidence to support this is limited. Here, we present data on the association between baroreceptor sensitivity (BRS) and interoceptive accuracy. Methods: 27 healthy volunteers (9 male) with age of 22.6 ± 5.1 years were studied. Interoceptive accuracy was m...
Article
Full-text available
Background: Sleep disorders are common in patients with kidney disease and on dialysis. The aim of this study was to assess the association between vitamin D deficiency and sleep quality in these patients. Methods: This cross-sectional study was done on patients under peritoneal dialysis. Demographic data, dialysis information, and sleep quality we...
Article
Full-text available
BACKGROUND: We investigated clinical and procedural factors associated with the no-reflow phenomenon following percutaneous coronary intervention (PCI) of the saphenous-vein grafts (SVG). METHODS: A cross-sectional study was done on patients who had undergone PCI of the SVG. Patients’ medical documents were reviewed for demographic, clinical, labor...
Article
Full-text available
Background: Sleep disturbances are common, but widely underdiagnosed in cancer patients. Thus, the aim of the present study was to evaluate sleep quality and its associated factors among women with breast cancer. Methods: This cross-sectional study was conducted on women with breast cancer referring to 2 outpatient clinics in Isfahan, Iran. Sleep...
Article
Full-text available
Dizziness could be categorized as one of the most common medical complaints of patients referred to the neurology clinics. The aim of this study was to evaluate the types of dizziness and its relationship with psychological disorders in patients with chronic complaints. We studied 179 patients ranging in age from 18 to 65 years old. Patients were a...
Article
Full-text available
Background: Inflammatory bowel diseases (IBD) are chronic diseases with significant impact on patients’ well-being. The aim of this study was the determination of stress coping strategies in IBD patients and their correlation with disease activity, psychological health, and quality of life (QOL). Methods: This cross-sectional study was conducted on...
Article
Evidence exists on the association between vitamin D deficiency and inflammatory bowel diseases (IBD). To investigate whether vitamin D level is associated with disease activity and quality of life in IBD patients. This cross-sectional study was conducted on known adult IBD patients referred to an outpatient clinic of gastroenterology in Isfahan ci...
Article
Full-text available
Various symptoms frequently affect cancer patients' quality of life. Appropriate assessment of these symptoms provides valuable data for cancer management. This study aimed to validate the Persian version of the M. D. Anderson Symptom Inventory (MDASI-P). This cross-sectional study was conducted at four cancer treatment centers in two cities in Ira...
Article
Full-text available
Background: Extraintestinal symptoms are common in patients with irritable bowel syndrome (IBS). In the present study, we determined the relationship between psychological disorders and extraintestinal symptoms in patients with IBS. Methods: Adult patients with IBS referred to 4 gastroenterology clinics in Isfahan, Iran, completed the irritable bow...
Article
Purpose: Radiation-induced injury to the normal tissues is a common complication of radiotherapy in cancer patients. Considering the role of vitamin D in mucosal barrier hemostasis and inflammatory responses, we investigated whether vitamin D deficiency is associated with the severity of radiation-induced acute proctitis in cancer patients. Methods...
Article
Background Adenosine deaminase activity is proposed as a marker of inflammation in some inflammatory conditions. Aims To investigate the association of serum adenosine deaminase activity and disease activity in Crohn’s disease patients. Methods In a cross-sectional study, 30 consecutive known cases of Crohn’s disease (15 with active disease and 15...
Article
Full-text available
We evaluated the effectiveness of a synbiotic in the treatment of childhood functional abdominal pain (FAP). Probiotics are effective in the treatment of functional gastrointestinal disorders in adult patients, but there is lack of information in children. Children with FAP, based on the Rome III criteria (n = 115, aged 6-18 years), were randomized...
Article
Full-text available
Objectives. We evaluated the psychometric properties of the Persian LupusQoL for the evaluation of quality of life in Iranian systemic lupus erythematosus (SLE) patients. Methods. The LupusQoL was translated to Persian language. Patients with SLE (n = 78) completed the LupusQoL and the Short-Form Health Survey (SF-36). Disease activity and cumulati...
Article
Full-text available
Some evidence has shown benefits of probiotics in the management of minimal hepatic encephalopathy (MHE). We evaluated the efficacy of a multistrain probiotic compound, alone and in combination with lactulose, in the treatment of MHE. This study has two parts. First, consecutive adult patients with MHE were randomized to receive lactulose (30-60 mL...
Article
Aim: Sleep quality disturbances are common in patients with systemic lupus erythematosus (SLE). We evaluated sleep quality and its contributors in women with SLE. Also we evaluated the effects of sleep quality disturbance on patients' health-related quality of life (HRQoL). Methods: Sleep quality was assessed in 77 women with SLE (age 36.5 ± 10....
Article
Objective: The aim of this study was linguistic validation of the Sleep Disturbance Scale for Children (SDSC) in Iranian children with Persian language. Methods: The study included a randomly selected sample of children, aged 6–15 years, from three primary and secondary schools located in Isfahan City, Iran. Following the forward–backward translati...
Article
Full-text available
Background: The European Organization for Research and Treatment of Cancer Quality of Life Questionnaire for Colorectal Cancer (EORTC QLQ-CR29) is developed to specifically evaluate the quality of life in patients with colorectal cancer. In this study, we aimed to validate the QLQ-CR29 in Iranian patients with Persian language linguistically and to...
Article
Objectives Sleep disorders are common among patients with systemic lupus erythematosus (SLE) with unclear underlying mechanisms. We assessed the role of vitamin D in sleep quality of patients with SLE.MethodsA retrospective study was conducted on women with SLE for whom the following data were available at the same time; sleep quality (Pittsburgh S...
Article
Full-text available
Background: Some evidence has shown a relationship between human cytomegalovirus (CMV) infection and pregnancy loss. However, whether recurrent or latent CMV infection or altered immune response to CMV is related to recurrent pregnancy loss (RPL) is unclear. We evaluated CMV infection and avidity of antibodies to CMV in women with RPL. Materials an...
Article
Full-text available
Background: The influence of various psychological factors and coping mechanisms on quality of life (QOL) in cancer patients has been well established. We evaluated locus of control and attributional styles, and their association with coping styles and quality of life (QOL) among Iranian cancer patients. Methods: This cross-sectional study was cond...
Article
Full-text available
Background: Quality of life is of the most important outcomes measured in patients with systemic lupus erythematosus (SLE). The Lupus Quality of Life (LupusQoL) questionnaire is designed to specifically assess quality of life in these patients. This study aimed to evaluate validity and reliability of the Persian version of this questionnaire in Ira...
Conference Paper
The underlying mechanisms of the association between obstructive sleep apnea (OSA) and atrial fibrillation (AF) remained unclear. We investigated P wave parameters as indicators of atrial conduction status among OSA patients. We studied 42 untreated OSA patients, categorized into mild (6), moderate (18), and severe (18) OSA based on the apnea/hypop...
Conference Paper
Introduction: Restless legs syndrome (RLS) is common among uremic patients.We assessed RLS and its association with sleep quality, psychological well-being, and one year cardiovascular mortality in patients on chronic hemodialysis (HD) and peritoneal dialysis (PD). Materials and methods: Patients on chronic HD and PD were consecutively included fro...
Conference Paper
Introduction There is a lack of data on sleep quality in women with systemic lupus erythematosus (SLE). We evaluated sleep quality and its possible determinants in Iranian women with SLE. Materials and methods Seventy-two women with SLE were investigated. Disease activity was assessed using the Systemic Lupus Erythematosus Disease Activity Index an...
Article
Full-text available
Background: Dizziness is one of the most commonly occurring chief complaints in neurology. The aim of this study was to differentiate patients with dizziness according to organic and somatoform vertigo and evaluate the relationship of dizziness/vertigo symptoms with psychological symptoms in patients with chronic vertigo and dizziness. Methods: Thi...
Article
Full-text available
Background: Sleep disturbances are common among uremic patients; however, limited data are available on predictors of sleep quality in this population. We assessed sleep quality in patients on hemodialysis (HD) and peritoneal dialysis (PD) and investigated predictors related to sleep quality. Methods: Patients on maintenance HD and PD were consecut...
Article
Full-text available
BACKGROUND: Functional constipation is one of the most prevalent childhood gastrointestinal disorders. We evaluated effects of adding a probiotic to mineral oil in the treatment of functional constipation in children. MATERIALS AND METHODS: This controlled trial was conducted on 60 children (2 to 14 years old) with functional constipation (Rome III...