Ali Amad

Ali Amad
Université de Lille · Faculty of Medicine

M.D., PhD

About

225
Publications
122,135
Reads
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2,014
Citations
Introduction
My research is organised around 3 main topics: 1] studying the interaction between environmental factors and the brain ; 2] I also develop the concept of plastic adaptation to the pathology in neuropsychiatric disorders & 3] I develop an approach about the definition of an objective psychiatry. I am pursuing these projects between the Lille University Hospital & the Institute of Psychiatry (London).
Additional affiliations
September 2017 - present
Université de Lille
Position
  • Professor (Assistant)
November 2015 - September 2017
Université de Lille
Position
  • Medical Doctor
November 2014 - present
King's College London
Position
  • PostDoc Position
Education
October 2009 - October 2010
Sorbonne Université
Field of study
  • Neurosciences
November 2006 - November 2011
Université de Lille
Field of study
  • Psychiatry
September 2002 - September 2004
Université de Lille
Field of study
  • Biology and Genetics

Publications

Publications (225)
Article
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Borderline personality disorder (BPD) is one of the most common mental disorders and is characterized by a pervasive pattern of emotional lability, impulsivity, interpersonal difficulties, identity disturbances, and disturbed cognition. Here, we performed a systematic review of the literature concerning the genetics of BPD, including familial and t...
Article
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Hallucinations constitute one of the most representative and disabling symptoms of schizophrenia. Several Magnetic Resonance Imaging (MRI) findings support the hypothesis that distinct patterns of connectivity, particularly within networks involving the hippocampal complex (HC), could be associated with different hallucinatory modalities. The aim o...
Article
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OBJECTIVE: Little is known about personality and personality disorders in the elderly. This paper summarizes the literature in these fields. METHODS: Articles were selected using a Medline and Google Scholar search. The keywords were personality, personality disorder, aging and elderly. RESULTS: Personality is not fixed and can change across the li...
Article
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Eighty years ago, schizophrenia was the first indication for electroconulsive therapy (ECT), and likewise ECT was one of the first treatments used for schizophrenia. This paper presents the history of ECT in the treatment of schizophrenia and its evolution, from it’s discovery in the 20 th century, which is an example of empiricism with a sequence...
Article
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Purpose: Women with Alcohol Use Disorder (AUD) might be particularly vulnerable to psychiatric comorbidities. However, population surveys have yielded disparate findings. We used data from the French Mental Health in the General Population survey to investigate gender-related risks of psychiatric comorbidities associated with AUD. Methods: A cross-...
Article
Résumé Objectifs L’hypersialorrhée iatrogène correspond à un excès de sécrétion salivaire causé par la prise d’un médicament. Cet effet indésirable, fréquent avec les psychotropes, peut être à l’origine d’une mauvaise observance et nécessite donc une prise en charge optimale. Méthodes Les études cliniques et rapports de cas décrivant une prise en...
Article
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Purpose We sought to measure the prevalence of psychotic symptoms (PSs) and psychotic disorders (PDs) in a sample of men entering jail and to compare these prevalences with those observed in the general population. We also aimed to explore the sociodemographic and clinical factors associated with PSs and PDs. Methods The Mental Health in the Priso...
Preprint
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Existing multimodal stress/pain recognition approaches generally extract features from different modalities independently and thus ignore cross-modality correlations. This paper proposes a novel geometric framework for multimodal stress/pain detection utilizing Symmetric Positive Definite (SPD) matrices as a representation that incorporates the cor...
Article
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Significance There is an acknowledged need for improved service provision in the context of autism spectrum disorders. Previous studies have demonstrated the positive role drum training can play in improving behavioral outcomes for children and adolescents with emotional and behavioral difficulties. However, to date, none of these studies has explo...
Conference Paper
Despite the increasing computerization of hospital information systems, segments of patient care are still in paper format. Data extracted automatically from the hospital databases for one specific project are thus supplemented by data collected manually. Data collection tools are usually developed entirely, which requires computer knowledge and is...
Article
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Background The external clinical manifestations (psychopathology) and internal subjective experience (phenomenology) of catatonia are of clinical importance but have received little attention. This study aimed to use a large dataset to describe the clinical signs of catatonia; to assess whether these signs are associated with underlying diagnosis a...
Article
Objective: Catatonia is a debilitating psychomotor disorder. Previous neuroimaging studies have used small samples with inconsistent results. The authors aimed to describe the structural neuroradiological abnormalities in clinical magnetic resonance imaging (MRI) brain scans of patients with catatonia, comparing them with scans of psychiatric inpa...
Article
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Background Criminal responsibility is a key concept in the criminal sanctioning of people diagnosed with mental health disorders who have committed crimes. In France, based on the recommendations of one or more expert psychiatrists, a judge can declare a person not criminally responsible on account of mental disorder (NCRMD) if, at the time of the...
Article
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Background Despite the poor mental health status of people who are incarcerated, few studies have examined the number of psychiatric hospitalisations in this population. Since 2010, France has progressively opened nine full-time inpatient psychiatric wards exclusively for people who are incarcerated, called “specially adapted hospital units” (unité...
Article
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Catatonia is a severe neuropsychiatric syndrome, usually treated by benzodiazepines and electroconvulsive therapy. However, therapeutic alternatives are limited, which is particularly critical in situations of treatment resistance or when electroconvulsive therapy is not available. Transcranial direct-current stimulation (tDCS) is a promising non-i...
Article
Résumé Contexte Le centre pénitentiaire de Château-Thierry accueille des personnes détenues dont l’intégration dans une détention « classique » est jugée compliquée du fait de troubles du comportement. Cet article présente la première étude visant à décrire le parcours judiciaire et de soins des personnes incarcérées dans cet établissement. Métho...
Article
(238 words) Research has consistently shown high levels of post-traumatic stress disorder (PTSD) in correctional settings. We aimed to compare the prevalence rates of trauma exposure, subthreshold PTSD, and full PTSD in incarcerated people with those observed in the general population. We used the Mini-International Neuropsychiatric Interview to sc...
Article
En médecine, l'approche standardisée désigne une démarche d'analyse et d'évaluation dans le cadre d'un processus méthodique avec des règles fixées. L'approche médicale standardisée s'attache donc à suivre une procédure rigoureuse et définie qui peut être répétée plusieurs fois à l'identique, si les conditions le permettent. En psychiatrie, les prem...
Article
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We aimed to examine the association between religious beliefs and observance and the prevalence of psychiatric disorders, psychotic symptoms and history of suicide attempts in the French general population. The cross-sectional survey interviewed 38,694 subjects between 1999 and 2003, using the MINI. Current religious beliefs and observance were ide...
Article
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Background Catatonia, a severe neuropsychiatric syndrome, has few studies of sufficient scale to clarify its epidemiology or pathophysiology. We aimed to characterise demographic associations, peripheral inflammatory markers and outcome of catatonia. Methods Electronic healthcare records were searched for validated clinical diagnoses of catatonia....
Article
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Background The COVID-19 pandemic has raised concerns regarding its psychological effect on university students, especially healthcare students. We aimed at assessing the risk of mental health problems according to the type of university studies, by adjusting for potential confounders. Methods We used data from the COSAMe study, a national cross-sec...
Article
Introduction: Deliberate self-harm and suicide attempts share common risk factors but are associated with different epidemiological features. While the rate of suicide after deliberate self-harm has been evaluated in meta-analyses, the specific rate of death by suicide after a previous suicide attempt has never been assessed. The aim of our study w...
Article
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Introduction: The procedure of involuntary psychiatric hospitalization has been recently modified in France. Indeed, since 2011, a liberty and custody judge is appointed for each measure, to guarantee the rights of psychiatric inpatients and to prevent abusive hospitalizations. As a result, if procedural errors are noted, the liberty and custody j...
Article
Background: Suicide is a leading yet underestimated cause of death in the world and in France. The goal of our study was to determine the impact at 3 months of a large-scale simulation program on suicide risk assessment for first-year medical residents. Methods: All the first-year medical residents participated in the simulation program that inc...
Article
Background: The risk factors for radicalization and terrorism represent a key research issue. While numerous data on the sociological, political, and criminological profiles of radicalized people and terrorists are available, knowledge about psychiatric disorders among these populations remains scarce and contradictory. Method: We conducted a syst...
Article
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Résumé Introduction Malgré une efficacité démontrée et une bonne tolérance, l’électro-convulsivothérapie (ECT) est sous-utilisée en pratique courante. Les représentations négatives dont souffre ce traitement pourraient expliquer en partie ce constat. L’objectif principal de cette étude était d’évaluer l’impact d’une vidéo pédagogique sur les croya...
Article
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The publication of the 2020 Royal Australian and New Zealand College of Psychiatrists clinical practice guidelines for the management of mood disorders was followed by a series of correspondences discussing the place of repetitive transcranial magnetic stimulation (rTMS) in the sequence care for the routine treatment of depression. The controversy...
Article
Introduction Recent pharmacoepidemiological studies have suggested that certain classes of psychotropic drugs could be considered protective or risk factors for suicidal behaviour. However, very few studies have explored the association between certain classes of psychotropic drugs and the risk of suicide attempt (SA) or death by suicide for patien...
Article
Résumé La tachypsychie est un des symptômes fréquemment retrouvée des troubles de l’humeur. Cet article a pour but de résumer les connaissances actuelles sur le contexte historique, la sémiologie et la fréquence de ce symptôme dans le spectre des troubles de l’humeur. La tachypsychie pourrait se scinder en deux composantes : les « pensées accélérée...
Article
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OBJECTIVE: Understanding the cumulative effect of several risk factors involved in suicidal behavior is crucial for the development of effective prevention plans. The objective of this study is to provide clinicians with a simple predictive model of the risk of suicide attempts and suicide within 6 months after suicide attempt. METHODS: A prospecti...
Article
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Background For incarcerated people, the immediate post-release period is characterized by a range of negative outcomes. The appointment scheduling delay for a psychiatric community consultation in this period is unknown. Methods A fictional 24-year-old patient with a diagnosis of bipolar disorder with comorbid cannabis use disorder was created and...
Article
Objective: To assess the prevalence of and risk factors for posttraumatic stress disorder (PTSD) in patients with COVID-19. Methods: We conducted a cohort study between March and May 2020 at the Lille University Hospital (France), including all patients with laboratory-confirmed COVID-19. Psychological distress symptoms were measured 3 weeks aft...
Article
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Late-onset Niemann-Pick type C (NP-C) is a rare, underdiagnosed lysosomal disease with neurological manifestations. A specific treatment, miglustat, can stabilize the disease if given early. Recently, three plasma screening biomarkers (PSBs) were developed [cholestane3β,5α,6βtriol (C-triol), 7-ketocholesterol (7-KC), and lysosphingomyelin-509 (LSM-...
Article
Objective: Several studies have shown that psychiatric disorders can be associated with venous thromboembolism (VTE) risk, i.e. pulmonary embolism (PE) and/or deep vein thrombosis (DVT). In this study, we provide a systematic review and meta-analyses of the studies addressing this issue. Methods: All studies addressing the risk of VTE phenomena...
Article
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Résumé Le trouble de stress post-traumatique (TSPT) est l’un des troubles psychiatriques les plus fréquents en milieu pénitentiaire, puisque sa prévalence « vie entière » atteint 17,8 % chez les hommes et 40,1 % chez les femmes en détention. Pourtant, le TSPT reste sous-diagnostiqué et peu étudié dans cette population. Cette revue de la littérature...
Article
Background: In French prisons, psychiatric care for inmates is organized into three levels: ambulatory care within each jail in "unités sanitaires en milieu pénitentiaire" (USMP: sanitary units in correctional settings), day hospitalizations in the 28 services médico-psychologiques régionaux (SMPR, "regional medical-psychological services") and fu...
Article
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We read with great interest Tilman Steinert’s recent letter to the Editor (1) highlighting the potential language bias in the international scoping review on the use of coercion in psychiatry, previously published by Gooding and colleagues (2). As underlined by Professor Steinert, excluding all papers in languages other than English suggests that t...
Article
Objectives/Aims Catatonia is an important neuropsychiatric disorder with a high morbidity and mortality. However, due to a perception that it is very infrequent and because of the acuity of the patients, it has remained poorly studied and research has often been confined to small groups. We hypothesised that: catatonia would remain a significant cl...
Article
Background Depersonalization is a complex phenomenological experience initially described as a psychological disturbance of self-awareness. Among the different dimensions underlying depersonalization, emotional numbing appears to be a key symptom but remains a poorly understood phenomenon. Method We conducted a systematic review, following PRISMA...
Article
Bipolar spectrum disorders encompass heterogeneous clinical manifestations and comorbidities. A latent class analysis (LCA) was performed in 1846 subjects who experienced an episode of abnormally elevated or irritable mood to identify homogeneous groups of subjects, based on the distribution of 11 manic and 7 psychotic symptoms. LCA identified five...
Article
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It is unclear to what extent cerebellar networks show long-term plasticity and accompanied changes in cortical structures. Using drumming as a demanding multimodal motor training, we compared cerebellar lobular volume and white matter microstructure, as well as cortical thickness of 15 healthy non-musicians before and after learning to drum, and 16...
Article
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Background Catatonia is a frequent, complex and severe identifiable syndrome of motor dysregulation. However, its pathophysiology is poorly understood. Methods We aimed to provide a systematic review of all brain imaging studies (both structural and functional) in catatonia. Results We identified 137 case reports and 18 group studies representing...
Method
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French version of the The Somatic Symptom Disorder – B Criteria Scale (SSD-12) adapted from the SSD-12 English version (Toussaint et al. 2016).
Article
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Résumé La pandémie du COVID-19 a des conséquences majeures sur l’organisation des soins. En France et dans le monde, les centres pratiquant l’électroconvulsivothérapie (ECT) ont vu leur activité diminuer, voire s’arrêter, pour de diverses raisons. Dans ce contexte, le maintien ou la reprise de cette activité thérapeutique essentielle pour de nombre...
Article
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Transcranial direct current stimulation (tDCS) recently appeared as a novel treatment that could be a potential therapeutic option for patients with bipolar depression. tDCS is an experimental treatment and should not be considered as a treatment that can replace medications or electroconvulsive therapy in bipolar depression tDCS could be a potenti...
Article
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Background.: The aim of the present study was to estimate prevalence rates of psychiatric and substance use disorders in male and female prisoners on admission to prison in the north of France and compare the frequency of these disorders to the general population. Methods.: This cross-sectional survey on Mental Health in the Prison Population (M...
Article
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Introduction: Infliximab (IFX) was the first anti-tumor necrosis factor (TNFα) antibody to be used in the treatment of severe chronic inflammatory diseases, such as Crohn's disease and rheumatoid arthritis. A number of serious adverse drug reactions are known to be associated with IFX use; they include infections, malignancies, and injection site...
Article
Objectives: No study has assessed utilization of hospital-level mental health care for French prisoners. In particular, the impact of unités hospitalières spécialement aménagées (UHSAs; "specially equipped hospital units"), the full-time inpatient psychiatric wards for inmates created in 2010, remains unknown. The aim of this study was to describe...
Article
Résumé A la fois le confinement lié au virus Covid-19 et le stress induit par la pandémie peuvent entraîner des perturbations importantes des rythmes et du sommeil. Des experts du sommeil de la section Sommeil et rythmes biologiques en Psychiatrie (SoPsy) de l’Association Française de Psychiatrie Biologique et de Neuropsychopharmacologie (AFPBN) et...
Article
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Résumé La pandémie récente de COVID-19 a entraîné des changements organisationnels majeurs dans les lieux de soins et notamment en hospitalisation en psychiatrie. Pour évaluer l’évolution de l’activité des différents centres pratiquant l’ECT, une enquête nationale en ligne a été réalisée. 65 réponses de toute la France ont été analysées. Plus de 90...