Ali Albarrati

• Doctor of Philosophy
• Professor (Associate) at King Saud University; Cardiff University

Intraoperative graft interrogation is crucial for ensuring graft patency and optimizing surgical outcomes in coronary artery bypass grafting (CABG). Various intraoperative imaging techniques aid in assessing graft function, allowing for immediate correction of technical issues and reducing postoperative complications. A 38-year-old male smoker pres...

This study employed bibliometric analysis using the Scopus database to evaluate Saudi disability research (SDR). From an initial dataset of 17,102 documents (0.54% of global output), the scope was refined to 13,246 data-driven publications for detailed examination. Trends, themes, and collaborations were analyzed using R packages and VOSviewer. Met...

Background: Early mobility (EM) is vital in the intensive care unit (ICU) to counteract immobility-related effects. A multidisciplinary approach is key, as it requires precise initiation knowledge. However, physicians’ understanding of EM in adult ICU settings remains unexplored. This study was conducted to investigate the knowledge and clinical co...

Background/Objective(s) Chronic obstructive pulmonary disease (COPD) can precipitate a deterioration of an individual’s physical performance and overall health. Evidence suggests that, along with pulmonary functions, several other factors are related to the significant impairment of walking performance in individuals with COPD. This study compared...

Anxiety and depression are two psychological illnesses that are linked to chronic obstructive pulmonary disease (COPD). In Saudi Arabia, no research has been done on the prevalence of psychological disorders among patients with COPD and their association with COPD severity. This study aims to screen for anxiety and depression among Saudi patients w...

Introduction Physical activity plays a crucial role in managing and improving health outcomes for people with chronic obstructive pulmonary disease (COPD). However, limited research has investigated specific barriers and facilitators of physical activity in Saudi Arabia. This qualitative study aims to explore the factors influencing physical activi...

Background: The Kansas City Cardiomyopathy Questionnaire (KCCQ) is the most specific and widely used questionnaire for assessing health-related quality of life (HRQoL) in chronic heart failure (CHF). This study aimed to examine reliability and validity of the KCCQ in Arabic patients with CHF. Material and Methods: Patients with CHF filled out the A...

Objective: To objectively quantify the effect of flattening the crimps in Dacron tube grafts on the radial compliance under pulsatile pressure. We aimed to minimize the dimensional changes in woven Dacron graft tubes by applying axial stretch to the graft. We hypothesize this might reduce the risk of coronary button misalignment in aortic root repl...

Depression is the most prevalent and devastating neuropsychiatric disorder. There are several conventional antidepressants used for the treatment of depression. But due to their undesired adverse effects, patient compliance is very poor. Thus, developing novel medications for the treatment of depression is a critical strategic priority for meeting...

Tecoma stans (Fam. Bignoniaceae) is also popularly known as yellow bells and yellow trumpet bush in vernacular terminology. Limited and variable data are available from the literature regarding the quantification of luteolin, apigenin and chrysoeriol, which are considered as the most active pharmacological active constituents. High-performance liqu...

Background While a lack of psychological preparedness and fear of movement may be linked with the anterior cruciate ligament (ACL) re-injury, these variables are rarely addressed throughout the therapy stages via educational sessions. Unfortunately, in terms of reducing fear, increasing function, and returning to play, no research has been done yet...

The role of anxiety and depression in functional performance during walking in patients with chronic obstructive pulmonary disease (COPD) is controversial. In this cross-sectional study, we aimed to assess the effects of anxiety, depression, and health-related quality of life (HRQOL) on the functional performance of this patient population. Seventy...

Introduction Chronic obstructive pulmonary disease (COPD) is characterised by persistent respiratory symptoms and airflow limitation. Physical Activity (PA) frequently induces breathlessness and thus patients often limit daily activities resulting in further deconditioning.¹ Several studies in COPD have shown that physical activity is associated wi...

Heart failure (HF) is a serious disorder that affects millions of people worldwide, with a high rate of exercise intolerance, rehospitalization, and death. HF has many underlying causes, including type 2 diabetes mellitus (T2DM), which corresponds with high mortality and short survival among patients with HF. Numerous studies have shown the crucial...

The aim of the study was to examine the measurement properties of the Arabic version of the Duke Activity Status Index (DASI) in patients with cardiovascular disease (CVD). A sample of 100 Arab patients with CVD completed the Arabic version of the DASI and underwent an exercise stress test (EST) on the first visit, and the metabolic equivalent (MET...

Background: Severe atherosclerosis of the ascending aorta (SAA) in patients undergoing surgical revascularization by coronary artery bypass grafting (CABG) is becoming an increasing problem as more elderly patients are diagnosed with coronary artery disease. Strokes and other neurologic insults are common complications in this group, with devastat...

The expeditious advancement of Alzheimer's Disease (AD) is a threat to the global healthcare system, that is further supplemented by therapeutic failure. The prevalence of this disorder has been expected to quadrupole by 2050, thereby exerting a tremendous economic pressure on medical sector, worldwide. Thus, there is a dire need of a change in con...

Type 2 diabetes mellitus (T2D) is a metabolic disorder that knows no boundaries and is spread across the globe. It is one of the most widely spread metabolic disorder, which has now been described as a ‘lifestyle’ disease. According to the recent study conducted by International Diabetes Federation, the number of diabetic patients will rise from 46...

Traumatic brain injury (TBI) is an important global health concern that represents a leading cause of death and disability. It occurs due to direct impact or hit on the head caused by factors such as motor vehicles, crushes, and assaults. During the past decade, an abundance of new evidence highlighted the importance of inflammation in the secondar...

Background: Exercise intolerance in patients with chronic heart failure (CHF) is associated with a number of factors, including breathlessness and respiratory muscle weakness. However, many studies reported controversial results, and as yet there is no study on Arabic patients with CHF. This study aimed to examine the impact of breathlessness and...

Obesity-related metabolic dysfunction, endothelium imbalance, chronic inflammation, immune dysregulation, and its comorbidities may all have a role in systemic inflammation, leading to the pulmonary fibrosis and cytokine storm, which leads to failure of lung function, which is a hallmark of severe SARS-CoV-2 infection. Obesity may also disrupt the...

The Timed Up and Go (TUG) is a global measure of mobility and has the ability to detect frail individuals. Frail patients with chronic obstructive pulmonary disease (COPD) are usually undiagnosed. We hypothesised that the TUG would identify frail patients with COPD. Frailty was assessed in 520 patients diagnosed with COPD and 150 controls using a C...

Immunotherapy, which stimulates the body’s immune system, has received a considerable amount of press in recent years because of its powerful benefits. Cancer immunotherapy has shown long-term results in patients with advanced disease that are not seen with traditional chemotherapy. Immune checkpoint inhibitors, cytokines like interleukin 2 (IL-2)...

Traditionally, herbal compounds have been the focus of scientific interest for the last several centuries, and continuous research into their medicinal potential is underway. Berberine (BBR) is an isoquinoline alkaloid extracted from plants that possess a broad array of medicinal properties, including anti-diarrheal, anti-fibrotic, antidiabetic, an...

Blunt chest trauma following a motor-vehicle accident is the leading cause of non-penetrating cardiac injuries. Major structural heart injuries are fatal due to acute tamponade. We present a case of a 17-year-old male who was involved in a motor vehicle accident. He had an isolated coronary sinus rupture, which was successfully repaired. We propose...

Diabetes is a condition that affects a large percentage of the population and it is the leading cause of a wide range of costly complications. Diabetes is linked to a multi-fold increase in mortality and when compared to non-diabetics, the intensity and prevalence of COVID-19 ailment among diabetic individuals are more. Since its discovery in Wuhan...

Cardiovascular and related diseases (CVRDs) are among the most prevalent chronic diseases in the 21st century, with a high mortality rate. This review summarizes the various nanomedicines for diagnostic and therapeutic applications in CVRDs, including nanomedicine for angina pectoris, myocarditis, myocardial infarction, pericardial disorder, thromb...

Purpose: To translate and cross-culturally adapt the original Duke Activity Status Index (DASI) into the Arabic language and examine its psychometric properties in Arabic speaking patients with Chronic Obstructive Pulmonary Disease (COPD). Materials and methods: The DASI was translated into the Arabic language and tested on 70 Arabic patients wi...

Purpose To examine the psychometric properties of the Arabic version of the Lower Extremity Functional Scale (LEFS-Ar) in people with chronic obstructive pulmonary disease (COPD). Materials and methods Stable individuals with COPD (N = 70) confirmed by spirometry were asked to complete the LEFS-Ar, St George’s Respiratory Questionnaire (SGRQ) and...

Introduction: During the coronavirus pandemic, an initiative was launched in Saudi Arabia to provide telerehabilitation for people with musculoskeletal conditions who were unable to access in-person physiotherapy due to the associated lockdown. The purpose of this study was to explore the therapeutic impact and acceptability of telerehabilitation a...

Purpose: The Anxiety Inventory for Respiratory Disease (AIR) is a reliable and valid scale for examining the anxiety in patients with COPD. This study aimed to cross-culturally adapt and translate the original AIR scale into the Arabic language and to examine its reliability and validity in Arab patients with COPD. Material and methods: This was...

The aim of the current study was to examine the psychometric properties of the upper extremity functional index (UEFI) in patients with chronic obstructive pulmonary disease (COPD). Seventy patients with stable COPD completed the UEFI and St. George Respiratory Questionnaire (SGRQ) and performed lung function tests in the first testing session. The...

Background: Diaphragmatic release technique and thoracolumbar manipulation have been found effective in restoring normal diaphragmatic movement in healthy and diseased populations. Smoking has deleterious effects on human systems, including the musculoskeletal system. Objective: The current study aimed to investigate the immediate effects of dia...

Purpose: Stress-gated myocardial perfusion scintigraphy (MPS) is used for prognosis in stable coronary artery disease (CAD). We sought to assess coronary artery bypass grafting (CABG) outcomes in stable coronary artery disease patients who had myocardial perfusion scintigraphy and left ventricular (LV) dysfunction. Methods: Stable CAD patients w...

Introduction: Early Mobilization (EM) of patients in Intensive Care Unit (ICU) has received considerable attention in scientific literature over the past several years. It has been reported that EM decrease Hospital Length of Stay (LOS).

Background Type 2 diabetes mellitus (T2DM) is usually associated with respiratory manifestations including inspiratory muscle weakness which affects exercise capacity. The present study aimed to determine the effect of inspiratory muscle training (IMT) on inspiratory muscle strength and exercise capacity in patients with Type 2 diabetes mellitus (T...

Hypertension (HTN) is among the leading global preventable risk factors for cardiovascular disease and premature mortality. Early detection and effective management of HTN has demonstrated significant reductions in mortality, morbidity rate, and healthcare costs. Furthermore, screening for HTN by non-physician healthcare providers improves detectio...

Background: Factors associated with reduced daily physical activity (DPA) in patients with COPD are still controversial. Physical inactivity in COPD increases risk of cardiovascular disease, frequent exacerbations, reduced health status, and increased symptoms. We hypothesised that reduced DPA in patients with COPD is independent of traditional ri...

Background : Factors associated with reduced daily physical activity (DPA) in patients with COPD are still controversial. Physical inactivity in COPD increases risk of cardiovascular disease, frequent exacerbations, reduced health status, and increased symptoms. We hypothesised that reduced DPA in patients with COPD is independent of traditional ri...

p.p1 {margin: 0.0px 0.0px 0.0px 0.0px; text-align: justify; font: 12.0px Times} Background : Factors associated with reduced daily physical activity (DPA) in patients with COPD are still controversial. Physical inactivity in COPD increases risk of cardiovascular disease, frequent exacerbations, reduced health status, and increased symptoms. We hypo...

Background: Coronary artery bypass grafting surgery has an increased risk of adverse events in obese patients. This increased risk might be explained in part by an increased intra-abdominal pressure and the development of intra-abdominal hypertension. Therefore, the objective of this study was to investigate the correlation between obesity and int...

Background and objectives: Cardiovascular (CV) disease is a major cause of morbidity and mortality in chronic obstructive pulmonary disease (COPD). Patients with COPD have increased arterial stiffness, which may predict future CV risk. However, the development of arterial stiffness in COPD has not yet been studied prospectively. The Assessment of R...

Chronic obstructive pulmonary disease (COPD) is a multisystem disease that resembles the accumulation of multiple impairments seen in aging. A comprehensive geriatric assessment (CGA) captures multisystem deficits, from which a frailty index (FI) can be derived. We hypothesized that patients with COPD would be frailer than a comparator group free f...

Background: Regular exercise reduces risk factors associated with cardiovascular disease (CVD). Elevated low-density lipoprotein (LDL) contributes to atherosclerosis formation, which is associated with an increased risk of CVD. The relationship between exercise therapy and lipid levels has been widely studied, but it is established that high-inten...

Supplemental Material, CGA_questionairre - Frailty: A global measure of the multisystem impact of COPD

Background Surgical site infections can have a significant impact on cardiac surgical outcome. The liver plays an important role in infection prevention. This study aimed to retrospectively determine whether transient postoperative liver dysfunction after coronary bypass surgery increased surgical site infections. Methods A modified version of the...

Normal respiration is a very intricate function that comprises mechanical as well as nonmechanical components. It is shown to be affected by various factors including age, lifestyle, disease, and change in posture. With the increased use of hand held devices, everyone is prone to poor sitting postures like forward head posture. The purpose of this...

Purpose: The aim of the study was to examine if the Timed Up and Go (TUG) Test would be a feasible, reproducible, and valid measure in patients post-coronary artery bypass grafting (CABG). Design: Cross-sectional study, controls and patients post-CABG, outpatient clinic. Methods: Participants performed the TUG Test and the 6-Minute Walking Dis...

Objectives: The purpose of the study was to investigate the effect of an exercise program using elastic tubing as a perturbation force on balance and functional performance in athletes with chronic ankle instability. Equipment and methods: Thirty young university-level competitive athletes with chronic ankle instability participated in this pre–pos...

Background: Physical therapists are recognized healthcare providers who play an important role in cardiovascular disease prevention. Heart rate (HR) and blood pressure (BP) are important parameters in cardiovascular risk assessment; however, physical therapists do not usually integrate them into clinical practice. Therefore, this study aimed to ex...

Objective The present study compared the effects of upright and slouched sitting postures on the respiratory muscle strength in healthy young males. Methods A total of 35 adult male subjects aged 18–35 years participated in this study. Respiratory muscle strength was determined by measurement of sniff nasal inspiratory pressure (SNIP) using a Micr...

Background: Topical cooling with ice slush as an adjunct for myocardial protection during cardiac surgery has been shown to cause freezing injury of the phrenic nerves. This can cause diaphragmatic dysfunction and respiratory complications. Methods: Twenty (n=20) male patients between the ages of 40 and 60 years were equally randomised to underg...

Purpose This study aimed to assess the acute effects of posture position (upright vs. semi recumbent) during mild to moderate-intensity cycling exercise and recovery on cardiovascular indices in young healthy adults as there is little information on this subject. Material and Methods A randomized cross-over study of young healthy volunteers perfor...

OBJECTIVE. This study’s objective was to discover whether a difference exists in four postural angles while performing a typing task on a laptop and a desktop computer. METHOD. Twenty healthy participants performed a 5-min typing task on each computer. RESULTS. Statistically significant differences for all angles were found when comparing sitting a...

Impaired physical performance is common in chronic obstructive pulmonary disease (COPD), but its assessment can be difficult in routine clinical practice. We compared the timed up and go (TUG) test and other easily applied assessments of physical performance with the 6-minute walk distance (6MWD). In a longitudinal study of comorbidities in COPD, s...

Background: Ankle sprains often result in ankle instability, which is most likely caused by damage to passive structures and neuromuscular impairment. Most ankle sprains are treated non-surgically with a rehabilitation program. Methods: A sample of 40 subacute grade II lateral ankle sprain with a mean age of 21.8±2.9 years were participated in this...

Introduction: Increased arterial stiffness is a marker of cardiovascular disease and suggested to beassociated with impaired lung function in chronic obstructive pulmonary disease (COPD). However, whether patients with mild COPD have increased arterial stiffness and what factors are linked to is still not explicitly studied. We hypothesised that pa...

Background COPD is a systemic disease with associated comorbidities including cardiovascular disease which have significant impact on morbidity and mortality.1 However, the progression of the disease is not well understood as there are few longitudinal studies of sufficient duration which include outcome data. The aim of this analysis was to evalua...

Introduction Cardiovascular disease (CVD) is the leading cause of morbidity and mortality in COPD in excess of the effect of smoking. Clarification of cardiovascular risk factors could clarify the extra risk and lead to appropriate clinical management. We hypothesise that COPD increases the 10 year risk for CVD in patients free of clinically overt...

Background COPD is a systemic disease with associated comorbidities including cardiovascular disease which have significant impact on morbidity and mortality. The heterogeneity of COPD has led to the concept of phenotypes; one of which may describe patients at greater cardiovascular risk. Aortic pulse wave velocity (aPWV) is a validated measure of...

Background Presence of comorbidities in chronic obstructive pulmonary disease (COPD) parallels the accumulation of multiple system deficits associated with ageing and assessed as frailty. An important association of frailty in the elderly is increased cardiovascular disease, which is also a major cause of mortality in COPD.1 However, frailty has no...

Chronic obstructive pulmonary disease (COPD) is a multisystem disease. Established comorbidities include cardiovascular disease, osteoporosis, loss of muscle mass and function, depression, and impaired quality of life. The natural history is not well understood. The Assessment of Risk in Chronic Airways Disease Evaluation (ARCADE) is a longitudinal...

Background Co-morbidities are of increasing importance in patients with COPD. However, the implications for function and health status have not been fully established. We hypothesised that the number of co-morbidities would relate to physical capacity, health status and impairments as measured by the comprehensive geriatric assessment (CGA) in COPD...

Background Steps measurement is a common measure of daily physical activity, but cannot define the intensity of physical activity. Moderate intensity activity is recommended type to maintain a basic level of health (1), but in patients with COPD, the effect of moderate intensity activity on systemic manifestations has not been studied. We hypothesi...

Background COPD is associated with extrapulmonary manifestations that worsen patient’s daily physical activity (DPA)(1). However, changes in DPA over time and contributing factors in this population have not been established. We hypothesise that patients with COPD would have lower DPA after one year. Method As part of a longitudinal study in COPD (...

Background: Increased arterial stiffness has been established in patients with COPD (1). However, the changes in aortic stiffness over time and contributing factors are still unknown. We hypothesise that there would be a significant change in aortic stiffness in COPD over one year. Methods: Aortic pulse wave velocity (PWV) was measured using the Sp...

Introduction Chronic obstructive pulmonary disease (COPD) is associated with progressive impairment of physical performance. However, determination of physical performance in routine clinical practise is difficult due to limited resources. This study compared the timed up and go (TUG) test and a range of assessments of physical performance, easily...

Background COPD is a multi-system disease, which has been linked to premature physiological ageing. Recognised co-morbidities include increased risk of cardiovascular events and osteoporosis, loss of muscle mass, function and impaired quality of life (QoL). The Chronic Geriatric Assessment (CGA) has been used to measure impairments, frailty and pre...