Alexis Wolfel

Alexis Wolfel
National Scientific and Technical Research Council | conicet · CCT Cordoba

PhD

About

11
Publications
502
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52
Citations
Introduction
Alexis Wolfel works in polymer chemistry at the National University of Cordoba, Argentina. Alexis’s main interest is aimed to the development of new smart materials at the macro and nano-scale by combining organic chemistry with materials science. He has worked in the development of soft actuators, drug-delivery platforms and the synthesis of cyclopeptidic nanotubes under the framework of international projects. Most recent projects are oriented to generate new materials for radiation dosimetry.
Additional affiliations
May 2019 - July 2019
National University of Cordoba, Argentina
Position
  • Professor (Assistant)
May 2019 - present
National University of Cordoba, Argentina
Position
  • Professor (Assistant)
April 2019 - present
National Scientific and Technical Research Council
Position
  • PostDoc Position

Publications

Publications (11)
Article
To enhance the performance of polymeric dosimeters it is necessary to design novel formulations considering the mechanisms that register the absorbed dose (e.g. induced polymerization) and the readout method. The combination of the advantages of polymeric dosimetry, such as response stability and high sensitivity in a tissue-equivalent material, to...
Article
The development of new materials with smart properties is currently expanding the development of new technologies. Therefore, the design of materials with novel sensitivities and smart behavior is important for the development of smart systems with automated responsivity. We have recently reported the synthesis of hy-drogels, cross-linked by N,N'-d...
Article
Polyphenols-based supramolecular hydrogels have recently attracted much attention as smart materials for applications in several technologies. Although great advances have been made in this field, there is a challenging need for creating new versatile materials that combine synthesis simplicity and suitable functional properties. In this work, insp...
Article
Supramolecular hydrogels have promising applications in a wide variety of fields including 3D bioprinting, sensors and actuators, biomedicine, and controlled drug delivery. This communication reports the facile reversible thermotriggered formation of novel pH‐responsive supramolecular hydrogels based on poly(vinyl alcohol) (PVA) bonded via dynamic...
Article
Currently, the chemistry of alpha-oxoaldehydes (α-oxo-ALD) is a versatile and useful tool in the field of bioconjugation of peptides and proteins. The combination of smart materials with biomolecules also represents an important opportunity for the development of smart functional materials in a wide range of applications. However, the development o...
Preprint
p>Design of materials with novel sensitivities and smart behaviour is important for the development of smart systems with automated responsiveness. We have recently reported the synthesis of hydrogels, cross-linked by N,N' -diallyltartardiamide (DAT). The covalent DAT-crosslinking points have vicinal diols which can be easily cleaved with periodate...
Chapter
Many electronic actuators of different dimensions, such as motors, relays, pumps, and mixers, have evolved rapidly, and many are commercially available. Its application into soft environments such as biological tissues is desirable to develop automated biomedical devices. However, they present innate difficulties. Limitations are mainly due to its...
Article
Full-text available
The use of a new reagent with the capacity of forming colored organo-metallic complexes with metal ions is herein studied for its application in X-Ray dosimetry, aiming to assess its effect on the dose-sensitivity of polymer gel dosimetry. The improvement of the sensitivity of polymeric dosimeters, commonly used to quantitatively register dose dist...
Article
Post-synthesis modification of hydrogels is frequently used for chemical functionalization, immobilization of molecules or optimization of mechanical properties. In this work, novel gels were developed using a divinyl compound (+) N, N′-diallyltartramide (DAT) as a crosslinking agent. DAT possesses a vicinal diol and it was found that can be select...
Article
The adequate use of water for irrigation in agriculture is a widespread concern. In this study, we developed an autonomous smart system consisting of a new hydrogel into a valve, which regulates the flow of water according to soil moisture. The main objective was to find an alternative to avoid waste of water. Yet, hydrogel development and study of...

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Projects

Project (1)
Project
The aim of this project is to control the crosslinking degree and functionalization of macro and nanogels in a post-synthesis step to enlarge the opportunities in the design of novel smart materials. Furthermore, the incorporation of pH-dependent dynamic covalent bonds is used to enhance the material properties while include a sensitivity to the environmental pH. The reactivity of new generated functional groups with different ligands and the pH dependence of the new bond are also studied. This approach is applied in macro and nanogels.