Alexis Wolfel

University of Twente | UT

To enhance the performance of polymeric dosimeters it is necessary to design novel formulations considering the mechanisms that register the absorbed dose (e.g. induced polymerization) and the readout method. The combination of the advantages of polymeric dosimetry, such as response stability and high sensitivity in a tissue-equivalent material, to...

The development of new materials with smart properties is currently expanding the development of new technologies. Therefore, the design of materials with novel sensitivities and smart behavior is important for the development of smart systems with automated responsivity. We have recently reported the synthesis of hy-drogels, cross-linked by N,N'-d...

Polyphenols-based supramolecular hydrogels have recently attracted much attention as smart materials for applications in several technologies. Although great advances have been made in this field, there is a challenging need for creating new versatile materials that combine synthesis simplicity and suitable functional properties. In this work, insp...

Supramolecular hydrogels have promising applications in a wide variety of fields including 3D bioprinting, sensors and actuators, biomedicine, and controlled drug delivery. This communication reports the facile reversible thermotriggered formation of novel pH‐responsive supramolecular hydrogels based on poly(vinyl alcohol) (PVA) bonded via dynamic...

Currently, the chemistry of alpha-oxoaldehydes (α-oxo-ALD) is a versatile and useful tool in the field of bioconjugation of peptides and proteins. The combination of smart materials with biomolecules also represents an important opportunity for the development of smart functional materials in a wide range of applications. However, the development o...

Polyacrylamide (PAM) hydrogels are extensively used as extracellular matrix mimics to study specific cell-materials interactions. However, chemistries typically applied for biofunctionalization of PAM lack chemo-selectivity and control over ligand density, which undermine reproducibility of cellular behavior, which can lead to inconclusive experime...

Advancements in nanogel (NG) applications require of precise control over their size, structure, and functionalization. However, synthesis methods have limitations which hinder the incorporation of some functional groups and hamper...

Hydrogel biomaterials in combination with living cells are applied in cell biology, tissue engineering and regenerative medicine. In particular, poly(acrylamide) (PAM) hydrogels are frequently used in cell biology laboratories as soft substrates for 2D cell culture. These biomaterials present advantages such as the straightforward synthesis, regula...

p>Design of materials with novel sensitivities and smart behaviour is important for the development of smart systems with automated responsiveness. We have recently reported the synthesis of hydrogels, cross-linked by N,N' -diallyltartardiamide (DAT). The covalent DAT-crosslinking points have vicinal diols which can be easily cleaved with periodate...

Many electronic actuators of different dimensions, such as motors, relays, pumps, and mixers, have evolved rapidly, and many are commercially available. Its application into soft environments such as biological tissues is desirable to develop automated biomedical devices. However, they present innate difficulties. Limitations are mainly due to its...

The use of a new reagent with the capacity of forming colored organo-metallic complexes with metal ions is herein studied for its application in X-Ray dosimetry, aiming to assess its effect on the dose-sensitivity of polymer gel dosimetry. The improvement of the sensitivity of polymeric dosimeters, commonly used to quantitatively register dose dist...

Post-synthesis modification of hydrogels is frequently used for chemical functionalization, immobilization of molecules or optimization of mechanical properties. In this work, novel gels were developed using a divinyl compound (+) N, N′-diallyltartramide (DAT) as a crosslinking agent. DAT possesses a vicinal diol and it was found that can be select...

The adequate use of water for irrigation in agriculture is a widespread concern. In this study, we developed an autonomous smart system consisting of a new hydrogel into a valve, which regulates the flow of water according to soil moisture. The main objective was to find an alternative to avoid waste of water. Yet, hydrogel development and study of...