Alexey Chiriapkin

• Lecturer at Pyatigorsk Medical Pharmaceutical Institute

Background. Allergies are a global medical and social problem. According to international statistics, the number of allergic diseases has increased dramatically in recent decades. In recent years, the largest increase in the incidence of bronchial asthma, pollinosis and dermatoses has been noted. Currently, significant success has been achieved in...

At the Scientific Centre of Innovative Medicines of Volgograd State Medical University, a number of pyrimidine derivatives of guanidine were designed and synthesised to study them as promising inhibitors of sodium-hydrogen exchanger isoform 1 (NHE-1), which can reduce tissue damage during ischemia. N-[2-[4-oxo-3(4H)-quinazolinyl]propionyl]-guanidin...

The review summarizes the literature data on the chemical composition and types of biological activity of extracts of Cuscuta campestris Yunck (field dodder), which belongs to the Convolvulaceae family. C. campestris is an aboveground parasite. Its stems wrap around the host plants and are attached to them by gaustoria, which are formed in places o...

Polyphenolic compounds are widely represented in objects of plant origin and have diverse types of biological activity. Since ancient times, the beneficial effect of various galenic preparations on human health has been known, and they acted as almost the only source of treatment for various diseases and improvement of well-being. The major compone...

The development of new therapeutic strategies for the treatment of various diseases associated with impaired protein kinase activity is one of the most urgent tasks in modern medicine. The search for new protein kinase inhibitors is an effective approach in the struggle against cancer. However, the existing protein kinase inhibitors may have limita...

Flavonoids are an extensive class of organic compounds that are secondary metabolites of plants and higher fungi. From a chemical point of view, flavonoids are hydroxy derivatives of flavone, 2,3-dihydroflavone isoflavone and 4-phenylcoumarin. Since ancient times, various parts of plants have been considered as sources of biologically active substa...

The pandemic of the new coronavirus infection SARS-CoV-2 (COVID-19) has put a significant strain on the healthcare system and revealed the need to develop effective medicines for the treatment of this disease. The research results presented in the article are devoted to the development of new compounds with anti-coronavirus action against SARS-CoV-...

Various parts of plants have long been widely used for the treatment and prevention of diseases. They are a valuable source of biologically active compounds, especially they are rich in polyphenolic structures. Rutin belongs to the group of some of the most common flavonoids in plant objects. Animal organisms do not have enzyme systems for its synt...

Relevance. Due to the wide spread of diseases of the cardiovascular system, the development and study of drugs aimed at the treatment of diseases of the circulatory system is relevant. A new biologically active compound (BAC) is synthesized at the Department of Pharmaceutical and Toxicological Chemistry of the Volgograd State Medical University – a...

Введение. Гиперпигментация кожи является важной проблемой дерматокосметологии. Образующиеся пигментные пятна на кожных покровах человека, особенно на открытых участках тела, влияют на его психоэмоциональное состояние и социальную адаптацию, а в некоторых случаях являются и триггерами формирования заболеваний дерматологического профиля.Целью исследо...

Relevance. Alzheimer's disease is one of the most common forms of dementia with a high mortality and disability rate. Some quinazolinone deriva-tives having methoxy groups in the quinazolinone scaffold may be potentially effective agents for the treatment of Alzheimer's disease. The aim of the study. To evaluate the effect of new derivatives of 6,7...

Eukaryotic protein kinases are represented by a large superfamily of homologous proteins similar in structure of the catalytic (kinase) domain, consisting of 250–300 amino acids [3]. Most human protein kinases share a common fold consisting of an N-terminal lobe, consisting of a five-stranded β-sheet with an α-helix called the C-helix, and a C-term...

Pyrimidine derivatives represent an extensive class of organic compounds that contain in their structure a six-membered heterocycle with two nitrogen atoms at positions 1 and 3. Substances of this group have a wide range of pharmacological activity, which makes it possible to consider the pyrimidine core as a promising scaffold for the development...

Neurodegenerative processes of the central nervous system are an important socially significant problem of modern society. They cause many diseases, such as Alzheimer's disease and cerebral ischemia, which significantly reduce the quality of human life and can lead to disability or death. The aim of this study was to synthesize novel 6,7-dimethoxyq...

Background: The high prevalence of skin hyperpigmentation makes it necessary to search for remedies that could hinder this process. Among such substances, tyrosinase inhibitors can be distinguished, which may be pyrimidine derivatives. Objectives: This study aimed to investigate new compounds with anti-tyrosinase activity in 2-substituted tetrah...

Flavonoids are an extensive class of secondary metabolites present in varying concentrations in different parts of plants. Medicinal raw materials containing flavonoids have been used in traditional medicine in various countries for centuries and are also used in modern medicine for the production of drugs. Compared to other groups of secondary met...

Alzheimer's disease is a chronic neurodegenerative disease, which is characterized mainly by a progressive decrease in intellectual abilities, memory impairment and a change in a person's personality. Unfortunately, there are practically no medicines that act on pathogenesis of Alzheimer's disease. The development of new highly effective medicines...

Alzheimer's disease is a chronic neurodegenerative disease with a high risk of social maladaptation. The number of cases of the disease is constantly increasing, which, with a shortage of effective drugs for the treatment and prevention of this disease, makes it urgent to develop new medicines for the treatment of Alzheimer's disease. In this regar...

The article presents a modified method for the synthesis of 2-substituted 5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidine-4(3H)-one and the predict of their anti-inflammatory activity. The proposed method for obtaining tetrahydrothienopyrimidine derivatives is preparatively effective and simple. Their synthesis was carried out by heterocyclizat...

An optimized multi-step synthesis of a new highly effective and low-toxicity derivative of o-benzoylaminobenzoic acid amides possessing anxiolytic activity is presented. Anthranylamide and propionic anhydride instead of acetic anhydride were used as starting materials. The number of synthetic steps did not increase as compared to the known method b...

В статье приведен оптимизированный многостадийный метод синтеза нового высокоэффективного и малотоксичного вещества, относящегося к ряду производных амидов о-бензоиламинобензойной кислоты и обладающего анксиолитическим действием. В качестве исходного вещества использовали антраниламид, вместо уксусного ангидрида — пропионовый. Количество стадий син...

The first of the most successfully implemented nootropic drugs in medical practice is piracetam, which should be attributed to cyclic derivatives of gamma-aminobutyric acid. The production of new piracetam derivatives with high nootropic activity is a promising direction in the development of new neuroprotective drugs. The aim of the study is to pr...

Introduction. Azomethine derivatives of 2-amino-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide are acyclic precursors of biologically active compounds derived from 5,6,7,8-tetrahydro-3H-benzoteopheno[2,3-d]pyrimidine-4-one. Examples of these groups of compounds with different pharmacological properties are given in the literature, but their cyto...

В работе представлены результаты разработки и валидации методики анализа арбутина в брусники обыкновенной листьях методом капиллярного электрофореза. Пробоподготовка извлечения проводилась в соответствии с ФС.2.5.0063.18 ГФ XIV издания. Установлено, что предложенным в ФС методом УФ-спектрофотометрии определяется количественное содержание не только...

В статье представлены результаты компьютерного прогноза биологи-ческой активности азаметинов 2-амино-4,5,6,7-тетрагидро-1-бензотиофен-3-карбоксамида в веб-ресурсе PASS Online. Согласно им моделируемые соединения обладают выраженной противораковой и антимикобактериальной активностями. Затем был осуществлен синтез исследуемых соединений. The article...

The article considers the study in silico of the affinity of 3-[2-oxo-2-(4-phenyl-1-piperazinyl)ethyl]-4(3H)-quinazolinone (VMA-10-21 compound) to the benzodiazepine binding site of the GABA А receptor by molecular docking method. The computational experiment was carried out using a set of Autodock programs. As a result, the method for predicting t...

Nootropic drugs are an extensive group of drugs that are used in the treatment of various disorders of the сentral nervous system. One of the widely used nootropic medicines is a piracetam, which is a cyclic derivative of γ-aminobutyric acid. Synthesis of new derivatives of the piracetam with a high nootropic activity is a promising direction of cr...

Computer simulation is a rapidly developing method of scientific researches. Currently, computational experiments are being conducted in various fields of human activity, including medical and pharmaceutical. This article discusses the latest achievements and scientific approaches of computer modeling of the cell wall, as well as three-dimensional...

The search for new compounds with а high nootropic biological activity is a promising scientific direction. A modern computational method for predicting pharmacological activity of the studied compounds is the molecular docking. The aim of this work is to study the affinity of new N-acyl derivatives of 2-oxo-1-pyrrolidine acetamide to the binding s...

Nowadays cardiovascular diseases are the main cause of death among the population around the word. The development of new drugs, giving a possibility to normalize blood pressure, is a promising direction in the field of pharmacy and medicine. Now inhibitors of angiotensinconverting enzyme (ACE) are widely adopted for the treatment of hypertension a...