Alexandre Sérgio Silva

Federal University of Paraíba | UFPB · Departamento de Educação Física

Purpose: Beetroot improves the performance of athletes mainly due to the action of nitrate, but it is also rich in antioxidants, and this juice property has been little explored. Thus, this study investigated the effects of beetroot juice on physical performance, nitrite plasmatic and oxidative stress in recreational runners. Method: Eighteen male...

Purpose To investigate the potential relation between methylation of miR-9-3 and stages of diabetic retinopathy (DR). Additionally, we explored whether miR-9-3 methylation impacts the serum levels of Vascular Endothelial Growth Factor (VEGF). Methods A cross-sectional study was conducted with 170 participants with type 2 diabetes, including a cont...

Background Walking/run promotes greater post-exercise hypotension (PEH) than resistance exercise (RE) which can be associated nitric oxide production. Then, we investigated if adding walking between RE increases PEH. Methods Thirteen hypertensive women (48 ± 1.9 years; 26.8 ± 0.3 kg/m²) performed five experimental sessions: 1—traditional RE with p...

We investigated the vasodilatory effects of Hymenaea rubriflora Ducke stem bark extract (HRHAc). Vascular reactivity of the aortic rings of Wistar rats was tested by in vitro cumulative doses (0.1 - 729 μg/mL). Rats (n=5) were treated with 25 (G25), 50 (G50) and 100 (G100) mg/kg of HR-HAc or saline (control group - CG) for four weeks. An in vitro a...

Background The influence of genetic polymorphisms on athletic performance has been widely explored. This study investigated the interactions between the polymorphisms ACTN3 (R577X), ACE (I/D), BDKRB2 (-9/+9), and AGT (M/T) and their association with endurance and strength phenotypes in Brazilian swimmers. Methods 123 athletes (aged 20–30 years) an...

Cajuína is a processed drink derived from cashew and is widely consumed in the northeast region of Brazil. This study evaluated the effect of a cajuína-based hydroelectrolytic drink on the aerobic performance and hydration status of recreational runners. Seventeen males (31.9 ± 1.6 years, 51.0 ± 1.4 ml/kg/min) performed three time-to-exhaustion run...

Background The pulmonary impairment in patients with bronchoconstriction induced by eucapnic voluntary hyperpnea(EVH) goes beyond the respiratory system, also impairing autonomic nervous modulation. This study aimed to evaluate the behavior of cardiac autonomic modulation in young asthmatics with and without EIB after the EVH test. Research design...

Purpose This study aimed to evaluate the capacity of peppermint essential oil to improve the physical performance of runners in running protocol until exhaustion. Methods In a clinical, randomized, double-blind, cross-over and controlled study, fourteen male recreational runners (37.1 ± 2.0 years; 24 ± 1.1 kg/m²; 53.1 ± 1.7 mL kg min) performed tw...

We evaluated the Parkia biglobosa pulp (PB) effects on food intake, body composition and oxidative and in-flammatory parameters related to gut and brain of rats. A total of 32 male Wistar rats were randomised into four groups: healthy (HG), obese (OG); and healthy (HPB) and obese (OPB) groups with PB (400 mg/kg body weight). The rats consumed a con...

Objectives: The aim of this study was to` investigate the effects of intermittent fasting (IF) and the possible association with aerobic exercise on performance, oxidative, biochemical, and somatic parameters of Wistar rats. Methods: Forty rats were randomized into the following groups: sedentary (SC) and trained (TC) controls, sedentary intermi...

We compared the effect of the treatment with strength training (ST) and raloxifene (RALOX) on bone weight, blood glucose, lipid, and antioxidant profile in ovariectomized rats. Twenty-four Wistar rats were distributed into four groups: ovariectomy + VEHICLE (control); ovariectomy + RALOX; ovariectomy + ST; ovariectomy + RALOX + ST. Thirty days afte...

Introduction: cystic fibrosis is a disease that causes inflammation, oxidative stress and metabolic changes that lead to nutrient deficiency, such as vitamin D deficiency. On the other hand, it is suggested that vitamin D has anti-inflammatory and antioxidant actions. Objective: to evaluate the prevalence of hypovitaminosis D and the association...

R e v i s t a B r a s i l e i r a d e N u t r i ç ã o E s p o r t i v a S ã o P a u l o , v. 1 7. n. 102. p. 51-5 8. J a n. / F e v. 202 3. I S S N 1 9 8 1-9927 V e r s ã o E l e t r ô n i c a w w w. r b ne. c o m. b r ABSTRACT Introduction and objective: This study aimed to evaluate the efficacy of babassu mesocarp flour (Orbignya pharelata Mart.)...

In sports, training needs to be done according to various training patterns to optimize performance. However, this has been a major challenge to athletes due to the COVID-19 pandemic, therefore describing the impacts of lockdown caused by the COVID-19 pandemic on the athlete's training routine is necessary. 52 Brazilian athletes (Age: 31.5±10.3 yea...

Background We examined the influence of superoxide dismutase 3 (SOD3) Arg213Gly and Peroxisome Proliferator-Activated α-Receptor (PPARα) 7G/C polymorphisms to a single dose of purple grape juice supplementation on time-to-exhaustion running test, redox balance and muscle damage in recreational runners. Methods Forty-seven male recreational runners...

Phase angle (PhA) is derived from bioimpedance analysis (BIA) and is widely used as an indicator of cellular health, cell membrane integrity, and cell function. Lower-body power and fitness capacity are of paramount importance in success in several sports, including badminton. This study aimed to evaluate the relationship between PhA and lower-body...

Erectile dysfunction (ED) is the inability to achieve and/or maintain a penile erection sufficient for sexual satisfaction. Currently, many patients do not respond to the pharmacotherapy. The effects of a supplementation with Spirulina platensis, were evaluated in a model of ED induced by hypercaloric diet consumption. Wistar rats were divided into...

Few studies have addressed the effect of extra virgin coconut oil (E-VCO) in obesity. Therefore, this study investigated the anti-adiposity effect of E-VCO focusing on biochemical parameters and liver health of obese rats. E-VCO contains caprilyc, capric and lauric fatty acids and rutin, 3,4-dihydroxybenzoic acid, salicylic acid as major phenolic c...

Spirulina platensis has shown effectiveness in the treatment of allergic rhinitis in rats, but its action in tracheal reactivity or on markers of relaxation and antioxidant profile has not yet been possible to determine. In this paper, the animals were divided into the groups healthy (SG) and supplemented with S. platensis at doses of 50 (SG50), 15...

Background Diabetes Mellitus (DM) is directly associated with cardiovascular dysfunctions and microvascular complications, such as diabetic retinopathy (DR). The association between DR and increased risks of developing cardiovascular diseases has been described. The low activity of the Methylenetetrahydrofolate reductase (MTHFR), an enzyme involved...

Purpose To verify associations between phase angle (PhA) and muscle mass, muscle function, and indicators related to health community-dwelling older adults, involved or not in systematic physical training programs. Methods They were evaluated by PhA values, anthropometric measurements, body composition, Timed Up and Go, hand grip strength test, an...

BACKGROUND: Garlic seems to have an influence on blood pressure levels, but the behavior of post-exercise blood pressure after garlic intake is not well established, therefore the present study evaluated the effect of aged garlic extract (AGE) on the hypotensive response to an exercise session. METHODS: Fifteen hypertensive (49.1±1.2 years), partic...

Ethnopharmacological relevance The Waltheria viscosissima A. St.- Hil (Malvaceae) is also known as ‘Malva branca’, has been reported as ethnopharmacologically useful plant containing antinociceptive and anti-inflammatory properties, but scientific evidence is absent. Aim of the study: Elucidate the antinociceptive, anti-inflammatory and antioxidant...

Aims To investigate the association between BsmI and DM2 in patients with and without DR and to correlate with clinical parameters in a population in northeastern Brazil. Methods Cross-sectional case-control study in which data were collected from 285 individuals, including 128 patients with DM2 and 157 with DR. Clinical, biochemical and anthropom...

Background: We examined the influence of superoxide dismutase 3 (SOD3) Arg213Gly and Peroxisome Proliferator-Activated α-Receptor (PPARα) 7G/C polymorphisms to a single dose of purple grape juice supplementation on time-to-exhaustion running test, redox balance and muscle damage in recreational runners. Methods: Forty-seven male recreational runner...

Heart rate variability (HRV) is a relevant physiological variable for the estimation of cardiac autonomic function. Although the gold standard for HRV registration is the electrocardiogram (ECG), several applications (APPs) have been increasingly developed. The evaluation carried out by these devices must be compatible with ECG standards. The aim o...

A hipovitaminose D é considerada uma epidemia mundial com implicações que podem afetar a saúde dos trabalhadores. Trata-se de um estudo transversal, realizado com 91 trabalhadores, a fim de avaliar a prevalência da hipovitaminose D e associações com parâmetros metabólicos. Os participantes foram avaliados quanto ao perfil sociodemográfico e ocupaci...

Zou and colleagues are publishing in this issue of The Journal of Clinical Hypertension, result of one of their studies in which they found that human corin genetic polymorphisms is involved in blood pressure control, more specifically in salt sensitivity. It is being published in this journal shortly after a literature review indicated another 18...

Background: Cystic fibrosis (CF) is a genetic disease that affects the transmembrane conductance regulator gene responsible for modulating chloride ion transportation in the cell membrane. Hypovitaminosis D is frequently observed among fibrocystic disease patients. Therefore, this study was aimed to evaluate the effect of vitamin D3 supplementation...

Strength training increases systemic oxygen consumption, causing the excessive generation of reactive oxygen species, which in turn, provokes oxidative stress reactions and cellular processes that induce uterine contraction. The aim of this study was to evaluate the possible protective effect of Spirulina platensis (SP), an antioxidant blue algae,...

Introduction: Cystic Fibrosis is a disease that causes inflammation, oxidative stress and metabolic changes that lead to nutrient deficiency, such as vitamin D. On the other hand, it is suggested that vitamin D has anti-inflammatory and antioxidant action. Objective: To evaluate the prevalence of hypovitaminosis D and the association between serum...

Considering the role of autonomic nerve activity in blood pressure control, this study aimed to investigate the cardiac autonomic nerve responses after an aerobic exercise session in Anabolic Androgenic Steroids (AAS) users. Twenty men (AAS, n = 9; control group, n = 11) performed an aerobic exercise session (60 min, 70 to 80% of HRmax). Heart rate...

This study tested the hypothesis that naturally and industrially produced trans-fatty acids can exert distinct effects on metabolic parameters and on gut microbiota of rats. Wistar rats were randomized into three groups according to the diet: CONT-control, with 5% soybean oil and normal amount of fat; HVF-20% of hydrogenated vegetable fat (industri...

Although the beneficial effects of aerobic training on cardiovascular risk factors are evident, the potential beneficial effect of strength and combined training on these risk factors is controversial. This study aimed to evaluate the effect of aerobic and strength training programmes, performed alone or in combination, on cardiovascular risk facto...

A deficiência de vitamina A e os distúrbios neurológicos em idososconstituem problemas de Saúde Pública que devem ter mais atençãopor parte das políticas públicas do idoso institucionalizado, devido àsua gravidade e diversidade de causas. Assim, este estudo objetivaavaliar os fatores de risco associados à deficiência de vitamina A emidosos instituc...

Background & Aims Low bone mineral density (BMD) for age in people with Cystic Fibrosis (CF) is associated with worse nutritional status. The aim of this study is to assess body composition by anthropometry as a predictor of bone mineral density in people with CF. Methods Multicenter cross-sectional study with 39 people aged 5 and 20 years with CF...

The objective of this study was to investigate the relationship of the polymorphism in Intron 7 G/C (rs 4253778) of the peroxisome proliferator-activated receptor alpha (PPARα) gene with the magnitude of changes in the body composition of an overweight and obese population that underwent an aerobic training program. Fifty-eight previously inactive...

Background Obesity contributes to several cardiometabolic diseases, such as dyslipidemia, as a result of an unhealthy lifestyle and genetic factors. The methylation profile of genes involved in appetite control and metabolism, such as LEP (leptin) and POMC (proopiomelanocortin) and altered lipid levels can contribute to obesity, and these epigeneti...

Epigenetic alterations such as DNA methylation have been associated with the etiology of inflammation-related diseases. The present study evaluated the association between the methylation levels of LPL , ADRB3 and MTHFR genes and the stage of inflammation in individuals with isolated or associated morbidities, as well as in individuals without morb...

Background: the biological activity of vitamin D depends on the activity of its receptor or VDR. On the other hand, the activity of this receptor is influenced by its state of methylation. The objective of this study was to verify if the BsmI polymorphism of the VDR gene influences its methylation profile in adolescents. Secondly, it was to verify...

Aims Analysis of the relationship between the methylation profile of miR-9-1 or miRs -9-1 / -9-3 and Diabetic Retinopathy. Background Diabetic Retinopathy (DR) is a frequent complication of Diabetes mellitus and it has a decisive impact on quality of life, as it is one of the biggest causes of blindness adult population. Levels of microRNA-9 have...

Exploring an alternative to improve the clinical management of hypertension, we tested the hypothesis that food supplementation with coconut oil (EVCO), alone or combined with aerobic exercise training, could exert an antihypertensive effect (primary outcome) in patients with stage 1 hypertension. Forty-five hypertensive volunteers of both genders...

This study tested the hypothesis that naturally and industrially produced trans fatty acids (TFA) exert distinct effects on rats’ metabolic parameters. Wistar rat groups were fed the diets: CONT - without added fat; HVF − 20% hydrogenated vegetable fat (HVF); and RUM − 20% ruminant fat. Biochemical markers, cytokine levels, fatty acid (FA) composit...

Aim The study aimed to evaluate the effects of vitamin D3 (VD3) supplementation on inflammation and oxidative stress markers in overweight and obese women with deficiency or insufficiency of vitamin D. Methods Twenty-nine overweight or obese women who had a deficiency or insufficiency of vitamin D were placed into two groups according to VD3 inter...

The article A single dose of purple grape juice improves physical performance and antioxidant activity in runners.

Background Clinical studies related to the obesity pandemic have intensified in recent years, being the animal studies are also considered of great relevance. However, despite the fact that many diets have been reported in the literature to induce obesity in animal models, there is still a gap regarding evidence of the efficacy of these models, con...

This study aimed to verify the association between the genotypic of the receptor gene activated by peroxisome proliferators gamma 2 (PPARy2) and the body composition and the specific indicators of adiposity in practitioners physical exercises, considering nutritional intake, age, and training load as influencing factors. It was conducted a cross-se...

Introduction MTHFR methylation status is associated with microvascular complications in diabetes, but the factors influencing this profile remain unknown. Objective The aim of this study was to evaluate the influence of physical activity level and nutritional status on the methylation profile of the MTHFR gene in patients with type 2 diabetes mell...

Purpose. To examine the concurrent validity of rating of perceived exertion (RPE) in resistance exercise with blood flow restriction (RE + BFR). Methods. Twelve trained men participated in an orientation session and 2 experimental sessions: RE + BFR and traditional resistance exercise (TRE). Arm curl and leg extension exercises were standardized by...

Low-density lipoprotein (LDL-C) concentrations are a standard of care in the prevention of cardiovascular disease and are influenced by different factors. This study compared the LDL-C concentrations estimated by two different equations and determined their associations with inflammatory status, oxidative stress, anthropometric variables, food inta...

In recent years, there have been studies in the literature reporting the ergogenic effect of some different foods on sports performance. Given the reasonable number of studies in which some food has shown improvement in some physiological variables related to physical performance, a review is pertinent in order to produce a compilation of these stu...

Aims to evaluate the effect of whole purple grape juice intake in the recovery of oxidative stress, inflammation and muscle injury after an intense training session. Fifteen high level men athletes were randomly distributed in supplemented (GJG; n=8; 28.7 ± 3.5 years) or control group (CG; n=7; 24.8 ± 2.7 years). 400 ml of juice or water was ingest...

Purpose To investigate the effects of a single dose of juice on physical performance, oxidative stress, inflammation and muscle damage in runners. Methods Fourteen recreational male runners (39 ± 9 years, VO2peak = 55.9 ± 6.5 ml/kg/min) performed two running tests to exhaustion at 80% of VO2max after ingesting grape juice or a placebo drink (10 ml...

Background & aims Non-alcoholic fatty liver disease (NAFLD) has been associated with small bowel bacterial overgrowth (SIBO) and cardiometabolic dysfunction. This cross-sectional study aimed to evaluate the cardio-metabolic parameters and SIBO in patients with different degrees of hepatic fibrosis estimated by NAFLD fibrosis score (NFS). Methods S...

This study aimed to evaluate the effects of acute babassu mesocarp flour (BM) supplementation on aerobic capacity, oxidative stress, and muscle damage in recreational runners. 14 men (26,4±8,3 years) were randomly assigned and ingested one single dose of (BM) and maltodextrin (PLA) supplements and performed the 3200m running test. There was a 7-day...

Objective: To evaluate the accuracy of the smartphone application (app) HRV Expert (CardioMood) and a chest strap (H10 Polar) for recording R-R intervals compared with electrocardiogram (ECG). Methods: A total of 31 male recreational runners (age 36.1 [6.3] y) volunteered for this study. R-R intervals were recorded simultaneously by the smartpho...

Spirulina platensis, an important source of bioactive compounds, is a multicellular, filamentous cyanobacterium rich in high-quality proteins, vitamins, minerals, and antioxidants. Due to its nutrient composition, the alga is considered a complete food and is recognized for its anti-inflammatory, antioxidant, antiobesity, and reproprotective effect...

The objective of this study was to verify the influence of the Pro12Ala polymorphism of the PPARγ2 gene in response of a training program on the body composition. Sixty-nine previously inactive men and women (32.8 ± 8.2 years) were genotyped and underwent a 12-week aerobic (running/walking) training program (3–5 sessions, 40 – 60 min per session, a...

The objective of this study was to verify the influence of the Pro12Ala polymorphism of the PPARγ2 gene in response of a training program on the body composition. Sixty-nine previously inactive men and women (32.8 ± 8.2 years) were genotyped and underwent a 12-week aerobic (running/walking) training program (3–5 sessions, 40 – 60 min per session, a...

Background: High levels of oxidative stress promote degradation of the cell membrane impairing cellular function in fat oxidation. However, the influence of oxidative stress on exercise-induced weight-loss has not yet been investigated. Therefore, the aim of this study was to verify the influence of a lipidic peroxidation marker (malondialdehyde,...

The purpose of this study was to verify the influence of ethnicity and polymorphism on the eNOS T-786C gene (rs2070744) in the response of blood pressure to an exercise session. Eighty-nine hypertensive subjects (age, 57.6 ± 8.7 yrs; 26 with white skin and 63 with dark skin) were initially genotyped and submitted to a 60-min running/walking session...