Alexandre Okano

Alexandre Okano
Universidade Federal do ABC (UFABC), São Bernardo do Campo · Center for Mathematics, Computation and Cognition

PhD

About

176
Publications
71,291
Reads
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1,735
Citations
Citations since 2017
71 Research Items
1298 Citations
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2017201820192020202120222023050100150200250300
2017201820192020202120222023050100150200250300
Additional affiliations
November 2017 - present
Universidade Federal do ABC (UFABC), São Bernardo do Campo
Position
  • Professor (Associate)
November 2017 - present
Universidade Federal do ABC (UFABC), São Bernardo do Campo
Position
  • Professor (Associate)
March 2015 - July 2015
California Institute of Technology
Position
  • Faculty Member - Visiting Researcher

Publications

Publications (176)
Article
Full-text available
Background/aim: Currently, the equipment and techniques available to assess brain function during dynamic exercise are limited, which has restricted our knowledge of how the brain regulates exercise. This study assessed the brain areas activated during cycling by making use of a novel cycle ergometer, constructed to measure functional MRI (fMRI) b...
Article
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The study evaluated the effect of transcranial direct current stimulation (tDCS) applied over prefrontal cortex on the oxygen uptake (V˙ O2) at rest and during post-exercise recovery. The V˙ O2 was assessed in eleven healthy subjects before, during tDCS (sham or anodal tDCS, 2 mA, 20 min), and 30-min following isocaloric aerobic exercise (~200 kcal...
Article
Full-text available
Background The temporal and insular cortex (TC, IC) have been associated with autonomic nervous system (ANS) control and the awareness of emotional feelings from the body. Evidence shows that the ANS and rating of perceived exertion (RPE) regulate exercise performance. Non-invasive brain stimulation can modulate the cortical area directly beneath t...
Article
This study investigated whether transcranial direct current stimulation (tDCS) on dorsolateral prefrontal cortex (DLPFC) isolated or combined with aerobic exercise influenced the desire to eat, hunger, and satiety in overweight subjects. Nine volunteers underwent anodal or sham tDCS (2 mA; 20 min) over DLPFC and isocaloric exercise bouts (70%VO(2)R...
Article
To investigate whether the manipulation of brain excitability by transcranial direct current stimulation (tDCS) modulates the heart rate variability (HRV), the effect of tDCS applied at rest on the left temporal lobe in athletes (AG) and non-athletes (NAG) was evaluated. The HRV parameters (natural logarithms of LF, HF, and LF/HF) was assessed in 2...
Article
Purpose: This study investigated the acute effect of anodal transcranial direct current stimulation (a-tDCS) over the left dorsolateral prefrontal cortex (DLPFC) on appetite, energy intake, food preferences, and mood states in the luteal and follicular phases of the menstrual cycle in women presenting premenstrual syndrome. Methods: Sixteen women (...
Article
Full-text available
BACKGROUND: With the increasing meta-analysis studies of noninvasive brain stimulation (NIBS) a major review has become a logical step to provide evidence to support decision-makers. OBJECTIVE: Umbrella reviews of the Working-Group of NAPeN Network (a Brazilian scientific network for NIBS development) will summarize the results of existing evidence...
Article
Full-text available
Background: With the increasing meta-analysis studies of noninvasive brain stimulation (NIBS) a major review has become a logical step to provide evidence to support decision-makers. Objective: Umbrella reviews of the Working-Group of NAPeN Network (a Brazilian scientific network for NIBS development) will summarize the results of existing evidence...
Article
Full-text available
BACKGROUND AND OBJECTIVES Chikungunya virus (CHIKV) chronic polyarthralgia deteriorates general functionality and work productivity. The objective of this study was to evaluate functionality, pain, quality of life, and sleep quality of individuals with chronic CHIKV arthralgia and correlate them with clinical symptoms, work productivity, and activi...
Article
Full-text available
Introduction The chikungunya virus infection is still an epidemic in Brazil with an incidence of 59.4 cases per 100 000 in the Northeast region. More than 60% of the patients present relapsing and remitting chronic arthralgia with debilitating pain lasting for years. Transcranial direct current stimulation (tDCS) appears promising as a novel neurom...
Article
Objective Although relatively costly and non-scalable, non-invasive neuromodulation interventions are treatment alternatives for neuropsychiatric disorders. The recent developments of highly-deployable transcranial electric stimulation (tES) systems, combined with mobile-Health technologies, could be incorporated in digital trials to overcome metho...
Article
Full-text available
Differentiated brain activation in high-performance athletes supports neuronal mechanisms relevant to sports performance. Preparation for the motor action involves cortical and sub-cortical regions that can be non-invasively modulated by electrical current stimulation. This study aimed to investigate the effect of high-definition transcranial direc...
Article
The negative effect of prolonged cognitive demands on psychomotor skills in athletes has been demonstrated. Transcranial direct current stimulation (tDCS) could be used to mitigate this effect. This study examined the effects of tDCS over the left dorsolateral prefrontal cortex (DLPFC) during a 30-min inhibitory Stroop task on cognitive and shootin...
Article
Full-text available
BACKGROUND AND OBJECTIVES Fibromyalgia (FM) is a chronic widespread musculoskeletal pain resulting in central sensitization of nociceptive signaling. Transcranial direct current stimulation (tDCS) over the left motor cortex (M1) is a non-invasive neuromodulation technique indicated for a broad range of chronic pain disorders, including FM. Studies...
Article
Full-text available
Background: Clinical impact of transcranial direct current stimulation (tDCS) alone for Parkinson's disease (PD) is still a challenge. Thus, there is a need to synthesize available results, analyze methodologically and statistically, and provide evidence to guide tDCS in PD. Objective: Investigate isolated tDCS effect in different brain areas and n...
Chapter
The central nervous system plays a crucial role in integrating body signals during exercise, and in generating a relevant response which modulates the pacing and exercise performance. In this regard, the neuromodulatory effects of transcranial direct current stimulation (tDCS) may modulate certain behaviors related to exercise, psychophysiological...
Article
Objective To investigate the effects of tDCS associated with functional exercise on pain, functional performance, psychological symptoms, and quality of life of fibromyalgia (FM) patients. Design Randomized controlled trial. Participants were randomized by blocks into two groups: tDCS associated with functional exercise (n=17) and sham-tDCS associ...
Article
Introduction: Bicycle commuting has economic, environmental, and health benefits. However, it is not clear whether adults meet the physical activity guidelines when performing bicycle commuting in ‘real-world’ scenarios. This study aimed: (1) to verify whether adults reach the maximum heart rate percentage (%HRmax) recommended by the physical activ...
Article
Full-text available
__ (FREE AT: https://www.nature.com/articles/s41598-021-92670-6)__ Transcranial direct current stimulation (tDCS) has been used aiming to boost exercise performance and inconsistent findings have been reported. One possible explanation is related to the limitations of the so-called “conventional” tDCS, which uses large rectangular electrodes, resul...
Article
Full-text available
Introduction: Chronic pain (CP) is highly prevalent and generally undertreated health condition. Noninvasive brain stimulation may contribute to decrease pain intensity and influence other aspects related to CP. Objective: To provide consensus-based recommendations for the use of noninvasive brain stimulation in clinical practice. Methods: Systemat...
Article
Background: Since people with Parkinson disease (PD) rely on limited prefrontal executive resources for the control of gait, interventions targeting the prefrontal cortex (PFC) may help in managing PD-related gait impairments. Transcranial direct current stimulation (tDCS) can be used to modulate PFC excitability and improve prefrontal cognitive f...
Article
This study aimed to examine the effect of transcranial direct current stimulation (tDCS) combined with a recovery training session on the well-being and self-perceived recovery of professional female soccer players after official matches. Data from 13 world-class players were analyzed after participating in four official soccer matches of the first...
Article
Background: due to the quarantine caused by the Coronavirus disease 2019 (COVID-19), professional team-sports adapted their training routine to maintain the athletes' performance and minimize the negative emotional effects. The purpose of the present study was to describe a home-based training program and extra-activities applied during the quarant...
Article
Full-text available
Context Thousands of people worldwide have been infected by the chikungunya virus (CHIKV), and the persistence of joint pain symptoms has been considered the main problem. The mechanisms of neuropathic pain include cortical areas. Neuromodulation techniques such as transcranial direct current stimulation (tDCS) act on brain areas involved in the pr...
Article
Objective: Evaluate the effects of Transcranial Direct Current Stimulation (tDCS) on central and peripheral fatigue in recreational runners. Methodology: A clinical randomized, sham-controlled, triple-blind, cross-over study. There will be 20 adult runners who will be randomized on the first day of the intervention to receive active or sham tDCS...
Article
This study aimed to examine the effect of transcranial direct current stimulation (tDCS) used as a recovery strategy, on heart rate (HR) measures and perceived well-being in 12 male professional soccer players. tDCS was applied in the days after official matches targeting the left dorsolateral prefrontal cortex (DLPFC) with 2 mA for 20 min (F3-F4 m...
Article
Full-text available
Background: Novel coronavirus disease (COVID-19) morbidity is not restricted to the respiratory system, but also affects the nervous system. Non-invasive neuromodulation may be useful in the treatment of the disorders associated with COVID-19. Objective: To describe the rationale and empirical basis of the use of non-invasive neuromodulation in the...
Article
Full-text available
The coronavirus disease 19 (COVID-19) pandemic has resulted in the urgent need to develop and deploy treatment approaches that can minimize mortality and morbidity. As infection, resulting illness, and the often prolonged recovery period continue to be characterized, therapeutic roles for transcranial electrical stimulation (tES) have emerged as pr...
Article
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This study investigated the residual effects of mental fatigue induced by the 30-minute incongruent Stroop Color Word task on subjectively perceived fatigue, reaction time, and heart rate variability (HRV) in 20 adult volunteers (10 men; 10 women). Dependent variables were assessed before, immediately after, and at 15, 30, 45, and 60 minutes after...
Preprint
Full-text available
Background: Novel coronavirus disease (COVID-19) is not restricted to the respiratory system, but also affects the peripheral (PNS) and central (CNS) nervous systems which appear to influence morbidity and mortality. It is urgent to approach all aspects of the disease in order to attenuate the impact of the pandemic. Noninvasive neuromodulation (Ni...
Article
Purpose: Some evidence suggests that sedentary women may be more vulnerable to cognitive task-induced mental fatigue. Mental fatigue, in turn, may worse aerobic exercise performance, presumably via increased perceived effort. However, remains unclear whether acute mental fatigue induction increases perceived effort and worsens endurance performanc...
Article
Full-text available
Background: Novel coronavirus disease (COVID-19) is not restricted to the respiratory system, but also affects the peripheral (PNS) and central (CNS) nervous systems which appear to influence morbidity and mortality. It is urgent to approach all aspects of the disease in order to attenuate the impact of the pandemic. Noninvasive neuromodulation (Ni...
Article
Full-text available
Transcranial Direct Current Stimulation (tDCS) is a non-invasive technique used to modulate neural tissue. Neuromodulation apparently improves cognitive functions in several neurologic diseases treatment and sports performance. In this study, we present a comprehensive, integrative review of tDCS for motor rehabilitation and motor learning in healt...
Article
Interoception has been shown to influence self-regulation of effort and perceived exertion during exercise. However, whether interoceptive accuracy influences submaximal and maximal exercise performance, as well as psychophysiological responses to it, remains elusive. We assessed poor (n = 15) and good (n = 17) heartbeat perceivers young men accord...
Article
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Aim: To investigate the effects of low-intensity walk training with and without blood flow restriction (BRF) on resting heart rate variability (HRV) and blood pressure (BP) in middle-aged men. Methods: Twenty-one men were randomly assigned into the walk training group with (BRF-W; n = 11) and without (NOR-W; n = 10) BFR. The resting HRV and blood...
Article
Background: Transcranial direct current stimulation (tDCS) has been used to improve exercise performance, though the protocols used, and results found are mixed. Objective: We aimed to analyze the effect of tDCS on improving exercise performance. Methods: A systematic search was performed on the following databases, until December 2017: PubMed/MEDL...
Article
Full-text available
Salivary cortisol increases in response to stressors, including physical exertion and psychological stress associated with sports competition. In addition, stress may induce change in brain-derived neurotrophic factor (BDNF). However, there are still no data available to compare the salivary BDNF level in sedentary male individuals and elite team-s...
Article
Full-text available
Background The hypothesis of the central effect of carbohydrate mouth rinse (CMR) on performance improvement in a fed state has not been established, and its psychophysiological responses have not yet been described. The aim of this study was to evaluate the effect of CMR in athletes fed state on performance, biochemical and psychophysiological res...
Article
Arboviral diseases have been considered a global public health problem due to their growing territorial dispersion and impact on the population around the world. Individuals affected by the chikungunya virus go through an acute febrile illness associated with severe pain and long-lasting polyarthralgia. After the initial stage, infected individuals...
Article
Background: Transcranial direct current stimulation (tDCS) is an appropriate treatment for Parkinson's disease (PD). It offers promising results and is known to improve symptoms. Nevertheless, consistent parameters need to be established for research purposes. Objective: To verify the effectiveness of acute tDCS on non-motor and motor symptoms in P...
Article
Full-text available
The Chikungunya (CHIK) virus is epidemic in Brazil, with 170,000 cases in the first half of 2016. More than 60% of patients present relapsing and remitting chronic arthralgia with debilitating pain lasting years. There are no specific therapeutic agents to treat and rehabilitee infected persons with CHIK. Persistent pain can lead to incapacitation,...
Article
This study investigated the effects of mental exertion on Small-Sided-Games (SSG) technical performance, salivary testosterone (T), cortisol (C), and alpha-amylase (sAA) responses in 32 basketball players (15.2±1.2 years; 180±11 cm; 72±15 kg). Technical performance and heart rate (HR) were assessed on two occasions, preceded by a 30-min incongruent...
Poster
Full-text available
INTRODUÇÃO: Os jogos reduzidos no futsal (JRF) são um método de treino bastante utilizado na atualidade. O futsal caracteriza-se por uma modalidade de caráter intermitente e de alta intensidade apresentando uma alta exigência fisiológica. Sendo necessário o monitoramento da carga interna dos atletas. OBJETIVO: Analisar o efeito dos jogos reduzidos...
Poster
Full-text available
INTRODUÇÃO: A reprodutibilidade é de fundamental importância para garantir a confiabilidade de uma medida, garantindo a análise de efetividade de uma determinada intervenção aguda ou crônica. O monitoramento da carga de treinamento tem sido um mecanismo no controle da carga interna de atletas. A Percepção Subjetiva de Esforço (PSE) e Frequência Car...
Article
Full-text available
The aim of this study was to investigate whether carbohydrate mouth rinse (CMR) improves physical performance of cyclists during a 30-km time trial test and its influence on water balance compared to other strategies of fluid intake. Eleven recreationally trained male cyclists completed a 30 km time trial cycle ergometer under three experimental in...
Article
Full-text available
The aim of the present study was to investigate the effect of a short period of supplementation with glutamine dipeptide (GDP) on the acute responses to resistance training on the executive functions of people with HIV/AIDS. The sample consisted of 10 HIV+ women (45.00±12.77 years old; 65.71±12.04 kg; 1.54±0.05 m) who were submitted to a randomized...
Article
Full-text available
Background Individuals with Substance Use Disorder (SUD) have lower baseline metabolic activity of the prefrontal cortex (PFC) associated with impairment of cognitive functions in decision-making and inhibitory control. Aerobic exercise has shown to improve PFC function and cognitive performance, however, its effects on SUD individuals remain uncle...
Article
Full-text available
Background: Pleasure is a key factor for physical activity behavior in sedentary individuals. Inhibitory cognitive control may play an important role in pleasure perception while exercising, especially at high intensities. In addition, separate work suggests that autonomic regulation and cerebral hemodynamics influence the affective and cognitive...
Data
Measures of the prefrontal cortex hemodynamics at rest and at different exercise intensities relative to baseline. (TIFF)
Data
Comparison between maximum exercise intensity and rest on inhibitory control, physiological, and psychological responses in young sedentary adults (n = 37). (PDF)
Data
Measures of inhibitory control and emotion perception at rest and at different exercise intensities. (TIFF)
Data
Measures of heart rate variability at rest and at different exercise intensities. (TIFF)
Data
Characteristics of the sample and individual responses to VO2; Stroop test: RT and Error; ADT; Affective; HRV: LF, HF and LF/HF; Brain oxygenation: O2HB, HHb and HbT. (XLSX)
Data
Correlations between affective responses and oxygen uptake, inhibitory control, associative/dissociative thoughts, heart rate variability, and prefrontal cortex oxygenation during each stage of the incremental exercise (n = 37). (PDF)
Article
Full-text available
The abusive use of alcohol has shown to be associated to cerebral damage, impaired cognition, poor autonomic nervous control, impaired cardiovascular health, increased levels of stress and anxiety, depression symptoms and poor quality of life. Aerobic exercise has shown to be an efficient tool to reduce and overcome these issues. In this case repor...
Article
Introduction: The Wingate Test (WAnT) has been used to evaluate anaerobic performance in cycle ergometer. Objective: The purpose of the present study was to analyze the EMG response of the superficial quadriceps femoris muscles during the Wingate anaerobic test (WAnT). In addition, we investigated the influence of these muscles in performance and f...
Article
This study evaluated whether transcranial direct current stimulation (tDCS) could change physiological and psychological responses during vigorous exercise with a constant load. 13 sedentary males (23.0±4.2 years; 25.6±4.2 kg/m²) took part in this randomized, crossed-over, sham-controlled, and double-blinded study. Participants underwent 2 sessions...
Article
Full-text available
Foram avaliados os efeitos do exercício físico na capacidade de atenção, na memória, no desejo de usar drogas, na percepção de esforço e prazer e no estado de humor de 16 indivíduos em tratamento para dependência de drogas. Foram usados a escala de Brunel, o teste de cancelamento de números, o teste dos blocos de Corsi, a escala de Borg e escala de...