Alexandre moreau-gaudry

Alexandre moreau-gaudry
Université Grenoble Alpes · TIMC-IMAG laboratory

PhD, MD

About

159
Publications
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Publications

Publications (159)
Chapter
Within the PREDIMED Clinical Data Warehouse (CDW) of Grenoble Alpes University Hospital (CHUGA), we have developed a hypergraph based operational data model, aiming at empowering physicians to explore, visualize and qualitatively analyze interactively the complex and massive information of the patients treated in CHUGA. This model constitutes a cen...
Chapter
PREDIMED, Clinical Data Warehouse of Grenoble Alps University Hospital, is currently participating in daily COVID-19 epidemic follow-up via spatial and chronological analysis of geographical maps. This monitoring is aimed for cluster detection and vulnerable population discovery. Our real-time geographical representations allow us to track the epid...
Chapter
Big Data and Deep Learning approaches offer new opportunities for medical data analysis. With these technologies, PREDIMED, the clinical data warehouse of Grenoble Alps University Hospital, sets up first clinical studies on retrospective data. In particular, ODIASP study, aims to develop and evaluate deep learning-based tools for automatic sarcopen...
Article
Full-text available
Analysis of kinematic and postural data of adolescent idiopathic scoliosis (AIS) patients seems relevant for a better understanding of biomechanical aspects involved in AIS and its etiopathogenesis. The present project aimed at investigating kinematic differences and asymmetries in early AIS in a static task and in uniplanar trunk movements (rotati...
Article
Objectifs La préservation nerveuse lors de la prostatectomie totale a été associée à un risque supérieur de marges positives. Nous présentons les Résultats préliminaires et difficultés rencontrées au cours d’une étude translationnelle ex-vivo visant à caractériser le tissu résiduel comme prostatique ou non-prostatique, à l’aide d’une sonde innovant...
Chapter
Full-text available
Gait analysis has evolved significantly during last years due to the great development of the Medical Internet of Things (MIoT) platforms that allow an easy integration of sensors (inertial, magnetic and pressure in our case) to the complex analytics required to compute, not only relevant parameters, but also meaningful indexes. In this paper, we e...
Article
The need for personal protective equipment increased exponentially in response to the Covid-19 pandemic. To cope with the mask shortage during springtime 2020, a French consortium was created to find ways to reuse medical and respiratory masks in healthcare departments. The consortium addressed the complex context of the balance between cleaning me...
Article
PurposeSurgical Data Science (SDS) is an emerging research domain offering data-driven answers to challenges encountered by clinicians during training and practice. We previously developed a framework to assess quality of practice based on two aspects: exposure of the surgical scene (ESS) and the surgeon’s profile of practice (SPP). Here, we wished...
Preprint
Full-text available
Analysis of kinematic and postural data of adolescent idiopathic scoliosis (AIS) patients seems relevant for a better understanding of biomechanical aspects involved in AIS and its etiopathogenesis. The present project aimed at investigating kinematic differences and asymmetries in early AIS in a static task and in uniplanar trunk movements (rotati...
Article
Full-text available
Background Cross‐sectional muscle area (CSMA) at the mid third lumbar vertebra (L3) can be used for sarcopenia diagnosis. The measurement of CSMA is time‐consuming and thus restricted to clinical research. We aimed to compare the automatic module ABACS (Automatic Body composition Analyser using Computed tomography image Segmentation software) with...
Article
Résumé Introduction L’objectif de cette étude était d’évaluer les cals vicieux diaphysaires fémoraux, opérés par enclouage centromédullaire antérograde à l’aide de la stéréoradiographie basse dose EOS. Notre hypothèse était que notre technique chirurgicale rapportait un taux de troubles de rotation radiologiques équivalent à ceux retrouvés dans la...
Article
Background Superselective clamping of tumor-targeted arteries aims to eliminate ischemia of the remnant kidney while keeping tumor bed bloodless during excision. Objective To evaluate the impact of superselective clamping on long-term renal function, compared with renal artery early unclamping. Design, setting, and participants A randomized monoc...
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Internal biliary stenting during biliary reconstruction in liver transplantation decrease anastomotic biliary complications. Implantation of a resorbable internal biliary stent (RIBS) is interesting since it would avoid an ablation gesture. The objective of present work was to evaluate adequacy of selected PLA-b-PEG-b-PLA copolymers for RIBS aimed...
Article
Full-text available
Motivation The principle of Breiman's random forest (RF) is to build and assemble complementary classification trees in a way that maximizes their variability. We propose a new type of random forest that disobeys Breiman’s principles and involves building trees with no classification errors in very large quantities. We used a new type of decision t...
Article
Introduction The aim of the present study was to assess femoral shaft malunion following anterograde intramedullary nailing, using low-dose EOS stereoradiography. The study hypothesis was that our surgical technique is associated with radiological rotation disorder rates equivalent to those reported in the literature. Methods All patients with uni...
Article
Résumé Introduction Certaines structures et pathologies peuvent s’avérer difficiles à mettre en évidence sous contrôle vidéoscopique seul au cours de procédures arthroscopiques. L’échographie est une modalité d’imagerie pouvant apporter une aide au clinicien lors des procédures diagnostiques et thérapeutiques arthroscopiques. L’objectif principal...
Article
Introduction: Certain structures and pathologies can be difficult to reveal under videoscopy alone during arthroscopic surgery. Ultrasound can be a useful contribution in arthroscopic diagnostic and therapeutic procedures. The main aim of the present study was to assess equivalence between endoscopic and external ultrasound for shoulder exploratio...
Article
Biostatistics is one of the transversal subjects that all future doctors must acquire and master. Nonetheless, it is a subject that has the reputation of being difficult, which has not been able to be corrected even with the application of new pedagogical methods such as blended learning. We address this problem with our acculturative and disruptiv...
Article
Full-text available
Grenoble Alpes University Hospital (CHUGA) is currently deploying a health data warehouse called PREDIMED [1], a platform designed to integrate and analyze for research, education and institutional management the data of patients treated at CHUGA. PREDIMED contains healthcare data, administrative data and, potentially, data from external databases....
Article
Full-text available
Background The development of an ultrasound probe that can be used through an arthroscopic portal would provide direct access to the deep tissues of the shoulder. These structures are sometimes barely seen with an external ultrasound system and are also difficult to analyze under arthroscopy. Therefore, this intraoperative imaging technique could r...
Article
Full-text available
Objective: According to a meta-analysis of 7 studies, the median number of patients with at least one adverse event during the surgery is 14.4%, and a third of those adverse events were preventable. The occurrence of adverse events forces surgeons to implement corrective strategies and, thus, deviate from the standard surgical process. Therefore, i...
Article
Objectives To compare sequential fluoroscopy guidance with spiral guidance in terms of safety, effectiveness, speed and radiation in interventional whole body procedures. Methods This study was a retrospective analysis of data from the prospective, randomised controlled, multicentre CTNAV2 study. The present analysis included 385 patients: 247 in...
Article
This article presents a new method to monitor beam shapes from strain measures. The beam is instrumented with strain sensors placed on its surface with an angle of orientation. The method developed is a 3D large deflection beam shape reconstruction based on a beam model incorporating Poisson effect and is thus able to take into account bending, tor...
Article
Purpose Evaluating the quality of surgical procedures is a major concern in minimally invasive surgeries. We propose a bottom-up approach based on the study of Sleeve Gastrectomy procedures, for which we analyze what we assume to be an important indicator of the surgical expertise: the exposure of the surgical scene. We first aim at predicting thi...
Preprint
Full-text available
Objective: A median of 14.4% of patient undergone at least one adverse event during surgery and a third of them are preventable. The occurrence of adverse events forces surgeons to implement corrective strategies and, thus, deviate from the standard surgical process. Therefore, it is clear that the automatic identification of adverse events is a ma...
Article
Grenoble Alpes University Hospital (CHUGA) currently deploys a clinical data warehouse PREDIMED to integrate and analyze for research, education and institutional management the data of patients treated at CHUGA. In this poster, we present the methodology used to implement PREDIMED and illustrate its functionality through three first research use c...
Conference Paper
Full-text available
This article illustrates the maturation process of innovative technologies in the healthcare domain. The role and the involvement of the stakeholders are explained, as well their interaction in the ecosystem. We focus on how the synergy between partners improves efficiency, boosts product development and accelerates market access. The spiral of the...
Article
Full-text available
Introduction: Lung cancer screening in individuals at risk has been recommended by various scientific institutions. One of the main concerns for CT screening is repeated radiation exposure, with the risk of inducing malignancies in healthy individuals. Therefore, lowering the radiation dose is one of the main objectives for radiologists. The aim o...
Article
Needles are tools that are used daily during minimally invasive procedures. During the insertions, needles may be affected by deformations which may threaten the success of the procedure. To tackle this problem, needles with embedded strain sensors have been developed and associated with navigation systems. The localization of the needle in the tis...
Article
Full-text available
Purpose Bracing is the most commonly used treatment for scoliosis. But braces remain predominantly “handcrafted.” Our objective was to create a novel brace simulator using a high-fidelity 3D “avatar” of the patient’s trunk. Methods An observational cross-sectional study was constructed. The inclusion criteria were patients with a moderate idiopath...
Article
This paper presents a new approach validated experimentally to reconstruct with strain gauges the deformed shape of a straight beam with circular cross section. It is based on a novel beam-specific strain gauge model that improves the strain measurement by taking into account the width of the gauges. These improved strain measurements are used by a...
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Introduction/Background As a primary cause of postural and gait disorders, lateropulsion must be systematically assessed after stroke. The current gold standard presenting unsatisfactory metrological properties, we propose a new scale optimized through 4 methodological steps: – conception based on scientific rationale, a critical review of the lite...
Conference Paper
The knowledge of needle location during insertions is essential for the success of interventional radiology procedures. As the needle is susceptible to undergo deformations during its insertion into tissues, several methods have been proposed to monitor the needle deformed shape. Thus, instrumented needles with U-shaped strain gauges are currently...
Article
Full-text available
Pressure ulcers (PU) are known to be a high-cost disease with a risk of severe morbidity. This work evaluates a new clinical strategy based on an innovative medical device (Tongue Display Unit - TDU) that implements perceptive supplementation in order to reduce prolonged excessive pressure, recognized as one of the main causes of PU. A randomized,...
Article
Purpose: To assess the accuracy of Light Puncture Robot (LPR) as a patient-mounted robot, in positioning a sham needle under MRI guidance for abdominal percutaneous interventions. Materials and methods: This monocentric, prospective and non-controlled study was approved by the ethics review board. The study evaluated the accuracy of LPR V3 to ac...
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Purpose: The purpose of this study was to evaluate the usefulness of computed tomography-texture analysis (CTTA) in differentiating between in-situ and minimally-invasive from invasive adenocarcinomas in subsolid lung nodules (SSLNs). Material and methods: Two radiologists retrospectively reviewed 49 SSLNs in 44 patients. There were 27 men and 1...
Article
Introduction Le développement d’une technique capable de détecter et de surveiller de façon précoce la dégénérescence cartilagineuse est crucial pour développer des stratégies préventives. Une meilleure évaluation du cartilage peut être possible grâce à la tomographie par cohérence optique grand champs (FFOCT). La FFOCT est une imagerie innovante q...
Article
Objective: The purpose of this study was to investigate the ability of full-field optical coherence tomography (FFOCT) to qualitatively and quantitatively evaluate cartilage degeneration using the qualitative evaluation of histology sections as the reference. Design: 33 human knee cartilage samples of variable degeneration were included in the s...
Article
Purpose: Evaluation of surgical technical abilities is a major issue in minimally invasive surgery. Devices such as training benches offer specific scores to evaluate surgeons but cannot transfer in the operating room (OR). A contrario, several scores measure performance in the OR, but have not been evaluated on training benches. Our aim was to de...
Article
Full-text available
Background Interventional radiology includes a range of minimally invasive image-guided diagnostic and therapeutic procedures that have become routine clinical practice. Each procedure involves a percutaneous needle insertion, often guided using computed tomography (CT) because of its availability and usability. However, procedures remain complicat...
Article
Full-text available
Purpose To assess the accuracy and usability of an electromagnetic navigation system designed to assist Computed Tomography (CT) guided interventions. Materials and methods 120 patients requiring a percutaneous CT intervention (drainage, biopsy, tumor ablation, infiltration, sympathicolysis) were included in this prospective randomized trial. Nine...
Article
Objective: Each surgical procedure is unique due to patient's and also surgeon's particularities. In this study, we propose a new approach to distinguish surgical behaviors between surgical sites, levels of expertise and individual surgeons thanks to a pattern discovery method. Methods: The developed approach aims to distinguish surgical behavio...
Patent
The invention relates to a method for analysing a surgical operation by endoscopy in an operation field in a space inside the body of an animal, characterised in that it comprises the steps of: detecting at least one tool (1, 2, 3) present in the operation field; detecting at least one portion of an organ (4) in the vicinity of the detected tool (1...
Article
Objectives: This synopsis presents a selection for the IMIA (International Medical Informatics Association) Yearbook 2016 of excellent research in the broad field of Sensor, Signal and Imaging Informatics published in the year 2015, with a focus on Unintended consequences: new problems and new solutions. Methods: We performed a systematic initia...
Article
Introduction L’analyse des lésions cartilagineuse lors d’une arthroscopie de genou est une étape indispensable de l’exploration articulaire car conditionnant la suite de la prise en charge thérapeutique chirurgicale. Cependant l’analyse quantitative des lésions est difficile voire impossible si on considère des paramètres comme l’épaisseur du carti...
Conference Paper
Needles are tools widely used in minimally invasive surgery. During such procedures the localization of the needle and its tip is a challenging situation because of the needle deformations due to its interactions with tissues. To tackle this problem, instrumented needles with sensors have been currently developed to allow needle reconstruction and...
Article
Objectives: The main goal of our phantom study was to compare the precision of adjustable periurethral balloons positioning depending whether the guidance was obtained by retrovision or rigid cystoscopy. Material and methods: A navigation guidance system was used to localize the introduction mandrel which was equipped with tracking targets. Two...
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Full-text available
Introduction We conducted a retrospective study to identify morphological subgroups of patients referred for AD or aMCI and to seek for differences across neuropsychological performances. Methods One hundred forty-five patients (mean age = 76.01, 88 women and 57 men) referred for AD, either at the stage of dementia or aMCI, were examined using stru...
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Purpose: A comanipulator for assisting endorectal prostate biopsies is evaluated through a first-in-man clinical trial. This lightweight system, based on conventional robotic components, possesses six degrees of freedom. It uses three electric motors and three brakes. It features a free mode, where its low friction and inertia allow for natural ma...
Article
Purpose: To guide the surgeon during laparoscopic or robot-assisted radical prostatectomy, an innovative laparoscopic/ultrasound fusion platform was developed, using a motorized 3D-transurethral ultrasound (TUUS) probe. The first preclinical evaluation of 3D-prostate visualization using TUUS and preliminary results of this new augmented reality ar...
Article
Introduction Cette etude monocentrique, prospective, randomisee concerne l’insertion de vis pediculaires (a ciel ouvert ou en percutanee) en comparant l’aide apportee par une imagerie intra-operatoire tri-dimensionnelle ou fluoronavigation 3D versus chirurgie conventionnelle. Methode Soixante-douze patients (42 hommes et 30 femmes + âge moyen de 56...
Article
This synopsis presents a selection for the IMIA (International Medical Informatics Association) Yearbook 2015 of excellent research in the broad field of Sensor, Signal, and Imaging Informatics published in the year 2014, with a focus on patient centered care coordination. The two section editors performed a systematic initial selection and a doubl...
Article
We report a single-center, prospective, randomized study for pedicle screw insertion in opened and percutaneous spine surgeries, using a computer-assisted surgery (CAS) technique with three-dimensional (3D) intra-operative images intensifier (without planification on pre-operative CT scan) vs conventional surgical procedure. We included 143 patient...
Article
Résumé Objectif L’objectif était d’évaluer sur fantôme un nouveau système de guidage électromagnétique par navigation en temps réel, comparativement au guidage par tomodensitométrie (TDM). Matériels et méthodes Une étude comparative, prospective, et randomisée a été réalisée pendant deux jours. Des opérateurs, novices du système de navigation, on...
Article
The purpose of this phantom study was to assess a new real time electromagnetically-guided navigation system and compare it to standard computed tomography (CT) guidance. A prospective, randomized, comparative study was carried out over a two-day period. Operators without prior experience on the new navigation system sequentially attempted to punct...
Patent
Full-text available
The invention concerns an imaging system to monitor at least one surgical instrument in an operative site inside a volume of the body of an animal, comprising: at least one endoscopic camera to obtain endoscopic data on the operative site, at least one ultrasound imaging device to obtain ultrasound data on the operative site, and a processing devic...
Article
The PROSBOT project aims to improve the clinical gesture of prostate biopsy sampling through a pedagogic simulator and a robotic assistance system. The objective of the simulator is to improve the learning curve of systematic and targeted prostate biopsy acquisition through realistic simulations of the gesture and a multitude of pedagogic modules....
Article
Full-text available
Background: Various surgical techniques to treat posterolateral knee instability have been described. To date, the recommended treatment is an anatomic form of reconstruction in which the 3 key structures of the posterolateral corner (PLC) are addressed: the popliteofibular ligament, the popliteus tendon, and the lateral collateral ligament. Purp...
Article
Objective: To retrospectively investigate the diagnostic value of pre-operative CT-features between pre/minimally invasive and invasive lesions in part-solid persistent pulmonary ground glass nodules in a Caucasian population. Materials and methods: Retrospective review of two pre-operative CTs for 31 nodules in 30 patients. There were 10 adenoc...