Alexandra Rouquette

Alexandra Rouquette
French Institute of Health and Medical Research | Inserm · Center for Research in Epidemiology and Population Health CESP

M.D. , Ph.D.

About

125
Publications
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1,434
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Publications

Publications (125)
Article
Importance: The onset of adult psychopathologic disorders can be traced to behavioral or emotional symptoms observed in childhood, which could be targeted in early interventions to prevent future mental disorders. The network perspective is a novel conceptualization of psychopathologic disorders that could help to identify target symptoms with a d...
Article
The Affective Neuroscience Personality Scales (ANPS) is a personality instrument based on six evolutionary-related brain systems that are at the foundation of human emotions and behaviors: SEEKING, CARING, PLAYFULNESS, FEAR, ANGER, and SADNESS. We sought to assess for the short and long versions of the ANPS: (a) the longitudinal measurement invaria...
Article
Determining the minimal clinically important difference (MCID) of questionnaires on an interval scale, the trait level (TL) scale, using item response theory (IRT) models could overcome its association with baseline severity. The aim of this study was to compare the sensitivity (Se), specificity (Sp), and predictive values (PVs) of the MCID determi...
Article
The ratio of subjects to variables (N/p), as a rule to calculate the sample size required in internal validity studies on measurement scales, has been recommended without any strict theoretical or empirical basis being provided. The purpose of the present study was to develop a tool to determine sample size for these studies in the field of psychia...
Preprint
Symptomatic COVID-19 appears to be associated with suicidal ideation but longitudinal evidence is still scarce. SARS-CoV2-induced neurological damages might underline this association, but findings are inconsistent. We therefore investigated the association between COVID-19 disease and subsequent suicidal ideation in the general population, using b...
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Objective The COVID-19 epidemic has spread worldwide since December 2019. To contain it, preventive measures including social distancing, economic shutdown, and school closures were introduced, carrying the risk of mental health burden in adults and children. Although the knowledge base regarding children's response to trauma and adverse events in...
Article
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Objective To assess whether lack of trust in the government and scientists reinforces social and racial inequalities in vaccination practices. Design A follow-up of the EpiCov random population-based cohort survey. Setting In July 2021, in France. Participants Eighty-thousand nine hundred and seventy-one participants aged 18 years and more. Mai...
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Emerging research suggests that the prevalence of child and adolescent mental health problems has increased considerably during the COVID-19 crisis. However, there have been few longitudinal studies on children’s mental health issues according to their social determinants in this context, especially in Europe. Our aim was to investigate the associa...
Article
Résumé Une faible exposition à la lumière naturelle extérieure et une forte exposition aux écrans sont des perturbateurs du sommeil et des rythmes circadiens. Lors du premier confinement en mars-mai 2020 en France, certains comportements ont pu être modifiés. Nous avons voulu décrire et étudier les relations entre l'exposition à la lumière (naturel...
Preprint
Objective To examine the relationship between young adults’ labor force participation and depression in the context of the COVID-19 pandemic. Design, Setting, Participants Data come from the nationally-representative EPICOV cohort study set up in France, and were collected in 2020 and 2021 (3 waves of online or telephone interviews) among 2217 par...
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Background The interplay between age and symptoms intensity on antibody response to SARS-CoV-2 infection has not been studied in a general population setting. Methods We explored the serologic profile of anti-SARS-CoV-2 antibodies after the first wave of the pandemic, by assessing IgG against the spike protein (ELISA-S), IgG against the nucleocaps...
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Inclusion of students with Autism Spectrum Disorder (ASD) in mainstream schools has a positive impact on their social and daily living behaviors. Our objective was to identify clinical and socio-demographic variables promoting or limiting inclusion in mainstream school through childhood and adolescence. The EpiTED study is a long-term, prospective,...
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Background We aimed to estimate the seroprevalence of SARS-CoV-2 infection in France and to identify the populations most exposed during the first epidemic wave. Methods Random selection of individuals aged 15 years or over, from the national tax register (96% coverage). Socio-economic data, migration history, and living conditions were collected...
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Background The Patient Reported Outcome Measurement Information System profile instruments include “high information” items drawn from large item banks following the application of modern psychometric criteria. The shortest adult profile, PROMIS-29, looks set to replace existing short-form instruments in research and clinical practice. The objectiv...
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COVID-19 limitation strategies have led to widespread school closures around the world. The present study reports children’s mental health and associated factors during the COVID-19 school closure in France in the spring of 2020. We conducted a cross-sectional analysis using data from the SAPRIS project set up during the COVID-19 pandemic in France...
Preprint
Background Our main objective was to study the early social dynamics of the COVID-19 epidemic in France, taking into account gender, class, and ethnicity inequalities in living conditions. Methods A random population-based survey was conducted in France in May 2020, during and post COVID-19 lockdown, in which 77,588 participants aged 18-64 were inc...
Article
Background: While randomized clinical trials have shown the benefit of thrombolysis and endovascular thrombectomy (EVT) in patients with acute ischemic stroke (AIS), we aimed to describe in a real-life study the differences between older (>80 years old) and younger patients treated for AIS. Methods: Thousand patients treated with thrombolysis an...
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Full-text available
Background: Several countries have implemented mobile apps in an attempt to trace close contacts of patients with COVID-19 and, in turn, reduce the spread of SARS-CoV-2. However, the effectiveness of this approach depends on the adherence of a large segment of the population. Objective: The aims of this study were to evaluate the acceptability of...
Article
Full-text available
Background: We aimed to estimate the seropositivity to anti-SARS-CoV-2 antibodies in May-June 2020 after the first lockdown period in adults living in three regions in France and to identify the associated risk factors. Methods: Between 4 May 2020 and 23 June 2020, 16 000 participants in a survey on COVID-19 from an existing consortium of three...
Article
Objective To simultaneously investigate the psychometric properties of three recently developed health literacy measurement scales throughout adolescence in the general population. Methods French versions of the Health Literacy for School-Aged Children (HLSAC, unidimensional) scale, the Health Literacy Assessment Scale for Adolescents (HAS-A, mult...
Poster
Introduction Dans le but de réduire le nombre de personnes infectées par la COVID-19, plusieurs pays ont mis en œuvre des applications mobiles pour retracer les contacts étroits de la personne infectée par le SARS-CoV-2. Cependant, cette approche nécessite une large adhésion de la population pour être efficace. Cependant, depuis mars, de telles app...
Preprint
Full-text available
Background: COVID-19 limitation strategies have led to widespread school closures around the world. The present study reports children’s mental health and associated factors during the COVID-19 school closure in France in the spring of 2020. Methods: We conducted a cross-sectional analysis using data from the SAPRIS project set up during the COVID-...
Article
Full-text available
Background The Catquest-9SF questionnaire is a patient reported outcome measure that quantifies the visual benefits from cataract surgery. The purpose of this study was to translate and adapt the Catquest-9SF questionnaire for France, to assess its psychometric properties via Rasch analysis, and to assess its validity when completed using an electr...
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Background Our main objectives were to estimate the incidence of illnesses presumably caused by SARS-CoV-2 infection during the lockdown period and to identify the associated risk factors. Methods Participants from 3 adult cohorts in the general population in France were invited to participate in a survey on COVID-19. The main outcome was COVID-19...
Preprint
BACKGROUND Several countries have implemented mobile apps in an attempt to trace close contacts of patients with COVID-19 and, in turn, reduce the spread of SARS-CoV-2. However, the effectiveness of this approach depends on the adherence of a large segment of the population. OBJECTIVE The aims of this study were to evaluate the acceptability of a...
Preprint
Full-text available
Background Our main objectives were to estimate the incidence of illnesses presumably caused by SARS-CoV-2 infection during the lockdown period and to identify the associated risk factors. Methods Participants from 3 adult cohorts in the general population in France were invited to participate in a survey on COVID-19. The main outcome was possible...
Preprint
Full-text available
Aim To estimate the seroprevalence of SARS-CoV-2 infection in May-June 2020 after the lockdown in adults living in three regions in France and to identify the associated risk factors. Methods Participants in a survey on COVID-19 from an existing consortium of three general adult population cohorts living in the Ile-de-France (IDF) or Grand Est (GE)...
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Objectives: Cultural variations complicate psychiatric care, especially for migrant children. Transcultural psychotherapy (TCP) is an original psychotherapeutic technique developed to address complex situations of resistant mental disorders in the context of migration. This research will aim to assess the efficacy, the acceptability, and describe...
Article
Introduction La surcharge d’informations liée au cancer (« Cancer Information Overload », CIO) est définie par Jensen en 2014 par le « sentiment de surcharge induit par la quantité de données relatives au cancer dans l’environnement informationnel ». Son intrication avec des phénomènes psycho-cognitifs tels que l’évitement informationnel, le scepti...
Article
Background Many people feel overwhelmed by the increasing amount of cancer-related material available in the information environment. Our aims was to evaluate the psychometric properties of the brief version of the cancer information overload (CIO) scale and to examine the association between CIO and multiple cancer prevention behaviors. Methods A...
Article
Objectives To demonstrate the best psychometric properties of the revised 5-item Cancer Information Overload (CIO) scale over the 10- and 8-item versions, for both English and French native speakers, and to explore the relationships between CIO and several cancer risk management behaviours in a large sample of caregivers, cancer survivors and healt...
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Background: Fibrinogen concentrate is widely used in traumatic hemorrhagic shock despite weak evidence in the literature. The aim of the study was to evaluate the effect of fibrinogen concentrate administration within the first 6 hours on 24-hour all-cause mortality in traumatic hemorrhagic shock using a causal inference approach. Methods: Obser...
Article
Context; The left ventricular filling pressure (LVFP) is correlated to right atrial pressure (RAP) in heart failure. We compared diagnostic value of the inferior vena cava (IVC) measurements to the one of the 2016 echocardiographic recommendations to estimate LVFP in patients with suspected heart failure with preserved ejection fraction (HFpEF). M...
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Background While patient-centered care is recommended as a key dimension for quality improvement, in case of serious illness, patients may have different expectations regarding information and participation in medical decision-making. In oncology, anticipation of disease worsening remains difficult, especially when patient’s preferences towards pro...
Article
Aims To evaluate the level of N-terminal pro brain natriuretic peptide and brain natriuretic peptide (NTproBNP and BNP) for acute heart failure (AHF) diagnosis in patients aged 75 or older. Background In a previous smaller study of very old patients with acute dyspnoea, despite being independently associated with the cardiac aetiology, BNP level w...
Article
Context Echocardiography is an essential tool for evaluation of left ventricular filling pressure (LVFP). We aimed to assess the usefulness of inferior vena cava (IVC) measurement and the 2016 ESC recommendations in patients with suspected heart failure with preserved ejection fraction (HFpEF). Methods Invasive hemodynamics and echocardiographic m...
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Background Transporting a severely injured patient directly to a trauma center (TC) is consensually considered optimal. Nevertheless, disagreement persists regarding the association between secondary transfer status and outcome. The aim of the study was to compare adjusted mortality between road traffic trauma patients directly or secondarily trans...
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Introduction Treatment credibility and patient expectancy of improvement have been increasingly considered in clinical research. Objectives The objective of this study was to carry out the cross-cultural validation of a French-language version of the credibility/expectancy questionnaire (CEQ), to further document the psychometric properties of the...
Article
Study question: Is the Sexual Activity Questionnaire (SAQ) a valid tool for patients treated for symptomatic endometriosis? Summary answer: For women having surgical treatment for endometriosis, we determined that the SAQ is a valid and responsive tool. What is known already: Endometriosis adversely affects sexual quality of life. Suitable val...
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Objective The aims were to review practices concerning Differential Item Functioning (DIF) detection in composite measurement scales, particularly those used in health research, and to provide guidance on how to proceed if statistically significant DIF is detected. Methods This work specifically addressed the Rasch model which is the subject of gr...
Data
Median of the rating (from 1-“strongly disagree” to 7-“strongly agree”) by the seven reviewers to each items of the Appraisal of Guidelines for Research & Evaluation II (AGREE II) adapted for the evaluation of methodological recommendations and score to each of the six domains. (DOCX)
Data
List of the references of the 285 articles included in the literature review. References with 2015 as year of publication were published online during the search period: November 11, 2013 and November 10, 2014. (DOCX)
Data
Median of the rating (from 1-“strongly disagree” to 7-“strongly agree”) by the seven reviewers to each items of the Appraisal of Guidelines for Research & Evaluation II (AGREE II) adapted for the evaluation of methodological recommendations and score to each of the six domains. (DOCX)
Data
Evaluation of the effects of the presence of DIF and practices and/or recommendation produced for its management in practice. N = 71 articles in which statistically significant DIF was found. (DOCX)
Article
Full-text available
RÉSUMÉ : Cette étude explore les expériences et désirs des étudiants concernant les programmes d’éducation à la santé mentale au cours de leur scolarité. La rareté de ces dispositifs nous a amené à approfondir le point de vue des anciens élèves pour dynamiser l’implantation de séances d’éducation à la santé mentale à l’école. En effet, ce type de p...
Article
Background:: The pain trajectory after ankle surgeries for osteoarthritis is relevant to describe. The purpose of this prospective study was to describe pain after ankle surgery and explore the link between perioperative factors and the development of postoperative pain. Methods:: Duration, severity, type of preoperative pain, psychological dist...
Article
Full-text available
Background Short versions of the European Health Literacy Survey (HLS-EU) questionnaire are increasingly used to measure and compare health literacy (HL) in populations worldwide. As no validated versions of these questionnaires have thus far appeared in French, this study aimed to study the psychometric properties of the French translation of the...
Data
Rasch person-item map of the European Health Literacy Survey Questionnaire with 16 items (HLS-EU-Q16) in the sample (N = 317). A higher (positive) location value indicates higher health literacy of the persons or greater item difficulty (logit scale). (DOCX)
Data
French version of the European Health Literacy Survey Questionnaire short form with 16 items (HLS-EU-Q16). (DOCX)
Data
Expected score on the European Health Literacy Survey Questionnaire with 16 items depending on education level and expected difference in score due to differential item functioning across education levels (reference “Post-secondary”) as a function of latent trait (as an example, for subjects with a health literacy level at 2 logits on the latent tr...
Data
Items from the European Health Literacy Survey Questionnaire short forms, 16 items (HLS-EU-Q16) and 6 items (HLS-EU-Q6, in bold, and the health contexts and health-information-processing skills to which they apply. (DOCX)
Data
HLSEUvalidFrench.xls is the database used in this study. (XLS)
Data
Frequencies (%) of responses to the 16 items of the European Health Literacy Survey Questionnaire short forms, HLS-EU-Q16 and HLS-EU-Q6 (in bold), in the sample (N = 317). (DOCX)
Article
Full-text available
Background: Haemorrhagic shock is the leading cause of early preventable death in severe trauma. Delayed treatment is a recognized prognostic factor that can be prevented by efficient organization of care. This study aimed to develop and validate Red Flag, a binary alert identifying blunt trauma patients with high risk of severe haemorrhage (SH),...
Article
Context Besides GNAS gene mutations, the molecular pathogenesis of somatotroph adenomas responsible for gigantism and acromegaly remains elusive. Objective To investigate alternative driver events in somatotroph tumorigenesis, focusing on a subgroup of acromegalic patients with a paradoxical increase in GH secretion after oral glucose, resulting f...
Article
Background: PROMIS-29 is a new generic standardized questionnaire measuring self-reported health status. It was developed as part of the Patient Reported Outcome Measurement Information System (PROMIS) in the United States. The objective of this study was to carry out the psychometric validation of a French-language version of PROMIS-29 and to est...
Article
PurposeSepsis and non-septic systemic inflammatory response syndrome (SIRS) are the same syndromes, differing by their cause, sepsis being secondary to microbial infection. Microbiological tests are not enough to detect infection early. While more than 50 biomarkers have been proposed to detect infection, none have been repeatedly validated. AimTo...