Alexandra Rouquette

• M.D. , Ph.D.
• French Institute of Health and Medical Research

Importance: The onset of adult psychopathologic disorders can be traced to behavioral or emotional symptoms observed in childhood, which could be targeted in early interventions to prevent future mental disorders. The network perspective is a novel conceptualization of psychopathologic disorders that could help to identify target symptoms with a d...

The Affective Neuroscience Personality Scales (ANPS) is a personality instrument based on six evolutionary-related brain systems that are at the foundation of human emotions and behaviors: SEEKING, CARING, PLAYFULNESS, FEAR, ANGER, and SADNESS. We sought to assess for the short and long versions of the ANPS: (a) the longitudinal measurement invaria...

Determining the minimal clinically important difference (MCID) of questionnaires on an interval scale, the trait level (TL) scale, using item response theory (IRT) models could overcome its association with baseline severity. The aim of this study was to compare the sensitivity (Se), specificity (Sp), and predictive values (PVs) of the MCID determi...

The ratio of subjects to variables (N/p), as a rule to calculate the sample size required in internal validity studies on measurement scales, has been recommended without any strict theoretical or empirical basis being provided. The purpose of the present study was to develop a tool to determine sample size for these studies in the field of psychia...

Background To examine the psychometrics properties of the French version of two scales measuring general (HLS19-Q12) and navigational (HLS19-NAV) health literacy (HL) using validation methods based on modern psychometric test theories: a Rasch model analysis. Methods The data on representative samples of the French adult population came from the H...

Introduction: Thrombolysis and endovascular thrombectomy (EVT) are standard treatments after stroke. We previously reported that these therapies benefit stroke patients over 80 years old. Now, we aimed to study reperfusion therapies specifically in nonagenarians, hypothesizing a poorer prognosis in this group. Methods: Nonagenarian stroke patien...

A redefinition of mental health literacy: Mental health literacy refers to the extent to which people are able to access, understand, appraise, and apply information to maintain and promote mental well-being and resilience, cope with psychosocial challenges and stress, and deal with mental health problems and illnesses. It is the result of the in...

Introduction : L’utilisation des dispositifs numériques en santé améliorerait certains résultats cliniques. Proposer des interventions « en ligne » efficaces visant l’amélioration du processus d’adaptation des patients vivant avec une maladie chronique nécessite de disposer d’une mesure validée de la littératie en santé numérique. La mesure autorap...

We aimed to explore the sexual health of young adults with perinatally acquired human immunodeficiency virus (PHIV). Eighteen to 25 years old PHIV participants were recruited in two tertiary care units in Paris. Sexually transmitted HIV was an exclusion criterion. Individual interviews were conducted. Transcripts were analyzed using a semio-pragmat...

Background While social disparities in depression are well-documented, the symptom experience across social positions remains less studied. Aims This study examines the connections between depressive symptoms and self-recognizing a depressive episode, on the one hand, and clinical diagnosis, on the other hand, by three social position indicators....

French Child and Adolescent Psychiatry (CAP) faces significant issues, primarily due to an overwhelming increase in demand and insufficient capacity. In response, the French Society for Child and Adolescent Psychiatry and Allied Professions (SFPEADA) initiated an action research project in June 2023 aimed at reimagining the future of CAP in France...

French Child and Adolescent Psychiatry (CAP) faces significant issues, primarily due to an overwhelming increase in demand and insufficient capacity. In response, the French Society for Child and Adolescent Psychiatry and Allied Professions (SFPEADA) initiated an action research project in June 2023 aimed at reimagining the future of CAP in France...

It is unclear how the risk of post-covid symptoms evolved during the pandemic, especially before the spread of Severe Acute Respiratory Syndrome Coronavirus 2 variants and the availability of vaccines. We used modified Poisson regressions to compare the risk of six-month post-covid symptoms and their associated risk factors according to the period...

Background We aimed to measure the variance due to examination conditions during the first sessions of objective structured clinical examinations (OSCEs) performed at a French medical school and identify factors associated with student success. Methods We conducted a retrospective, observational study using data from the first three OSCEs sessions...

Objectif : L’innovation biomédicale est amenée à prendre de plus en plus de place dans les parcours de soins et les débats sur la santé. Dans les mesures de littératie en santé qui se développent, le rapport à la recherche médicale est encore absent. Dans cet article, nous explorons la relation entre la littératie en santé et le rapport à la recher...

School refusal (SR) is a form of school attendance problem (SAP) that requires specific mental health care. Despite improvements in the definition of SAPs, the course of SR is not well characterized. To explore three-year patterns of SR course in children, as reported by their parents, we deployed an anonymous web-based survey. We defined SR onset...

Introduction : Une étude observationnelle multicentrique a été réalisée dans dix ESMS et mobilisait une méthodologie mixte (visite des structures, enquête par questionnaires, entretiens semi-directifs collectifs avec des professionnels et individuels avec des usagers). But de l’étude : Cet article vise à décrire la gestion et la prévention du tabag...

Symptomatic effects of mental disorders in parents could bias their reporting on their child’s mental health. This study aimed to investigate the measurement invariance of the French version of the parental Strengths and Difficulties Questionnaire (SDQ) across parental mental health in a sample (N = 20,765) of parents of children aged 3 to 17 years...

Le handicap est un vécu personnel et relationnel mais aussi un enjeu de société, car il met au défi les valeurs théoriquement partagées de l’autonomie et de l’inclusion. Sur fond de ces valeurs, le handicap est désormais confronté à la question brûlante de la désinstitutionnalisation, dont se saisissent à la fois des acteurs et actrices du droit in...

Le décours de la crise sanitaire du COVID-19 fut marqué par des observations inquiétantes concernant la santé mentale des enfants, adolescents et jeunes adultes. L’épidémiologie psychiatrique française a longtemps manqué de données fiables et régulières pour estimer les troubles psychiatriques et documenter les déterminants de la santé mentale des...

Diagnosis of herpes simplex keratitis (HSK) is mostly based on clinical findings, yet biological confirmation supports management of challenging cases. This study evaluated the place of real-time quantitative PCR (RT-qPCR) on tear samplings in the management of HSK. Clinical records of patients who underwent tear sampling tested by RT-qPCR for herp...

Background: To examine the psychometrics properties of the French version of two scales measuring general (HLS19-Q12) and navigational (HLS19-NAV) health literacy (HL) using two validation methods based on modern psychometric test theories: a Rasch model analysis and structural equation models (SEM). Methods: The data on representative samples of t...

Background School refusal (SR) is a form of school attendance problem (SAP) that requires specific mental health care. Despite improvements in the definition of SAPs, the course of SR is not well characterized. Methods To explore three-year patterns of SR course in children, as reported by their parents, we deployed an anonymous web-based survey....

Symptomatic effects of mental disorders in parents could bias their reporting on their child’s mental health. This study aimed to investigate the measurement invariance of the French version of the parental Strengths and Difficulties Questionnaire (SDQ) across parental mental health in a sample (N=20,765) of parents of children aged 3 to 17 years i...

Background Improving eHealth Literacy (eHL) is a biggest challenge facing the global healthcare community. Indeed, the use of digital services has the potential to engage patients in care, it remains highly dependent on patients’ specific skills. The aim of this study was to systematically review currently available instruments of eHL for adult pop...

IntroductionThe context of the COVID-19 pandemic has changed the daily life of families and children. Screen exposure was increased during this period to maintain social relationships, work remotely, and occupy leisure time. Objectives To explore the association of continued above-recommendation screen use for one year since May 2020 with behaviour...

Background: The development of telehealth and telemedicine, in the form of increased teleconsultation and medical telemonitoring, accelerated during the COVID-19 health crisis in France to ensure continued access to care for the population. Since these new information and communication technologies (ICTs) are diverse and likely to transform how th...

Retrouvez toutes nos données sur data.drees juin 2023 n° 1271 Près d'un enfant sur six a eu besoin de soins pour un motif psychologique entre mars 2020 et juillet 2021 La détresse psychologique dont souffrent une minorité grandissante d'enfants et d'adolescents a été aggravée par la crise sanitaire. Ce phénomène, observé dans d'autres pays, semble...

https://www.cairn-int.info/journal-population-2023-3-page-479.htm?contenu=resume Implemented on a massive scale during the Covid-19 pandemic, telework is now an established form of work organization, but its effects on workers’ well-being remain a subject of debate. Drawing on data from a longitudinal survey representative of the French population...

Importance: The long-term consequences of COVID-19 on mental health are a critical issue given the number of people infected with SARS-CoV-2 worldwide since the beginning of the pandemic. Objective: To investigate the associations between self-reported COVID-19-like symptoms or SARS-CoV-2 seropositivity and subsequent depression or anxiety. Des...

Objectives: Findings from a birth cohort study indicated that the mental health of young adults had not worsened during the first wave of the COVID-19 pandemic, compared to 2018. This study examined longitudinal changes in mental health between March 2018 and June 2021 in the context of protracted public health mitigation measures about 12 months...

Several risk factors of children’s mental health issues have been identified during the pandemic of COronaVIrus Disease first appeared in 2019 (COVID-19). This study aims to fill the knowledge gap regarding the association between parents’ and children’s mental health issues during the COVID-19 school closure in France. We conducted a cross-section...

Objectives: To estimate the proportion of users of the TousAntiCovid app(lication) and identify factors associated with its non-use for contact tracing. Methods: We conducted an online survey of a quota sample of French adults between 8 and 18 January 2021. Three categories of TousAntiCovid use were considered: contact tracing, other or temporar...

Aims To investigate associations between outdoor and screen time and changes in sleep patterns in children from two nationwide birth‐cohorts in the SAPRIS project. Methods During the first French COVID‐19 pandemic lockdown, volunteer parents of children enrolled in the ELFE and EPIPAGE2 birth‐cohorts completed online questions about their child's...

Background A higher risk of suicidal ideation associated with self-report of Coronavirus Disease 2019 (COVID-19)-like symptoms or COVID-19 infection has been observed in cross-sectional studies, but evidence from longitudinal studies remains limited. The aims of this study were 2-fold: (1) to explore if self-reported COVID-19-like symptoms in 2020...

Children’s screen time increased as a result of the COVID-19 pandemic. In the summer of 2021, we explored the association between high screen time over a period of one year since May 2020 and behavioural problems among children and adolescents. The data were derived from the French EpiCov cohort study, collected in spring 2020, autumn 2020, and spr...

Objective Children's screen time increased as a result of the COVID-19 pandemic. In summer 2021 we explored the association between high screen time over a period of one year since May 2020 and behavioural problems among children and adolescents. Methods The data was derived from the French EpiCov cohort study, collected in spring 2020, autumn 2020...

Objectives: To assess the psychometric properties of the Coronavirus Information Overload scale (CovIO) and explore relationships between CovIO, its predictors and several health behaviours related to the COVID-19 pandemic, using Cancer Information Overload (CIO) scale results as a reference for comparison. Methods: 2003 participants representat...

BACKGROUND The development of telehealth and telemedicine, in the form of increased teleconsultation and medical telemonitoring, accelerated during the COVID-19 health crisis in France to ensure continued access to care for the population. Since these new information and communication technologies (ICTs) are diverse and likely to transform how the...

The purpose of this study is to clarify the relationship between having a chronic condition (CC) and several types of risky sexual behaviour (RSB) among adolescents and young adults. We used data from a multicentre cross-sectional study carried out on 14,431 adolescents from 137 French schools. Logistic regression was used to assess the association...

The sudden and unanticipated shocks to employment and the almost total retreat into the domestic sphere caused by the COVID-19 lockdowns provide a unique opportunity to explore the resilience of the three classical theoretical paradigms of the gendered division of labor within couples, that is, the time availability theory, the relative resource th...

Objective To examine the relationship between young adults' labor force participation and depression in the context of the COVID-19 pandemic. Design, setting, participants Data come from the nationally-representative EPICOV cohort study set up in France, and were collected in 2020 and 2021 (3 waves of online or telephone interviews: 02/05/2020–12/...

Background Improving eHealth literacy (eHL) is one of the biggest challenges currently facing the global healthcare community. Indeed the use of digital services has the potential to engage patients in care as well as improve the effectiveness of chronic disease self-management, it remains highly dependent on a patient’s specific skills and experie...

Introduction The COVID-19 pandemic seems associated with a worsening in mental health issues as well as a widening of pre-existing social and health inequalities. Assessment of its impact on suicidal behavior might therefore be relevant. Objectives To assess factors associated with suicidal ideation in the general population, using data from the F...

Objectives Multidisciplinary approaches to treating chronic pain have been proven effective. Currently, chronic pain patients face lengthy waitlists in pain medicine departments. To overcome this problem, we developed the “FastSchool” program to educate patients about pain management and treatment. In this study, we evaluated the benefit of a “Fast...

Symptomatic COVID-19 appears to be associated with suicidal ideation but longitudinal evidence is still scarce. SARS-CoV2-induced neurological damages might underline this association, but findings are inconsistent. We therefore investigated the association between COVID-19 disease and subsequent suicidal ideation in the general population, using b...

Objective The COVID-19 epidemic has spread worldwide since December 2019. To contain it, preventive measures including social distancing, economic shutdown, and school closures were introduced, carrying the risk of mental health burden in adults and children. Although the knowledge base regarding children's response to trauma and adverse events in...

Emerging research suggests that the prevalence of child and adolescent mental health problems has increased considerably during the COVID-19 crisis. However, there have been few longitudinal studies on children’s mental health issues according to their social determinants in this context, especially in Europe. Our aim was to investigate the associa...

Résumé Une faible exposition à la lumière naturelle extérieure et une forte exposition aux écrans sont des perturbateurs du sommeil et des rythmes circadiens. Lors du premier confinement en mars-mai 2020 en France, certains comportements ont pu être modifiés. Nous avons voulu décrire et étudier les relations entre l'exposition à la lumière (naturel...

Objective To examine the relationship between young adults’ labor force participation and depression in the context of the COVID-19 pandemic. Design, Setting, Participants Data come from the nationally-representative EPICOV cohort study set up in France, and were collected in 2020 and 2021 (3 waves of online or telephone interviews) among 2217 par...

Background The interplay between age and symptoms intensity on antibody response to SARS-CoV-2 infection has not been studied in a general population setting. Methods We explored the serologic profile of anti-SARS-CoV-2 antibodies after the first wave of the pandemic, by assessing IgG against the spike protein (ELISA-S), IgG against the nucleocaps...

Inclusion of students with Autism Spectrum Disorder (ASD) in mainstream schools has a positive impact on their social and daily living behaviors. Our objective was to identify clinical and socio-demographic variables promoting or limiting inclusion in mainstream school through childhood and adolescence. The EpiTED study is a long-term, prospective,...

Background We aimed to estimate the seroprevalence of SARS-CoV-2 infection in France and to identify the populations most exposed during the first epidemic wave. Methods Random selection of individuals aged 15 years or over, from the national tax register (96% coverage). Socio-economic data, migration history, and living conditions were collected...

Background The Patient Reported Outcome Measurement Information System profile instruments include “high information” items drawn from large item banks following the application of modern psychometric criteria. The shortest adult profile, PROMIS-29, looks set to replace existing short-form instruments in research and clinical practice. The objectiv...

COVID-19 limitation strategies have led to widespread school closures around the world. The present study reports children’s mental health and associated factors during the COVID-19 school closure in France in the spring of 2020. We conducted a cross-sectional analysis using data from the SAPRIS project set up during the COVID-19 pandemic in France...

Background COVID-19 limitation strategies led to widespread school closures around the world. The present study aims to provide a description of children's mental health and associated factors during the COVID-19 school closure in France. Methods We conducted a cross-sectional analysis in the SAPRIS study during the COVID-19 pandemic in France, re...

Objective To contain the COVID-19 epidemic preventive measures including social distancing, economic shutdown, and school closures were introduced, carrying risk of mental health burden in adults and children. Although the knowledge base regarding children's response to trauma and adverse events has broadened, descriptions of their mental health du...

Background Our main objective was to study the early social dynamics of the COVID-19 epidemic in France, taking into account gender, class, and ethnicity inequalities in living conditions. Methods A random population-based survey was conducted in France in May 2020, during and post COVID-19 lockdown, in which 77,588 participants aged 18-64 were inc...

Background: While randomized clinical trials have shown the benefit of thrombolysis and endovascular thrombectomy (EVT) in patients with acute ischemic stroke (AIS), we aimed to describe in a real-life study the differences between older (>80 years old) and younger patients treated for AIS. Methods: Thousand patients treated with thrombolysis an...

Background: Several countries have implemented mobile apps in an attempt to trace close contacts of patients with COVID-19 and, in turn, reduce the spread of SARS-CoV-2. However, the effectiveness of this approach depends on the adherence of a large segment of the population. Objective: The aims of this study were to evaluate the acceptability of...

Background: We aimed to estimate the seropositivity to anti-SARS-CoV-2 antibodies in May-June 2020 after the first lockdown period in adults living in three regions in France and to identify the associated risk factors. Methods: Between 4 May 2020 and 23 June 2020, 16 000 participants in a survey on COVID-19 from an existing consortium of three...

Objective To simultaneously investigate the psychometric properties of three recently developed health literacy measurement scales throughout adolescence in the general population. Methods French versions of the Health Literacy for School-Aged Children (HLSAC, unidimensional) scale, the Health Literacy Assessment Scale for Adolescents (HAS-A, mult...

Introduction Dans le but de réduire le nombre de personnes infectées par la COVID-19, plusieurs pays ont mis en œuvre des applications mobiles pour retracer les contacts étroits de la personne infectée par le SARS-CoV-2. Cependant, cette approche nécessite une large adhésion de la population pour être efficace. Cependant, depuis mars, de telles app...

Background: COVID-19 limitation strategies have led to widespread school closures around the world. The present study reports children’s mental health and associated factors during the COVID-19 school closure in France in the spring of 2020. Methods: We conducted a cross-sectional analysis using data from the SAPRIS project set up during the COVID-...

Background The Catquest-9SF questionnaire is a patient reported outcome measure that quantifies the visual benefits from cataract surgery. The purpose of this study was to translate and adapt the Catquest-9SF questionnaire for France, to assess its psychometric properties via Rasch analysis, and to assess its validity when completed using an electr...

Background Our main objectives were to estimate the incidence of illnesses presumably caused by SARS-CoV-2 infection during the lockdown period and to identify the associated risk factors. Methods Participants from 3 adult cohorts in the general population in France were invited to participate in a survey on COVID-19. The main outcome was COVID-19...

BACKGROUND Several countries have implemented mobile apps in an attempt to trace close contacts of patients with COVID-19 and, in turn, reduce the spread of SARS-CoV-2. However, the effectiveness of this approach depends on the adherence of a large segment of the population. OBJECTIVE The aims of this study were to evaluate the acceptability of a...

Background Our main objectives were to estimate the incidence of illnesses presumably caused by SARS-CoV-2 infection during the lockdown period and to identify the associated risk factors. Methods Participants from 3 adult cohorts in the general population in France were invited to participate in a survey on COVID-19. The main outcome was possible...

Aim To estimate the seroprevalence of SARS-CoV-2 infection in May-June 2020 after the lockdown in adults living in three regions in France and to identify the associated risk factors. Methods Participants in a survey on COVID-19 from an existing consortium of three general adult population cohorts living in the Ile-de-France (IDF) or Grand Est (GE)...

Objectives Cultural variations complicate psychiatric care, especially for migrant children. Transcultural psychotherapy (TCP) is an original psychotherapeutic technique developed to address complex situations of resistant mental disorders in the context of migration. This research will aim to assess the efficacy, the acceptability, and describe th...

Introduction La surcharge d’informations liée au cancer (« Cancer Information Overload », CIO) est définie par Jensen en 2014 par le « sentiment de surcharge induit par la quantité de données relatives au cancer dans l’environnement informationnel ». Son intrication avec des phénomènes psycho-cognitifs tels que l’évitement informationnel, le scepti...

Background Many people feel overwhelmed by the increasing amount of cancer-related material available in the information environment. Our aims was to evaluate the psychometric properties of the brief version of the cancer information overload (CIO) scale and to examine the association between CIO and multiple cancer prevention behaviors. Methods A...

Objectives To demonstrate the best psychometric properties of the revised 5-item Cancer Information Overload (CIO) scale over the 10- and 8-item versions, for both English and French native speakers, and to explore the relationships between CIO and several cancer risk management behaviours in a large sample of caregivers, cancer survivors and healt...

Background: Fibrinogen concentrate is widely used in traumatic hemorrhagic shock despite weak evidence in the literature. The aim of the study was to evaluate the effect of fibrinogen concentrate administration within the first 6 hours on 24-hour all-cause mortality in traumatic hemorrhagic shock using a causal inference approach. Methods: Obser...

Context; The left ventricular filling pressure (LVFP) is correlated to right atrial pressure (RAP) in heart failure. We compared diagnostic value of the inferior vena cava (IVC) measurements to the one of the 2016 echocardiographic recommendations to estimate LVFP in patients with suspected heart failure with preserved ejection fraction (HFpEF). M...

Context Echocardiography is an essential tool for evaluation of left ventricular filling pressure (LVFP). We aimed to assess the usefulness of inferior vena cava (IVC) measurement and the 2016 ESC recommendations in patients with suspected heart failure with preserved ejection fraction (HFpEF). Methods Invasive hemodynamics and echocardiographic m...

Background While patient-centered care is recommended as a key dimension for quality improvement, in case of serious illness, patients may have different expectations regarding information and participation in medical decision-making. In oncology, anticipation of disease worsening remains difficult, especially when patient’s preferences towards pro...

Aims To evaluate the level of N-terminal pro brain natriuretic peptide and brain natriuretic peptide (NTproBNP and BNP) for acute heart failure (AHF) diagnosis in patients aged 75 or older. Background In a previous smaller study of very old patients with acute dyspnoea, despite being independently associated with the cardiac aetiology, BNP level w...

Background Transporting a severely injured patient directly to a trauma center (TC) is consensually considered optimal. Nevertheless, disagreement persists regarding the association between secondary transfer status and outcome. The aim of the study was to compare adjusted mortality between road traffic trauma patients directly or secondarily trans...

Introduction Treatment credibility and patient expectancy of improvement have been increasingly considered in clinical research. Objectives The objective of this study was to carry out the cross-cultural validation of a French-language version of the credibility/expectancy questionnaire (CEQ), to further document the psychometric properties of the...