Alexandra M. Fenton

Oregon State University | OSU · College of Veterinary Medicine

Rationale: Prospective cohort studies question the value of HDL-C for stroke risk prediction. Objective: Investigate the relationship between long-term functional recovery and HDL proteome and function. Methods and Results: Changes in HDL protein composition and function (cholesterol efflux capacity, or CEC) in patients after acute ischemic stroke...

Rationale Elevated serum lipoprotein(a) [Lp(a)] levels are associated with increased cardiovascular disease risk. ABCA1-mediated cholesterol efflux from macrophages is believed to be an anti-atherogenic process. We recently identified plasminogen as a driver of ABCA1-mediated cholesterol efflux and showed that its action is inhibited by purified hu...

In a GM-CSF driven myeloid cell deficient mouse model (Csf2−/−) that has preserved insulin sensitivity despite increased adiposity, we used unbiased three-dimensional integration of proteome profiles, metabolic profiles, and gene regulatory networks to understand adipose tissue proteome-wide changes and their metabolic implications. Multi-dimension...

Background: Prospective cohort studies and meta-analyses examining the relationship between HDL-cholesterol (C) and stroke risk are discordant and question the value of HDL-C as a marker for stroke risk prediction. Changes in HDL-C protein composition and function after acute ischemic stroke, and their relationship to stroke recovery have not been...

Background: Plasminogen, is a potent acceptor of cholesterol by the ABCA1 transporter in peripheral cells, and this function is inhibited by lipoprotein (a) [Lp(a)]. Patients with high Lp(a) have increased cardiovascular disease risk, but the mechanism for this effect is not known. The interplay of plasminogen and Lp(a) in contributing to the total...

Background: Prospective cohort studies and meta-analyses examining the relationship between HDL-cholesterol (C) and stroke are discordant and question the value of HDL-C as a marker for stroke risk prediction. Other properties of HDL-C such as cholesterol efflux capacity (CEC) and proteome, are less studied. Methods: We investigated the changes in...

The lack of high-throughput methods to analyze the adipose tissue protein composition limits our understanding of the protein networks responsible for age and diet related metabolic response. We have developed an approach using multiple-dimension liquid chromatography tandem mass spectrometry and extended multiplexing (24 biological samples) with T...