Alexandra Dimitri

• New York University Abu Dhabi

Background & Aim: Medication errors are a significant concern in healthcare, with effective management largely dependent on understanding its causes and reporting practices. This study aims to explore the experiences of Jordanian nurses in relation to medication error occurrence and reporting within the Jordanian context and the factors that may in...

Background Quantitative studies have provided valuable statistical insights into Health-Related Quality of Life (HRQoL) among patients with Heart Failure (HF), yet they often lack the depth to fully capture the nuanced, subjective experiences of living with HF particularly in the specific context of Jordan. This study explores the personal narrativ...

BACKGROUND: Many studies described Health-Related Quality of Life among patients with Heart Failure objectively and statistically using quantitative designs in developed and developing countries. Despite the significance of these studies, some aspects remained unclear and not well understood because Health-Related Quality of Life is subjective in n...

Background: Nursing education that moved online during the COVID19 pandemic was a technical success. However, nurses may have suffered increased anxiety in the months following the initial rollout of the courses. Faculty that want to best prepare nurses for the clinical setting could prepare nurses for the increased anxiety that accompanies an onli...

IntroductionDNA RepairTranscription Elongation and DNA DamageRNA Polymerases: A Brief OverviewRNA Polymerase Elongation Past DNA DamageConclusions AcknowledgementsReferences

O6-Methylguanine (O6-meG) is a major mutagenic, carcinogenic and cytotoxic DNA adduct produced by various endogenous and exogenous methylating agents. We report the results of transcription past a site-specifically modified O6-meG DNA template by bacteriophage T7 RNA polymerase and human RNA polymerase II. These data show that O6-meG partially bloc...

Damage in transcribed DNA presents a challenge to the cell because it can partially or completely block the progression of an RNA polymerase, interfering with transcription and compromising gene expression. While blockage of RNA polymerase progression is thought to trigger the recruitment of transcription-coupled DNA repair (TCR), bypass of the les...

The DNA lesion 1,N(2)-ethenoguanine (1,N(2)-epsilon G) is formed endogenously as a by-product of lipid peroxidation or by reaction with epoxides that result from the metabolism of the industrial pollutant vinyl chloride, a known human carcinogen. DNA replication past 1,N(2)-epsilon G and site-specific mutagenesis studies on mammalian cells have est...

DNA damage located within a gene's transcription unit can cause RNA polymerase to stall at the modified site, resulting in a truncated transcript, or progress past, producing full-length RNA. However, it is not immediately apparent why some lesions pose strong barriers to elongation while others do not. Studies using site-specifically damaged DNA t...