About
26
Publications
8,019
Reads
How we measure 'reads'
A 'read' is counted each time someone views a publication summary (such as the title, abstract, and list of authors), clicks on a figure, or views or downloads the full-text. Learn more
829
Citations
Introduction
Skills and Expertise
Current institution
Publications
Publications (26)
Background: Rheumatoid arthritis is a chronic autoimmune disease that leads to severe disability and requires improved therapeutic strategies to optimize anti-inflammatory treatment. This study aimed to address this challenge by developing and characterizing an extended-release polymer matrix tablet containing ketoprofen and a ketoprofen–β-cyclodex...
Background: Diabetes is a growing global health crisis that requires effective therapeutic strategies to optimize treatment outcomes. This study aims to address this challenge by developing and characterizing extended-release polymeric matrix tablets containing metformin hydrochloride (M-HCl), a first-line treatment for type 2 diabetes, and honokio...
Background: This study explored the potential of MCM-48 mesoporous silica matrices as a drug delivery system for metformin hydrochloride, aimed at improving the therapeutic management of type 2 diabetes mellitus. The objectives included the synthesis and characterization of MCM-48, assessment of its drug loading capacity, analysis of drug release p...
Enrofloxacin (ENR), a member of the fluoroquinolone class of antibiotics, is widely used in veterinary medicine to treat bacterial infections. Like many antibiotics, ENR has limited water solubility and low bioavailability. To address these challenges, drug formulations using solid dispersions, nanosuspensions, surfactants, cocrystal/salt formation...
For quantitative determination of honokiol (HNK) and metformin hydrochloride (M-HCl) by HPLC from formulations and from dissolution studies, a QbD approach using three factors - three levels design was implemented to optimize the chromatographic conditions. To study the impact of each variable on the peak area of both compounds and retention time o...
The cosmetic industry is not a recent phenomenon, but a long-standing practice dating back hundreds of years. Both women and men used cosmetics not only to enhance physical appearance, but also to convey social and cultural meanings. Many of the products used were based on copper minerals, copper oxide, charcoal obtained by burning almonds, ash, po...
Capsules as a pharmaceutical dosage form have evolved
through the years in many ways, from the development
of capsule content for various modified release models,
to innovations for new capsule shells, as an alternative
to conventional gelatin shells. Hard capsules offer a
wide range of alternative gelatin substituents for shell
formulation, given...
The study aim was to develop and validate a high-performance liquid chromatography–electrospray ionization mass spectrometry (HPLC-ESI-MS) method to simultaneously determine glibenclamide (Gli) and silymarin (Sil) released from chitosan (CS) microparticles in aqueous solutions. The CS microparticles were synthesized using an ionic gelation method,...
The current studies entail quality by design (QbD)-enabled development of a simple, rapid, precise, accurate, and cost-effective high-performance liquid chromatographic method for estimation of metformin hydrochloride (M-HCl). Design of experiments (DoE) was applied for multivariate optimization of the experimental conditions of the HPLC method. Ri...
Onychosis therapy is an ongoing challenge considering the diversity of nail pathology and the barrier function of the nail plate. Among the nail diseases, we identify the primary onychodystrophies, caused by tics or mental disorders, as well as severe onychoses, caused by bacterial and/or fungal infections, manifested by the degradation of the matr...
Endothelial dysfunction (impaired vasodi-lation, prothrombotic, proinflammatory and prooxi-dant states) is involved in the development of cardiovascular diseases (atherosclerosis, hyperten-sion, heart failure, stroke) and vascular complications of diabetes mellitus. Reduced production of endothelium-derived relaxing factors, increased release of en...
The Publisher regrets that a part of the abstract not missing in the published article. Below is the complete abstract:
Abstract
Ethnopharmacological relevance: Crataegus leaves, flowers and fruits have been traditionally used to improve blood circulation, numerous preclinical and clinical studies supporting the cardiovascular benefits of Crataeg...
Featured Application
This article presents the development and characterization of new chitosan based polymeric systems containing glibenclamide and lipoic acid for diabetes mellitus therapy. The systems were designed as multi-target systems, aiming for optimal glycemic control, as well as the reactive oxygen species generated by hyperglycemia.
Ab...
Oligomeric proanthocyanidins are among the most widely distributed polyphenols in the plant kingdom, being endowed with antioxidant, anti-inflammatory, antimicrobial, immunomodulatory, antitumor and cardioprotective activities. Since oligomeric proanthocyanidins are found in limited amounts in plants and plant-derived products, there is a great nee...
Type 2 non-insulin-dependent diabetes mellitus (T2DM), the most common form of diabetes that affects more than 90% of diabetic patients, is characterized by insulin r e-sistance, β-pancreatic cells dysfunction, and increased hepatic glucose synthesis. The aim of the present paper was to review data on the efficacy of conventional oral dosage forms...
The purposes of the study were the comparison between the levels of different polyphenol groups in Crataegus pentagyna (CP) leaf and Viburnum opulus (VO) fruit extracts, the assessment of their 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging activity and the in vitro determination of their permeability parameters. CP extract had higher tota...
The present study aimed to characterize the phenolic extracts obtained from fruits of Pimpinella anisum L., Carum carvi L. and Coriandrum sativum L. (Apiaceae), and to assess their antifungal activity against main etiological agents involved in onychomycosis and other dermatomycoses (Trichophyton rubrum, T. mentagrophytes, Microsporum canis, M. gyp...
Ethnopharmacological relevance:
Crataegus leaves, flowers and fruits have been traditionally used to improve blood circulation, numerous preclinical and clinical studies supporting the cardiovascular benefits of Crataegus preparations. In this respect, there is very limited data on Crataegus pentagyna; in addition, the chemical profile of this spe...
A polyphenol-rich diet protects against chronic pathologies by modulating numerous physiological processes, such as cellular redox potential, enzymatic activity, cell proliferation and signaling transduction pathways. However, polyphenols have a low oral bioavailability mainly due to an extensive biotransformation mediated by phase I and phase II r...
The present study investigated the effects of Cornus mas, Sorbus aucuparia and Viburnum opulus fruit extracts on arginase activity and arterial vasodilation. V. opulus fruit extract exerted the highest vasorelaxant activity in phenylephrine precontracted rat aortic rings (EC50 = 6.31 ± 1.61 μg/mL) and a significant inhibition of arginase (IC50 = 71...
The technological achievements of the past decades have allowed the development of the pharmaceutical form of tablet both in terms of formulation and preparation technologies, and in terms of quality parameter evaluation. The aim of our article is to continue to analyze the development of this pharmaceutical dosage form by describing the methods fo...
Caffeine is a drug substance primarily known in the form of refreshing and energizing drinks such as tea, coffee, hot chocolate etc. Although the origin of using coffee beans ‘toners’ is lost in the mists of time, scientific data on this substance, classified as cortical stimulant, are relatively recent and begin in 1820 when it was isolated from c...
Caffeine is a drug substance primarily known in the form of refreshing and energizing drinks such as tea, coffee, hot chocolate etc. Although the origin of using coffee beans ‘toners’ is lost in the mists of time, scientific data on this substance, classified as cortical stimulant, are relatively recent and begin in 1820 when it was isolated from c...
Nowadays, European Pharmacopoeia defines tablets
as solid dosage forms containing one or more active
substances obtained by compressing a volume of powder
or by extrusion, moulding or lyophilization techniques.
This pharmaceutical form has experienced a spectacular
evolution over the years. The first patents for some
tablet formulations were regist...
Wax represents an important group of ingredients used for the implementation of cosmetic and decorative products. From a chemical point of view, waxes are complex mixtures of hydrocarbons and fatty acids combined with esters. They have a long-lasting consistency and are highly resistant to moisture, oxidation and microbial attack. The paper aims to...
Gram-negative bacteria cause infections that are difficult to treat due to the emergence of multidrug resistance. This review summarizes the current status of the studies investigating the capacity of essential oils and their components to modulate antibiotic activity against Gram-negative bacteria. Synergistic interactions are particularly discuss...
